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ProTeAN SIGNED

Production and Testing of humAn-derived Neurons and brain organoids: advanced model probing in neurodevelopmental disorders

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ProTeAN project word cloud

Explore the words cloud of the ProTeAN project. It provides you a very rough idea of what is the project "ProTeAN" about.

core    structures    progression    vitro    animal    2020    pathogenic    perform    audiences    researcher    spreading    protean    arise    contain    proof    afflict    models    atilde    guoping    combine    generation    ferreira    outreach    enabled    organoids    pe    feng    autism    sequencing    chronic    horizon    adult    fellowship    of    personalized    strategy    neurodevelopmental    expertise    create    brain    reduce    neuronal    invasive    supervisor    improvement    assure    mature    lino    networks    platform    minimally    biobank    expert    context    ri    bioengineering    explore    differentiation    neurobiological    biotechnology    career    breakthroughs    cells    stem    society    ccedil    controls    partake    dental    patients    drug    counts    disorders    biomedical    jo    goals    medical    lack    tissue    defects    pertaining    hindered    dampen    realistic    human    evolution    68    science    drugs    organoid    cell    single    identification    responsibility    bioinformatics    ef    plan    leadership    engage    children   

Project "ProTeAN" data sheet

The following table provides information about the project.

Coordinator
CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO 

Organization address
address: UNIVERSIDADE DE COIMBRA, LARGO DE POMBAL
city: COIMBRA
postcode: 3004 517
website: www.cnbc.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 148˙635 €
 EC max contribution 148˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-05-07   to  2020-05-06

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO PT (COIMBRA) coordinator 148˙635.00

Map

 Project objective

Autism and associated neurodevelopmental disorders are chronic conditions that afflict 1 in 68 children and produce great costs to society. Lack of realistic models has hindered progression in our understanding of these disorders since core pathogenic defects may only arise in the context of complex human neuronal structures. Two recent breakthroughs have now enabled the development of improved models: the identification of stem cells in adult tissue; and the development of human organoids in vitro that allow the study of complex human neuronal networks. The ProTeAN projects aims to combine Neurobiological and Biotechnology research (key field in Horizon 2020), to: i) establish a dental stem cell biobank from autism patients and controls; ii) develop dental cell-derived brain organoids to explore neurobiological properties; iii) perform single-cell sequencing during the organoid generation process; iv) create proof-of-concept applications of brain organoids as a biomedical platform to test drugs. When developed, this platform will dampen the need for animal studies, reduce and contain the costs associated with drug developments and provide personalized medical testing devices with a minimally invasive strategy. This project counts on the applicant’s expertise on stem cells, differentiation and bioinformatics, and on the expertise of supervisor João Peça and collaboration from Lino Ferreira (expert in bioengineering) and Guoping Feng (expert in autism research) to assure the success of all tasks. The applicant has established a career development plan and will partake in outreach activities to engage different target audiences in issues pertaining to this project. An EF-RI fellowship will facilitate the responsibility of spreading the researcher's knowledge to European partners, improve leadership and mature research goals while contributing to the evolution of science and improvement of society.

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The information about "PROTEAN" are provided by the European Opendata Portal: CORDIS opendata.

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