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LSO SIGNED

Liver Spatial Omics

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LSO project word cloud

Explore the words cloud of the LSO project. It provides you a very rough idea of what is the project "LSO" about.

shaped    profiling    genome    uncover    refined    zone    models    proteome    massive    deep    tissues    ex    coordinates    metabolic    surface    redefine    types    spatial    differing    centripetal    lobule    resolution    hepatocytes    broad    homeostasis    performs    health    function    transcriptomics    zonal    heterogeneity    metabolome    hepatocyte    performed    organismal    identical    polarized    phenomenon    perform    microenvironment    epigenome    markers    extended    identities    mammalian    question    mrna    cellular    organs    fact    localizing    cell    discovered    form    inter    resolved    operate    omics    units    fat    tackle    disease    diet    organ    layers    liver    scales    sorting    uniform    biology    mouse    stimuli    opening    hexagonally    vivo    zonated    lobules    fundamental    termed    50    techniques    optimal    single    raises    genes    inputs    tissue    graded    facilitates    methylome    differs    amounts    functions    reporter    transcriptome    convert    input    zonation    diverse    population    flow    repeating    blood    surprisingly    structured    experiments    functionally    avenues    morphogens    content    zones    heterogeneous   

Project "LSO" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙000˙000.00

Map

 Project objective

The mammalian liver is a heterogeneous, yet highly structured organ, which performs diverse functions to maintain organismal homeostasis. Hepatocytes operate in repeating hexagonally shaped units termed lobules that are polarized by centripetal blood flow and morphogens. This polarized microenvironment facilitates optimal function by localizing specific processes to distinct lobule layers, a phenomenon known as ‘liver zonation’. While zonation of some key liver functions has been known for years, using spatially resolved single cell transcriptomics, we recently discovered that about 50% of liver genes are zonated. This surprisingly broad spatial heterogeneity raises a fundamental question - do hepatocytes form a uniform population that differs due to spatially graded inputs or are hepatocytes at different zones in fact distinct cell types? In this proposal we will tackle this question by developing techniques for sorting massive amounts of hepatocytes from defined tissue coordinates at high spatial resolution using zonated surface markers, new zonated reporter mouse models and mRNA content. We will perform a deep and comprehensive profiling of the hepatocyte genome, methylome, epigenome, transcriptome, proteome and metabolome at each zone to characterize liver zonation at all relevant cellular scales. We will also develop an ex-vivo system to functionally characterize the response of hepatocytes from distinct zones to identical input stimuli and the ability of hepatocytes to inter-convert to hepatocytes with differing zonal identities. These experiments will be performed in different metabolic states and along a high fat diet. This project will uncover new features of liver zonation in health and disease and redefine the hepatocyte cell state. Our approach for spatially refined tissue omics can be extended to other structured mammalian organs, thus opening new avenues of research in Systems Biology of mammalian tissues.

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The information about "LSO" are provided by the European Opendata Portal: CORDIS opendata.

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