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IN-Fo-trace-DG SIGNED

Role of GABAergic interneurons in the formation of new memory traces in the Dentate Gyrus ofbehaving mice

Total Cost €

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EC-Contrib. €

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Partnership

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 IN-Fo-trace-DG project word cloud

Explore the words cloud of the IN-Fo-trace-DG project. It provides you a very rough idea of what is the project "IN-Fo-trace-DG" about.

association    cell    environment    question    dentate    principal    unknown    dg    discrete    populations    ins    innovative    form    area    plasticity    spatial    theories    mechanisms    interference    progress    structure    gabaergic    constraints    processed    examine    brain    made    first    temporal    patterns    associations    group    inhibitory    visualize    acquisition    trace    fundamental    granule    emerge    assembly    little    output    excitatory    cells    differently    synapses    optogenetic    traces    despite    changing    signals    excitation    modifications    molecular    neurons    largely    neuronal    gyrus    networks    suggest    insights    cellular    time    interneurons    analyze    recruitment    tools    individual    vivo    memory    recordings    disciplinary    fo    adapt    dependent    balance    intensive    organisms    learning    gcs    imaging    photon    adult    virtual    space    cortical    memories    born    interconnectivity    population    ones    difficult    inhibition    mature   

Project "IN-Fo-trace-DG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM FREIBURG 

Organization address
address: HUGSTETTER STRASSE 49
city: FREIBURG
postcode: 79106
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙463˙693 €
 EC max contribution 2˙463˙693 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM FREIBURG DE (FREIBURG) coordinator 2˙463˙693.00

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 Project objective

Despite intensive study in the past on the problem of how information is processed in the brain to enable individual organisms to adapt to their continuously changing environment, little progress has been made on how new similar but discrete memory traces emerge in neuronal networks during learning. Current theories suggest that experience-dependent modifications in excitation-inhibition balance enable a selected group of neurons to form a new cell association during learning which represent the new memory trace. It was further proposed that particularly GABAergic inhibitory interneurons (INs) have a large impact on population activity in neuronal networks by means of their inhibitory output synapses. However, how cell associations emerge in space and time and how INs may contribute to this process is still largely unknown. This complex topic was so far difficult to address due to technical constraints. IN-Fo-Trace-DG aims to address this fundamental question in the dentate gyrus (DG), a brain structure essential for the acquisition of similar but discrete new memories. Based on our detailed knowledge on DG’s cellular elements, their interconnectivity and our recently established molecular interference tools, we will first, visualize the spatial and temporal activity patterns of cell populations during spatial learning in a virtual-reality using 2-Photon imaging. Second, we will determine the role of IN recruitment and plasticity in assembly formation by optogenetic and molecular interference. Third, we will analyze changes in excitatory and inhibitory signals in granule cells (GCs), the principal cells in this brain area, and INs during learning using whole-cell recordings in vivo. Finally, we will examine whether adult-born GCs contribute differently to learning-associated population activity compared to mature ones in the adult DG. This innovative multi-disciplinary approach will provide new insights on the mechanisms of new memory formation in cortical networks.

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