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ParallelMemories

Cooperative and competitive parallel memory units for choice behaviors

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ParallelMemories project word cloud

Explore the words cloud of the ParallelMemories project. It provides you a very rough idea of what is the project "ParallelMemories" about.

flexibility    punishment    extensive    mb    decay    manipulating    memories    cooperatively    store    16    individual    mushroom    storage    memory    dynamics    associations    learning    draw    insect    cells    optogenetic    retrieve    guide    write    stimuli    sparse    circuit    experiments    manipulate    drivers    activation    cues    dopaminergic    allowed    capacity    rate    kenyon    probe    anatomical    shown    parallel    body    activate    nearly    units    forms    competitively    output    center    identity    flies    drosophila    action    downstream    form    understand    60    event    types    intersectional    cell    underlying    anatomically    integrate    genetic    axonal    model    update    fibers    associative    imaging    biological    molecules    functions    differences    matched    predictive    molecular    selectively    latest    compartmental    mechanisms    neurons    reward    map    diverse    plasticity    synaptic    dopamine    rules    sensory    independently    brains   

Project "ParallelMemories" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙500˙000.00

Map

 Project objective

This proposal seeks to understand the molecular and circuit mechanisms used to store information in parallel memory units, and how these memories are integrated to guide action selection. We will use the Drosophila mushroom body (MB), a key center for associative learning in insect brains, as a model system. We recently generated intersectional genetic drivers that allowed us to draw a comprehensive anatomical map and selectively manipulate nearly all of the MB’s ~60 cell types. Sparse activity in the 2,000 Kenyon cells of the MB represents the identity of sensory stimuli. Along the parallel axonal fibers of Kenyon cells, we have shown that dopaminergic neurons and MB output neurons form 16 matched compartmental units. These anatomically defined units are also units of associative learning: reward and punishment activate distinct subsets of dopaminergic neurons. Our latest optogenetic activation experiments demonstrate that individual dopaminergic neurons independently write and update memories in each unit with cell-type-specific rules. We find extensive differences in the rate of memory formation, decay dynamics, storage capacity and flexibility to learn new associations across different units. Thus individual memory units within the mushroom body store different information about the same learning event. Together, these memories cooperatively or competitively represent the predictive value of sensory cues. We will now identify molecules and cell biological features that enable dopamine neurons to produce diverse forms of synaptic plasticity underlying distinct learning rules in different memory units. We will anatomically identify downstream neurons of the mushroom body output neurons that integrate information from parallel memory units, and make genetic drivers for them. Then, we will probe functions of these downstream neurons by imaging or manipulating their activity while flies retrieve and integrate memories for action selection.

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