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NANO4LIFE SIGNED

High-throughput 4D imaging for nanoscale cellular studies

Total Cost €

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EC-Contrib. €

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Partnership

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 NANO4LIFE project word cloud

Explore the words cloud of the NANO4LIFE project. It provides you a very rough idea of what is the project "NANO4LIFE" about.

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Project "NANO4LIFE" data sheet

The following table provides information about the project.

Coordinator
FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH 

Organization address
address: CAMPUS-VIENNA-BIOCENTER 1
city: WIEN
postcode: 1030
website: www.imp.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙778˙325 €
 EC max contribution 1˙778˙325 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH AT (WIEN) coordinator 1˙778˙325.00

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 Project objective

Fluorescence microscopy is an invaluable tool for exploring the structure and function of biological processes. It provides high specificity and contrast for the observation of cellular components tagged with fluorescent molecules in a minimally invasive fashion, allowing the study of live specimens. Furthermore, the development of super resolution (SR) fluorescence microscopy has unlocked the access to spatial resolutions beyond the diffraction limit of visible light (~250nm), fuelling the discovery of new biological structures and dynamics. Nevertheless, achieving resolutions below ~10nm is challenged by multiple trade-offs between spatial and temporal resolutions, depth of observation and photo toxicity, making it difficult or impossible to obtain a molecular resolution. Additionally, axial resolutions are inevitably poorer than lateral ones, unless utilizing a complex multi-objective lens approach. I recently developed MINFLUX, a localization technique that merges concepts of SR with information theory. It achieves isotropic nanometer resolution in three dimensions with a single objective lens and has unrivaled spatio temporal resolution. However, a platform that enables these capabilities in a high-throughput manner for entire cells and tissue has not yet been developed. I aim to fill this technological gap; with my background and experience, I am in a unique position to assure the success of this project and establish these technologies in the scientific community. The performance of fluorescence imaging and tracking will progress orders of magnitude in the years to come, signaling yet another revolution for optical nanoscopy.

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The information about "NANO4LIFE" are provided by the European Opendata Portal: CORDIS opendata.

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