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ANIMATE SIGNED

Adaptive Immunity in Human Atherosclerosis: Understanding its Cellular Basis to Define Novel Immunomodulatory Therapies

Total Cost €

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EC-Contrib. €

0

Partnership

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 ANIMATE project word cloud

Explore the words cloud of the ANIMATE project. It provides you a very rough idea of what is the project "ANIMATE" about.

inflammatory    cytof    helper    tracing    pathogenic    population    chronic    unclear    regulatory    sequencing    adoptive    decipher    reactive    traits    cellular    framework    autoimmune    pool    scrna    transfers    suggest    complications    seq    transformation    spatial    detect    single    inferred    phenotypes    atherosclerotic    vaccination    models    causes    temporal    density    conceptual    tested    association    ldl    live    map    cytometry    lineage    mouse    protective    stabilize    immune    clinical    narrowing    effector    prevent    disease    therapeutically    course    anticipated    myocardial    patients    immunity    direct    atheroprotective    share    imaging    acute    data    dimension    atherosclerosis    cd4    infarction    explore    correlation    transform    employs    blockade    multimers    stroke    natural    mass    arteries    elusive    death    function    vessel    apob    plaques    preliminary    rna    cell    therapeutic    cells    lipoprotein    cytokine    antigens    mhc    indirect    functional    vivo    tools    immunomodulatory    anti    self    strategies    antigen    accompanied    insights    existence    protein    worldwide    recognize    pro    auto    cholesterol   

Project "ANIMATE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM FREIBURG 

Organization address
address: HUGSTETTER STRASSE 49
city: FREIBURG
postcode: 79106
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙946 €
 EC max contribution 1˙499˙946 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM FREIBURG DE (FREIBURG) coordinator 1˙499˙946.00

Map

 Project objective

Atherosclerosis is a chronic immune disease of arteries that causes vessel-narrowing atherosclerotic plaques. Its acute complications, myocardial infarction and stroke, are the leading causes of death worldwide. Atherosclerosis is accompanied by an inflammatory and autoimmune response with CD4 T-helper cells that recognize self-antigens, including ApoB-100 (ApoB), the main protein in low-density lipoprotein (LDL) cholesterol. Although their existence has been inferred from indirect evidence, the existence and function of atherosclerosis-specific, self-reactive CD4 T cells on a single-cell level remains elusive. In particular, it is unclear whether these are pro- or anti-inflammatory. Preliminary data suggest the existence of a natural pool of ApoB-reactive T-helper cells that share properties with atheroprotective T-regulatory cells but transform into pathogenic T-effector cells in the natural course of disease. This proposal aims to explore this loss of protective immunity on a cellular and function level. It employs novel tools to detect antigen-specific T cells in vivo by MHC-II multimers, mass cytometry (CyTOF), single cell RNA-sequencing (scRNA-seq), lineage-tracing mouse models, and live cell imaging. Based on the anticipated findings, this study will define a map of auto-reactive T-helper cell phenotypes in a temporal, spatial, and functional dimension. These insights will be used to identify novel immunomodulatory strategies to therapeutically stabilize the population of protective ApoB-specific T-helper cells, or to prevent their transformation into pathogenic T cell phenotypes by adoptive cells transfers, vaccination, or cytokine-blockade. In clinical association studies, a direct correlation of auto-immunity and clinical atherosclerosis will be tested. This proposal will decipher traits of protective immunity in atherosclerosis and help to build the conceptual framework to define novel therapeutic strategies for patients.

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The information about "ANIMATE" are provided by the European Opendata Portal: CORDIS opendata.

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