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IN-FET SIGNED

Ionic Neuromodulation For Epilepsy Treatment

Total Cost €

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EC-Contrib. €

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Partnership

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 IN-FET project word cloud

Explore the words cloud of the IN-FET project. It provides you a very rough idea of what is the project "IN-FET" about.

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Project "IN-FET" data sheet

The following table provides information about the project.

Coordinator
SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE 

Organization address
address: VIA BONOMEA 265
city: TRIESTE
postcode: 34136
website: www.sissa.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙369˙758 €
 EC max contribution 3˙369˙758 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE IT (TRIESTE) coordinator 847˙812.00
2    IBM RESEARCH GMBH CH (RUESCHLIKON) participant 800˙562.00
3    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 569˙238.00
4    UNIVERSITE DE GENEVE CH (GENEVE) participant 498˙290.00
5    CONSORZIO NAZIONALE INTERUNIVERSITARIO PER LA NANOELETTRONICA IT (BOLOGNA) participant 430˙000.00
6    MULTI CHANNEL SYSTEMS MCS GMBH DE (REUTLINGEN) participant 223˙855.00

Map

 Project objective

There is a need for a paradigm shift in the treatment of drug-resistant epilepsy. Several routes have been explored to modulate or silence dysfunctional neural circuits, through genetic, electrical, magnetic or optical means. All have serious limitations due to the unphysiological mechanisms used to regulate neuronal activity. In IN-FET, we address this issue by manipulating the elementary building blocks of cell excitability: ions. IN-FET tackles the visionary idea of altering neuronal firing and synaptic transmission by direct ionic actuation at the microscopic scale, while monitoring cell responses by arrays of nanoscale transistors. We will develop and test, in vitro, the use of active polymers to trap or release electrochemically specific ions in the extracellular milieu surrounding neurons. These will be integrated with ion sensors and ultra-sensitive nanowire arrays, offering closed-loop regulation of cellular electrical activity. We will deliver for the first time a device that can physiologically modulate the neuronal membrane potential, the synaptic release probability, and glutamatergic NMDA receptors activation by altering potassium, calcium, and magnesium ionic concentrations in a controlled and spatially-confined manner. High-resolution simultaneous probing of cell activity will be performed by Si-nanowire vertical transistors, penetrating the membranes and detecting the cell electrical activity at unprecedented spatial and temporal resolutions. In conclusion, IN-FET's multidisciplinary consortium brings together state-of-the-art electrochemistry, 3-d nanofabrication, nanoelectronics, and numerical simulations, and combines neuronal biophysics to device modeling. IN-FET will thus establish the proof-of-principle for a breakthrough biocompatible neuromodulation technology, with a clear impact for future brain implants for epilepsy treatment, advancing neuroscience, biomedical microsystems engineering, and nano-neurotechnology.

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