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ANIMATE SIGNED

Adaptive Immunity in Human Atherosclerosis: Understanding its Cellular Basis to Define Novel Immunomodulatory Therapies

Total Cost €

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EC-Contrib. €

0

Partnership

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 ANIMATE project word cloud

Explore the words cloud of the ANIMATE project. It provides you a very rough idea of what is the project "ANIMATE" about.

seq    temporal    worldwide    mass    reactive    accompanied    pro    arteries    causes    existence    tested    cells    models    complications    transformation    vivo    pool    suggest    lipoprotein    therapeutically    vessel    indirect    immunity    immunomodulatory    cytometry    apob    stabilize    atherosclerosis    cellular    autoimmune    effector    regulatory    narrowing    infarction    self    population    disease    dimension    ldl    acute    preliminary    prevent    multimers    sequencing    spatial    decipher    tools    inferred    rna    detect    cholesterol    myocardial    scrna    single    cytof    transfers    antigen    density    unclear    patients    natural    mouse    tracing    transform    auto    cd4    antigens    phenotypes    chronic    anti    mhc    framework    direct    pathogenic    vaccination    functional    anticipated    live    helper    atherosclerotic    adoptive    stroke    recognize    cytokine    lineage    elusive    therapeutic    correlation    share    clinical    conceptual    association    protective    protein    course    map    imaging    explore    function    plaques    atheroprotective    traits    employs    cell    blockade    death    data    inflammatory    immune    strategies    insights   

Project "ANIMATE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM FREIBURG 

Organization address
address: HUGSTETTER STRASSE 49
city: FREIBURG
postcode: 79106
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙946 €
 EC max contribution 1˙499˙946 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM FREIBURG DE (FREIBURG) coordinator 1˙499˙946.00

Map

 Project objective

Atherosclerosis is a chronic immune disease of arteries that causes vessel-narrowing atherosclerotic plaques. Its acute complications, myocardial infarction and stroke, are the leading causes of death worldwide. Atherosclerosis is accompanied by an inflammatory and autoimmune response with CD4 T-helper cells that recognize self-antigens, including ApoB-100 (ApoB), the main protein in low-density lipoprotein (LDL) cholesterol. Although their existence has been inferred from indirect evidence, the existence and function of atherosclerosis-specific, self-reactive CD4 T cells on a single-cell level remains elusive. In particular, it is unclear whether these are pro- or anti-inflammatory. Preliminary data suggest the existence of a natural pool of ApoB-reactive T-helper cells that share properties with atheroprotective T-regulatory cells but transform into pathogenic T-effector cells in the natural course of disease. This proposal aims to explore this loss of protective immunity on a cellular and function level. It employs novel tools to detect antigen-specific T cells in vivo by MHC-II multimers, mass cytometry (CyTOF), single cell RNA-sequencing (scRNA-seq), lineage-tracing mouse models, and live cell imaging. Based on the anticipated findings, this study will define a map of auto-reactive T-helper cell phenotypes in a temporal, spatial, and functional dimension. These insights will be used to identify novel immunomodulatory strategies to therapeutically stabilize the population of protective ApoB-specific T-helper cells, or to prevent their transformation into pathogenic T cell phenotypes by adoptive cells transfers, vaccination, or cytokine-blockade. In clinical association studies, a direct correlation of auto-immunity and clinical atherosclerosis will be tested. This proposal will decipher traits of protective immunity in atherosclerosis and help to build the conceptual framework to define novel therapeutic strategies for patients.

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The information about "ANIMATE" are provided by the European Opendata Portal: CORDIS opendata.

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