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AGRICON SIGNED

Ancient genomic reconstruction of convergent evolution to agriculture

Total Cost €

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EC-Contrib. €

0

Partnership

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 AGRICON project word cloud

Explore the words cloud of the AGRICON project. It provides you a very rough idea of what is the project "AGRICON" about.

adaptive    ago    computational    admixture    snp    basis    adaptations    model    850    population    posed    multiple    questions    independent    dog    evolution    biodiversity    as    central    warmed    phenotypic    day    reconstruct    episode    genomic    convergent    occurred    designed    edge    variation    regions    differed    cutting    data    opportunity    underpinning    sequencing    genomics    africa    shapes    direct    watershed    populations    transformation    copy    domesticated    gatherer    humans    southeast    did    generate    human    prior    asia    remarkable    architecture    continuous    transition    act    came    ancient    instances    panel    evolutionary    continents    genetic    subsistence    presented    domestic    models    organisms    answer    rates    capture    global    dogs    eurasian    species    leveraging    hunter    phenomena    ca    agricultural    universal    statistically    catalysed    food    genomes    independently    lifestyles    convergence    climates    bias    ancestry    america   

Project "AGRICON" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 1˙500˙000.00

Map

 Project objective

As global climates warmed ca. 10,000 years ago came a remarkable convergent transformation of human lifestyles that occurred independently in multiple continents and human populations. This transition from hunter-gatherer subsistence to food-production catalysed large-scale population growth, offering the opportunity for increased rates of adaptation, but also rapidly presented a large number of independent human populations with a new evolutionary challenge. This project will use ancient population genomics—the only way to directly reconstruct human genetic evolution—to study whether evolutionary processes during the agricultural transition differed in differed regions. Which genomic adaptations were associated with the agricultural transition? Did adaptation to hunter-gatherer and agricultural lifestyles act on similar genetic architecture in different instances? To which extent did adaptation in domestic dogs—the only species domesticated prior to the agricultural transition—occur in convergence with humans? To answer these questions, the project will generate ancient genomic data from pre-agricultural and early agricultural populations from multiple human- and domestic dog populations from Africa, Central America, and Southeast Asia. This will be achieved with direct sequencing as well as a new human ~850,000 SNP capture panel designed to avoid bias towards Eurasian ancestry. We will also develop new computational methods robust to the challenges posed by ancient genomes to identify adaptive admixture, analyse copy number variation, test continuous population models, and statistically assess convergence in the genomic architecture of adaptation. Leveraging cutting-edge ancient genomics and two model organisms for the genomic basis of phenotypic variation, this project aims to reconstruct the universal evolutionary phenomena underpinning a watershed evolutionary episode that shapes global biodiversity and the human condition to this day.

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The information about "AGRICON" are provided by the European Opendata Portal: CORDIS opendata.

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