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MOAB SIGNED

Miniaturised optically accessible bioreactor for drug discovery and biological research

Total Cost €

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EC-Contrib. €

0

Partnership

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 MOAB project word cloud

Explore the words cloud of the MOAB project. It provides you a very rough idea of what is the project "MOAB" about.

organoids    market    patients    continuous    identification    subjected    chamber    flat    original    animals    diagnostics    cell    erc    culture    time    perfusion    cultivation    consolidator    infusion    ipr    integrating       interactions    vitro    efficacy    patent    pathologies    vivo    frame    italian    neurodegeneration    dish    agents    3d    obsolete    move    drugs    ten    approvals    billion    originated    few    suitable    occurring    nichoid    fact    post    patents    dynamics    cultured    bioreactor    demonstrations    poc    regulatory    feasibility    pharmaceutical    pct    drug    commercial    moab    valorising    trial    cog    optically    99    clinical    animal    size    actionable    millimetres    dimensions    companies    single    fluid    patterned    therapeutic       discovery    tested    anymore    context    substrate    lab    populations    confirmed    strategy    nano    96    extended    covered    perform    miniaturised    modified    lasts    stem    accommodate    radically    grant    cancer    device    measured    inventions    accessible    medium    added   

Project "MOAB" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI MILANO 

Organization address
address: PIAZZA LEONARDO DA VINCI 32
city: MILANO
postcode: 20133
website: www.polimi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI MILANO IT (MILANO) coordinator 105˙000.00
2    UNIVERSITA' DEGLI STUDI DI BERGAMO IT (BERGAMO) participant 45˙000.00

Map

 Project objective

The problem that we address is that the pharmaceutical companies do not develop radically new drugs anymore, because the development process lasts ten years and costs around one billion euro. Development of a new drug is subjected to regulatory approvals following three demonstrations: lab discovery in vitro, animal testing in vivo and clinical trial on patients. This process has 99.9% overall failure, of which 96.4% because the drug efficacy measured in vitro is not confirmed in animals. In fact, the most widespread technology used to test therapeutic agents in vitro, a flat culture dish in which single cell populations are cultured and the drug to be tested is added to the culture, is obsolete. In many pathologies such as cancer and neurodegeneration, in vivo response to drugs is based on complex interactions, occurring in three-dimensions (3D) between several cell populations. To solve this problem, in the context of an ERC consolidator grant (CoG) that I currently lead, I integrated a novel nano-patterned 3D substrate for stem cell culture, called the “nichoid”, into an existing miniaturised optically accessible bioreactor (MOAB). The MOAB allows to culture 3D organoids of few millimetres in size, under continuous perfusion of the culture medium, infusion of the drug to be tested and diagnostics of cell response both in real time and also post-cultivation. Both the original inventions (the nichoid and the MOAB) are covered by Italian patents originated in the frame of the CoG project and already extended as PCT. The goal of this PoC proposal is to perform a technical and commercial feasibility to move to the market the MOAB device integrating the nichoid-patterned substrate. I will characterize the fluid-dynamics of the bioreactor chamber that has been modified to accommodate the nichoid substrate. Also, I will set a market assessment and an actionable IPR strategy with identification of a suitable exploitation strategy for valorising the patent/know how.

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The information about "MOAB" are provided by the European Opendata Portal: CORDIS opendata.

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