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SM-Epigen SIGNED

Revealing the Epigenetic Regulatory Network with Single-Molecule Precision

Total Cost €

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EC-Contrib. €

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Partnership

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 SM-Epigen project word cloud

Explore the words cloud of the SM-Epigen project. It provides you a very rough idea of what is the project "SM-Epigen" about.

fuelled    nucleosomes    circulating    reveal    lacks    diseases    hypothesis    origin    octamer    detection    tf    histone    yield    directions    transcription    free    devise    therapeutic    tfs    impeding    speculation    single    cell    differentiated    ascertained    combinatorial    proof    combinations    powerful    tissue    locations    marks    direct    nucleosome    pave    interface    light    proteomics    stem    combinatorially    genomics    form    harness    strategies    solution    basic    cancer    human    shed    genome    outcomes    molecule    genomic    interactions    language    cells    functional    packaged    genes    technologies    remodelers    bridging    network    holds    interact    multiple    transformative    dna    structures    regulate    modifications    unravel    throughput    chromatin    act    methylation    modules    gap    blood    fundamental    regulation    successful    mapping    diagnostic    core    histones    epigenetic    technological    regulatory    questions    tools   

Project "SM-Epigen" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙500˙000.00

Map

 Project objective

Genes and genomic elements are packaged by chromatin structures that regulate their activity. The fundamental unit of chromatin is the nucleosome, composed of an octamer of histones. The large numbers of histone modifications, chromatin remodelers and transcription factors (TFs) that interact with our genome has fuelled speculation that multiple elements act combinatorially to direct specific outcomes. However, the field lacks technologies for detection and analysis of such combinations, thus impeding our ability to test this hypothesis and shed light on human genome regulation. Our recent proof-of-principle for a single-molecule system for mapping combinatorial chromatin modifications holds the technological solution. This powerful method can identify directly unique combinations of epigenetic marks and reveal regulatory modules that can only be ascertained by single-molecule studies. The proposed project will scale-up and advance our technology to establish robust high-throughput systems for investigating combinatorial chromatin and TF interactions and identify their genomic locations, thus bridging the gap between single-molecule proteomics and genomics. We will apply it to address basic questions in epigenetic regulation during early development, and define the network of interactions between histone marks, DNA methylation and the core TFs in stem cells and differentiated cells. We will also harness our technology to reveal the tissue-of-origin of cell-free DNA circulating in our blood in the form of nucleosomes, and apply it to devise novel strategies for early detection of cancer and other diseases. Successful implementation and dissemination of these novel systems will yield a transformative new technology for functional genomics that will unravel the chromatin language during early development. This work will open new research directions at the interface of genomics and proteomics, and pave the way for the development of therapeutic and diagnostic tools.

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The information about "SM-EPIGEN" are provided by the European Opendata Portal: CORDIS opendata.

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