Opendata, web and dolomites

PLASTINET SIGNED

Plasticity of the Pluripotency Network

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PLASTINET project word cloud

Explore the words cloud of the PLASTINET project. It provides you a very rough idea of what is the project "PLASTINET" about.

na    underlaid    dogma    origin    exclude    few    experimentation    modulation    fresh    stem    producing    species    tissues    hitherto    chimaera    cells    farm    embryos    restriction    ve    vivo    fertilisation    capture    governing    embryo    ineffective    formal    transcriptomics    comprised    examine    extraembryonic    evolutionary    self    regulatory    consequently    elusive    indicate    biological    animals    textbook    epiblast    cell    discovered    concomitant    mammalian    founder    entwined    consistent    compatible    extended    hypoblast    lineage    implantation    blastocyst    definitions    disciplinary    employ    forms    intrinsic    days    competent    embryonic    determined    embryological    form    ancestral    cross    computational    obtain    undergo    transcription    specification    mouse    improvement    iuml    molecular    forebears    marsupial    primates    paradigm    unlike    biomedical    human    pluripotency    derivatives    proper    segregation    core    evolution    potencies    networks    representative    source    logic    mammals    identity    signal    pluripotent    plasticity    generally    livestock    template    uncover    hypothesise    moulded    structures    competence    trophoblast    renewal    naive    suppress   

Project "PLASTINET" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙499˙970 €
 EC max contribution 2˙499˙970 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 2˙499˙970.00

Map

 Project objective

A few days after fertilisation mammalian embryos form a blastocyst comprised of three tissues; trophoblast and hypoblast are the forebears of extraembryonic structures, while naive epiblast cell are the pluripotent source of the embryo proper. Classical mouse embryological studies indicate that lineage potencies are determined concomitant with segregation of the three founder tissues. Textbook definitions of pluripotency thus exclude extraembryonic potential. Consistent with this paradigm, mouse embryonic stem cells are generally ineffective in producing trophoblast or hypoblast derivatives. However, we have discovered that human naïve pluripotent cells have high intrinsic competence for trophoblast formation. Furthermore, unlike in mouse, extraembryonic transcription factors are present in human epiblast in vivo. These findings challenge the dogma of early lineage restriction but may be compatible with the ancestral origin of pluripotency. We hypothesise that extraembryonic plasticity underlaid by entwined regulatory networks is the evolutionary template of pluripotency. Consequently, signal modulation to suppress extraembryonic specification may be crucial for capture of stem cells representative of naïve epiblast in most mammals. We will examine human and non-human primates, farm animals in which embryos undergo extended development before implantation, and a marsupial in which pluripotent cells are generated from the trophoblast. In a cross-disciplinary approach we will employ transcriptomics, embryo and stem cell experimentation, and formal computational modelling to uncover the core biological program moulded by evolution into different forms. We aim to establish hitherto elusive chimaera-competent embryonic stem cells from species of importance for research, biomedical applications and livestock improvement. We will obtain fresh insight into the molecular logic governing early development, lineage plasticity, pluripotent identity, and stem cell self-renewal.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PLASTINET" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PLASTINET" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

NeuroMag (2019)

The Neurological Basis of the Magnetic Sense

Read More  

BioSilica (2020)

Materials synthesis in vivo – intracellular formation of nanostructured silica by microalgae

Read More  

CITISENSE (2019)

Evolving communication systems in response to altered sensory environments

Read More