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MS-fMRI-QSM SIGNED

Studying Multiple Sclerosis with a novel simultaneous functional Magnetic Resonance Imaging (fMRI) and Quantitative Susceptibility Mapping (QSM) sequence.

Total Cost €

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EC-Contrib. €

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Partnership

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 MS-fMRI-QSM project word cloud

Explore the words cloud of the MS-fMRI-QSM project. It provides you a very rough idea of what is the project "MS-fMRI-QSM" about.

neurologists    demyelination    action    magnetic    resting    insights    host    active    sp    sequence    electrical    resonance    examine    revealing    relapsing    leads    mapping    connectivity    shown    progressive    simultaneously    cognitive    cells    tissues    supervision    pathogenesis    relation    vital    stands    queensland    deposits    whereas    signals    barth    iron    function    susceptibility    university    drastically    mri    nervous    provides    ms    autoimmune    acquired    shows    nerve    quantitative    disruption    researcher    diagnosis    mood    images    plays    instance    functional    genders    motor    benefit    rr    plaques    separate    primary    decline    pp    aberrant    data    subtypes    stay    central    multiple    fmri    visual    lesions    sensorimotor    identification    interdisciplinary    enzinger    supervise    time    prof    sclerosis    qsm    scan    physicist    remitting    proposes    imaging    secondary    return    clinical    deficits    mr    programming    neuronal    susceptibilities    reorganization    slowing    scans    networks    international    area    activation    hard    reduce    causing    combined    biomarkers    patients    disorder   

Project "MS-fMRI-QSM" data sheet

The following table provides information about the project.

Coordinator		 MEDIZINISCHE UNIVERSITAT GRAZ 

Organization address
address: AUENBRUGGERPLATZ 2
city: GRAZ
postcode: 8036
website: http://www.medunigraz.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Austria [AT]
 Total cost 267˙458 €
 EC max contribution 267˙458 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2022-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAT GRAZ AT (GRAZ) coordinator 267˙458.00
2    THE UNIVERSITY OF QUEENSLAND AU (BRISBANE) partner 0.00

Map

 Project objective

Multiple sclerosis (MS) is the most common autoimmune disorder to affect the central nervous system. Demyelination of nerve cells leads to a slowing of electrical signals, causing visual and sensorimotor deficits, cognitive decline and mood changes. Magnetic Resonance Imaging (MRI) plays a central role to in diagnosis through the identification of plaques and active lesions. Recently, functional MRI (fMRI) and Quantitative Susceptibility Mapping (QSM) have been shown to provide insights into the pathogenesis of MS and possible biomarkers of MS subtypes (relapsing-remitting (RR), primary progressive (PP) and secondary progressive (SP)). fMRI shows aberrant neuronal activation in response to motor tasks and changes to the motor resting state networks which are different in RR, PP and SP MS, for instance, whereas QSM provides images of the magnetic susceptibilities of different tissues, revealing iron deposits and demyelination.

This action proposes the development of a new MRI sequence which will allow fMRI and QSM data to be acquired simultaneously rather than in two separate scans. This will drastically reduce the scan time, which is vital as many MS patients find it hard to stay still during an MRI. The combined fMRI-QSM sequence used to examine, in different MS subtypes and genders, reorganization of motor function and disruption of functional connectivity (from fMRI) in relation to the distribution of plaques, iron and demyelination (from QSM).

The sequence programming in this interdisciplinary project will be carried out under the supervision of Prof. Barth, a physicist who developed the MR method on which the fMRI-QSM scan will be based, at the University of Queensland. In the return phase Prof. Enzinger, one of Europe’s leading MS neurologists, will supervise the clinical study with the combined sequence. This action stands to lead to a step-change in the international standing of the researcher and benefit the host and the European research area.

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The information about "MS-FMRI-QSM" are provided by the European Opendata Portal: CORDIS opendata.

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