Opendata, web and dolomites

IN-FET SIGNED

Ionic Neuromodulation For Epilepsy Treatment

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 IN-FET project word cloud

Explore the words cloud of the IN-FET project. It provides you a very rough idea of what is the project "IN-FET" about.

concentrations    electrochemically    resistant    nanowire    paradigm    electrical    extracellular    microscopic    direct    routes    surrounding    regulate    ions    detecting    manipulating    unprecedented    mechanisms    magnesium    potassium    silence    proof    calcium    biophysics    probability    nano    confined    epilepsy    nanofabrication    modeling    time    there    milieu    altering    resolutions    treatment    membrane    neurotechnology    simultaneous    vitro    numerical    sensitive    idea    monitoring    penetrating    clear    activation    issue    resolution    elementary    shift    arrays    regulation    ion    closed    si    optical    nanoscale    circuits    performed    synaptic    probing    limitations    brings    spatial    manner    trap    dysfunctional    advancing    polymers    cellular    visionary    neuroscience    release    fet    brain    receptors    cell    biocompatible    first    transistors    serious    excitability    temporal    physiologically    tackles    vertical    microsystems    neurons    drug    loop    actuation    unphysiological    explored    electrochemistry    magnetic    active    implants    blocks    engineering    simulations    combines    neuromodulation    multidisciplinary    neural    sensors    device    transmission    nanoelectronics    ultra    neuronal    firing    breakthrough    membranes    biomedical    ionic    nmda    glutamatergic    building    genetic    modulate   

Project "IN-FET" data sheet

The following table provides information about the project.

Coordinator
SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE 

Organization address
address: VIA BONOMEA 265
city: TRIESTE
postcode: 34136
website: www.sissa.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙369˙758 €
 EC max contribution 3˙369˙758 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE IT (TRIESTE) coordinator 847˙812.00
2    IBM RESEARCH GMBH CH (RUESCHLIKON) participant 800˙562.00
3    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 569˙238.00
4    UNIVERSITE DE GENEVE CH (GENEVE) participant 498˙290.00
5    CONSORZIO NAZIONALE INTERUNIVERSITARIO PER LA NANOELETTRONICA IT (BOLOGNA) participant 430˙000.00
6    MULTI CHANNEL SYSTEMS MCS GMBH DE (REUTLINGEN) participant 223˙855.00

Map

 Project objective

There is a need for a paradigm shift in the treatment of drug-resistant epilepsy. Several routes have been explored to modulate or silence dysfunctional neural circuits, through genetic, electrical, magnetic or optical means. All have serious limitations due to the unphysiological mechanisms used to regulate neuronal activity. In IN-FET, we address this issue by manipulating the elementary building blocks of cell excitability: ions. IN-FET tackles the visionary idea of altering neuronal firing and synaptic transmission by direct ionic actuation at the microscopic scale, while monitoring cell responses by arrays of nanoscale transistors. We will develop and test, in vitro, the use of active polymers to trap or release electrochemically specific ions in the extracellular milieu surrounding neurons. These will be integrated with ion sensors and ultra-sensitive nanowire arrays, offering closed-loop regulation of cellular electrical activity. We will deliver for the first time a device that can physiologically modulate the neuronal membrane potential, the synaptic release probability, and glutamatergic NMDA receptors activation by altering potassium, calcium, and magnesium ionic concentrations in a controlled and spatially-confined manner. High-resolution simultaneous probing of cell activity will be performed by Si-nanowire vertical transistors, penetrating the membranes and detecting the cell electrical activity at unprecedented spatial and temporal resolutions. In conclusion, IN-FET's multidisciplinary consortium brings together state-of-the-art electrochemistry, 3-d nanofabrication, nanoelectronics, and numerical simulations, and combines neuronal biophysics to device modeling. IN-FET will thus establish the proof-of-principle for a breakthrough biocompatible neuromodulation technology, with a clear impact for future brain implants for epilepsy treatment, advancing neuroscience, biomedical microsystems engineering, and nano-neurotechnology.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IN-FET" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IN-FET" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.2.1.)

BRIEFING (2018)

Bridging the FET Innovation Gap

Read More  

ATEMPGRAD (2019)

Analysing Temperature Effects with a Mobile and Precise Gradient Device

Read More  

NanoBRIGHT (2019)

BRInGing nano-pHoTonics into the brain

Read More