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LSO SIGNED

Liver Spatial Omics

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LSO project word cloud

Explore the words cloud of the LSO project. It provides you a very rough idea of what is the project "LSO" about.

content    deep    models    facilitates    organs    inter    blood    health    mouse    mammalian    organ    units    coordinates    ex    differs    hepatocytes    genes    flow    avenues    convert    function    mrna    omics    markers    zones    redefine    graded    tackle    repeating    surface    zone    genome    heterogeneous    fact    refined    resolution    form    lobule    input    massive    transcriptomics    diverse    stimuli    biology    tissues    vivo    zonal    localizing    functionally    uncover    morphogens    metabolic    surprisingly    performed    termed    opening    broad    hepatocyte    zonation    uniform    inputs    reporter    types    identical    differing    raises    lobules    heterogeneity    perform    resolved    optimal    disease    amounts    layers    shaped    profiling    liver    polarized    tissue    spatial    centripetal    microenvironment    fat    metabolome    methylome    experiments    cell    cellular    fundamental    transcriptome    epigenome    identities    structured    scales    population    performs    phenomenon    homeostasis    organismal    50    functions    proteome    question    single    diet    operate    extended    sorting    discovered    hexagonally    techniques    zonated   

Project "LSO" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙000˙000.00

Map

 Project objective

The mammalian liver is a heterogeneous, yet highly structured organ, which performs diverse functions to maintain organismal homeostasis. Hepatocytes operate in repeating hexagonally shaped units termed lobules that are polarized by centripetal blood flow and morphogens. This polarized microenvironment facilitates optimal function by localizing specific processes to distinct lobule layers, a phenomenon known as ‘liver zonation’. While zonation of some key liver functions has been known for years, using spatially resolved single cell transcriptomics, we recently discovered that about 50% of liver genes are zonated. This surprisingly broad spatial heterogeneity raises a fundamental question - do hepatocytes form a uniform population that differs due to spatially graded inputs or are hepatocytes at different zones in fact distinct cell types? In this proposal we will tackle this question by developing techniques for sorting massive amounts of hepatocytes from defined tissue coordinates at high spatial resolution using zonated surface markers, new zonated reporter mouse models and mRNA content. We will perform a deep and comprehensive profiling of the hepatocyte genome, methylome, epigenome, transcriptome, proteome and metabolome at each zone to characterize liver zonation at all relevant cellular scales. We will also develop an ex-vivo system to functionally characterize the response of hepatocytes from distinct zones to identical input stimuli and the ability of hepatocytes to inter-convert to hepatocytes with differing zonal identities. These experiments will be performed in different metabolic states and along a high fat diet. This project will uncover new features of liver zonation in health and disease and redefine the hepatocyte cell state. Our approach for spatially refined tissue omics can be extended to other structured mammalian organs, thus opening new avenues of research in Systems Biology of mammalian tissues.

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The information about "LSO" are provided by the European Opendata Portal: CORDIS opendata.

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