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ANAT-MEC SIGNED

Developing 2-photon optical imaging for neural-network studies in medial entorhinal cortex of freely moving mice

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ANAT-MEC project word cloud

Explore the words cloud of the ANAT-MEC project. It provides you a very rough idea of what is the project "ANAT-MEC" about.

object    organization    transformations    behavior    anatomical    single    adjacent    optical    function    specificity    functionally    move    exploring    weight    doors    shedding    directed    absence    fast    appropriate    mechanisms    motor    unprecedented    matched    direction    anat    cortices    recording    micro    performed    computational    imaging    dimensional    2g    spaces    unfortunately    phd    clear    refine    technique    time    prevented    vector    question    parasubiculum    exploratory    medial    cells    largely    head    light    hundreds    cell    calcium    position    photon    macro    microscopy    networks    types    resolution    portable    cortex    map    border    division    self    mice    scales    algorithms    grid    naturalistic    unravel    fundamental    multiple    internal    obvious    circuit    sensory    power    layer    functional    thought    fhirm    behaving    speed    code    environments    population    mammalian    invented    output    first    overlapping    animals    space    engage    mec    tpm    uses    entorhinal    miniaturized    spatial    microscope    navigation    populations    neural    association    examine    create    input    besides   

Project "ANAT-MEC" data sheet

The following table provides information about the project.

Coordinator
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU 

Organization address
address: HOGSKOLERINGEN 1
city: TRONDHEIM
postcode: 7491
website: www.ntnu.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 214˙158 €
 EC max contribution 214˙158 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NO (TRONDHEIM) coordinator 214˙158.00

Map

 Project objective

The medial entorhinal cortex (MEC) and the adjacent pre- and parasubiculum are thought to create an internal map of self-position that animals may use for goal-directed navigation. This map uses a set of functionally specific and largely non-overlapping cell types: grid cells, border cells, speed cells, object-vector cells, and head-direction cells. The presence of multiple distinct functional cell types, matched in specificity only by cell populations in some of the sensory and motor cortices, allows us to examine input-output transformations and computational algorithms in association cortices with unprecedented power and detail. In order to examine these algorithms, however, an obvious and crucial first step is to map the division of function across cells in anatomical space. This requires recording of hundreds of cells at the same time in freely-behaving animals exploring open spatial environments. Unfortunately the absence of appropriate methods for neural recording at the population level has so far prevented a clear understanding of the broader organization of multi-cell-type and multi-layer networks of MEC, at both micro and macro scales.    During my PhD, I invented a technique called “fast high-resolution miniaturized two-photon microscopy (FHIRM-TPM)”, which, through the use of a portable light-weight (2g) two-photon microscope, allows animals to move freely while large scale, single-cell-resolution calcium imaging is performed. In ANAT-MEC, I will refine this optical imaging method to study neural activity during spatial navigation in two-dimensional environments. I shall characterize in detail the anatomical organization of distinct cell types in MEC while mice engage in naturalistic, exploratory behavior in open spaces. Besides shedding light on this specific question, the project will – by developing a new technology - also open doors to unravel fundamental mechanisms of neural code formation in the mammalian space circuit.

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