Opendata, web and dolomites

NANO-MEMEC SIGNED

Membrane-based nano-mechanobiology: Role of mechanical forces in remodelling the spatiotemporal nanoarchitecture of the plasma membrane

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 NANO-MEMEC project word cloud

Explore the words cloud of the NANO-MEMEC project. It provides you a very rough idea of what is the project "NANO-MEMEC" about.

membrane    mechanosensitive    events    avenues    living    fangled    through    mechanical    nano    biochemical    recruitment    models    ultimately    mechanoresponse    cell    overlooking    resolution    opening    migratory    biophysical    regime    integrin    visualise    coupling    molecules    force    first    mechanobiology    molecule    mechanotransduction    modulating    completely    dynamics    receptors    difficult    mechanistic    super    lateral    signal    nanoscopy    progress    generate    fundamental    adhesion    cells    levels    mechanosensing    chief    simultaneous    shows    dissect    proteins    forces    signals    rooted    molecular    overcome    tools    influences    nanocompartments    immune    plasma    scales    lab    spatiotemporal    organisation    optical    size    evolution    cuttingedge    exquisite    nanoscale    stimuli    coordinated    stimulation    appropriate    conformations    combine    conjunction    capacity    platforms    signalling    memec    function    transduction    nanoarchitecture    sense    roles    remodelling    hindering    integrate    conveys    probing    single    transduce    exclusively    dynamic   

Project "NANO-MEMEC" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE CIENCIES FOTONIQUES 

Organization address
address: AVINGUDA CARL FRIEDRICH GAUSS 3
city: Castelldefels
postcode: 8860
website: www.icfo.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙212˙063 €
 EC max contribution 2˙212˙063 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) coordinator 2˙212˙063.00

Map

 Project objective

Through evolution, cells have developed the exquisite ability to sense, transduce and integrate mechanical and biochemical signals (i.e. mechanobiology) to generate appropriate responses. These key events are rooted at the molecular and nanoscale levels, a size regime difficult to access, hindering our progress towards mechanistic understanding of mechanobiology. Recent evidence from my Lab (and others) shows that the lateral nanoscale organisation of mechanosensitive membrane receptors and signalling molecules is crucial for cell function. Yet, current models of mechanosensing are based on force-induced molecular conformations, completely overlooking the chief role of mechanical forces on the nanoscale spatiotemporal organisation of the plasma membrane.

The GOAL of NANO-MEMEC is to provide mechanistic understanding on the role of mechanical stimuli in the spatiotemporal nanoarchitecture of adhesion signalling platforms at the cell membrane. To overcome the technical challenges of probing these processes at the relevant spatiotemporal scales, I will exploit cuttingedge biophysical tools exclusively developed in my Lab that combine super-resolution optical nanoscopy and single molecule dynamics in conjunction with simultaneous mechanical stimulation of living cells. Using this integrated approach, I will: First: dissect mechanical and biochemical coupling of membrane mechanosensing at the nanoscale. Second: visualise the coordinated recruitment of integrin-associated signalling proteins in response to force, i.e., mechanotransduction. Third: test how force-induced spatiotemporal membrane remodelling influences the migratory capacity of immune cells, i.e., mechanoresponse. NANO-MEMEC conveys a new fundamental concept to the field of mechanobiology: the roles of mechanical stimuli in the dynamic remodelling of membrane nanocompartments, modulating signal transduction and ultimately affecting cell response, opening new-fangled research avenues in the years to come.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NANO-MEMEC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NANO-MEMEC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PSYDISC (2020)

Developing and Testing the Psychological Distance to Science Model

Read More  

ChaperoneRegulome (2020)

ChaperoneRegulome: Understanding cell-type-specificity of chaperone regulation

Read More  

ImmUne (2019)

Towards identification of the unifying principles of vertebrate adaptive immunity

Read More