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MICROCRYO SIGNED

Microsystems for Cryomicroscopy

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 MICROCRYO project word cloud

Explore the words cloud of the MICROCRYO project. It provides you a very rough idea of what is the project "MICROCRYO" about.

systematically    reversed    transport    create    cryopreservation    model    sophisticated    vitrification    combined    cryofixation    optics    technologies    breakthroughs    context    revolutionize    imaged    resolved    fast    spatial    cell    millisecond    proteins    stem    incrementally    synaptic    revealing    electron    cryo    sperm    imaging    modes    time    instrumentation    resume    reversibility    extremely    rapid    microfluidic    class    temporal    dynamic    oocytes    structure    trafficking    small    cryogenic    ultrastructural    cellular    biological    temperature    single    structural    nanometer    function    untapped    microscopy    molecular    light    microscope    first    reversible    basis    organisms    dynamics    preparation    cooling    warming    synergy    ultimately    elucidate    resolution    ultra    microsystems    direct    emerged    despite    limitations    decade    cells    division    events    live    powerful    heating    1960s    infancy    progress    unperturbed    transmission    membrane   

Project "MICROCRYO" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAT DARMSTADT 

Organization address
address: KAROLINENPLATZ 5
city: DARMSTADT
postcode: 64289
website: www.tu-darmstadt.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙994˙562 €
 EC max contribution 1˙994˙562 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAT DARMSTADT DE (DARMSTADT) coordinator 1˙994˙562.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 0.00

Map

 Project objective

This proposal aims to revolutionize time-resolved light and electron cryo-microscopy of fast cellular dynamics using a new class of cryogenic microsystems for the reversible cryofixation of cells and small model organisms by ultra-rapid cooling. This will contribute to our understanding of biological structure and function by revealing the dynamics of specific proteins in the ultrastructural context of a cell at nanometer spatial and millisecond temporal resolution.

Despite rapid progress in the field, much of the potential of microscopy at cryogenic temperature today is still untapped due to limitations in methods and instrumentation for sample preparation. First, vitrification technologies for cryo-microscopy have evolved only incrementally since the 1960s and cannot be combined with many of the sophisticated live imaging methods that have emerged over the past decade. Second, while the synergy of light and electron cryo-microscopy is extremely powerful, cryo-microscopy with light is still in its infancy. Finally, new technologies for ultra-rapid heating and cooling of single cells are needed to systematically advance our understanding of reversibility in the cryopreservation of e.g. stem cells, oocytes, or sperm cells. Here I propose to create a microfluidic technology for the direct vitrification of cells in the light microscope by ultra-rapid cooling with millisecond time resolution. The cells will then be imaged at high resolution using electron microscopy and advanced modes of light microscopy combined with new optics adapted to cryogenic conditions. Ultimately, we will elucidate if and under which conditions cryofixation can be reversed by ultra-rapid warming such that dynamic cellular processes resume unperturbed.

We expect that the research proposed here will enable breakthroughs in understanding the structural and molecular basis of fast cellular events including transport, membrane trafficking, cell division, and synaptic transmission.

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The information about "MICROCRYO" are provided by the European Opendata Portal: CORDIS opendata.

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relatedResult rcn (827172) AGGIORNATO correttamente
lastchecktime (2022-05-18 6:58:12) correctly updated