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LINCE SIGNED

Light INduced Cell control by Exogenous organic semiconductors

Total Cost €

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EC-Contrib. €

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Partnership

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 LINCE project word cloud

Explore the words cloud of the LINCE project. It provides you a very rough idea of what is the project "LINCE" about.

cell    polymer    investigations    spatio    functions    tissue    central    medical    electrical    yield    broaden    vitro    medicine    thermal    os    regulate    biocompatibility    efficacy    organic    selectivity    tool    neuroscience    vast    drugs    resolution    behavior    disorders    biomolecules    standard    reversibility    achievable    vivo    excitation    dysfunctions    animal    box    combination    regulation    possibility    sensitive    relevance    ideal    temporal    mediated    search    neuroscientists    cells    candidates    differentiation    specificity    invasiveness    living    easily    electronic    neuronal    materials    semiconductors    stimuli    combine    visible    sustain    modulation    lince    regenerative    functionalized    reported    technologies    fundamental    inherently    provides    tools    flexible    hot    mission    lower    active    understand    biological    biocompatible    optically    doctors    modulates    chemical    physiology    stem    unprecedented    light    respect    nervous    nir    sensitivity    optical    regeneration    device    astrocytes    extremely    conduction    first    majority    ionic    significantly    pathological    bear    timeless   

Project "LINCE" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙866˙250 €
 EC max contribution 1˙866˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 1˙866˙250.00

Map

 Project objective

LINCE will develop light-sensitive devices based on organic semiconductors (OS) for optical regulation of living cells functions. The possibility to control the activity of biological systems is a timeless mission for neuroscientists, since it allows both to understand specific functions and to manage dysfunctions. Optical modulation provides, respect to traditional electrical methods, unprecedented spatio-temporal resolution, lower invasiveness, and higher selectivity. However, the vast majority of animal cells does not bear specific sensitivity to light. Search for new materials capable to optically regulate cell activity is thus an extremely hot topic. OS are ideal candidates, since they are inherently sensitive to visible light and highly biocompatible, sustain both ionic and electronic conduction, can be functionalized with biomolecules and drugs. Recently, it was reported that polymer-mediated optical excitation efficiently modulates the neuronal electrical activity. LINCE will significantly broaden the application of OS to address key, open issues of high biological relevance, in both neuroscience and regenerative medicine. In particular, it will develop new devices for: (i) regulation of astrocytes functions, active in many fundamental processes of the central nervous system and in pathological disorders; (ii) control of stem cell differentiation and tissue regeneration; (iii) control of animal behavior, to first assess device biocompatibility and efficacy in vivo. LINCE tools will be sensitive to visible and NIR light, flexible, biocompatible, and easily integrated with any standard physiology set-up. They will combine electrical, chemical and thermal stimuli, offering high spatio-temporal resolution, reversibility, specificity and yield. The combination of all these features is not achievable by current technologies. Overall, LINCE will provide neuroscientists and medical doctors with an unprecedented tool-box for in vitro and in vivo investigations.

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The information about "LINCE" are provided by the European Opendata Portal: CORDIS opendata.

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