Explore the words cloud of the BRAV3 project. It provides you a very rough idea of what is the project "BRAV3" about.
The following table provides information about the project.
UNIVERSIDAD DE NAVARRA
|Coordinator Country||Spain [ES]|
|Total cost||8˙000˙000 €|
|EC max contribution||8˙000˙000 € (100%)|
1. H2020-EU.3.1.3. (Treating and managing disease)
|Duration (year-month-day)||from 2020-01-01 to 2024-12-31|
Take a look of project's partnership.
|1||UNIVERSIDAD DE NAVARRA||ES (PAMPLONA)||coordinator||800˙500.00|
|2||INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA||PT (OEIRAS)||participant||770˙000.00|
|3||FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA||ES (BARCELONA)||participant||740˙000.00|
|4||UNIVERSITAIR MEDISCH CENTRUM UTRECHT||NL (UTRECHT)||participant||740˙000.00|
|5||UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT||DE (WURZBURG)||participant||683˙125.00|
|6||LEARTIKER, SCOOP||ES (MARKINA-XEMEIN)||participant||579˙375.00|
|7||UNIVERSIDAD DE ZARAGOZA||ES (ZARAGOZA)||participant||560˙000.00|
|8||EBERS MEDICAL TECHNOLOGY SL||ES (ZARAGOZA)||participant||559˙375.00|
|9||KATHOLIEKE UNIVERSITEIT LEUVEN||BE (LEUVEN)||participant||555˙250.00|
|10||TECHNISCHE UNIVERSITEIT EINDHOVEN||NL (EINDHOVEN)||participant||490˙000.00|
|11||BOSTON SCIENTIFIC LIMITED||IE (Galway)||participant||471˙750.00|
|12||PNO INNOVATION SL||ES (BARCELONA)||participant||458˙750.00|
|13||SERVICIO MADRILENO DE SALUD||ES (MADRID)||participant||441˙875.00|
|14||AE MEDICALIS BV||NL (WAALWIJK)||participant||150˙000.00|
Ischemic heart disease is the main cause of death in the EU, straining patients and economies. Regenerative Medicine has failed at delivering a definitive solution, and even the breakthrough of cell reprogramming, biomaterials or 3D printing, have not been able to find a curative solution. Generating a muscle with efficient pumping requires a careful recapitulation of the myocardial architecture. BRAV∃ is born with the ambition of shaping this quantum leap in the field. The overall concept is to provide a lasting functional support to injured hearts through the fabrication of regenerative personalized advanced tissue engineering-based biological ventricular assist devices (BioVADs). To do so, we will apply multimodal deep cardiac phenotyping, coupled to advanced Computational Modelling and biomechanical analysis in a large animal model of disease, to create a personalised 3D printable design. We will for the first time create a fibre-reinforced human heart-sized cardiac tissue able to recapitulate the low Young´s Modulus of the myocardium while withstanding pressures generated during the cardiac circle. Using the latest human induced pluripotent stem cell (hiPSC) technology and industrial-scale growth and differentiation, we will cellularize this novel human heart-sized constructs, creating a highly efficiently aligned cardiac tissue (including vasculature). BioVADs will be matured in in-Consortium built electromechanical stimulation bioreactors before transplantation in a porcine model of disease. We anticipate our BioVADs will constitute a one-shot regenerative treatment of IHD, decreasing the burden on healthcare providers and improving the quality of life of patients. Crucially, we will for the first time generate a wealth of information on heart development at a human scale. Delivering this novel application whilst developing the technological environment (bioreactor, chamber, pacemaker) will boost the capacity of the EU to grow economically and lead the field.
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The information about "BRAV3" are provided by the European Opendata Portal: CORDIS opendata.
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