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MIRACLE SIGNED

Metabolic Imaging with RF Antennas to predict Chemotherapy Efficacy

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MIRACLE project word cloud

Explore the words cloud of the MIRACLE project. It provides you a very rough idea of what is the project "MIRACLE" about.

imaging    5t    formed    resonance    mri    nuclear    cancer    detection    university    world    7t    predict    validation    shown    immediately    innovation    list    leads    75    subjects    uses    phosphoethanolamine    small    membranes    fet    breast    vegas    metabolic    metastasis    deliverable    clinical    magnetic    detecting    strength    powerful    ismrm    houses    demonstrated    liver    2016    glycerophosphocholine    recognised    strongest    minnesota    2018    scanned    prediction    biomarkers    newly    approval    utrecht    idea    meeting    fda    discussed    joint    2017    doctors    ratio    efficacy    image    nici    breakdown    801075    invasive    spin    international    radiology    provides    umc    chemistry    track    medicine    medical    pe    conduct    invasively    validate    chemotherapy    las    metabolites    hardware    patients    phospholipid    accuracy    gpc    society    d6    oncology    antennas    groups    01    establishing    96    clearance       clinically    rf    stakeholders    fast    company    linked    cell    biomarker    eusobi    surgery   

Project "MIRACLE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 102˙500 €
 EC max contribution 100˙000 € (98%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-03
 Funding Scheme CSA
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 18˙750.00
2    WAVETRONICA BV NL (UTRECHT) participant 62˙500.00
3    REGENTS OF UNIVERSITY OF MINNESOTA US (MINNEAPOLIS MN) participant 18˙750.00

Map

 Project objective

Metabolic Imaging with RF Antennas to predict Chemotherapy Efficacy: We will validate the phospholipid biomarker that can predict response of chemotherapy in patients with breast cancer using the most powerful MRI system in the world. In particular the ratio of phosphoethanolamine (PE) to glycerophosphocholine (GPC), metabolites from the build up and breakdown of cell membranes, have been shown to increase accuracy in prediction of chemotherapy response from 75% to 96% [1]. At the clinically available field strength of 7T, we have recently demonstrated that we can image these phospholipid biomarkers non-invasively. In order to assess accuracy and bring the detection of the biomarker to FDA approval, we will spin out a validation study to investigate the accuracy in detecting the biomarker by comparing the results from the same subjects obtained at clinical MRI as well as at 10.5T MRI. The innovation idea is linked to the Non-Invasive-Chemistry-Imaging (NICI) project of FET-OPEN-01-2016-2017-801075. More specifically to the deliverable D6.1: “List of groups and stakeholders for targeted dissemination”. Here the potential of the NICI project that uses multi-nuclear 7T MRI in patients with metastasis in liver was shown to the stakeholders in breast cancer imaging (joint meeting of International Society of Magnetic Resonance in Medicine (ISMRM) with EUropean Society Of Breast Imaging (Eusobi) in Las Vegas 2018). The importance of imaging chemistry was immediately recognised by all medical doctors present (radiology, surgery and oncology), and fast track to FDA clearance was discussed. By establishing a small consortium of the UMC Utrecht that leads the project, a newly formed spin out company that provides the 7T and 10.5T specific hardware, and University of Minnesota that has access to patients and houses the world’s strongest MRI, we will conduct the biomarker validation in 10 subjects scanned at both systems.

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The information about "MIRACLE" are provided by the European Opendata Portal: CORDIS opendata.

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