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Light INduced Cell control by Exogenous organic semiconductors

Total Cost €


EC-Contrib. €






 LINCE project word cloud

Explore the words cloud of the LINCE project. It provides you a very rough idea of what is the project "LINCE" about.

inherently    doctors    technologies    regulate    stem    optically    electronic    pathological    physiology    os    provides    neuronal    search    ideal    nervous    biocompatibility    ionic    relevance    materials    stimuli    fundamental    significantly    chemical    mediated    central    excitation    visible    standard    unprecedented    modulates    broaden    sensitivity    investigations    efficacy    modulation    candidates    biological    thermal    drugs    vitro    conduction    resolution    optical    hot    cells    regulation    regenerative    medicine    tissue    biomolecules    sustain    respect    electrical    specificity    sensitive    neuroscientists    animal    semiconductors    invasiveness    organic    first    lince    achievable    behavior    disorders    combination    spatio    understand    regeneration    polymer    flexible    easily    cell    mission    differentiation    vivo    medical    extremely    living    possibility    bear    device    dysfunctions    selectivity    nir    biocompatible    vast    functions    active    reversibility    timeless    light    majority    lower    astrocytes    functionalized    combine    reported    box    tools    tool    neuroscience    temporal    yield   

Project "LINCE" data sheet

The following table provides information about the project.


Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙866˙250 €
 EC max contribution 1˙866˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

LINCE will develop light-sensitive devices based on organic semiconductors (OS) for optical regulation of living cells functions. The possibility to control the activity of biological systems is a timeless mission for neuroscientists, since it allows both to understand specific functions and to manage dysfunctions. Optical modulation provides, respect to traditional electrical methods, unprecedented spatio-temporal resolution, lower invasiveness, and higher selectivity. However, the vast majority of animal cells does not bear specific sensitivity to light. Search for new materials capable to optically regulate cell activity is thus an extremely hot topic. OS are ideal candidates, since they are inherently sensitive to visible light and highly biocompatible, sustain both ionic and electronic conduction, can be functionalized with biomolecules and drugs. Recently, it was reported that polymer-mediated optical excitation efficiently modulates the neuronal electrical activity. LINCE will significantly broaden the application of OS to address key, open issues of high biological relevance, in both neuroscience and regenerative medicine. In particular, it will develop new devices for: (i) regulation of astrocytes functions, active in many fundamental processes of the central nervous system and in pathological disorders; (ii) control of stem cell differentiation and tissue regeneration; (iii) control of animal behavior, to first assess device biocompatibility and efficacy in vivo. LINCE tools will be sensitive to visible and NIR light, flexible, biocompatible, and easily integrated with any standard physiology set-up. They will combine electrical, chemical and thermal stimuli, offering high spatio-temporal resolution, reversibility, specificity and yield. The combination of all these features is not achievable by current technologies. Overall, LINCE will provide neuroscientists and medical doctors with an unprecedented tool-box for in vitro and in vivo investigations.

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The information about "LINCE" are provided by the European Opendata Portal: CORDIS opendata.

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