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GPCR-MS SIGNED

Molecular Details of Membrane Protein Receptor Dynamics

Total Cost €

0

EC-Contrib. €

0

Partnership

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 GPCR-MS project word cloud

Explore the words cloud of the GPCR-MS project. It provides you a very rough idea of what is the project "GPCR-MS" about.

family    interrelated    quality    tools    40    drug    regulating    extensive    professional    spectrometry    host    lipids    fellowship    chemistry    international    training    activation    health    alzheimer    receptors    conformational    connection    diversify    disease    inform    protein    forefront    thereby    lipid    tolerance    expand    uses    binding    off    diseases    conformations    fundamental    ligand    competences    native    context    curie    sk    gpcr    turn    efforts    gaining    laboratory    reveal    inactivation    market    aligns    owdowska    network    library    gpcrs    despite    implicated    goals    personal    structure    governing    excellent    hypothesis    analytical    proteins    mutation    profile    structural    marie    dynamics    ms    selective    fuse    implications    human    influence    environment    biology    life    cancer    transducing    molecular    stimuli    assembly    provides    mobility    expression    discovery    propensities    understand    multidisciplinary    modulate    mass    membrane    drugs    coupled   

Project "GPCR-MS" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 224˙933.00

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 Project objective

G-protein coupled receptors (GPCRs) are the largest family of membrane proteins. They are involved in transducing stimuli and are implicated in many diseases including cancer and Alzheimer’s disease. As a result, they are the target of ~40% of drugs on the market. Despite an extensive library of known binding partners, dynamics related to GPCR activation (and inactivation) are not fully understood.

The proposal uses a hypothesis driven approach to address three interrelated objectives. Objective 1 aims to reveal the propensities for lipids to modulate ligand binding to GPCRs. Objective 2 seeks to understand the intra-molecular factors regulating GPCR and G-protein assembly and their connection with the lipid environment. Objective 3 targets GPCR assembly and binding in the context of a native membrane.

This project will use fuse knowledge and tools from molecular biology (e.g. protein expression and mutation) and analytical chemistry (mass spectrometry (MS)) to facilitate a comprehensive understanding of the molecular environment governing GPCR dynamics and assembly. The results of this project will contribute to our understanding of the influence of lipids on conformational dynamics to inform efforts to better understand off-target drug effects and drug tolerance. This information could in turn reveal novel GPCR conformations that facilitate state-selective structure-based drug discovery, with great implications for human health and quality of life.

This proposal aligns with goals of the Marie Skłowdowska-Curie Fellowship: I will diversify my professional profile, which has focused on fundamental MS in the US, by gaining new competences in molecular and structural biology in Europe and thereby expand my personal and professional network through international mobility. The host laboratory is at the forefront of MS in structural biology and provides an excellent multidisciplinary training environment.

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The information about "GPCR-MS" are provided by the European Opendata Portal: CORDIS opendata.

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