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AGRICON SIGNED

Ancient genomic reconstruction of convergent evolution to agriculture

Total Cost €

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EC-Contrib. €

0

Partnership

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 AGRICON project word cloud

Explore the words cloud of the AGRICON project. It provides you a very rough idea of what is the project "AGRICON" about.

edge    prior    africa    warmed    reconstruct    admixture    genomic    ago    850    instances    gatherer    lifestyles    catalysed    multiple    global    shapes    rates    leveraging    genomes    episode    presented    eurasian    differed    act    hunter    human    universal    dogs    cutting    data    capture    computational    transition    variation    genomics    genetic    basis    ancient    model    direct    continents    posed    humans    sequencing    convergence    phenotypic    agricultural    ancestry    bias    southeast    central    models    evolutionary    opportunity    species    asia    panel    as    populations    day    transformation    snp    phenomena    occurred    did    ca    climates    biodiversity    domesticated    america    independent    adaptations    dog    came    designed    continuous    organisms    watershed    food    independently    evolution    generate    remarkable    copy    adaptive    questions    population    statistically    answer    underpinning    regions    architecture    convergent    domestic    subsistence   

Project "AGRICON" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 1˙500˙000.00

Map

 Project objective

As global climates warmed ca. 10,000 years ago came a remarkable convergent transformation of human lifestyles that occurred independently in multiple continents and human populations. This transition from hunter-gatherer subsistence to food-production catalysed large-scale population growth, offering the opportunity for increased rates of adaptation, but also rapidly presented a large number of independent human populations with a new evolutionary challenge. This project will use ancient population genomics—the only way to directly reconstruct human genetic evolution—to study whether evolutionary processes during the agricultural transition differed in differed regions. Which genomic adaptations were associated with the agricultural transition? Did adaptation to hunter-gatherer and agricultural lifestyles act on similar genetic architecture in different instances? To which extent did adaptation in domestic dogs—the only species domesticated prior to the agricultural transition—occur in convergence with humans? To answer these questions, the project will generate ancient genomic data from pre-agricultural and early agricultural populations from multiple human- and domestic dog populations from Africa, Central America, and Southeast Asia. This will be achieved with direct sequencing as well as a new human ~850,000 SNP capture panel designed to avoid bias towards Eurasian ancestry. We will also develop new computational methods robust to the challenges posed by ancient genomes to identify adaptive admixture, analyse copy number variation, test continuous population models, and statistically assess convergence in the genomic architecture of adaptation. Leveraging cutting-edge ancient genomics and two model organisms for the genomic basis of phenotypic variation, this project aims to reconstruct the universal evolutionary phenomena underpinning a watershed evolutionary episode that shapes global biodiversity and the human condition to this day.

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The information about "AGRICON" are provided by the European Opendata Portal: CORDIS opendata.

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