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GIOTTO SIGNED

Active aGeIng and Osteoporosis: The next challenge for smarT nanobiOmaterials and 3D technologies

Total Cost €

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EC-Contrib. €

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Partnership

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 GIOTTO project word cloud

Explore the words cloud of the GIOTTO project. It provides you a very rough idea of what is the project "GIOTTO" about.

share    validating    osteoporosis    bone    nanobiomaterials    measurable    graded    giotto    magnetic    release    collate    men    vertebral    anti    degenerative    cement    stabilise    pelvic    activate    smart    people    fractures    solutions    ultimately    dependent    tool    deal    molecules    temporalised    women    regeneration    treatment    scaffold    device    injectable    confined    match    stimulate    software    healing    clinical    cell    small    radiopaque    effectiveness    align    recruitment    decision    chain    disorder    anatomy    3d    half    manufacture    designing    personalisation    fifth    things    materials    nanoparticles    serious    data    internet    screws    osteoporotic    platform    cues    die    mechanotransduction    fracture    systematic    nanofunctionalisation    chemical    gather    types    elderly    remote    specificity    manufacturing    predominantly    additive    postmenopausal    meet    service    prevalence    systemic    biological    functionalised    age    suffering    active    risk    fixated    activation    reducing    tissue    parallel    oscillating    stimulating    technologies    patient    function    bioresorbable    inputs    boost    fibrous    external    appropriate    drugs    treat   

Project "GIOTTO" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI TORINO 

Organization address
address: CORSO DUCA DEGLI ABRUZZI 24
city: TORINO
postcode: 10129
website: www.polito.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 5˙660˙096 €
 EC max contribution 5˙660˙096 € (100%)
 Programme 1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-TR-IND-2018
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI TORINO IT (TORINO) coordinator 920˙750.00
2    BIOMECH INNOVATIONS AG CH (NIDAU) participant 622˙067.00
3    NOVAICOS SRLS IT (NOVARA (NO)) participant 550˙312.00
4    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 392˙490.00
5    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) participant 375˙000.00
6    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) participant 362˙445.00
7    DUBLIN CITY UNIVERSITY IE (DUBLIN) participant 355˙608.00
8    UNIVERSITA DI PISA IT (PISA) participant 332˙000.00
9    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) participant 326˙047.00
10    BEWARRANT BE (BRUXELLES) participant 324˙625.00
11    CELLINK AB SE (GOTEBORG) participant 300˙000.00
12    YODIWO ANONYMI ETAIREIA SCHEDIASISOLOKLIROMENON KYKLOMATON EL (RIO PATRAS) participant 297˙750.00
13    TECNOLOGIA NAVARRA DE NANOPRODUCTOS SL ES (LOS ARCOS) participant 263˙500.00
14    FLUIDINOVA SA PT (MAIA) participant 237˙500.00

Map

 Project objective

Osteoporosis is a systemic, degenerative disorder, predominantly affecting postmenopausal women (1 out of 3) but also men at an advanced age (1 out of 5) and it increases the prevalence of fracture risk. One fifth of people suffering an osteoporotic fracture will die within a year and half will become dependent. Appropriate anti-osteoporotic drugs are available but have serious side effects and they do not promote fracture healing. The concept behind GIOTTO is to develop a platform of technologies and materials for the treatment of different types of osteoporotic fractures, designing, manufacturing and validating three different solutions: 1) 3D graded scaffold, which can be fixated with screws, to treat long bone fractures 2) Fibrous scaffold to deal with small, not confined pelvic fractures; 3) Radiopaque, bioresorbable, injectable cement to stabilise vertebral fractures. The three devices will share smart nanobiomaterials that release chemical and biological cues to stimulate bone regeneration while reducing bone loss. Nanofunctionalisation and the smart, temporalised release of active molecules will allow for the systematic cell recruitment and activation needed to face the challenges of stimulating bone tissue regeneration in the elderly. The use of additive manufacturing technologies will enable device personalisation to match and better align with the patient’s anatomy and fracture type. A further boost to meet patient specificity and needs, will be provided through the use of functionalised magnetic nanoparticles in order to provide, via the application of an external oscillating magnetic field, a remote tool to activate mechanotransduction. In parallel, an Internet of Things platform will be developed to gather and collate measurable data inputs about device effectiveness and to provide decision support software as a service to improve the design, manufacture and clinical function of the proposed devices, ultimately managing the overall value chain.

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The information about "GIOTTO" are provided by the European Opendata Portal: CORDIS opendata.

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