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GPCR-MS SIGNED

Molecular Details of Membrane Protein Receptor Dynamics

Total Cost €

0

EC-Contrib. €

0

Partnership

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 GPCR-MS project word cloud

Explore the words cloud of the GPCR-MS project. It provides you a very rough idea of what is the project "GPCR-MS" about.

selective    assembly    competences    curie    understand    spectrometry    mutation    excellent    modulate    40    propensities    profile    professional    provides    network    discovery    environment    native    context    international    activation    diversify    market    stimuli    host    structure    connection    expression    despite    alzheimer    cancer    owdowska    diseases    gaining    goals    chemistry    implications    marie    extensive    quality    protein    binding    sk    proteins    molecular    efforts    fellowship    off    aligns    mobility    tolerance    mass    lipids    fuse    receptors    ms    ligand    membrane    interrelated    conformations    human    laboratory    reveal    disease    expand    health    dynamics    conformational    fundamental    turn    family    gpcr    transducing    influence    lipid    hypothesis    tools    implicated    training    multidisciplinary    drug    drugs    biology    governing    coupled    thereby    library    personal    uses    inactivation    life    inform    analytical    structural    gpcrs    forefront    regulating   

Project "GPCR-MS" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 224˙933.00

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 Project objective

G-protein coupled receptors (GPCRs) are the largest family of membrane proteins. They are involved in transducing stimuli and are implicated in many diseases including cancer and Alzheimer’s disease. As a result, they are the target of ~40% of drugs on the market. Despite an extensive library of known binding partners, dynamics related to GPCR activation (and inactivation) are not fully understood.

The proposal uses a hypothesis driven approach to address three interrelated objectives. Objective 1 aims to reveal the propensities for lipids to modulate ligand binding to GPCRs. Objective 2 seeks to understand the intra-molecular factors regulating GPCR and G-protein assembly and their connection with the lipid environment. Objective 3 targets GPCR assembly and binding in the context of a native membrane.

This project will use fuse knowledge and tools from molecular biology (e.g. protein expression and mutation) and analytical chemistry (mass spectrometry (MS)) to facilitate a comprehensive understanding of the molecular environment governing GPCR dynamics and assembly. The results of this project will contribute to our understanding of the influence of lipids on conformational dynamics to inform efforts to better understand off-target drug effects and drug tolerance. This information could in turn reveal novel GPCR conformations that facilitate state-selective structure-based drug discovery, with great implications for human health and quality of life.

This proposal aligns with goals of the Marie Skłowdowska-Curie Fellowship: I will diversify my professional profile, which has focused on fundamental MS in the US, by gaining new competences in molecular and structural biology in Europe and thereby expand my personal and professional network through international mobility. The host laboratory is at the forefront of MS in structural biology and provides an excellent multidisciplinary training environment.

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