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ParallelMemories

Cooperative and competitive parallel memory units for choice behaviors

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ParallelMemories project word cloud

Explore the words cloud of the ParallelMemories project. It provides you a very rough idea of what is the project "ParallelMemories" about.

activation    punishment    mushroom    center    genetic    manipulate    flies    associations    brains    forms    form    cell    matched    neurons    capacity    molecular    molecules    individual    model    anatomically    nearly    axonal    body    memory    draw    manipulating    sparse    identity    action    insect    60    output    dopaminergic    circuit    guide    flexibility    storage    reward    underlying    update    predictive    allowed    drosophila    mechanisms    synaptic    parallel    imaging    sensory    extensive    rate    dynamics    compartmental    mb    event    understand    experiments    downstream    probe    functions    stimuli    latest    cooperatively    units    dopamine    optogenetic    drivers    memories    activate    anatomical    write    fibers    rules    independently    retrieve    diverse    types    16    cues    intersectional    competitively    map    decay    shown    kenyon    learning    store    selectively    cells    differences    biological    integrate    plasticity    associative   

Project "ParallelMemories" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙500˙000.00

Map

 Project objective

This proposal seeks to understand the molecular and circuit mechanisms used to store information in parallel memory units, and how these memories are integrated to guide action selection. We will use the Drosophila mushroom body (MB), a key center for associative learning in insect brains, as a model system. We recently generated intersectional genetic drivers that allowed us to draw a comprehensive anatomical map and selectively manipulate nearly all of the MB’s ~60 cell types. Sparse activity in the 2,000 Kenyon cells of the MB represents the identity of sensory stimuli. Along the parallel axonal fibers of Kenyon cells, we have shown that dopaminergic neurons and MB output neurons form 16 matched compartmental units. These anatomically defined units are also units of associative learning: reward and punishment activate distinct subsets of dopaminergic neurons. Our latest optogenetic activation experiments demonstrate that individual dopaminergic neurons independently write and update memories in each unit with cell-type-specific rules. We find extensive differences in the rate of memory formation, decay dynamics, storage capacity and flexibility to learn new associations across different units. Thus individual memory units within the mushroom body store different information about the same learning event. Together, these memories cooperatively or competitively represent the predictive value of sensory cues. We will now identify molecules and cell biological features that enable dopamine neurons to produce diverse forms of synaptic plasticity underlying distinct learning rules in different memory units. We will anatomically identify downstream neurons of the mushroom body output neurons that integrate information from parallel memory units, and make genetic drivers for them. Then, we will probe functions of these downstream neurons by imaging or manipulating their activity while flies retrieve and integrate memories for action selection.

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lastchecktime (2022-08-18 10:31:20) correctly updated