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INSPIRE SIGNED

INfraStructure in Proton International REsearch

Total Cost €

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EC-Contrib. €

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Partnership

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Project "INSPIRE" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 4˙999˙867 €
 EC max contribution 4˙999˙867 € (100%)
 Programme 1. H2020-EU.1.4.1.2. (Integrating and opening existing national and regional  research infrastructures of European interest)
 Code Call H2020-INFRAIA-2017-1-two-stage
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 1˙017˙344.00
2    PAUL SCHERRER INSTITUT CH (VILLIGEN PSI) participant 348˙798.00
3    AARHUS UNIVERSITET DK (AARHUS C) participant 345˙637.00
4    KOMMUNALFORBUNDET AVANCERAD STRALBEHANDLING SE (UPPSALA) participant 338˙637.00
5    INSTITUT CURIE FR (PARIS) participant 333˙632.00
6    GSI HELMHOLTZZENTRUM FUER SCHWERIONENFORSCHUNG GMBH DE (DARMSTADT) participant 308˙250.00
7    TECHNISCHE UNIVERSITAET DRESDEN DE (DRESDEN) participant 294˙516.00
8    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) participant 261˙625.00
9    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) participant 260˙202.00
10    USTAV JADERNE FYZIKY AV CR CZ (REZ - PRAHA) participant 250˙450.00
11    THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS, POLISH ACADEMY OF SCIENCES PL (KRAKOW) participant 221˙899.00
12    ION BEAM APPLICATIONS SA BE (OTTIGNIES LOUVAIN LA NEUVE) participant 206˙497.00
13    VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH DE (TROISDORF) participant 204˙071.00
14    INTERNET-SIMULATION EVALUATION ENVISION SRL IT (TORINO) participant 201˙125.00
15    UNIVERSITE DE NAMUR ASBL BE (NAMUR) participant 196˙870.00
16    LIETUVOS SVEIKATOS MOKSLU UNIVERSITETAS LT (KAUNAS) participant 152˙123.00
17    THE CHRISTIE NHS FOUNDATION TRUST UK (MANCHESTER) participant 58˙185.00
18    ISTITUTO NAZIONALE DI FISICA NUCLEARE IT (FRASCATI) participant 0.00

Map

 Project objective

Proton beam therapy (PBT) is a radical new type of advanced radiotherapy, capable of delivering and conforming a targeted dose of radiation to the tumour while causing minimal damage to the surrounding healthy tissue. In the past 5 years there has been a huge investment in high energy PBT across Europe and eleven member states now either have PBT in operation or are developing this capability. In addition, the two largest manufactures of PBT equipment have based their manufacturing in Europe. This integrating activity INSPIRE, aims to link these clinical PBT centres in eleven different countries together with two associated centres in USA. It also brings in two of the worlds largest manufacturers of PBT equipment and an SME. The trans-national access in INSPIRE will provide European researchers with access to “state of the art” research capabilities employing proton beams at clinical energies. INSPIRE represents an integrating activity across Europe in a multi-disciplinary field that is growing exponentially. Through its Networking, Transnational Access and Joint Research Activities, INSPIRE seeks to provide the “state of the art” capabilities that are needed to address the key challenges in this rapidly developing field. INSPIRE has at its heart the principles of responsible research and innovation and will communicate its research and give access to its databases and software through an Open Access Gateway. INSPIRE will contain a pipeline of innovation through its Innovation Gateway, to accelerate research for patient and commercial benefit. INSPIRE will provide its researchers with an unrivalled research and training and opportunities to “discipline hop” into the industrial, clinical or industrial environment. INSPIRE integrates activities across Europe in this rapidly growing area and offers European researchers unrivalled access to state of the art research capabilities in an area where there has already been significant government investment.

 Deliverables

List of deliverables.
User selection Panel appointed Other 2020-03-23 17:36:32
Access Gateway designed and launched Websites, patent fillings, videos etc. 2020-03-23 17:36:32
Open Nights programme commenced Other 2020-03-23 17:36:32
TNA providers have QA documentation in place Documents, reports 2020-03-23 17:36:32
Incorporation of PBT indications into Malthus decision trees Demonstrators, pilots, prototypes 2020-03-23 17:36:32
Definition of key parameters for NTCP based patient selection and tumour sites Documents, reports 2020-03-23 17:36:32

