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MIRACLE SIGNED

Metabolic Imaging with RF Antennas to predict Chemotherapy Efficacy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MIRACLE project word cloud

Explore the words cloud of the MIRACLE project. It provides you a very rough idea of what is the project "MIRACLE" about.

eusobi    invasively    deliverable    liver    antennas    phospholipid    vegas    ratio    clearance    formed    rf    utrecht    metabolic    cell    biomarker    7t    detection    metabolites    meeting    01    nici    prediction    validate    strongest    medical    society    membranes    scanned    75    world    houses    fet    nuclear    strength    oncology    chemistry    linked    university    list    accuracy    subjects    newly    company    predict    recognised    96    groups    5t    track    d6    establishing    image    clinically    immediately    cancer    fast    surgery    joint    shown    ismrm    detecting    demonstrated    umc    phosphoethanolamine    stakeholders    breakdown    glycerophosphocholine    uses    las    idea    hardware    fda    minnesota    provides    international    biomarkers    spin    powerful    gpc    801075    validation    2018    patients    approval    doctors    medicine    mri    pe    leads       imaging    efficacy    small    metastasis    resonance    clinical    conduct    chemotherapy    2017    innovation    breast    discussed    radiology    2016    magnetic    invasive   

Project "MIRACLE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 102˙500 €
 EC max contribution 100˙000 € (98%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-03
 Funding Scheme CSA
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 18˙750.00
2    WAVETRONICA BV NL (UTRECHT) participant 62˙500.00
3    REGENTS OF UNIVERSITY OF MINNESOTA US (MINNEAPOLIS MN) participant 18˙750.00

Map

 Project objective

Metabolic Imaging with RF Antennas to predict Chemotherapy Efficacy: We will validate the phospholipid biomarker that can predict response of chemotherapy in patients with breast cancer using the most powerful MRI system in the world. In particular the ratio of phosphoethanolamine (PE) to glycerophosphocholine (GPC), metabolites from the build up and breakdown of cell membranes, have been shown to increase accuracy in prediction of chemotherapy response from 75% to 96% [1]. At the clinically available field strength of 7T, we have recently demonstrated that we can image these phospholipid biomarkers non-invasively. In order to assess accuracy and bring the detection of the biomarker to FDA approval, we will spin out a validation study to investigate the accuracy in detecting the biomarker by comparing the results from the same subjects obtained at clinical MRI as well as at 10.5T MRI. The innovation idea is linked to the Non-Invasive-Chemistry-Imaging (NICI) project of FET-OPEN-01-2016-2017-801075. More specifically to the deliverable D6.1: “List of groups and stakeholders for targeted dissemination”. Here the potential of the NICI project that uses multi-nuclear 7T MRI in patients with metastasis in liver was shown to the stakeholders in breast cancer imaging (joint meeting of International Society of Magnetic Resonance in Medicine (ISMRM) with EUropean Society Of Breast Imaging (Eusobi) in Las Vegas 2018). The importance of imaging chemistry was immediately recognised by all medical doctors present (radiology, surgery and oncology), and fast track to FDA clearance was discussed. By establishing a small consortium of the UMC Utrecht that leads the project, a newly formed spin out company that provides the 7T and 10.5T specific hardware, and University of Minnesota that has access to patients and houses the world’s strongest MRI, we will conduct the biomarker validation in 10 subjects scanned at both systems.

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The information about "MIRACLE" are provided by the European Opendata Portal: CORDIS opendata.

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