Explore the words cloud of the IMPACT-HEALTH project. It provides you a very rough idea of what is the project "IMPACT-HEALTH" about.
The following table provides information about the project.
OSPEDALE SAN RAFFAELE SRL
|Coordinator Country||Italy [IT]|
|Total cost||168˙277 €|
|EC max contribution||168˙277 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2018-09-17 to 2020-09-16|
Take a look of project's partnership.
|1||OSPEDALE SAN RAFFAELE SRL||IT (MILANO)||coordinator||168˙277.00|
Excess of plasma glucagon is frequently reported in diabetic patients, a misregulation that exacerbates hyperglycemia, a major complication of diabetes. This has spurred research into alpha-cell function and glucagon regulation, to find potential treatments, independent from insulin, for diabetes. To normalize glucagon secretion as a therapeutic strategy, it is crucial to have a better understanding of its regulatory mechanisms and the expression of specific genes regulating those mechanisms. Unfortunately, there is no consensus model explaining the regulation of glucagon secretion from pancreatic alpha-cells. However, calcium is known to be required for glucagon secretion, but its role is not completely understood. We propose to evaluate the role of free calcium activity across islet α-cells in the regulation of glucagon secretion from mice, using a custom built light-sheet fluorescence microscope, allowing fast three-dimensional imaging for an extended amount of time. The interest will be focused on the heterogeneity of the response, which forms subpopulations of α-cells. After, the attention will be addressed in discovering cellular expression patterns of transcription factors known to be relevant in alpha-cells through immunofluorescence, and to determine how these regulate their target genes using single molecule Fluorescence In Situ Hybridization (smFISH). Particular attention will be focused on correlating the heterogeneities of calcium activity in subpopulations of alpha-cells with their differential gene expression. By finding this differential expression, it will be possible to target specific genes in order to trigger various single-cells behaviors and discover novel therapeutic targets.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IMPACT-HEALTH" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "IMPACT-HEALTH" are provided by the European Opendata Portal: CORDIS opendata.