Opendata, web and dolomites


Adaptive Immunity in Human Atherosclerosis: Understanding its Cellular Basis to Define Novel Immunomodulatory Therapies

Total Cost €


EC-Contrib. €






 ANIMATE project word cloud

Explore the words cloud of the ANIMATE project. It provides you a very rough idea of what is the project "ANIMATE" about.

mass    regulatory    ldl    therapeutically    auto    mhc    cellular    phenotypes    rna    spatial    live    narrowing    anti    reactive    cd4    models    inferred    mouse    antigens    worldwide    data    recognize    death    anticipated    explore    helper    pro    vaccination    blockade    therapeutic    map    transformation    tested    protein    apob    direct    clinical    transform    function    prevent    natural    unclear    antigen    plaques    pathogenic    accompanied    share    traits    sequencing    autoimmune    cytometry    tools    cholesterol    acute    immunomodulatory    immunity    multimers    tracing    population    preliminary    course    functional    inflammatory    self    detect    cells    infarction    decipher    elusive    causes    employs    myocardial    suggest    seq    immune    disease    atherosclerotic    vivo    framework    pool    cytokine    chronic    existence    cytof    protective    density    scrna    stroke    transfers    association    complications    patients    effector    indirect    adoptive    temporal    insights    strategies    atheroprotective    conceptual    cell    lineage    single    arteries    stabilize    correlation    imaging    atherosclerosis    dimension    lipoprotein    vessel   

Project "ANIMATE" data sheet

The following table provides information about the project.


Organization address
postcode: 79106
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙946 €
 EC max contribution 1˙499˙946 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Atherosclerosis is a chronic immune disease of arteries that causes vessel-narrowing atherosclerotic plaques. Its acute complications, myocardial infarction and stroke, are the leading causes of death worldwide. Atherosclerosis is accompanied by an inflammatory and autoimmune response with CD4 T-helper cells that recognize self-antigens, including ApoB-100 (ApoB), the main protein in low-density lipoprotein (LDL) cholesterol. Although their existence has been inferred from indirect evidence, the existence and function of atherosclerosis-specific, self-reactive CD4 T cells on a single-cell level remains elusive. In particular, it is unclear whether these are pro- or anti-inflammatory. Preliminary data suggest the existence of a natural pool of ApoB-reactive T-helper cells that share properties with atheroprotective T-regulatory cells but transform into pathogenic T-effector cells in the natural course of disease. This proposal aims to explore this loss of protective immunity on a cellular and function level. It employs novel tools to detect antigen-specific T cells in vivo by MHC-II multimers, mass cytometry (CyTOF), single cell RNA-sequencing (scRNA-seq), lineage-tracing mouse models, and live cell imaging. Based on the anticipated findings, this study will define a map of auto-reactive T-helper cell phenotypes in a temporal, spatial, and functional dimension. These insights will be used to identify novel immunomodulatory strategies to therapeutically stabilize the population of protective ApoB-specific T-helper cells, or to prevent their transformation into pathogenic T cell phenotypes by adoptive cells transfers, vaccination, or cytokine-blockade. In clinical association studies, a direct correlation of auto-immunity and clinical atherosclerosis will be tested. This proposal will decipher traits of protective immunity in atherosclerosis and help to build the conceptual framework to define novel therapeutic strategies for patients.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ANIMATE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ANIMATE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ModGravTrial (2019)

Modified Gravity on Trial

Read More  

MuFLOART (2018)

Microbiological fluorescence observatory for antibiotic resistance tracking

Read More  

OptimHist (2020)

Optimization and historical contingency in living systems: a biophysical approach

Read More