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AstroMiRimage SIGNED

Super-resolution imaging to uncover microRNA control of astrocytes in epilepsy

Total Cost €

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EC-Contrib. €

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Partnership

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 AstroMiRimage project word cloud

Explore the words cloud of the AstroMiRimage project. It provides you a very rough idea of what is the project "AstroMiRimage" about.

training    drug    pathophysiology    epilepsy    independent    expression    morphology    cleft    employ    mobility    refractory    first    neurologic    excess    microrna    fellowship    ground    disease    prevents    brain    networks    post    visualise    gene    astrocyte    strategy    super    structure    data    imaging    neurotransmitter    me    transcriptionally    biology    sklodowska    actions    translation    underlie    million    generate    channels    glutamate    coding    chronic    aberrant    creative    breaking    secondments    neuroscience    people    seizure    showing    builds    career    locally    grant    microscopy    individual    neuronal    therapeutic    diversify    approximately    purpose    cells    human    translational    international    principal    clearing    marie    mrnas    micrornas    patients    excitable    hence    molecular    synchronous    scientific    astrocytic    astrocytes    resolution    proteins    relevance    disorders    time    investigator    turn    benefit    mechanisms    regulate    machinery    nature    skills    hyper    rnas    seizures    innovative    synaptic    local    potassium    transitioning    horizon2020    resistant    suppressive    acquire    candidate    discharges    influence    ion    curie    modifying    exploring    rodent   

Project "AstroMiRimage" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 175˙866.00

Map

 Project objective

This Horizon2020 – Marie Sklodowska Curie Actions – Individual Fellowship grant proposal focuses on exploring mechanisms controlling the structure of support cells (astrocytes) in the brain that promote hyper-excitable neuronal networks and underlie common, chronic neurologic disorders such as epilepsy. My research builds on emerging data showing the molecular machinery for microRNAs - short non-coding RNAs that regulate gene expression post-transcriptionally by targeting mRNAs - is present locally, within astrocyte processes. For this purpose, I will employ for the first time super-resolution microscopy to visualise astrocyte processes and microRNAs in rodent and human brain. I will then target candidate microRNAs to influence astrocyte morphology, and increase local translation of neurotransmitter and ion channels in astrocytic processes. In turn, this allows the clearing of excess glutamate and potassium from the synaptic cleft and hence prevents synchronous neuronal discharges that generate seizures. During the fellowship, I will acquire new research skills in modelling epilepsy and through training and secondments, where I will visualise locally produced proteins in astrocyte processes after microRNA targeting. The ground-breaking nature of the project will enhance my creative and innovative potential. With advanced training and international mobility, the fellowship will help me to diversify my scientific and non-scientific skills needed to help me reach my career goal of transitioning into an independent principal investigator in molecular imaging and translational neuroscience focused on astrocyte biology and pathophysiology. These findings will have strong therapeutic relevance, offering a novel strategy for seizure-suppressive or disease-modifying actions via targeting microRNAs that regulate aberrant astrocyte morphology that could benefit patients with drug-resistant, refractory epilepsy, which affects approximately 2 million people in Europe.

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The information about "ASTROMIRIMAGE" are provided by the European Opendata Portal: CORDIS opendata.

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