Opendata, web and dolomites

BRAV3 SIGNED

Computational biomechanics and bioengineering 3D printing to develop a personalized regenerative biological ventricular assist device to provide lasting functional support to damaged hearts

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 BRAV3 project word cloud

Explore the words cloud of the BRAV3 project. It provides you a very rough idea of what is the project "BRAV3" about.

ambition    3d    circle    reinforced    pluripotent    pumping    whilst    capacity    young    exist    model    architecture    latest    functional    bioreactors    lasting    treatment    constitute    porcine    healthcare    pacemaker    medicine    careful    stem    phenotyping    born    matured    injured    muscle    economies    time    regenerative    computational    electromechanical    constructs    solution    patients    quantum    multimodal    animal    heart    definitive    hipsc    stimulation    generating    printing    cell    tissue    decreasing    recapitulation    ventricular    coupled    recapitulate    boost    quality    deep    environment    biomaterials    cellularize    first    shot    engineering    leap    curative    efficient    ischemic    life    wealth    anticipate    personalised    death    crucially    fibre    bioreactor    reprogramming    failed    cardiac    economically    generate    modulus    hearts    create    printable    assist    withstanding    acute    breakthrough    biomechanical    shaping    chamber    providers    vasculature    biovads    fabrication    industrial    grow    aligned    straining    myocardium    transplantation    human    differentiation    technological    personalized    brav    biological    disease    sized    delivering    myocardial    burden    pressures    ihd   

Project "BRAV3" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE NAVARRA 

Organization address
address: CAMPUS UNIVERSITARIO EDIFICIO CENTRAL
city: PAMPLONA
postcode: 31080
website: www.unav.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 8˙000˙000 €
 EC max contribution 8˙000˙000 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE NAVARRA ES (PAMPLONA) coordinator 800˙500.00
2    INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA PT (OEIRAS) participant 770˙000.00
3    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) participant 740˙000.00
4    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 740˙000.00
5    UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT DE (WURZBURG) participant 683˙125.00
6    LEARTIKER, SCOOP ES (MARKINA-XEMEIN) participant 579˙375.00
7    UNIVERSIDAD DE ZARAGOZA ES (ZARAGOZA) participant 560˙000.00
8    EBERS MEDICAL TECHNOLOGY SL ES (ZARAGOZA) participant 559˙375.00
9    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 555˙250.00
10    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) participant 490˙000.00
11    BOSTON SCIENTIFIC LIMITED IE (Galway) participant 471˙750.00
12    PNO INNOVATION SL ES (BARCELONA) participant 458˙750.00
13    SERVICIO MADRILENO DE SALUD ES (MADRID) participant 441˙875.00
14    AE MEDICALIS BV NL (WAALWIJK) participant 150˙000.00

Map

 Project objective

Ischemic heart disease is the main cause of death in the EU, straining patients and economies. Regenerative Medicine has failed at delivering a definitive solution, and even the breakthrough of cell reprogramming, biomaterials or 3D printing, have not been able to find a curative solution. Generating a muscle with efficient pumping requires a careful recapitulation of the myocardial architecture. BRAV∃ is born with the ambition of shaping this quantum leap in the field. The overall concept is to provide a lasting functional support to injured hearts through the fabrication of regenerative personalized advanced tissue engineering-based biological ventricular assist devices (BioVADs). To do so, we will apply multimodal deep cardiac phenotyping, coupled to advanced Computational Modelling and biomechanical analysis in a large animal model of disease, to create a personalised 3D printable design. We will for the first time create a fibre-reinforced human heart-sized cardiac tissue able to recapitulate the low Young´s Modulus of the myocardium while withstanding pressures generated during the cardiac circle. Using the latest human induced pluripotent stem cell (hiPSC) technology and industrial-scale growth and differentiation, we will cellularize this novel human heart-sized constructs, creating a highly efficiently aligned cardiac tissue (including vasculature). BioVADs will be matured in in-Consortium built electromechanical stimulation bioreactors before transplantation in a porcine model of disease. We anticipate our BioVADs will constitute a one-shot regenerative treatment of IHD, decreasing the burden on healthcare providers and improving the quality of life of patients. Crucially, we will for the first time generate a wealth of information on heart development at a human scale. Delivering this novel application whilst developing the technological environment (bioreactor, chamber, pacemaker) will boost the capacity of the EU to grow economically and lead the field.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BRAV3" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "BRAV3" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.3.1.3.)

PREFERABLE (2019)

Project on Exercise for Fatigue Eradication in Advanced Breast cancer to improve quality of life

Read More  

ESCALON (2019)

European-Latin American network for the assessment of biomarkers to predict and diagnose hepatobiliary malignancies and characterization of risk factors for cancer development

Read More  

CLOSER (2019)

Childhood Leukemia: Overcoming distance between South America and Europe Regions

Read More