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BRAV3 SIGNED

Computational biomechanics and bioengineering 3D printing to develop a personalized regenerative biological ventricular assist device to provide lasting functional support to damaged hearts

Total Cost €

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EC-Contrib. €

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Partnership

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 BRAV3 project word cloud

Explore the words cloud of the BRAV3 project. It provides you a very rough idea of what is the project "BRAV3" about.

transplantation    regenerative    wealth    curative    biomechanical    pressures    sized    industrial    reprogramming    recapitulate    human    fibre    medicine    cardiac    muscle    deep    time    straining    capacity    porcine    shot    circle    printable    acute    constructs    grow    myocardium    stem    generate    decreasing    generating    latest    pumping    assist    crucially    ambition    ischemic    definitive    architecture    quality    personalized    multimodal    careful    treatment    life    ventricular    providers    phenotyping    biovads    myocardial    injured    efficient    pluripotent    shaping    born    delivering    brav    young    burden    aligned    cellularize    lasting    coupled    matured    heart    hearts    bioreactors    anticipate    economies    healthcare    patients    pacemaker    exist    constitute    withstanding    cell    create    first    leap    economically    solution    whilst    modulus    vasculature    animal    engineering    disease    differentiation    technological    chamber    death    biomaterials    electromechanical    tissue    hipsc    quantum    ihd    computational    printing    personalised    fabrication    failed    functional    3d    biological    reinforced    bioreactor    model    boost    stimulation    environment    breakthrough    recapitulation   

Project "BRAV3" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE NAVARRA 

Organization address
address: CAMPUS UNIVERSITARIO EDIFICIO CENTRAL
city: PAMPLONA
postcode: 31080
website: www.unav.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 8˙000˙000 €
 EC max contribution 8˙000˙000 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE NAVARRA ES (PAMPLONA) coordinator 800˙500.00
2    INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA PT (OEIRAS) participant 770˙000.00
3    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) participant 740˙000.00
4    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 740˙000.00
5    UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT DE (WURZBURG) participant 683˙125.00
6    LEARTIKER, SCOOP ES (MARKINA-XEMEIN) participant 579˙375.00
7    UNIVERSIDAD DE ZARAGOZA ES (ZARAGOZA) participant 560˙000.00
8    EBERS MEDICAL TECHNOLOGY SL ES (ZARAGOZA) participant 559˙375.00
9    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 555˙250.00
10    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) participant 490˙000.00
11    BOSTON SCIENTIFIC LIMITED IE (Galway) participant 471˙750.00
12    PNO INNOVATION SL ES (BARCELONA) participant 458˙750.00
13    SERVICIO MADRILENO DE SALUD ES (MADRID) participant 441˙875.00
14    AE MEDICALIS BV NL (WAALWIJK) participant 150˙000.00

Map

 Project objective

Ischemic heart disease is the main cause of death in the EU, straining patients and economies. Regenerative Medicine has failed at delivering a definitive solution, and even the breakthrough of cell reprogramming, biomaterials or 3D printing, have not been able to find a curative solution. Generating a muscle with efficient pumping requires a careful recapitulation of the myocardial architecture. BRAV∃ is born with the ambition of shaping this quantum leap in the field. The overall concept is to provide a lasting functional support to injured hearts through the fabrication of regenerative personalized advanced tissue engineering-based biological ventricular assist devices (BioVADs). To do so, we will apply multimodal deep cardiac phenotyping, coupled to advanced Computational Modelling and biomechanical analysis in a large animal model of disease, to create a personalised 3D printable design. We will for the first time create a fibre-reinforced human heart-sized cardiac tissue able to recapitulate the low Young´s Modulus of the myocardium while withstanding pressures generated during the cardiac circle. Using the latest human induced pluripotent stem cell (hiPSC) technology and industrial-scale growth and differentiation, we will cellularize this novel human heart-sized constructs, creating a highly efficiently aligned cardiac tissue (including vasculature). BioVADs will be matured in in-Consortium built electromechanical stimulation bioreactors before transplantation in a porcine model of disease. We anticipate our BioVADs will constitute a one-shot regenerative treatment of IHD, decreasing the burden on healthcare providers and improving the quality of life of patients. Crucially, we will for the first time generate a wealth of information on heart development at a human scale. Delivering this novel application whilst developing the technological environment (bioreactor, chamber, pacemaker) will boost the capacity of the EU to grow economically and lead the field.

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The information about "BRAV3" are provided by the European Opendata Portal: CORDIS opendata.

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