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RememberEx SIGNED

Human Subcortical-Cortical Circuit Dynamics for Remembering the Exceptional

Total Cost €

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EC-Contrib. €

0

Partnership

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 RememberEx project word cloud

Explore the words cloud of the RememberEx project. It provides you a very rough idea of what is the project "RememberEx" about.

retrieve    dynamics    structures    subcortico    accumbens    episodic    invasive    focal    underlying    hippocampal    events    ventral    stimuli    enhanced    recordings    intracranial    function    regarding    detecting    remember    hippocampus    interventions    motivated    neuropsychiatric    imaging    midbrain    electrical    our    subcortical    gained    neuronal    combating    mundane    models    fundamental    form    unpredicted    circuit    conceptual    event    memories    discover    extend    surprise    breakthroughs    prevailing    critical    burden    unpredictable    elucidate    human    remembering    pathologies    econonomic    upregulating    socio    stimulation    mechanisms    scarce    predictions    cortical    emotional    predicted    experimental    dopamine    mechanistic    humans    dopaminergic    profile    orchestrating    requirement    animal    amygdala    cortex    coupling    memory    stimulus    disorders    framework    nucleus    context    preliminary    direct    huge    violate    patients    electrophysiological    lesion    data    dysfunction    exceptional    contexts    deficits    designing    mesolimbic    functional    therapeutic    encoding    characterise    incidence    salient   

Project "RememberEx" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD POLITECNICA DE MADRID 

Organization address
address: CALLE RAMIRO DE MAEZTU 7 EDIFICIO RECTORADO
city: MADRID
postcode: 28040
website: www.upm.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD POLITECNICA DE MADRID ES (MADRID) coordinator 2˙000˙000.00

Map

 Project objective

Our memory system is optimised for remembering the exceptional over the mundane. We remember better those events that violate predictions generated by the prevailing context, particularly because of surprise or emotional impact. Understanding how we form and retrieve long-term memories for important or salient events is critical for combating the rapidly growing incidence of pathologies associated with memory dysfunction with huge socio-econonomic burden. Human lesion and non-invasive functional imaging data, motivated by findings from animal models, have identified subcortical structures that are critical for upregulating hippocampal function during salient event memory. However, mechanistic understanding of these processes in humans remains scarce, and requires better experimental approaches such as direct intracranial recordings from, and focal electrical stimulation of, these subcortical structures. This project will characterise human subcortico-cortical neuronal circuit dynamics associated with enhanced episodic memory for salient stimuli by studying direct recordings from human hippocampus, amygdala, nucleus accumbens, ventral midbrain and cortex. Within this framework, I will elucidate the electrophysiological mechanisms underlying amygdala-hippocampal-cortical coupling that lead to better memory for emotional stimuli, extend the hippocampal role in detecting unpredicted stimuli to define its role in orchestrating cortical dynamics in unpredictable contexts, and discover the neuronal response profile of the human mesolimbic dopamine system during salient stimulus encoding. The predicted results, based on my own preliminary data, will offer several conceptual breakthroughs, particularly regarding hippocampal function and the role of dopaminergic ventral midbrain in memory. The knowledge gained from this project is a fundamental requirement for designing therapeutic interventions for patients with memory deficits and other neuropsychiatric disorders.

 Deliverables

List of deliverables.
Data Management Plan Open Research Data Pilot 2019-11-11 10:19:30

Take a look to the deliverables list in detail:  detailed list of RememberEx deliverables.

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The information about "REMEMBEREX" are provided by the European Opendata Portal: CORDIS opendata.

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