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ANIMATE SIGNED

Adaptive Immunity in Human Atherosclerosis: Understanding its Cellular Basis to Define Novel Immunomodulatory Therapies

Total Cost €

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EC-Contrib. €

0

Partnership

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 ANIMATE project word cloud

Explore the words cloud of the ANIMATE project. It provides you a very rough idea of what is the project "ANIMATE" about.

inflammatory    unclear    pathogenic    map    narrowing    temporal    functional    dimension    chronic    immunomodulatory    lipoprotein    tools    antigens    phenotypes    effector    existence    cd4    helper    auto    employs    blockade    inferred    protein    transformation    worldwide    cholesterol    accompanied    ldl    data    apob    imaging    self    pool    spatial    share    mhc    strategies    atheroprotective    transfers    density    tracing    infarction    immune    prevent    mass    models    clinical    conceptual    multimers    therapeutic    live    immunity    anti    single    stabilize    anticipated    vaccination    death    reactive    transform    stroke    autoimmune    cells    complications    therapeutically    association    cytokine    decipher    insights    preliminary    cell    natural    cellular    disease    vessel    cytof    antigen    myocardial    scrna    sequencing    mouse    cytometry    elusive    acute    regulatory    direct    framework    patients    course    correlation    plaques    population    rna    traits    arteries    tested    vivo    detect    function    lineage    atherosclerosis    indirect    seq    recognize    pro    atherosclerotic    causes    suggest    explore    adoptive    protective   

Project "ANIMATE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM FREIBURG 

Organization address
address: HUGSTETTER STRASSE 49
city: FREIBURG
postcode: 79106
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙946 €
 EC max contribution 1˙499˙946 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM FREIBURG DE (FREIBURG) coordinator 1˙499˙946.00

Map

 Project objective

Atherosclerosis is a chronic immune disease of arteries that causes vessel-narrowing atherosclerotic plaques. Its acute complications, myocardial infarction and stroke, are the leading causes of death worldwide. Atherosclerosis is accompanied by an inflammatory and autoimmune response with CD4 T-helper cells that recognize self-antigens, including ApoB-100 (ApoB), the main protein in low-density lipoprotein (LDL) cholesterol. Although their existence has been inferred from indirect evidence, the existence and function of atherosclerosis-specific, self-reactive CD4 T cells on a single-cell level remains elusive. In particular, it is unclear whether these are pro- or anti-inflammatory. Preliminary data suggest the existence of a natural pool of ApoB-reactive T-helper cells that share properties with atheroprotective T-regulatory cells but transform into pathogenic T-effector cells in the natural course of disease. This proposal aims to explore this loss of protective immunity on a cellular and function level. It employs novel tools to detect antigen-specific T cells in vivo by MHC-II multimers, mass cytometry (CyTOF), single cell RNA-sequencing (scRNA-seq), lineage-tracing mouse models, and live cell imaging. Based on the anticipated findings, this study will define a map of auto-reactive T-helper cell phenotypes in a temporal, spatial, and functional dimension. These insights will be used to identify novel immunomodulatory strategies to therapeutically stabilize the population of protective ApoB-specific T-helper cells, or to prevent their transformation into pathogenic T cell phenotypes by adoptive cells transfers, vaccination, or cytokine-blockade. In clinical association studies, a direct correlation of auto-immunity and clinical atherosclerosis will be tested. This proposal will decipher traits of protective immunity in atherosclerosis and help to build the conceptual framework to define novel therapeutic strategies for patients.

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The information about "ANIMATE" are provided by the European Opendata Portal: CORDIS opendata.

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