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Miniaturised optically accessible bioreactor for drug discovery and biological research

Total Cost €


EC-Contrib. €






 MOAB project word cloud

Explore the words cloud of the MOAB project. It provides you a very rough idea of what is the project "MOAB" about.

dynamics    device    optically    animal    fact    miniaturised    discovery    ipr    confirmed    infusion    drug    therapeutic       anymore    actionable    radically    accommodate    approvals    grant    move    strategy    bioreactor    erc    trial    valorising    perform    efficacy    interactions    dish    post    populations    market    nano    obsolete    inventions    substrate    clinical    cancer    pathologies    lab    continuous    italian    demonstrations    commercial    lasts    drugs    measured    tested    millimetres    cog    feasibility    companies    99    few    size    regulatory    fluid    3d    agents    animals    flat    medium    consolidator    ten    patents    covered    subjected    pct    extended    originated    patients    accessible    96    vitro    billion    organoids    pharmaceutical    time    integrating    culture    perfusion    cultured    dimensions    original    modified    cell    stem    poc    frame    identification    single    patterned    suitable    patent    vivo    nichoid    chamber    neurodegeneration    context    cultivation    occurring    moab       diagnostics    added   

Project "MOAB" data sheet

The following table provides information about the project.


Organization address
city: MILANO
postcode: 20133

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2020-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI MILANO IT (MILANO) coordinator 105˙000.00


 Project objective

The problem that we address is that the pharmaceutical companies do not develop radically new drugs anymore, because the development process lasts ten years and costs around one billion euro. Development of a new drug is subjected to regulatory approvals following three demonstrations: lab discovery in vitro, animal testing in vivo and clinical trial on patients. This process has 99.9% overall failure, of which 96.4% because the drug efficacy measured in vitro is not confirmed in animals. In fact, the most widespread technology used to test therapeutic agents in vitro, a flat culture dish in which single cell populations are cultured and the drug to be tested is added to the culture, is obsolete. In many pathologies such as cancer and neurodegeneration, in vivo response to drugs is based on complex interactions, occurring in three-dimensions (3D) between several cell populations. To solve this problem, in the context of an ERC consolidator grant (CoG) that I currently lead, I integrated a novel nano-patterned 3D substrate for stem cell culture, called the “nichoid”, into an existing miniaturised optically accessible bioreactor (MOAB). The MOAB allows to culture 3D organoids of few millimetres in size, under continuous perfusion of the culture medium, infusion of the drug to be tested and diagnostics of cell response both in real time and also post-cultivation. Both the original inventions (the nichoid and the MOAB) are covered by Italian patents originated in the frame of the CoG project and already extended as PCT. The goal of this PoC proposal is to perform a technical and commercial feasibility to move to the market the MOAB device integrating the nichoid-patterned substrate. I will characterize the fluid-dynamics of the bioreactor chamber that has been modified to accommodate the nichoid substrate. Also, I will set a market assessment and an actionable IPR strategy with identification of a suitable exploitation strategy for valorising the patent/know how.

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The information about "MOAB" are provided by the European Opendata Portal: CORDIS opendata.

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