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SINERGIA SIGNED

advanced technologieS for drug dIscovery and precisioN mEdicine: in vitRo modellinG human physiology and diseAse

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SINERGIA" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI MILANO 

Organization address
address: PIAZZA LEONARDO DA VINCI 32
city: MILANO
postcode: 20133
website: www.polimi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙951˙996 €
 EC max contribution 3˙951˙996 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI MILANO IT (MILANO) coordinator 522˙999.00
2    Ente Ospedaliero Cantonale CH (Bellinzona) participant 562˙553.00
3    UNIVERSITAT BASEL CH (BASEL) participant 562˙553.00
4    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 531˙239.00
5    FAKULTNI NEMOCNICE U SV. ANNY V BRNE CZ (Brno) participant 469˙743.00
6    LIFETEC GROUP BV NL (EINDHOVEN) participant 265˙619.00
7    ACCELERA SRL IT (NERVIANO MI) participant 261˙499.00
8    BIOMIMX SRL IT (MILANO) participant 261˙499.00
9    MTTLAB SRL IT (Trieste) participant 261˙499.00
10    UNIVERSITAETSKLINIKUM AACHEN DE (AACHEN) participant 252˙788.00

Map

 Project objective

A key step in the drug development process is to predict information on safety, efficacy and mechanisms of action of a candidate molecule as early as possible in the pipeline (drug screening). To accomplish this aim, physiological and pathological pre-clinical models that closely approximate the human body are required. The limited capabilities of most of the existing pre-clinical screening tools, unable to meet the physiological relevance required to screen out failing drug candidates, reflect in the current weak performances of drug discovery: high attrition rates indeed affect the process of taking drugs from lab to market. Despite emerging new technologies exist with potential for advancing the field of in vitro modelling, their successfully implementation in the drug discovery pipeline to make it more efficient is still challenging. This is also imputable to a lack of structured dialogue between academic technology providers, market-oriented and regulatory-aware CROs, Biotechs and Pharma companies, which finally affects the research, training and development pipeline. SINERGIA aims at integrating a training network where academic and non-academic actors contribute to unravel the potential of the synergistic and rational use of four key bioengineering technologies. In particular, SINERGIA features academic leading experts of i) organs-on-chip and microfabrication technologies; ii) bioreactor and tissue engineering; iii) 3D Bioprinting; iv) induced-pluripotent human stem cells. These techniques are deployed to CROs and Biotech Consortium members that will ensure rational development, exploitation, validation and compliancy with regulatory and industrial aspects. Ultimately, this concerted action will lead to advanced models of human physiology and diseases to be introduced in preclinical stages of an innovative and improved drug discovery pipeline.

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The information about "SINERGIA" are provided by the European Opendata Portal: CORDIS opendata.

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