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ParallelMemories

Cooperative and competitive parallel memory units for choice behaviors

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ParallelMemories project word cloud

Explore the words cloud of the ParallelMemories project. It provides you a very rough idea of what is the project "ParallelMemories" about.

allowed    retrieve    mushroom    dopaminergic    nearly    independently    capacity    write    cues    storage    downstream    types    parallel    probe    drosophila    kenyon    drivers    rate    matched    insect    model    manipulate    16    predictive    learning    memories    molecular    draw    center    stimuli    reward    memory    anatomically    event    circuit    decay    60    compartmental    forms    brains    output    neurons    fibers    activate    mechanisms    identity    activation    competitively    store    integrate    associative    biological    units    latest    associations    functions    mb    flexibility    sparse    extensive    update    punishment    anatomical    sensory    imaging    body    rules    guide    underlying    understand    synaptic    optogenetic    axonal    dopamine    selectively    cell    intersectional    shown    experiments    individual    manipulating    cells    molecules    form    action    plasticity    map    diverse    flies    dynamics    genetic    differences    cooperatively   

Project "ParallelMemories" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙500˙000.00

Map

 Project objective

This proposal seeks to understand the molecular and circuit mechanisms used to store information in parallel memory units, and how these memories are integrated to guide action selection. We will use the Drosophila mushroom body (MB), a key center for associative learning in insect brains, as a model system. We recently generated intersectional genetic drivers that allowed us to draw a comprehensive anatomical map and selectively manipulate nearly all of the MB’s ~60 cell types. Sparse activity in the 2,000 Kenyon cells of the MB represents the identity of sensory stimuli. Along the parallel axonal fibers of Kenyon cells, we have shown that dopaminergic neurons and MB output neurons form 16 matched compartmental units. These anatomically defined units are also units of associative learning: reward and punishment activate distinct subsets of dopaminergic neurons. Our latest optogenetic activation experiments demonstrate that individual dopaminergic neurons independently write and update memories in each unit with cell-type-specific rules. We find extensive differences in the rate of memory formation, decay dynamics, storage capacity and flexibility to learn new associations across different units. Thus individual memory units within the mushroom body store different information about the same learning event. Together, these memories cooperatively or competitively represent the predictive value of sensory cues. We will now identify molecules and cell biological features that enable dopamine neurons to produce diverse forms of synaptic plasticity underlying distinct learning rules in different memory units. We will anatomically identify downstream neurons of the mushroom body output neurons that integrate information from parallel memory units, and make genetic drivers for them. Then, we will probe functions of these downstream neurons by imaging or manipulating their activity while flies retrieve and integrate memories for action selection.

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