Opendata, web and dolomites

MICROCRYO SIGNED

Microsystems for Cryomicroscopy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MICROCRYO project word cloud

Explore the words cloud of the MICROCRYO project. It provides you a very rough idea of what is the project "MICROCRYO" about.

division    light    cryo    warming    fast    microfluidic    resolution    create    oocytes    extremely    imaged    proteins    basis    temporal    small    limitations    synaptic    ultrastructural    decade    cryogenic    elucidate    molecular    electron    single    temperature    vitrification    structure    emerged    millisecond    ultimately    untapped    model    unperturbed    resolved    reversibility    live    sophisticated    heating    reversible    events    modes    ultra    biological    sperm    infancy    direct    function    organisms    optics    class    cell    time    stem    despite    breakthroughs    spatial    revealing    microscopy    progress    preparation    context    reversed    synergy    imaging    cellular    rapid    instrumentation    trafficking    nanometer    cryopreservation    resume    structural    dynamic    microsystems    transmission    powerful    1960s    dynamics    membrane    transport    cryofixation    microscope    first    cooling    revolutionize    cells    combined    systematically    technologies    incrementally   

Project "MICROCRYO" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAT DARMSTADT 

Organization address
address: KAROLINENPLATZ 5
city: DARMSTADT
postcode: 64289
website: www.tu-darmstadt.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙994˙562 €
 EC max contribution 1˙994˙562 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAT DARMSTADT DE (DARMSTADT) coordinator 1˙994˙562.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 0.00

Map

 Project objective

This proposal aims to revolutionize time-resolved light and electron cryo-microscopy of fast cellular dynamics using a new class of cryogenic microsystems for the reversible cryofixation of cells and small model organisms by ultra-rapid cooling. This will contribute to our understanding of biological structure and function by revealing the dynamics of specific proteins in the ultrastructural context of a cell at nanometer spatial and millisecond temporal resolution.

Despite rapid progress in the field, much of the potential of microscopy at cryogenic temperature today is still untapped due to limitations in methods and instrumentation for sample preparation. First, vitrification technologies for cryo-microscopy have evolved only incrementally since the 1960s and cannot be combined with many of the sophisticated live imaging methods that have emerged over the past decade. Second, while the synergy of light and electron cryo-microscopy is extremely powerful, cryo-microscopy with light is still in its infancy. Finally, new technologies for ultra-rapid heating and cooling of single cells are needed to systematically advance our understanding of reversibility in the cryopreservation of e.g. stem cells, oocytes, or sperm cells. Here I propose to create a microfluidic technology for the direct vitrification of cells in the light microscope by ultra-rapid cooling with millisecond time resolution. The cells will then be imaged at high resolution using electron microscopy and advanced modes of light microscopy combined with new optics adapted to cryogenic conditions. Ultimately, we will elucidate if and under which conditions cryofixation can be reversed by ultra-rapid warming such that dynamic cellular processes resume unperturbed.

We expect that the research proposed here will enable breakthroughs in understanding the structural and molecular basis of fast cellular events including transport, membrane trafficking, cell division, and synaptic transmission.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MICROCRYO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MICROCRYO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Growth regulation (2019)

The wide-spread bacterial toxin delivery systems and their role in multicellularity

Read More  

inhibiTOR (2020)

Novel selective mTORC1 inhibitors

Read More  

ARCTIC (2020)

Air Transport as Information and Computation

Read More