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AstroMiRimage SIGNED

Super-resolution imaging to uncover microRNA control of astrocytes in epilepsy

Total Cost €

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EC-Contrib. €

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Partnership

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 AstroMiRimage project word cloud

Explore the words cloud of the AstroMiRimage project. It provides you a very rough idea of what is the project "AstroMiRimage" about.

investigator    patients    synaptic    super    training    million    gene    proteins    astrocyte    potassium    hence    time    marie    skills    expression    influence    disorders    rnas    human    horizon2020    networks    sklodowska    principal    independent    candidate    aberrant    morphology    post    career    synchronous    refractory    relevance    first    seizure    excess    transcriptionally    secondments    nature    visualise    channels    local    actions    resolution    microrna    resistant    mrnas    approximately    creative    data    therapeutic    strategy    regulate    biology    innovative    underlie    neurologic    breaking    locally    fellowship    disease    modifying    translation    generate    people    microscopy    international    brain    diversify    structure    prevents    pathophysiology    suppressive    neuronal    chronic    coding    cells    acquire    drug    translational    transitioning    individual    imaging    astrocytic    seizures    cleft    grant    curie    rodent    discharges    micrornas    showing    benefit    molecular    mechanisms    hyper    neuroscience    ground    machinery    exploring    builds    me    glutamate    scientific    neurotransmitter    purpose    clearing    employ    mobility    excitable    astrocytes    epilepsy    turn    ion   

Project "AstroMiRimage" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2020-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 175˙866.00

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 Project objective

This Horizon2020 – Marie Sklodowska Curie Actions – Individual Fellowship grant proposal focuses on exploring mechanisms controlling the structure of support cells (astrocytes) in the brain that promote hyper-excitable neuronal networks and underlie common, chronic neurologic disorders such as epilepsy. My research builds on emerging data showing the molecular machinery for microRNAs - short non-coding RNAs that regulate gene expression post-transcriptionally by targeting mRNAs - is present locally, within astrocyte processes. For this purpose, I will employ for the first time super-resolution microscopy to visualise astrocyte processes and microRNAs in rodent and human brain. I will then target candidate microRNAs to influence astrocyte morphology, and increase local translation of neurotransmitter and ion channels in astrocytic processes. In turn, this allows the clearing of excess glutamate and potassium from the synaptic cleft and hence prevents synchronous neuronal discharges that generate seizures. During the fellowship, I will acquire new research skills in modelling epilepsy and through training and secondments, where I will visualise locally produced proteins in astrocyte processes after microRNA targeting. The ground-breaking nature of the project will enhance my creative and innovative potential. With advanced training and international mobility, the fellowship will help me to diversify my scientific and non-scientific skills needed to help me reach my career goal of transitioning into an independent principal investigator in molecular imaging and translational neuroscience focused on astrocyte biology and pathophysiology. These findings will have strong therapeutic relevance, offering a novel strategy for seizure-suppressive or disease-modifying actions via targeting microRNAs that regulate aberrant astrocyte morphology that could benefit patients with drug-resistant, refractory epilepsy, which affects approximately 2 million people in Europe.

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The information about "ASTROMIRIMAGE" are provided by the European Opendata Portal: CORDIS opendata.

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