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PLASTINET SIGNED

Plasticity of the Pluripotency Network

Total Cost €

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EC-Contrib. €

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Partnership

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 PLASTINET project word cloud

Explore the words cloud of the PLASTINET project. It provides you a very rough idea of what is the project "PLASTINET" about.

marsupial    improvement    producing    embryonic    compatible    competence    restriction    intrinsic    farm    core    iuml    trophoblast    blastocyst    cells    modulation    days    self    computational    epiblast    examine    signal    naive    mammals    definitions    biological    discovered    chimaera    employ    obtain    hitherto    form    moulded    ineffective    lineage    evolutionary    governing    mammalian    primates    generally    competent    formal    indicate    entwined    logic    consequently    cross    hypothesise    paradigm    disciplinary    elusive    underlaid    identity    biomedical    suppress    experimentation    comprised    exclude    livestock    structures    human    segregation    ve    regulatory    embryological    molecular    stem    na    embryos    uncover    hypoblast    specification    concomitant    implantation    transcription    extended    textbook    founder    fresh    transcriptomics    template    undergo    mouse    determined    cell    vivo    embryo    pluripotency    forms    plasticity    species    animals    capture    unlike    derivatives    source    extraembryonic    tissues    potencies    networks    proper    pluripotent    consistent    origin    forebears    evolution    fertilisation    representative    few    ancestral    renewal    dogma   

Project "PLASTINET" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙499˙970 €
 EC max contribution 2˙499˙970 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 2˙499˙970.00

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 Project objective

A few days after fertilisation mammalian embryos form a blastocyst comprised of three tissues; trophoblast and hypoblast are the forebears of extraembryonic structures, while naive epiblast cell are the pluripotent source of the embryo proper. Classical mouse embryological studies indicate that lineage potencies are determined concomitant with segregation of the three founder tissues. Textbook definitions of pluripotency thus exclude extraembryonic potential. Consistent with this paradigm, mouse embryonic stem cells are generally ineffective in producing trophoblast or hypoblast derivatives. However, we have discovered that human naïve pluripotent cells have high intrinsic competence for trophoblast formation. Furthermore, unlike in mouse, extraembryonic transcription factors are present in human epiblast in vivo. These findings challenge the dogma of early lineage restriction but may be compatible with the ancestral origin of pluripotency. We hypothesise that extraembryonic plasticity underlaid by entwined regulatory networks is the evolutionary template of pluripotency. Consequently, signal modulation to suppress extraembryonic specification may be crucial for capture of stem cells representative of naïve epiblast in most mammals. We will examine human and non-human primates, farm animals in which embryos undergo extended development before implantation, and a marsupial in which pluripotent cells are generated from the trophoblast. In a cross-disciplinary approach we will employ transcriptomics, embryo and stem cell experimentation, and formal computational modelling to uncover the core biological program moulded by evolution into different forms. We aim to establish hitherto elusive chimaera-competent embryonic stem cells from species of importance for research, biomedical applications and livestock improvement. We will obtain fresh insight into the molecular logic governing early development, lineage plasticity, pluripotent identity, and stem cell self-renewal.

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The information about "PLASTINET" are provided by the European Opendata Portal: CORDIS opendata.

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