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SM-Epigen SIGNED

Revealing the Epigenetic Regulatory Network with Single-Molecule Precision

Total Cost €

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EC-Contrib. €

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Partnership

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 SM-Epigen project word cloud

Explore the words cloud of the SM-Epigen project. It provides you a very rough idea of what is the project "SM-Epigen" about.

tools    therapeutic    pave    outcomes    form    origin    stem    direct    nucleosomes    free    language    solution    speculation    marks    successful    unravel    devise    circulating    methylation    network    combinations    diagnostic    genes    nucleosome    core    multiple    questions    epigenetic    combinatorial    harness    powerful    light    basic    interface    structures    tf    regulate    packaged    interactions    detection    transformative    holds    differentiated    reveal    cell    genomics    fuelled    proof    transcription    regulatory    shed    modules    cells    strategies    locations    act    yield    histone    proteomics    histones    technological    molecule    throughput    tfs    bridging    lacks    genome    genomic    fundamental    combinatorially    blood    hypothesis    ascertained    directions    remodelers    human    mapping    chromatin    gap    functional    interact    single    cancer    impeding    modifications    diseases    tissue    octamer    regulation    dna    technologies   

Project "SM-Epigen" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙500˙000.00

Map

 Project objective

Genes and genomic elements are packaged by chromatin structures that regulate their activity. The fundamental unit of chromatin is the nucleosome, composed of an octamer of histones. The large numbers of histone modifications, chromatin remodelers and transcription factors (TFs) that interact with our genome has fuelled speculation that multiple elements act combinatorially to direct specific outcomes. However, the field lacks technologies for detection and analysis of such combinations, thus impeding our ability to test this hypothesis and shed light on human genome regulation. Our recent proof-of-principle for a single-molecule system for mapping combinatorial chromatin modifications holds the technological solution. This powerful method can identify directly unique combinations of epigenetic marks and reveal regulatory modules that can only be ascertained by single-molecule studies. The proposed project will scale-up and advance our technology to establish robust high-throughput systems for investigating combinatorial chromatin and TF interactions and identify their genomic locations, thus bridging the gap between single-molecule proteomics and genomics. We will apply it to address basic questions in epigenetic regulation during early development, and define the network of interactions between histone marks, DNA methylation and the core TFs in stem cells and differentiated cells. We will also harness our technology to reveal the tissue-of-origin of cell-free DNA circulating in our blood in the form of nucleosomes, and apply it to devise novel strategies for early detection of cancer and other diseases. Successful implementation and dissemination of these novel systems will yield a transformative new technology for functional genomics that will unravel the chromatin language during early development. This work will open new research directions at the interface of genomics and proteomics, and pave the way for the development of therapeutic and diagnostic tools.

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The information about "SM-EPIGEN" are provided by the European Opendata Portal: CORDIS opendata.

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