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XHaLe SIGNED

Hanover experimental lung research project

Total Cost €

0

EC-Contrib. €

0

Partnership

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 XHaLe project word cloud

Explore the words cloud of the XHaLe project. It provides you a very rough idea of what is the project "XHaLe" about.

ultima    biology    transplantation    non    limited    last    death    suppression    urgently    immune    showed    irreversible    group    matters    techniques    promise    risk    relentless    human    modulating    nnlds    myofibroblast    whereas    dysfunctional    focusses    treatment    wholesale    reaction    utilize    patented    events    singular    lack    understand    nintedanib    orchestrate    tissue    barely    explanted    particulate    pulmonary    mo    international    world    neoplastic    function    cascades    subduing    appear    healing    surpasses    regulators    fresh    ratio    500    viability    24h    rank    interstitial    ultimately    efficient    remodeling    obstacles    translational    prevent    causes    models    pharmaceuticals    worked    therapeutics    slows    ischemia    50    progression    grafts    platform    actually    copd    inflammome    specimens    disease    hereby    therapeutic    mos    animal    injury    lutx    imaging    holds    cell    lung    therapy    signalling    workflow    nnld    cure    30    effector    macrophages    lungs    diseases    difference    medicine    multiplier    survival    7d    acted    triggered   

Project "XHaLe" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE HOCHSCHULE HANNOVER 

Organization address
address: Carl-Neuberg-Strasse 1
city: HANNOVER
postcode: 30625
website: www.mh-hannover.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙989˙250 €
 EC max contribution 1˙989˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE HOCHSCHULE HANNOVER DE (HANNOVER) coordinator 1˙989˙250.00

Map

 Project objective

Non-neoplastic lung diseases (NNLD), such as COPD and interstitial lung diseases rank second among the causes of death and NNLD appear as a growing EU wide challenge. They are characterized by irreversible remodeling with a relentless loss of lung function and a 5-year survival of only 30%. This dysfunctional reaction to injury can be triggered by particulate matters with macrophages (MO) as the key regulators. Wholesale therapeutic suppression of the inflammome actually increases the risk of death, whereas targeted therapy of signalling cascades by novel pharmaceuticals, e.g. nintedanib, only slows disease progression. Thus lung transplantation remains the ultima ratio. However, available grafts are limited, treatment costs are high and the 5-year survival barely surpasses 50%. Therefore novel approaches to understand, prevent and ultimately cure NNLDs are urgently needed. Towards this goal my group focusses on both, the main effector cell in NNLD, the myofibroblast, and the inflammome and particularly MOs, as these orchestrate both, lung healing and remodeling. Modulating the pulmonary immune system, rather than subduing it, holds significant promise. To this end, we have to understand the very early events in NNLDs. There are 2 major obstacles for efficient research: i) the lack of adequate animal models and ii) the availability of human specimens. Therefore we established a unique platform for NNLD: we utilize fresh explanted human lungs from Europe’s largest LuTx program and set up a singular 24h/7d workflow, ensuring short ischemia and tissue viability. In the last years, we have worked up over 500 lungs, acted as an international multiplier for pulmonary research, patented new imaging techniques and described novel diseases. Our understanding MO biology in NNLDs showed us the great potential in macrophages. Now we are going to use these macrophages as potential therapeutics. Hereby we will make a difference in translational medicine in Europe and the world.

 Publications

year authors and title journal last update
List of publications.
2018 F. Länger, H. Stark, P. Braubach, M. Ackermann, K. Hussein, K. Teiken, L. Maegel, M. Kuehnel, D. Jonigk
Schädigungsmuster interstitieller Lungenerkrankungen
published pages: 262-271, ISSN: 0172-8113, DOI: 10.1007/s00292-018-0503-1
Der Pathologe 39/S2 2020-02-05
2019 J. Wohlschlaeger, F. Laenger, J. Gottlieb, T. Hager, A. Seidel, D. Jonigk
Lungentransplantation
published pages: 281-291, ISSN: 0172-8113, DOI: 10.1007/s00292-019-0598-z
Der Pathologe 40/3 2020-02-05
2019 Maximilian Ackermann, Helge Stark, Lavinia Neubert, Stephanie Schubert, Paul Borchert, Friedemann Linz, Willi L. Wagner, Wolfram Stiller, Mark Wielpütz, Anne Hoefer, Axel Haverich, Steven J. Mentzer, Harshit R. Shah, Tobias Welte, Mark Kuehnel, Danny Jonigk
Morphomolecular motifs of pulmonary neoangiogenesis in interstitial lung diseases
published pages: 1900933, ISSN: 0903-1936, DOI: 10.1183/13993003.00933-2019
European Respiratory Journal 2020-01-30
2019 Danny Jonigk, Helge Stark, Peter Braubach, Lavinia Neubert, Hoen‐oh Shin, Nicole Izykowski, Tobias Welte, Sabina Janciauskiene, Gregor Warnecke, Axel Haverich, Mark Kuehnel, Florian Laenger
Morphological and molecular motifs of fibrosing pulmonary injury patterns
published pages: 256-271, ISSN: 2056-4538, DOI: 10.1002/cjp2.141
The Journal of Pathology: Clinical Research 5/4 2020-01-30

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