Take a look to the deliverables list in detail:  detailed list of INSPIRE deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 M. Tambas, H.P. van der Laan, A.V.D. Hoek, H.P. Bijl, M. Dieters, D. Scandurra, S. Both, R. Steenbakkers, J.A. Langendijk
Preselection Tool for the Model-Based Selection of Head and Neck Cancer Patients for Proton Therapy
published pages: E384, ISSN: 0360-3016, DOI: 10.1016/j.ijrobp.2019.06.1647
International Journal of Radiation Oncology*Biology*Physics 105/1 2020-03-23
2019 M. Tambas, H.P. Van der Laan, J.G.M. Van den Hoek, H.P. Bijl, M. Dieters, R.G.J. Kierkels, D. Scandurra, S. Both, R.J.H.M. Steenbakkers, J.A. Langendijk
OC-0563 First experience with the model-based selection of head and neck cancer patients for proton therapy
published pages: S293-S294, ISSN: 0167-8140, DOI: 10.1016/s0167-8140(19)30983-1
Radiotherapy and Oncology 133 2020-03-23
2019 N. T. Henthorn, J. W. Warmenhoven, M. Sotiropoulos, A. H. Aitkenhead, E. A. K. Smith, S. P. Ingram, N. F. Kirkby, A. L. Chadwick, N. G. Burnet, R. I. Mackay, K. J. Kirkby, M. J. Merchant
Clinically relevant nanodosimetric simulation of DNA damage complexity from photons and protons
published pages: 6845-6858, ISSN: 2046-2069, DOI: 10.1039/c8ra10168j
RSC Advances 9/12 2020-03-23
2019 J. Schuemann, A. L. McNamara, J. W. Warmenhoven, N. T. Henthorn, K. J. Kirkby, M. J. Merchant, S. Ingram, H. Paganetti, K. D. Held, J. Ramos-Mendez, B. Faddegon, J. Perl, D. T. Goodhead, I. Plante, H. Rabus, H. Nettelbeck, W. Friedland, P. Kundrát, A. Ottolenghi, G. Baiocco, S. Barbieri, M. Dingfelder, S. Incerti, C. Villagrasa, M. Bueno, M. A. Bernal, S. Guatelli, D. Sakata, J. M. C. Brown, Z. F
A New Standard DNA Damage (SDD) Data Format
published pages: 76, ISSN: 0033-7587, DOI: 10.1667/rr15209.1
Radiation Research 191/1 2020-03-23
2018 Steffen Nielsen, Niels Bassler, Leszek Grzanka, Jan Swakon, Pawel Olko, Christian Nicolaj Andreassen, Jan Alsner, Brita Singers Sørensen
Optimal reference genes for normalization of qPCR gene expression data from proton and photon irradiated dermal fibroblasts
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-30946-0
Scientific Reports 8/1 2020-03-23
2018 Anna Michaelidesová
Cellular response to proton radiation.
published pages: , ISSN: , DOI:
2020-03-23
2019 L. De Marzi, A. Da Fonseca, C. Moignier, A. Patriarca, F. Goudjil, A. Mazal, I. Buvat, J. Hérault
Experimental characterisation of a proton kernel model for pencil beam scanning techniques
published pages: 195-203, ISSN: 1120-1797, DOI: 10.1016/j.ejmp.2019.07.013
Physica Medica 64 2020-03-23
2019 Walter Tinganelli, Timna Hitrec, Fabrizio Romani, Palma Simoniello, Fabio Squarcio, Agnese Stanzani, Emiliana Piscitiello, Valentina Marchesano, Marco Luppi, Maximiliano Sioli, Alexander Helm, Gaetano Compagnone, Alessio Morganti, Roberto Amici, Matteo Negrini, Antonio Zoccoli, Marco Durante, Matteo Cerri
Hibernation and Radioprotection: Gene Expression in the Liver and Testicle of Rats Irradiated under Synthetic Torpor
published pages: 352, ISSN: 1422-0067, DOI: 10.3390/ijms20020352
International Journal of Molecular Sciences 20/2 2020-03-23
2019 Marco Durante, Silvia Formenti
Harnessing radiation to improve immunotherapy: better with particles?
published pages: 20190224, ISSN: 0007-1285, DOI: 10.1259/bjr.20190224
The British Journal of Radiology 2020-03-23
2019 Pierre Lansonneur, Vincent Favaudon, Sophie Heinrich, Charles Fouillade, Pierre Verrelle, Ludovic De Marzi
Simulation and experimental validation of a prototype electron beam linear accelerator for preclinical studies
published pages: 50-57, ISSN: 1120-1797, DOI: 10.1016/j.ejmp.2019.03.016
Physica Medica 60 2020-03-23

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