Opendata, web and dolomites

NANO-MEMEC SIGNED

Membrane-based nano-mechanobiology: Role of mechanical forces in remodelling the spatiotemporal nanoarchitecture of the plasma membrane

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 NANO-MEMEC project word cloud

Explore the words cloud of the NANO-MEMEC project. It provides you a very rough idea of what is the project "NANO-MEMEC" about.

cell    chief    cells    ultimately    mechanosensitive    capacity    stimuli    signalling    adhesion    proteins    molecule    membrane    organisation    remodelling    first    modulating    mechanotransduction    dynamics    force    mechanical    living    scales    dissect    function    overlooking    biochemical    fangled    integrin    evolution    stimulation    levels    memec    nanocompartments    dynamic    forces    completely    molecules    mechanistic    simultaneous    progress    rooted    exquisite    biophysical    transduce    avenues    signal    visualise    probing    through    cuttingedge    platforms    exclusively    hindering    generate    recruitment    single    size    super    receptors    nanoarchitecture    immune    regime    integrate    difficult    transduction    optical    coordinated    conformations    combine    conveys    fundamental    events    shows    molecular    resolution    conjunction    plasma    nanoscopy    models    roles    mechanoresponse    sense    nano    nanoscale    signals    appropriate    lateral    lab    mechanosensing    migratory    mechanobiology    tools    coupling    opening    spatiotemporal    overcome    influences   

Project "NANO-MEMEC" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE CIENCIES FOTONIQUES 

Organization address
address: AVINGUDA CARL FRIEDRICH GAUSS 3
city: Castelldefels
postcode: 8860
website: www.icfo.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙212˙063 €
 EC max contribution 2˙212˙063 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) coordinator 2˙212˙063.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Through evolution, cells have developed the exquisite ability to sense, transduce and integrate mechanical and biochemical signals (i.e. mechanobiology) to generate appropriate responses. These key events are rooted at the molecular and nanoscale levels, a size regime difficult to access, hindering our progress towards mechanistic understanding of mechanobiology. Recent evidence from my Lab (and others) shows that the lateral nanoscale organisation of mechanosensitive membrane receptors and signalling molecules is crucial for cell function. Yet, current models of mechanosensing are based on force-induced molecular conformations, completely overlooking the chief role of mechanical forces on the nanoscale spatiotemporal organisation of the plasma membrane.

The GOAL of NANO-MEMEC is to provide mechanistic understanding on the role of mechanical stimuli in the spatiotemporal nanoarchitecture of adhesion signalling platforms at the cell membrane. To overcome the technical challenges of probing these processes at the relevant spatiotemporal scales, I will exploit cuttingedge biophysical tools exclusively developed in my Lab that combine super-resolution optical nanoscopy and single molecule dynamics in conjunction with simultaneous mechanical stimulation of living cells. Using this integrated approach, I will: First: dissect mechanical and biochemical coupling of membrane mechanosensing at the nanoscale. Second: visualise the coordinated recruitment of integrin-associated signalling proteins in response to force, i.e., mechanotransduction. Third: test how force-induced spatiotemporal membrane remodelling influences the migratory capacity of immune cells, i.e., mechanoresponse. NANO-MEMEC conveys a new fundamental concept to the field of mechanobiology: the roles of mechanical stimuli in the dynamic remodelling of membrane nanocompartments, modulating signal transduction and ultimately affecting cell response, opening new-fangled research avenues in the years to come.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NANO-MEMEC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NANO-MEMEC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

HyperCube (2020)

HyperCube: Gram scale production of ferrite nanocubes and thermo-responsive polymer coated nanocubes for medical applications and further exploitation in other hyperthermia fields

Read More  

PGErepro (2019)

How to break Mendel’s laws? The role of sexual conflict in the evolution of unusual transmission genetics

Read More