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ProstOmics SIGNED

'Tissue is the issue': a multi-omics approach to improve prostate cancer diagnosis

Total Cost €

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EC-Contrib. €

0

Partnership

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 ProstOmics project word cloud

Explore the words cloud of the ProstOmics project. It provides you a very rough idea of what is the project "ProstOmics" about.

human    edge    data    omics    succinate    transcriptomics    protocol    analyze    prognostic    spectroscopic    suggested    prostate    tissue    prostatectomy    tools    snap    health    care    vivo    biological    metabolic    slices    100    recurrence    speed    guided    mr    stage    view    burden    follow    shot    made    heterogeneity    pca    biobanks    cell    maps    molecular    clinical    reveal    polyamines    diagnostic    citrate    markers    biopsies    genomics    disciplinary    life    metabolite    explore    fresh    connection    metabolomics    patients    cohorts    histopathology    immune    diagnosis    techniques    samples    community    strategies    personalize    treatment    quality    innovative    performed    correct    maldi    inter    imaging    economy    cutting    limitations    clinic    tissuetyper    inspire    fundamentally    spatial       frozen    biomarkers    technologies    zinc    scientific    overtreatment    mechanisms    platforms    cancer    tissues    rapiflex    matched    1000    resolution   

Project "ProstOmics" data sheet

The following table provides information about the project.

Coordinator
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU 

Organization address
address: HOGSKOLERINGEN 1
city: TRONDHEIM
postcode: 7491
website: www.ntnu.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NO (TRONDHEIM) coordinator 1˙500˙000.00

Map

 Project objective

Overtreatment in prostate cancer (PCa) is a burden for health care economy and for quality of life. Correct diagnosis of early stage PCa is challenging given the limitations of the currently available clinical tools and the biological understanding of PCa. In this inter-disciplinary project, I propose an innovative approach enabling several cutting-edge ‘omics’ technologies (spatial metabolomics, genomics, transcriptomics) as well as histopathology to be performed on the same tissue sample. My goal is to reveal the molecular mechanisms of novel, but also promising metabolite biomarkers (citrate, polyamines, succinate and zinc) and their connection to recurrence, tissue heterogeneity and immune responses in complex human tissues. Such markers can personalize PCa diagnosis, open up new treatment strategies and fundamentally change the view of how to analyze tissue samples in the future. Furthermore, I want to demonstrate that citrate and polyamines are reliable prognostic markers that can be analyzed both in tissue and in patients in vivo by MR spectroscopic imaging. This work is made possible by the availability of high-quality fresh frozen tissue biobanks of prostatectomy biopsies with 5-10 years of follow-up data (N=1000)/slices (N=1000) and targeted in vivo snap-shot biopsies from clinical MR guided procedures (N=100). Among other techniques, I will implement high speed MALDI imaging (RapifleX MALDI TissueTyper) to the multi-omics protocol to study the spatial distribution and provide high resolution metabolic maps for each cell type, and which can be matched to both histopathology and MR Imaging. Multi-disciplinary platforms on large cohorts are needed to explore the clinical potential of the suggested molecular mechanisms. I expect that this ambitious proposal will address the diagnostic challenges of PCa and will further inspire the clinic and scientific community to follow the multi-omics approach within diagnosis and cancer research.

 Publications

year authors and title journal last update
List of publications.
2018 Kirsten M. Selnæs, Brage Krüger-Stokke, Mattijs Elschot, Frode Willoch, Øystein Størkersen, Elise Sandsmark, Siver A. Moestue, May-Britt Tessem, Dag Halvorsen, Eirik Kjøbli, Anders Angelsen, Sverre Langørgen, Helena Bertilsson, Tone F. Bathen
18F-Fluciclovine PET/MRI for preoperative lymph node staging in high-risk prostate cancer patients
published pages: 3151-3159, ISSN: 0938-7994, DOI: 10.1007/s00330-017-5213-1
European Radiology 28/8 2019-10-03
2018 Guro F. Giskeødegård, Torfinn S. Madssen, Leslie R. Euceda, May-Britt Tessem, Siver A. Moestue, Tone F. Bathen
NMR-based metabolomics of biofluids in cancer
published pages: e3927, ISSN: 0952-3480, DOI: 10.1002/nbm.3927
NMR in Biomedicine 2019-10-03
2018 Maria K. Andersen, Kjersti Rise, Guro F. Giskeødegård, Elin Richardsen, Helena Bertilsson, Øystein Størkersen, Tone F. Bathen, Morten Rye, May-Britt Tessem
Integrative metabolic and transcriptomic profiling of prostate cancer tissue containing reactive stroma
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-32549-1
Scientific Reports 8/1 2019-10-03
2019 Guro F. Giskeødegård, Trygve Andreassen, Helena Bertilsson, May-Britt Tessem, Tone F. Bathen
The effect of sampling procedures and day-to-day variations in metabolomics studies of biofluids
published pages: 93-102, ISSN: 0003-2670, DOI: 10.1016/j.aca.2019.07.026
Analytica Chimica Acta 1081 2019-10-03

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The information about "PROSTOMICS" are provided by the European Opendata Portal: CORDIS opendata.

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