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LSO SIGNED

Liver Spatial Omics

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LSO project word cloud

Explore the words cloud of the LSO project. It provides you a very rough idea of what is the project "LSO" about.

functionally    refined    functions    single    repeating    identities    amounts    deep    uniform    differing    surprisingly    tissues    organs    zonated    localizing    facilitates    hepatocytes    operate    surface    polarized    extended    uncover    spatial    mouse    identical    cellular    diet    heterogeneous    methylome    zones    coordinates    population    lobules    raises    broad    performs    proteome    differs    tackle    form    tissue    content    hepatocyte    techniques    massive    units    cell    omics    genes    resolved    mammalian    biology    types    graded    fundamental    reporter    opening    organ    health    diverse    resolution    morphogens    hexagonally    function    zonal    zone    homeostasis    transcriptomics    question    mrna    inputs    input    convert    shaped    inter    metabolome    blood    fact    sorting    models    avenues    microenvironment    termed    heterogeneity    stimuli    experiments    profiling    genome    redefine    phenomenon    centripetal    zonation    liver    transcriptome    vivo    fat    optimal    layers    organismal    metabolic    flow    disease    ex    perform    markers    50    structured    discovered    performed    scales    lobule    epigenome   

Project "LSO" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙000˙000.00

Map

 Project objective

The mammalian liver is a heterogeneous, yet highly structured organ, which performs diverse functions to maintain organismal homeostasis. Hepatocytes operate in repeating hexagonally shaped units termed lobules that are polarized by centripetal blood flow and morphogens. This polarized microenvironment facilitates optimal function by localizing specific processes to distinct lobule layers, a phenomenon known as ‘liver zonation’. While zonation of some key liver functions has been known for years, using spatially resolved single cell transcriptomics, we recently discovered that about 50% of liver genes are zonated. This surprisingly broad spatial heterogeneity raises a fundamental question - do hepatocytes form a uniform population that differs due to spatially graded inputs or are hepatocytes at different zones in fact distinct cell types? In this proposal we will tackle this question by developing techniques for sorting massive amounts of hepatocytes from defined tissue coordinates at high spatial resolution using zonated surface markers, new zonated reporter mouse models and mRNA content. We will perform a deep and comprehensive profiling of the hepatocyte genome, methylome, epigenome, transcriptome, proteome and metabolome at each zone to characterize liver zonation at all relevant cellular scales. We will also develop an ex-vivo system to functionally characterize the response of hepatocytes from distinct zones to identical input stimuli and the ability of hepatocytes to inter-convert to hepatocytes with differing zonal identities. These experiments will be performed in different metabolic states and along a high fat diet. This project will uncover new features of liver zonation in health and disease and redefine the hepatocyte cell state. Our approach for spatially refined tissue omics can be extended to other structured mammalian organs, thus opening new avenues of research in Systems Biology of mammalian tissues.

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The information about "LSO" are provided by the European Opendata Portal: CORDIS opendata.

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