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GIOTTO SIGNED

Active aGeIng and Osteoporosis: The next challenge for smarT nanobiOmaterials and 3D technologies

Total Cost €

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EC-Contrib. €

0

Partnership

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 GIOTTO project word cloud

Explore the words cloud of the GIOTTO project. It provides you a very rough idea of what is the project "GIOTTO" about.

men    software    scaffold    3d    half    nanobiomaterials    types    screws    die    stimulating    treat    inputs    anatomy    match    active    risk    activate    service    serious    stabilise    small    cement    boost    age    nanofunctionalisation    device    cues    functionalised    designing    elderly    materials    mechanotransduction    anti    radiopaque    treatment    systemic    osteoporotic    pelvic    manufacture    specificity    share    graded    dependent    drugs    appropriate    manufacturing    decision    bone    confined    personalisation    external    gather    suffering    data    people    predominantly    meet    fractures    cell    healing    tissue    patient    smart    effectiveness    solutions    giotto    magnetic    tool    injectable    activation    vertebral    function    chemical    prevalence    oscillating    validating    collate    things    align    postmenopausal    osteoporosis    deal    fibrous    women    clinical    bioresorbable    molecules    stimulate    nanoparticles    fracture    regeneration    internet    reducing    chain    disorder    ultimately    fifth    recruitment    additive    fixated    temporalised    remote    biological    technologies    measurable    parallel    platform    systematic    degenerative    release   

Project "GIOTTO" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI TORINO 

Organization address
address: CORSO DUCA DEGLI ABRUZZI 24
city: TORINO
postcode: 10129
website: www.polito.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 5˙660˙096 €
 EC max contribution 5˙660˙096 € (100%)
 Programme 1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-TR-IND-2018
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI TORINO IT (TORINO) coordinator 920˙750.00
2    BIOMECH INNOVATIONS AG CH (NIDAU) participant 622˙067.00
3    NOVAICOS SRLS IT (NOVARA (NO)) participant 550˙312.00
4    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 392˙490.00
5    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) participant 375˙000.00
6    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) participant 362˙445.00
7    DUBLIN CITY UNIVERSITY IE (DUBLIN) participant 355˙608.00
8    UNIVERSITA DI PISA IT (PISA) participant 332˙000.00
9    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) participant 326˙047.00
10    BEWARRANT BE (BRUXELLES) participant 324˙625.00
11    CELLINK AB SE (GOTEBORG) participant 300˙000.00
12    YODIWO ANONYMI ETAIREIA SCHEDIASISOLOKLIROMENON KYKLOMATON EL (RIO PATRAS) participant 297˙750.00
13    TECNOLOGIA NAVARRA DE NANOPRODUCTOS SL ES (LOS ARCOS) participant 263˙500.00
14    FLUIDINOVA SA PT (MAIA) participant 237˙500.00

Map

 Project objective

Osteoporosis is a systemic, degenerative disorder, predominantly affecting postmenopausal women (1 out of 3) but also men at an advanced age (1 out of 5) and it increases the prevalence of fracture risk. One fifth of people suffering an osteoporotic fracture will die within a year and half will become dependent. Appropriate anti-osteoporotic drugs are available but have serious side effects and they do not promote fracture healing. The concept behind GIOTTO is to develop a platform of technologies and materials for the treatment of different types of osteoporotic fractures, designing, manufacturing and validating three different solutions: 1) 3D graded scaffold, which can be fixated with screws, to treat long bone fractures 2) Fibrous scaffold to deal with small, not confined pelvic fractures; 3) Radiopaque, bioresorbable, injectable cement to stabilise vertebral fractures. The three devices will share smart nanobiomaterials that release chemical and biological cues to stimulate bone regeneration while reducing bone loss. Nanofunctionalisation and the smart, temporalised release of active molecules will allow for the systematic cell recruitment and activation needed to face the challenges of stimulating bone tissue regeneration in the elderly. The use of additive manufacturing technologies will enable device personalisation to match and better align with the patient’s anatomy and fracture type. A further boost to meet patient specificity and needs, will be provided through the use of functionalised magnetic nanoparticles in order to provide, via the application of an external oscillating magnetic field, a remote tool to activate mechanotransduction. In parallel, an Internet of Things platform will be developed to gather and collate measurable data inputs about device effectiveness and to provide decision support software as a service to improve the design, manufacture and clinical function of the proposed devices, ultimately managing the overall value chain.

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The information about "GIOTTO" are provided by the European Opendata Portal: CORDIS opendata.

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