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VASA SIGNED

Vaccine Against Schistosomiasis for Africa. A Phase I clinical study of the SchistoShield® anti-schistosomiasis vaccine in adults in endemic areas of sub-Saharan Africa

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 VASA project word cloud

Explore the words cloud of the VASA project. It provides you a very rough idea of what is the project "VASA" about.

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Project "VASA" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 0 €
 EC max contribution 6˙619˙342 € (0%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2018-Two-Stage-RTD
 Funding Scheme RIA-LS
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙537˙385.00
2    INTERNATIONAL VACCINE INSTITUTE KR (Seoul) participant 1˙217˙823.00
3    UNIVERSITY OF ANTANANARIVO MG (Antananarivo) participant 864˙420.00
4    TEXAS TECH UNIVERSITY SYSTEM US (LUBBOCK) participant 704˙831.00
5    GROUPE DE RECHERCHE ACTION EN SANTE SARL BF (OUAGADOUGOU) participant 643˙812.00
6    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 612˙856.00
7    PAI LIFE SCIENCES INC. US (WILMINGTON) participant 387˙290.00
8    GOETEBORGS UNIVERSITET SE (GOETEBORG) participant 350˙000.00
9    UNIVERSITE OUAGA I PROFESSEUR JOSEPH KI-ZERBO BF (OUAGADOUGOU 03) participant 259˙672.00
10    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 41˙250.00

Map

 Project objective

Schistosomiasis is a poverty-related neglected tropical disease, impacting one billion people in 74 countries. Science ranked a schistosomiasis-vaccine as one of the top-10 vaccines urgently needed. Chemotherapy is the preferred method for schistosomiasis control; but the effectiveness of mass-treatment programs is compromised by reinfection requiring regular re-treatment. An efficacious vaccine, with long-lasting protection against all schistosomiasis forms, would impact disease control. We request funding for the clinical development of our SchistoShield®-vaccine (Sm-p80 antigenGLA-SE adjuvant) in Burkina Faso and Madagascar, where Schistosoma mansoni (causing intestinal/hepatic schistosomiasis) and S. haematobium (causing urinary schistosomiasis) are endemic. In baboon studies, SchistoShield® has been effective against all major schistosome species. It is the only vaccine candidate having consistently exhibited potent prophylactic, anti-fecundity, egg-induced pathology resolving, transmission-blocking and therapeutic efficacy. The objectives are to 1) transfer vaccine manufacturing technology for cGMP production to a European manufacturer; 2) assess the safety/immunogenicity of SchistoShield® in a Phase I clinical study in healthy African adults; 3) refine a schistosomiasis human challenge model to identify correlates of protection, innate and adaptive immune signatures, gene expression and the role of antibodies in the prevention/control of Schistosoma infections; and 4) foster a global consortium to advance research on schistosomiasis vaccines and address downstream access constraints in resource-poor settings. The funding requested will allow the clinical development of SchistoShield®. GMP production will be transferred to a European partner. African site research capacity will be improved and epidemiological burden data using novel diagnostic techniques will be used to advance clinical development to Phase 2 and potential future elimination project

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