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MS-fMRI-QSM SIGNED

Studying Multiple Sclerosis with a novel simultaneous functional Magnetic Resonance Imaging (fMRI) and Quantitative Susceptibility Mapping (QSM) sequence.

Total Cost €

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EC-Contrib. €

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Partnership

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 MS-fMRI-QSM project word cloud

Explore the words cloud of the MS-fMRI-QSM project. It provides you a very rough idea of what is the project "MS-fMRI-QSM" about.

leads    signals    benefit    interdisciplinary    active    remitting    progressive    host    revealing    mri    proposes    quantitative    shown    enzinger    simultaneously    connectivity    susceptibilities    secondary    resonance    scans    clinical    disorder    supervision    data    imaging    plays    shows    supervise    tissues    genders    whereas    pathogenesis    queensland    disruption    iron    provides    multiple    functional    lesions    sensorimotor    deposits    university    nerve    drastically    researcher    ms    scan    motor    stay    demyelination    slowing    identification    examine    images    neurologists    action    networks    separate    rr    relapsing    cognitive    return    central    pp    mr    mapping    prof    primary    sequence    deficits    acquired    instance    function    relation    resting    insights    visual    decline    cells    hard    biomarkers    patients    diagnosis    time    electrical    mood    nervous    sclerosis    stands    international    combined    magnetic    activation    programming    plaques    vital    barth    susceptibility    neuronal    sp    causing    physicist    reduce    area    reorganization    qsm    fmri    subtypes    autoimmune    aberrant   

Project "MS-fMRI-QSM" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE UNIVERSITAT GRAZ 

Organization address
address: AUENBRUGGERPLATZ 2
city: GRAZ
postcode: 8036
website: http://www.medunigraz.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 267˙458 €
 EC max contribution 267˙458 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2022-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAT GRAZ AT (GRAZ) coordinator 267˙458.00
2    THE UNIVERSITY OF QUEENSLAND AU (BRISBANE) partner 0.00

Map

 Project objective

Multiple sclerosis (MS) is the most common autoimmune disorder to affect the central nervous system. Demyelination of nerve cells leads to a slowing of electrical signals, causing visual and sensorimotor deficits, cognitive decline and mood changes. Magnetic Resonance Imaging (MRI) plays a central role to in diagnosis through the identification of plaques and active lesions. Recently, functional MRI (fMRI) and Quantitative Susceptibility Mapping (QSM) have been shown to provide insights into the pathogenesis of MS and possible biomarkers of MS subtypes (relapsing-remitting (RR), primary progressive (PP) and secondary progressive (SP)). fMRI shows aberrant neuronal activation in response to motor tasks and changes to the motor resting state networks which are different in RR, PP and SP MS, for instance, whereas QSM provides images of the magnetic susceptibilities of different tissues, revealing iron deposits and demyelination.

This action proposes the development of a new MRI sequence which will allow fMRI and QSM data to be acquired simultaneously rather than in two separate scans. This will drastically reduce the scan time, which is vital as many MS patients find it hard to stay still during an MRI. The combined fMRI-QSM sequence used to examine, in different MS subtypes and genders, reorganization of motor function and disruption of functional connectivity (from fMRI) in relation to the distribution of plaques, iron and demyelination (from QSM).

The sequence programming in this interdisciplinary project will be carried out under the supervision of Prof. Barth, a physicist who developed the MR method on which the fMRI-QSM scan will be based, at the University of Queensland. In the return phase Prof. Enzinger, one of Europe’s leading MS neurologists, will supervise the clinical study with the combined sequence. This action stands to lead to a step-change in the international standing of the researcher and benefit the host and the European research area.

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The information about "MS-FMRI-QSM" are provided by the European Opendata Portal: CORDIS opendata.

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