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LINCE SIGNED

Light INduced Cell control by Exogenous organic semiconductors

Total Cost €

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EC-Contrib. €

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Partnership

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 LINCE project word cloud

Explore the words cloud of the LINCE project. It provides you a very rough idea of what is the project "LINCE" about.

regeneration    semiconductors    reported    tools    stem    excitation    lower    investigations    spatio    respect    yield    tissue    regenerative    behavior    optically    extremely    animal    understand    nervous    temporal    ionic    central    doctors    modulation    medical    polymer    biocompatible    active    drugs    combination    easily    materials    medicine    flexible    disorders    sensitive    biomolecules    possibility    sensitivity    achievable    nir    sustain    first    mission    search    box    light    pathological    organic    vitro    astrocytes    differentiation    electrical    device    biocompatibility    broaden    inherently    resolution    technologies    relevance    conduction    optical    lince    timeless    living    combine    majority    invasiveness    functions    neuroscience    cells    functionalized    neuroscientists    visible    significantly    chemical    fundamental    candidates    modulates    selectivity    stimuli    mediated    efficacy    cell    ideal    standard    provides    regulate    bear    hot    unprecedented    vast    biological    electronic    regulation    reversibility    os    tool    thermal    dysfunctions    vivo    neuronal    specificity    physiology   

Project "LINCE" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙866˙250 €
 EC max contribution 1˙866˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 1˙866˙250.00

Map

 Project objective

LINCE will develop light-sensitive devices based on organic semiconductors (OS) for optical regulation of living cells functions. The possibility to control the activity of biological systems is a timeless mission for neuroscientists, since it allows both to understand specific functions and to manage dysfunctions. Optical modulation provides, respect to traditional electrical methods, unprecedented spatio-temporal resolution, lower invasiveness, and higher selectivity. However, the vast majority of animal cells does not bear specific sensitivity to light. Search for new materials capable to optically regulate cell activity is thus an extremely hot topic. OS are ideal candidates, since they are inherently sensitive to visible light and highly biocompatible, sustain both ionic and electronic conduction, can be functionalized with biomolecules and drugs. Recently, it was reported that polymer-mediated optical excitation efficiently modulates the neuronal electrical activity. LINCE will significantly broaden the application of OS to address key, open issues of high biological relevance, in both neuroscience and regenerative medicine. In particular, it will develop new devices for: (i) regulation of astrocytes functions, active in many fundamental processes of the central nervous system and in pathological disorders; (ii) control of stem cell differentiation and tissue regeneration; (iii) control of animal behavior, to first assess device biocompatibility and efficacy in vivo. LINCE tools will be sensitive to visible and NIR light, flexible, biocompatible, and easily integrated with any standard physiology set-up. They will combine electrical, chemical and thermal stimuli, offering high spatio-temporal resolution, reversibility, specificity and yield. The combination of all these features is not achievable by current technologies. Overall, LINCE will provide neuroscientists and medical doctors with an unprecedented tool-box for in vitro and in vivo investigations.

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The information about "LINCE" are provided by the European Opendata Portal: CORDIS opendata.

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