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REMATCH SIGNED

Image-based analysis for drug discovery and repurposing

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "REMATCH" data sheet

The following table provides information about the project.

Coordinator
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG 

Organization address
address: IM NEUENHEIMER FELD 280
city: HEIDELBERG
postcode: 69120
website: www.dkfz.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 149˙500 €
 EC max contribution 149˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2020-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) coordinator 149˙500.00

Map

 Project objective

Drug discovery and development has become a lengthy and resource-intensive process which is characterized by high attrition rates of candidate molecules. Candidate molecules are often identified in high-throughput screening experiments that capture only a small fraction of its biological activities and too many candidates fail in clinical development due to unwanted side-effects and lack of a therapeutic window. In addition, many approved drugs harbor unrecognized therapeutic efficacy in other indications that were not covered during development. Necessary deep characterization of candidate molecules during pre-clinical development demands further efficient and cost-effective methods and data rich assays. Providing a solution to compare phenotypic measurements to a reference database can facilitate the profiling of unwanted effects and the identification of drugs with potential for repurposing. High-content imaging provides a cost-effective solution to capture a broad range of biological responses, however, analysis of such data requires extensive expertise and data processing pipelines. This project has the following objectives: (i) to develop a cloud-based infrastructure for analyses of image-based drug screening (WP1), (ii) to perform a proof-of-concept screen to create a reference database and a showcase for commercialization (WP2), (iii) to conduct market analyses and development of a business plan for a spin-off company (WP3). The ERC Proof of Concept Grant will thus enable us, based on methods pioneered in our ERC Advanced Grant, to develop and perform a proof-of-concept as well as to develop an innovative knowledge base and cloud-IT product for drug development and repositioning.

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The information about "REMATCH" are provided by the European Opendata Portal: CORDIS opendata.

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