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LSO SIGNED

Liver Spatial Omics

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LSO project word cloud

Explore the words cloud of the LSO project. It provides you a very rough idea of what is the project "LSO" about.

extended    redefine    heterogeneity    zonal    performed    vivo    organ    diverse    cellular    shaped    optimal    uncover    refined    flow    broad    methylome    transcriptomics    ex    centripetal    blood    homeostasis    differs    resolved    perform    structured    diet    zonation    fundamental    form    deep    zone    single    massive    hepatocytes    reporter    tissue    sorting    stimuli    repeating    omics    hexagonally    disease    units    mammalian    operate    genes    mrna    hepatocyte    techniques    performs    inputs    layers    identical    models    functionally    amounts    mouse    cell    resolution    transcriptome    inter    fat    content    organismal    liver    polarized    uniform    metabolic    avenues    surface    coordinates    types    fact    localizing    biology    population    zonated    facilitates    zones    lobule    proteome    markers    surprisingly    termed    heterogeneous    organs    epigenome    microenvironment    opening    graded    scales    lobules    differing    experiments    input    tissues    metabolome    discovered    genome    tackle    profiling    50    raises    convert    health    identities    function    functions    phenomenon    morphogens    question    spatial   

Project "LSO" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙000˙000.00

Map

 Project objective

The mammalian liver is a heterogeneous, yet highly structured organ, which performs diverse functions to maintain organismal homeostasis. Hepatocytes operate in repeating hexagonally shaped units termed lobules that are polarized by centripetal blood flow and morphogens. This polarized microenvironment facilitates optimal function by localizing specific processes to distinct lobule layers, a phenomenon known as ‘liver zonation’. While zonation of some key liver functions has been known for years, using spatially resolved single cell transcriptomics, we recently discovered that about 50% of liver genes are zonated. This surprisingly broad spatial heterogeneity raises a fundamental question - do hepatocytes form a uniform population that differs due to spatially graded inputs or are hepatocytes at different zones in fact distinct cell types? In this proposal we will tackle this question by developing techniques for sorting massive amounts of hepatocytes from defined tissue coordinates at high spatial resolution using zonated surface markers, new zonated reporter mouse models and mRNA content. We will perform a deep and comprehensive profiling of the hepatocyte genome, methylome, epigenome, transcriptome, proteome and metabolome at each zone to characterize liver zonation at all relevant cellular scales. We will also develop an ex-vivo system to functionally characterize the response of hepatocytes from distinct zones to identical input stimuli and the ability of hepatocytes to inter-convert to hepatocytes with differing zonal identities. These experiments will be performed in different metabolic states and along a high fat diet. This project will uncover new features of liver zonation in health and disease and redefine the hepatocyte cell state. Our approach for spatially refined tissue omics can be extended to other structured mammalian organs, thus opening new avenues of research in Systems Biology of mammalian tissues.

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The information about "LSO" are provided by the European Opendata Portal: CORDIS opendata.

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