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AlternativesToGd SIGNED

Hyperpolarised MR technologies and molecular probes as alternatives for conventional metal-containing contrast agents for MRI examinations

Total Cost €

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EC-Contrib. €

0

Partnership

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 AlternativesToGd project word cloud

Explore the words cloud of the AlternativesToGd project. It provides you a very rough idea of what is the project "AlternativesToGd" about.

sends    eliminated    gd    paradigm    hp    completely    outcomes    gadolinium    detection    diagnosis    food    contrast    doses    endogenous    scan    arises    small    society    relates    diagnostic    mr    undergoing    validate    ing    agency    bearing    sensitivity    safe    spins    shift    free    made    tested    bodies    animal    suspension    resonance    enhanced    innovative    patients    species    ones    molecules    message    gbcas    consist    alternatives    recommended    individuals    models    drug    technologies    seek    recently    warning    unobtained    sufficiently    diseases    clear    beneficial    decision    clinical    body    medicines    risk    containing    tumour    accumulation    imaging    cas    alternativestogd    gbca    absence    administration    characterisation    nuclear    hyperpolarisation    hyperpolarised    agents    labels    techniques    metal    magnetic    class    brain    mri    scientific    rapid    human    exam    decay    ema    radically    ca    carefully    fda    compounds    disease    organs    health    lifetimes    community    injection    vision    showing   

Project "AlternativesToGd" data sheet

The following table provides information about the project.

Coordinator
HADASSAH MEDICAL ORGANIZATION 

Organization address
address: N/A
city: JERUSALEM
postcode: 91120
website: www.hadassah.org.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 3˙065˙956 €
 EC max contribution 3˙065˙956 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HADASSAH MEDICAL ORGANIZATION IL (JERUSALEM) coordinator 346˙250.00
2    RS2D FR (MUNDOLSHEIM) participant 450˙750.00
3    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 339˙985.00
4    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) participant 339˙975.00
5    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 332˙226.00
6    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 326˙250.00
7    EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG AT (WIEN) participant 300˙625.00
8    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) participant 270˙000.00
9    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) participant 180˙207.00
10    UNIVERSITAET ULM DE (ULM) participant 179˙687.00

Map

 Project objective

Recently, the European Medicines Agency (EMA) and the U.S. Food & Drug Administration (FDA) recommended suspension and warning labels for Gadolinium (Gd)-bearing CAs (GBCA) used in magnetic resonance imaging (MRI). This decision, although made in the absence of any clinical evidence, relates to potential major health concerns resulting from long-term accumulation of Gd containing species in patients’ bodies. This sends a clear message that we need to carefully consider the necessity of each contrast injection in individuals undergoing an MRI scan. However, for a number of diagnostic procedures, such as tumour characterisation, the use of a CA is often essential. The accumulation of Gd in different organs (including the brain) and GBCA-related diseases requires the scientific community to seek radically new alternatives. The AlternativesToGd vision is to identify and validate radically new compounds and technologies as alternatives to GBCAs. The new compounds and technologies developed in this proposal will be tested in animal models of disease and the most promising ones selected for further clinical development. The expected outcomes should radically impact the field, likely leading to a paradigm shift in MR-based diagnosis and thus being highly beneficial to society. The AlternativesToGd consortium will develop a new class of MRI CAs that will be metal-free, safe, and completely eliminated from the human body after the MRI exam. The agents will consist of small endogenous molecules, in which nuclear spins will be hyperpolarised to ensure high sensitivity to MR detection, even at very low doses. A major challenge and risk arises from the rapid decay of the hyperpolarised (HP) state. As enabling technologies, AlternativesToGd focuses on three leading and innovative hyperpolarisation techniques and on unique agents showing HP state lifetimes that are sufficiently long to enable diagnostic contrast-enhanced MRI approaches with so far unobtained sensitivity.

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The information about "ALTERNATIVESTOGD" are provided by the European Opendata Portal: CORDIS opendata.

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