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MIRACLE SIGNED

Metabolic Imaging with RF Antennas to predict Chemotherapy Efficacy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MIRACLE project word cloud

Explore the words cloud of the MIRACLE project. It provides you a very rough idea of what is the project "MIRACLE" about.

medicine    shown    international    pe    hardware    phospholipid    7t    mri    immediately    accuracy    metabolites    conduct    ratio    small    strongest    recognised    strength    surgery    invasively    scanned    groups    linked    newly    stakeholders    provides    clearance    establishing    cell    utrecht    biomarker    radiology    idea    imaging    prediction    efficacy    phosphoethanolamine    joint    validate    clinical    5t    meeting    patients    umc    detecting    medical    las    demonstrated    nuclear    breakdown    deliverable    houses    list    d6    glycerophosphocholine    minnesota    company    01    nici    eusobi    fda    liver    cancer    uses    oncology    doctors    2016    2018    801075    innovation    biomarkers    membranes    magnetic    powerful    75    formed    discussed    track    spin    rf    image    fet    invasive    chemotherapy    clinically    fast    predict    metabolic    resonance    gpc    world    breast    96    approval    society    antennas    vegas    chemistry    ismrm    subjects    leads    detection    validation    metastasis       2017    university   

Project "MIRACLE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 102˙500 €
 EC max contribution 100˙000 € (98%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-03
 Funding Scheme CSA
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 18˙750.00
2    WAVETRONICA BV NL (UTRECHT) participant 62˙500.00
3    REGENTS OF UNIVERSITY OF MINNESOTA US (MINNEAPOLIS MN) participant 18˙750.00

Map

 Project objective

Metabolic Imaging with RF Antennas to predict Chemotherapy Efficacy: We will validate the phospholipid biomarker that can predict response of chemotherapy in patients with breast cancer using the most powerful MRI system in the world. In particular the ratio of phosphoethanolamine (PE) to glycerophosphocholine (GPC), metabolites from the build up and breakdown of cell membranes, have been shown to increase accuracy in prediction of chemotherapy response from 75% to 96% [1]. At the clinically available field strength of 7T, we have recently demonstrated that we can image these phospholipid biomarkers non-invasively. In order to assess accuracy and bring the detection of the biomarker to FDA approval, we will spin out a validation study to investigate the accuracy in detecting the biomarker by comparing the results from the same subjects obtained at clinical MRI as well as at 10.5T MRI. The innovation idea is linked to the Non-Invasive-Chemistry-Imaging (NICI) project of FET-OPEN-01-2016-2017-801075. More specifically to the deliverable D6.1: “List of groups and stakeholders for targeted dissemination”. Here the potential of the NICI project that uses multi-nuclear 7T MRI in patients with metastasis in liver was shown to the stakeholders in breast cancer imaging (joint meeting of International Society of Magnetic Resonance in Medicine (ISMRM) with EUropean Society Of Breast Imaging (Eusobi) in Las Vegas 2018). The importance of imaging chemistry was immediately recognised by all medical doctors present (radiology, surgery and oncology), and fast track to FDA clearance was discussed. By establishing a small consortium of the UMC Utrecht that leads the project, a newly formed spin out company that provides the 7T and 10.5T specific hardware, and University of Minnesota that has access to patients and houses the world’s strongest MRI, we will conduct the biomarker validation in 10 subjects scanned at both systems.

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The information about "MIRACLE" are provided by the European Opendata Portal: CORDIS opendata.

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