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LSO SIGNED

Liver Spatial Omics

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LSO project word cloud

Explore the words cloud of the LSO project. It provides you a very rough idea of what is the project "LSO" about.

omics    zones    heterogeneous    uniform    identities    hepatocytes    zonated    genome    function    differs    question    blood    shaped    deep    graded    functionally    lobules    discovered    50    reporter    health    repeating    input    liver    genes    metabolome    transcriptome    mrna    mouse    localizing    mammalian    single    structured    identical    profiling    convert    zone    tissues    raises    biology    organismal    organs    vivo    content    perform    inter    opening    amounts    fact    massive    surprisingly    flow    functions    diet    resolution    models    sorting    resolved    operate    uncover    methylome    polarized    spatial    types    refined    microenvironment    facilitates    disease    proteome    zonal    markers    fundamental    hexagonally    ex    transcriptomics    hepatocyte    organ    form    tissue    layers    techniques    termed    optimal    experiments    heterogeneity    zonation    population    fat    cellular    units    phenomenon    morphogens    avenues    extended    diverse    metabolic    scales    centripetal    tackle    cell    inputs    performed    redefine    broad    surface    differing    homeostasis    lobule    stimuli    epigenome    coordinates    performs   

Project "LSO" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙000˙000.00

Map

 Project objective

The mammalian liver is a heterogeneous, yet highly structured organ, which performs diverse functions to maintain organismal homeostasis. Hepatocytes operate in repeating hexagonally shaped units termed lobules that are polarized by centripetal blood flow and morphogens. This polarized microenvironment facilitates optimal function by localizing specific processes to distinct lobule layers, a phenomenon known as ‘liver zonation’. While zonation of some key liver functions has been known for years, using spatially resolved single cell transcriptomics, we recently discovered that about 50% of liver genes are zonated. This surprisingly broad spatial heterogeneity raises a fundamental question - do hepatocytes form a uniform population that differs due to spatially graded inputs or are hepatocytes at different zones in fact distinct cell types? In this proposal we will tackle this question by developing techniques for sorting massive amounts of hepatocytes from defined tissue coordinates at high spatial resolution using zonated surface markers, new zonated reporter mouse models and mRNA content. We will perform a deep and comprehensive profiling of the hepatocyte genome, methylome, epigenome, transcriptome, proteome and metabolome at each zone to characterize liver zonation at all relevant cellular scales. We will also develop an ex-vivo system to functionally characterize the response of hepatocytes from distinct zones to identical input stimuli and the ability of hepatocytes to inter-convert to hepatocytes with differing zonal identities. These experiments will be performed in different metabolic states and along a high fat diet. This project will uncover new features of liver zonation in health and disease and redefine the hepatocyte cell state. Our approach for spatially refined tissue omics can be extended to other structured mammalian organs, thus opening new avenues of research in Systems Biology of mammalian tissues.

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The information about "LSO" are provided by the European Opendata Portal: CORDIS opendata.

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