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BRAV3 SIGNED

Computational biomechanics and bioengineering 3D printing to develop a personalized regenerative biological ventricular assist device to provide lasting functional support to damaged hearts

Total Cost €

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EC-Contrib. €

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Partnership

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BRAV3 project word cloud

Explore the words cloud of the BRAV3 project. It provides you a very rough idea of what is the project "BRAV3" about.

cellularize environment deep shot hearts tissue wealth modulus biovads decreasing animal bioreactor latest constitute cell model circle quality disease aligned time born patients human breakthrough hipsc transplantation reprogramming myocardial economies bioreactors healthcare printable porcine leap ihd efficient curative electromechanical assist printing economically acute matured first delivering solution ambition treatment brav pluripotent ventricular recapitulation careful stem stimulation pressures injured differentiation pacemaker fabrication definitive fibre whilst industrial biomaterials shaping coupled constructs withstanding cardiac multimodal functional burden providers computational anticipate myocardium death heart quantum life biological regenerative capacity generate sized vasculature straining failed muscle personalised 3d personalized create recapitulate reinforced medicine chamber grow phenotyping pumping engineering biomechanical architecture boost lasting generating exist technological crucially young ischemic

Project "BRAV3" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD DE NAVARRA Organization address address: CAMPUS UNIVERSITARIO EDIFICIO CENTRAL city: PAMPLONA postcode: 31080 website: www.unav.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	8˙000˙000 €
EC max contribution	8˙000˙000 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2019-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2024-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD DE NAVARRA UNIVERSIDAD DE NAVARRA Organization address address: CAMPUS UNIVERSITARIO EDIFICIO CENTRAL city: PAMPLONA postcode: 31080 website: www.unav.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (PAMPLONA)	coordinator	800˙500.00
2	INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA Organization address address: AVENIDA DA REPUBLICA QUINTO DO MARQUES city: OEIRAS postcode: 2781 901 website: www.ibet.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (OEIRAS)	participant	770˙000.00
3	FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA Organization address address: CARRER BALDIRI REIXAC PLANTA 2A 10-12 city: BARCELONA postcode: 8028 website: http://www.ibecbarcelona.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	740˙000.00
4	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	740˙000.00
5	UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT Organization address address: JOSEF-SCHNEIDER-STRASSE 2 city: WURZBURG postcode: 97080 website: www.uk-wuerzburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (WURZBURG)	participant	683˙125.00
6	LEARTIKER, SCOOP LEARTIKER, SCOOP Organization address address: AV/ XEMEIN, 12 city: MARKINA-XEMEIN postcode: 48270 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MARKINA-XEMEIN)	participant	579˙375.00
7	UNIVERSIDAD DE ZARAGOZA UNIVERSIDAD DE ZARAGOZA Organization address address: CALLE PEDRO CERBUNA 12 city: ZARAGOZA postcode: 50009 website: www.unizar.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (ZARAGOZA)	participant	560˙000.00
8	EBERS MEDICAL TECHNOLOGY SL EBERS MEDICAL TECHNOLOGY SL Organization address address: AVENIDA DE MADRID 117 5 A city: ZARAGOZA postcode: 50010 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (ZARAGOZA)	participant	559˙375.00
9	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	555˙250.00
10	TECHNISCHE UNIVERSITEIT EINDHOVEN TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	participant	490˙000.00
11	BOSTON SCIENTIFIC LIMITED BOSTON SCIENTIFIC LIMITED Organization address address: BALLYBRIT BUSINESS PARK city: Galway postcode: H91 website: www.bostonscientific.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	participant	471˙750.00
12	PNO INNOVATION SL PNO INNOVATION SL Organization address address: CALLE GRAN DE GRACIA 1 PLANTA 2 PUERTA 3 city: BARCELONA postcode: 8012 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	458˙750.00
13	SERVICIO MADRILENO DE SALUD SERVICIO MADRILENO DE SALUD Organization address address: PLAZA CARLOS TRIAS BERTRAN 7 city: MADRID postcode: 28020 website: http://cort.as/10Yf contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	441˙875.00
14	AE MEDICALIS BV AE MEDICALIS BV Organization address address: INDUSTRIEWEG 78 city: WAALWIJK postcode: 5145 PW website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (WAALWIJK)	participant	150˙000.00

Map

Project objective

Ischemic heart disease is the main cause of death in the EU, straining patients and economies. Regenerative Medicine has failed at delivering a definitive solution, and even the breakthrough of cell reprogramming, biomaterials or 3D printing, have not been able to find a curative solution. Generating a muscle with efficient pumping requires a careful recapitulation of the myocardial architecture. BRAV∃ is born with the ambition of shaping this quantum leap in the field. The overall concept is to provide a lasting functional support to injured hearts through the fabrication of regenerative personalized advanced tissue engineering-based biological ventricular assist devices (BioVADs). To do so, we will apply multimodal deep cardiac phenotyping, coupled to advanced Computational Modelling and biomechanical analysis in a large animal model of disease, to create a personalised 3D printable design. We will for the first time create a fibre-reinforced human heart-sized cardiac tissue able to recapitulate the low Young´s Modulus of the myocardium while withstanding pressures generated during the cardiac circle. Using the latest human induced pluripotent stem cell (hiPSC) technology and industrial-scale growth and differentiation, we will cellularize this novel human heart-sized constructs, creating a highly efficiently aligned cardiac tissue (including vasculature). BioVADs will be matured in in-Consortium built electromechanical stimulation bioreactors before transplantation in a porcine model of disease. We anticipate our BioVADs will constitute a one-shot regenerative treatment of IHD, decreasing the burden on healthcare providers and improving the quality of life of patients. Crucially, we will for the first time generate a wealth of information on heart development at a human scale. Delivering this novel application whilst developing the technological environment (bioreactor, chamber, pacemaker) will boost the capacity of the EU to grow economically and lead the field.

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