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BRAV3 SIGNED

Computational biomechanics and bioengineering 3D printing to develop a personalized regenerative biological ventricular assist device to provide lasting functional support to damaged hearts

Total Cost €

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EC-Contrib. €

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Partnership

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 BRAV3 project word cloud

Explore the words cloud of the BRAV3 project. It provides you a very rough idea of what is the project "BRAV3" about.

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Project "BRAV3" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE NAVARRA 

Organization address
address: CAMPUS UNIVERSITARIO EDIFICIO CENTRAL
city: PAMPLONA
postcode: 31080
website: www.unav.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 8˙000˙000 €
 EC max contribution 8˙000˙000 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE NAVARRA ES (PAMPLONA) coordinator 800˙500.00
2    INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA PT (OEIRAS) participant 770˙000.00
3    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) participant 740˙000.00
4    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 740˙000.00
5    UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT DE (WURZBURG) participant 683˙125.00
6    LEARTIKER, SCOOP ES (MARKINA-XEMEIN) participant 579˙375.00
7    UNIVERSIDAD DE ZARAGOZA ES (ZARAGOZA) participant 560˙000.00
8    EBERS MEDICAL TECHNOLOGY SL ES (ZARAGOZA) participant 559˙375.00
9    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 555˙250.00
10    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) participant 490˙000.00
11    BOSTON SCIENTIFIC LIMITED IE (Galway) participant 471˙750.00
12    PNO INNOVATION SL ES (BARCELONA) participant 458˙750.00
13    SERVICIO MADRILENO DE SALUD ES (MADRID) participant 441˙875.00
14    AE MEDICALIS BV NL (WAALWIJK) participant 150˙000.00

Map

 Project objective

Ischemic heart disease is the main cause of death in the EU, straining patients and economies. Regenerative Medicine has failed at delivering a definitive solution, and even the breakthrough of cell reprogramming, biomaterials or 3D printing, have not been able to find a curative solution. Generating a muscle with efficient pumping requires a careful recapitulation of the myocardial architecture. BRAV∃ is born with the ambition of shaping this quantum leap in the field. The overall concept is to provide a lasting functional support to injured hearts through the fabrication of regenerative personalized advanced tissue engineering-based biological ventricular assist devices (BioVADs). To do so, we will apply multimodal deep cardiac phenotyping, coupled to advanced Computational Modelling and biomechanical analysis in a large animal model of disease, to create a personalised 3D printable design. We will for the first time create a fibre-reinforced human heart-sized cardiac tissue able to recapitulate the low Young´s Modulus of the myocardium while withstanding pressures generated during the cardiac circle. Using the latest human induced pluripotent stem cell (hiPSC) technology and industrial-scale growth and differentiation, we will cellularize this novel human heart-sized constructs, creating a highly efficiently aligned cardiac tissue (including vasculature). BioVADs will be matured in in-Consortium built electromechanical stimulation bioreactors before transplantation in a porcine model of disease. We anticipate our BioVADs will constitute a one-shot regenerative treatment of IHD, decreasing the burden on healthcare providers and improving the quality of life of patients. Crucially, we will for the first time generate a wealth of information on heart development at a human scale. Delivering this novel application whilst developing the technological environment (bioreactor, chamber, pacemaker) will boost the capacity of the EU to grow economically and lead the field.

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The information about "BRAV3" are provided by the European Opendata Portal: CORDIS opendata.

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