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MIRACLE SIGNED

Metabolic Imaging with RF Antennas to predict Chemotherapy Efficacy

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MIRACLE project word cloud

Explore the words cloud of the MIRACLE project. It provides you a very rough idea of what is the project "MIRACLE" about.

biomarker    clinical    linked    establishing    cancer    deliverable    metastasis    glycerophosphocholine    membranes    minnesota    detection    magnetic       phospholipid    clearance    801075    powerful    nuclear    liver    subjects    demonstrated    phosphoethanolamine    strongest    fda    innovation    75    breakdown    track    cell    patients    efficacy    world    groups    5t    stakeholders    fast    list    idea    eusobi    biomarkers    invasively    imaging    96    society    detecting    spin    company    utrecht    umc    university    breast    d6    predict    discussed    01    chemistry    scanned    2016    gpc    mri    clinically    nici    image    validate    joint    strength    newly    prediction    hardware    shown    invasive    immediately    leads    2018    recognised    surgery    vegas    formed    validation    small    medicine    oncology    resonance    houses    las    antennas    ratio    accuracy    medical    rf    fet    uses    metabolic    2017    doctors    approval    radiology    ismrm    metabolites    conduct    chemotherapy    meeting    pe    international    provides    7t   

Project "MIRACLE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 102˙500 €
 EC max contribution 100˙000 € (98%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-03
 Funding Scheme CSA
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 18˙750.00
2    WAVETRONICA BV NL (UTRECHT) participant 62˙500.00
3    REGENTS OF UNIVERSITY OF MINNESOTA US (MINNEAPOLIS MN) participant 18˙750.00

Map

 Project objective

Metabolic Imaging with RF Antennas to predict Chemotherapy Efficacy: We will validate the phospholipid biomarker that can predict response of chemotherapy in patients with breast cancer using the most powerful MRI system in the world. In particular the ratio of phosphoethanolamine (PE) to glycerophosphocholine (GPC), metabolites from the build up and breakdown of cell membranes, have been shown to increase accuracy in prediction of chemotherapy response from 75% to 96% [1]. At the clinically available field strength of 7T, we have recently demonstrated that we can image these phospholipid biomarkers non-invasively. In order to assess accuracy and bring the detection of the biomarker to FDA approval, we will spin out a validation study to investigate the accuracy in detecting the biomarker by comparing the results from the same subjects obtained at clinical MRI as well as at 10.5T MRI. The innovation idea is linked to the Non-Invasive-Chemistry-Imaging (NICI) project of FET-OPEN-01-2016-2017-801075. More specifically to the deliverable D6.1: “List of groups and stakeholders for targeted dissemination”. Here the potential of the NICI project that uses multi-nuclear 7T MRI in patients with metastasis in liver was shown to the stakeholders in breast cancer imaging (joint meeting of International Society of Magnetic Resonance in Medicine (ISMRM) with EUropean Society Of Breast Imaging (Eusobi) in Las Vegas 2018). The importance of imaging chemistry was immediately recognised by all medical doctors present (radiology, surgery and oncology), and fast track to FDA clearance was discussed. By establishing a small consortium of the UMC Utrecht that leads the project, a newly formed spin out company that provides the 7T and 10.5T specific hardware, and University of Minnesota that has access to patients and houses the world’s strongest MRI, we will conduct the biomarker validation in 10 subjects scanned at both systems.

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The information about "MIRACLE" are provided by the European Opendata Portal: CORDIS opendata.

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