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XHaLe SIGNED

Hanover experimental lung research project

Total Cost €

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EC-Contrib. €

0

Partnership

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 XHaLe project word cloud

Explore the words cloud of the XHaLe project. It provides you a very rough idea of what is the project "XHaLe" about.

particulate    ultimately    animal    biology    cell    urgently    barely    signalling    transplantation    nintedanib    lack    interstitial    risk    explanted    wholesale    slows    efficient    rank    mo    difference    immune    causes    myofibroblast    platform    actually    lung    utilize    medicine    healing    workflow    fresh    remodeling    group    human    last    function    progression    showed    nnld    ratio    holds    suppression    limited    30    triggered    promise    hereby    cascades    inflammome    singular    understand    reaction    subduing    techniques    regulators    viability    grafts    prevent    appear    therapeutic    macrophages    24h    pulmonary    translational    ischemia    death    worked    lutx    treatment    specimens    dysfunctional    models    copd    diseases    neoplastic    mos    lungs    modulating    therapy    events    relentless    7d    focusses    multiplier    acted    international    irreversible    surpasses    cure    50    500    injury    obstacles    patented    nnlds    therapeutics    survival    imaging    world    disease    non    orchestrate    matters    tissue    ultima    pharmaceuticals    effector    whereas   

Project "XHaLe" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE HOCHSCHULE HANNOVER 

Organization address
address: Carl-Neuberg-Strasse 1
city: HANNOVER
postcode: 30625
website: www.mh-hannover.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙989˙250 €
 EC max contribution 1˙989˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE HOCHSCHULE HANNOVER DE (HANNOVER) coordinator 1˙989˙250.00

Map

 Project objective

Non-neoplastic lung diseases (NNLD), such as COPD and interstitial lung diseases rank second among the causes of death and NNLD appear as a growing EU wide challenge. They are characterized by irreversible remodeling with a relentless loss of lung function and a 5-year survival of only 30%. This dysfunctional reaction to injury can be triggered by particulate matters with macrophages (MO) as the key regulators. Wholesale therapeutic suppression of the inflammome actually increases the risk of death, whereas targeted therapy of signalling cascades by novel pharmaceuticals, e.g. nintedanib, only slows disease progression. Thus lung transplantation remains the ultima ratio. However, available grafts are limited, treatment costs are high and the 5-year survival barely surpasses 50%. Therefore novel approaches to understand, prevent and ultimately cure NNLDs are urgently needed. Towards this goal my group focusses on both, the main effector cell in NNLD, the myofibroblast, and the inflammome and particularly MOs, as these orchestrate both, lung healing and remodeling. Modulating the pulmonary immune system, rather than subduing it, holds significant promise. To this end, we have to understand the very early events in NNLDs. There are 2 major obstacles for efficient research: i) the lack of adequate animal models and ii) the availability of human specimens. Therefore we established a unique platform for NNLD: we utilize fresh explanted human lungs from Europe’s largest LuTx program and set up a singular 24h/7d workflow, ensuring short ischemia and tissue viability. In the last years, we have worked up over 500 lungs, acted as an international multiplier for pulmonary research, patented new imaging techniques and described novel diseases. Our understanding MO biology in NNLDs showed us the great potential in macrophages. Now we are going to use these macrophages as potential therapeutics. Hereby we will make a difference in translational medicine in Europe and the world.

 Publications

year authors and title journal last update
List of publications.
2018 F. Länger, H. Stark, P. Braubach, M. Ackermann, K. Hussein, K. Teiken, L. Maegel, M. Kuehnel, D. Jonigk
Schädigungsmuster interstitieller Lungenerkrankungen
published pages: 262-271, ISSN: 0172-8113, DOI: 10.1007/s00292-018-0503-1
Der Pathologe 39/S2 2020-02-05
2019 J. Wohlschlaeger, F. Laenger, J. Gottlieb, T. Hager, A. Seidel, D. Jonigk
Lungentransplantation
published pages: 281-291, ISSN: 0172-8113, DOI: 10.1007/s00292-019-0598-z
Der Pathologe 40/3 2020-02-05
2019 Maximilian Ackermann, Helge Stark, Lavinia Neubert, Stephanie Schubert, Paul Borchert, Friedemann Linz, Willi L. Wagner, Wolfram Stiller, Mark Wielpütz, Anne Hoefer, Axel Haverich, Steven J. Mentzer, Harshit R. Shah, Tobias Welte, Mark Kuehnel, Danny Jonigk
Morphomolecular motifs of pulmonary neoangiogenesis in interstitial lung diseases
published pages: 1900933, ISSN: 0903-1936, DOI: 10.1183/13993003.00933-2019
European Respiratory Journal 2020-01-30
2019 Danny Jonigk, Helge Stark, Peter Braubach, Lavinia Neubert, Hoen‐oh Shin, Nicole Izykowski, Tobias Welte, Sabina Janciauskiene, Gregor Warnecke, Axel Haverich, Mark Kuehnel, Florian Laenger
Morphological and molecular motifs of fibrosing pulmonary injury patterns
published pages: 256-271, ISSN: 2056-4538, DOI: 10.1002/cjp2.141
The Journal of Pathology: Clinical Research 5/4 2020-01-30

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