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ANAT-MEC SIGNED

Developing 2-photon optical imaging for neural-network studies in medial entorhinal cortex of freely moving mice

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ANAT-MEC project word cloud

Explore the words cloud of the ANAT-MEC project. It provides you a very rough idea of what is the project "ANAT-MEC" about.

question    largely    unravel    direction    matched    exploring    imaging    medial    miniaturized    specificity    position    macro    weight    technique    spaces    layer    sensory    motor    exploratory    dimensional    circuit    engage    fundamental    object    calcium    light    internal    behavior    fast    examine    directed    algorithms    portable    first    tpm    mice    power    organization    adjacent    environments    create    prevented    neural    time    functional    space    input    navigation    invented    output    speed    microscopy    absence    unfortunately    division    unprecedented    refine    single    anatomical    micro    overlapping    scales    mammalian    phd    hundreds    code    population    parasubiculum    cortex    shedding    mechanisms    2g    entorhinal    naturalistic    types    multiple    thought    photon    fhirm    besides    functionally    animals    resolution    association    self    performed    populations    map    obvious    spatial    computational    grid    behaving    cortices    appropriate    transformations    vector    networks    head    cell    mec    function    uses    border    anat    optical    clear    cells    microscope    doors    recording    move   

Project "ANAT-MEC" data sheet

The following table provides information about the project.

Coordinator
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU 

Organization address
address: HOGSKOLERINGEN 1
city: TRONDHEIM
postcode: 7491
website: www.ntnu.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 214˙158 €
 EC max contribution 214˙158 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NO (TRONDHEIM) coordinator 214˙158.00

Map

 Project objective

The medial entorhinal cortex (MEC) and the adjacent pre- and parasubiculum are thought to create an internal map of self-position that animals may use for goal-directed navigation. This map uses a set of functionally specific and largely non-overlapping cell types: grid cells, border cells, speed cells, object-vector cells, and head-direction cells. The presence of multiple distinct functional cell types, matched in specificity only by cell populations in some of the sensory and motor cortices, allows us to examine input-output transformations and computational algorithms in association cortices with unprecedented power and detail. In order to examine these algorithms, however, an obvious and crucial first step is to map the division of function across cells in anatomical space. This requires recording of hundreds of cells at the same time in freely-behaving animals exploring open spatial environments. Unfortunately the absence of appropriate methods for neural recording at the population level has so far prevented a clear understanding of the broader organization of multi-cell-type and multi-layer networks of MEC, at both micro and macro scales.    During my PhD, I invented a technique called “fast high-resolution miniaturized two-photon microscopy (FHIRM-TPM)”, which, through the use of a portable light-weight (2g) two-photon microscope, allows animals to move freely while large scale, single-cell-resolution calcium imaging is performed. In ANAT-MEC, I will refine this optical imaging method to study neural activity during spatial navigation in two-dimensional environments. I shall characterize in detail the anatomical organization of distinct cell types in MEC while mice engage in naturalistic, exploratory behavior in open spaces. Besides shedding light on this specific question, the project will – by developing a new technology - also open doors to unravel fundamental mechanisms of neural code formation in the mammalian space circuit.

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