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AGRICON SIGNED

Ancient genomic reconstruction of convergent evolution to agriculture

Total Cost €

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EC-Contrib. €

0

Partnership

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 AGRICON project word cloud

Explore the words cloud of the AGRICON project. It provides you a very rough idea of what is the project "AGRICON" about.

catalysed    questions    continuous    transition    convergence    direct    ago    sequencing    organisms    reconstruct    regions    hunter    lifestyles    gatherer    bias    episode    central    genomic    america    humans    occurred    species    independent    did    differed    subsistence    independently    posed    multiple    dog    human    remarkable    genomes    evolution    presented    basis    shapes    edge    asia    prior    instances    phenomena    snp    continents    data    domestic    southeast    climates    variation    capture    generate    convergent    copy    population    day    ancestry    answer    leveraging    domesticated    panel    populations    model    cutting    adaptive    africa    dogs    as    ca    universal    computational    warmed    genomics    food    biodiversity    architecture    agricultural    watershed    act    transformation    ancient    admixture    opportunity    genetic    850    statistically    global    rates    underpinning    evolutionary    models    adaptations    designed    eurasian    came    phenotypic   

Project "AGRICON" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 1˙500˙000.00

Map

 Project objective

As global climates warmed ca. 10,000 years ago came a remarkable convergent transformation of human lifestyles that occurred independently in multiple continents and human populations. This transition from hunter-gatherer subsistence to food-production catalysed large-scale population growth, offering the opportunity for increased rates of adaptation, but also rapidly presented a large number of independent human populations with a new evolutionary challenge. This project will use ancient population genomics—the only way to directly reconstruct human genetic evolution—to study whether evolutionary processes during the agricultural transition differed in differed regions. Which genomic adaptations were associated with the agricultural transition? Did adaptation to hunter-gatherer and agricultural lifestyles act on similar genetic architecture in different instances? To which extent did adaptation in domestic dogs—the only species domesticated prior to the agricultural transition—occur in convergence with humans? To answer these questions, the project will generate ancient genomic data from pre-agricultural and early agricultural populations from multiple human- and domestic dog populations from Africa, Central America, and Southeast Asia. This will be achieved with direct sequencing as well as a new human ~850,000 SNP capture panel designed to avoid bias towards Eurasian ancestry. We will also develop new computational methods robust to the challenges posed by ancient genomes to identify adaptive admixture, analyse copy number variation, test continuous population models, and statistically assess convergence in the genomic architecture of adaptation. Leveraging cutting-edge ancient genomics and two model organisms for the genomic basis of phenotypic variation, this project aims to reconstruct the universal evolutionary phenomena underpinning a watershed evolutionary episode that shapes global biodiversity and the human condition to this day.

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The information about "AGRICON" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2021-05-15 11:00:39) correctly updated