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VASA SIGNED

Vaccine Against Schistosomiasis for Africa. A Phase I clinical study of the SchistoShield® anti-schistosomiasis vaccine in adults in endemic areas of sub-Saharan Africa

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 VASA project word cloud

Explore the words cloud of the VASA project. It provides you a very rough idea of what is the project "VASA" about.

manufacturer    clinical    adults    schistosome    countries    global    ranked    diagnostic    protection    impacting    data    gene    baboon    burkina    prevention    constraints    antibodies    re    vaccines    transfer    epidemiological    people    treatment    chemotherapy    mass    intestinal    african    expression    programs    causing    immunogenicity    poor    faso    disease    downstream    correlates    pathology    consistently    efficacious    candidate    site    elimination    haematobium    gmp    settings    immune    refine    74    exhibited    transmission    hepatic    endemic    project    sm    cgmp    forms    lasting    antigengla    efficacy    therapeutic    adjuvant    request    transferred    requiring    infections    science    requested    healthy    signatures    adaptive    resolving    innate    tropical    reg    preferred    poverty    capacity    fecundity    prophylactic    madagascar    egg    reinfection    urinary    schistosoma    techniques    species    effectiveness    vaccine    compromised    safety    schistoshield    schistosomiasis    model    potent    manufacturing    regular    anti    resource    human    mansoni    urgently    billion    blocking    burden    p80    se   

Project "VASA" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 0 €
 EC max contribution 6˙619˙342 € (0%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2018-Two-Stage-RTD
 Funding Scheme RIA-LS
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙537˙385.00
2    INTERNATIONAL VACCINE INSTITUTE KR (Seoul) participant 1˙217˙823.00
3    UNIVERSITY OF ANTANANARIVO MG (Antananarivo) participant 864˙420.00
4    TEXAS TECH UNIVERSITY SYSTEM US (LUBBOCK) participant 704˙831.00
5    GROUPE DE RECHERCHE ACTION EN SANTE SARL BF (OUAGADOUGOU) participant 643˙812.00
6    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 612˙856.00
7    PAI LIFE SCIENCES INC. US (WILMINGTON) participant 387˙290.00
8    GOETEBORGS UNIVERSITET SE (GOETEBORG) participant 350˙000.00
9    UNIVERSITE OUAGA I PROFESSEUR JOSEPH KI-ZERBO BF (OUAGADOUGOU 03) participant 259˙672.00
10    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 41˙250.00

Map

 Project objective

Schistosomiasis is a poverty-related neglected tropical disease, impacting one billion people in 74 countries. Science ranked a schistosomiasis-vaccine as one of the top-10 vaccines urgently needed. Chemotherapy is the preferred method for schistosomiasis control; but the effectiveness of mass-treatment programs is compromised by reinfection requiring regular re-treatment. An efficacious vaccine, with long-lasting protection against all schistosomiasis forms, would impact disease control. We request funding for the clinical development of our SchistoShield®-vaccine (Sm-p80 antigenGLA-SE adjuvant) in Burkina Faso and Madagascar, where Schistosoma mansoni (causing intestinal/hepatic schistosomiasis) and S. haematobium (causing urinary schistosomiasis) are endemic. In baboon studies, SchistoShield® has been effective against all major schistosome species. It is the only vaccine candidate having consistently exhibited potent prophylactic, anti-fecundity, egg-induced pathology resolving, transmission-blocking and therapeutic efficacy. The objectives are to 1) transfer vaccine manufacturing technology for cGMP production to a European manufacturer; 2) assess the safety/immunogenicity of SchistoShield® in a Phase I clinical study in healthy African adults; 3) refine a schistosomiasis human challenge model to identify correlates of protection, innate and adaptive immune signatures, gene expression and the role of antibodies in the prevention/control of Schistosoma infections; and 4) foster a global consortium to advance research on schistosomiasis vaccines and address downstream access constraints in resource-poor settings. The funding requested will allow the clinical development of SchistoShield®. GMP production will be transferred to a European partner. African site research capacity will be improved and epidemiological burden data using novel diagnostic techniques will be used to advance clinical development to Phase 2 and potential future elimination project

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The information about "VASA" are provided by the European Opendata Portal: CORDIS opendata.

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