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AGRICON SIGNED

Ancient genomic reconstruction of convergent evolution to agriculture

Total Cost €

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EC-Contrib. €

0

Partnership

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 AGRICON project word cloud

Explore the words cloud of the AGRICON project. It provides you a very rough idea of what is the project "AGRICON" about.

domestic    gatherer    warmed    biodiversity    lifestyles    adaptive    basis    bias    statistically    ancestry    global    asia    model    subsistence    remarkable    organisms    convergence    answer    architecture    transition    dog    did    humans    catalysed    direct    cutting    edge    population    continents    panel    transformation    genomes    admixture    sequencing    food    agricultural    phenomena    rates    america    variation    central    genetic    ancient    underpinning    occurred    eurasian    universal    ca    evolutionary    dogs    independent    questions    multiple    generate    instances    africa    convergent    presented    shapes    came    southeast    data    populations    prior    day    watershed    differed    snp    computational    act    capture    models    leveraging    human    independently    posed    as    850    climates    reconstruct    hunter    genomics    adaptations    opportunity    continuous    phenotypic    copy    species    evolution    genomic    designed    ago    regions    domesticated    episode   

Project "AGRICON" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 1˙500˙000.00

Map

 Project objective

As global climates warmed ca. 10,000 years ago came a remarkable convergent transformation of human lifestyles that occurred independently in multiple continents and human populations. This transition from hunter-gatherer subsistence to food-production catalysed large-scale population growth, offering the opportunity for increased rates of adaptation, but also rapidly presented a large number of independent human populations with a new evolutionary challenge. This project will use ancient population genomics—the only way to directly reconstruct human genetic evolution—to study whether evolutionary processes during the agricultural transition differed in differed regions. Which genomic adaptations were associated with the agricultural transition? Did adaptation to hunter-gatherer and agricultural lifestyles act on similar genetic architecture in different instances? To which extent did adaptation in domestic dogs—the only species domesticated prior to the agricultural transition—occur in convergence with humans? To answer these questions, the project will generate ancient genomic data from pre-agricultural and early agricultural populations from multiple human- and domestic dog populations from Africa, Central America, and Southeast Asia. This will be achieved with direct sequencing as well as a new human ~850,000 SNP capture panel designed to avoid bias towards Eurasian ancestry. We will also develop new computational methods robust to the challenges posed by ancient genomes to identify adaptive admixture, analyse copy number variation, test continuous population models, and statistically assess convergence in the genomic architecture of adaptation. Leveraging cutting-edge ancient genomics and two model organisms for the genomic basis of phenotypic variation, this project aims to reconstruct the universal evolutionary phenomena underpinning a watershed evolutionary episode that shapes global biodiversity and the human condition to this day.

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The information about "AGRICON" are provided by the European Opendata Portal: CORDIS opendata.

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