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ANAT-MEC SIGNED

Developing 2-photon optical imaging for neural-network studies in medial entorhinal cortex of freely moving mice

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ANAT-MEC project word cloud

Explore the words cloud of the ANAT-MEC project. It provides you a very rough idea of what is the project "ANAT-MEC" about.

anatomical    sensory    power    dimensional    single    question    besides    unravel    spaces    vector    grid    technique    specificity    map    scales    self    imaging    association    overlapping    internal    functional    uses    speed    examine    tpm    microscope    time    parasubiculum    mice    doors    animals    refine    fast    weight    space    resolution    largely    create    environments    multiple    mec    unprecedented    neural    thought    direction    border    portable    miniaturized    naturalistic    medial    population    phd    matched    move    optical    position    cortices    navigation    types    shedding    macro    function    motor    photon    exploratory    transformations    behaving    spatial    division    mammalian    engage    clear    cells    behavior    input    circuit    mechanisms    2g    calcium    performed    code    populations    cell    networks    head    algorithms    light    unfortunately    appropriate    absence    invented    obvious    cortex    prevented    organization    fundamental    computational    exploring    first    layer    functionally    output    micro    entorhinal    object    adjacent    recording    fhirm    hundreds    anat    directed    microscopy   

Project "ANAT-MEC" data sheet

The following table provides information about the project.

Coordinator
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU 

Organization address
address: HOGSKOLERINGEN 1
city: TRONDHEIM
postcode: 7491
website: www.ntnu.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 214˙158 €
 EC max contribution 214˙158 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NO (TRONDHEIM) coordinator 214˙158.00

Map

 Project objective

The medial entorhinal cortex (MEC) and the adjacent pre- and parasubiculum are thought to create an internal map of self-position that animals may use for goal-directed navigation. This map uses a set of functionally specific and largely non-overlapping cell types: grid cells, border cells, speed cells, object-vector cells, and head-direction cells. The presence of multiple distinct functional cell types, matched in specificity only by cell populations in some of the sensory and motor cortices, allows us to examine input-output transformations and computational algorithms in association cortices with unprecedented power and detail. In order to examine these algorithms, however, an obvious and crucial first step is to map the division of function across cells in anatomical space. This requires recording of hundreds of cells at the same time in freely-behaving animals exploring open spatial environments. Unfortunately the absence of appropriate methods for neural recording at the population level has so far prevented a clear understanding of the broader organization of multi-cell-type and multi-layer networks of MEC, at both micro and macro scales.    During my PhD, I invented a technique called “fast high-resolution miniaturized two-photon microscopy (FHIRM-TPM)”, which, through the use of a portable light-weight (2g) two-photon microscope, allows animals to move freely while large scale, single-cell-resolution calcium imaging is performed. In ANAT-MEC, I will refine this optical imaging method to study neural activity during spatial navigation in two-dimensional environments. I shall characterize in detail the anatomical organization of distinct cell types in MEC while mice engage in naturalistic, exploratory behavior in open spaces. Besides shedding light on this specific question, the project will – by developing a new technology - also open doors to unravel fundamental mechanisms of neural code formation in the mammalian space circuit.

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