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Developing 2-photon optical imaging for neural-network studies in medial entorhinal cortex of freely moving mice

Total Cost €


EC-Contrib. €






 ANAT-MEC project word cloud

Explore the words cloud of the ANAT-MEC project. It provides you a very rough idea of what is the project "ANAT-MEC" about.

appropriate    function    fundamental    behaving    obvious    navigation    2g    cell    macro    populations    prevented    refine    phd    head    exploring    hundreds    photon    single    population    cortex    sensory    spaces    object    anatomical    types    absence    directed    self    space    besides    code    exploratory    overlapping    output    environments    portable    unfortunately    dimensional    optical    layer    mice    tpm    mammalian    position    computational    performed    time    networks    map    internal    doors    division    algorithms    animals    light    examine    spatial    transformations    naturalistic    imaging    unravel    border    organization    medial    power    clear    matched    first    functional    functionally    create    fhirm    recording    entorhinal    adjacent    resolution    engage    input    invented    mechanisms    grid    multiple    micro    motor    specificity    cortices    largely    miniaturized    move    association    direction    anat    technique    speed    circuit    microscopy    shedding    neural    thought    weight    question    fast    scales    unprecedented    uses    calcium    vector    microscope    mec    parasubiculum    behavior    cells   

Project "ANAT-MEC" data sheet

The following table provides information about the project.


Organization address
postcode: 7491

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 214˙158 €
 EC max contribution 214˙158 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The medial entorhinal cortex (MEC) and the adjacent pre- and parasubiculum are thought to create an internal map of self-position that animals may use for goal-directed navigation. This map uses a set of functionally specific and largely non-overlapping cell types: grid cells, border cells, speed cells, object-vector cells, and head-direction cells. The presence of multiple distinct functional cell types, matched in specificity only by cell populations in some of the sensory and motor cortices, allows us to examine input-output transformations and computational algorithms in association cortices with unprecedented power and detail. In order to examine these algorithms, however, an obvious and crucial first step is to map the division of function across cells in anatomical space. This requires recording of hundreds of cells at the same time in freely-behaving animals exploring open spatial environments. Unfortunately the absence of appropriate methods for neural recording at the population level has so far prevented a clear understanding of the broader organization of multi-cell-type and multi-layer networks of MEC, at both micro and macro scales.    During my PhD, I invented a technique called “fast high-resolution miniaturized two-photon microscopy (FHIRM-TPM)”, which, through the use of a portable light-weight (2g) two-photon microscope, allows animals to move freely while large scale, single-cell-resolution calcium imaging is performed. In ANAT-MEC, I will refine this optical imaging method to study neural activity during spatial navigation in two-dimensional environments. I shall characterize in detail the anatomical organization of distinct cell types in MEC while mice engage in naturalistic, exploratory behavior in open spaces. Besides shedding light on this specific question, the project will – by developing a new technology - also open doors to unravel fundamental mechanisms of neural code formation in the mammalian space circuit.

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The information about "ANAT-MEC" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2021-05-07 9:25:44) correctly updated