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PLASTINET SIGNED

Plasticity of the Pluripotency Network

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EC-Contrib. €

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Partnership

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 PLASTINET project word cloud

Explore the words cloud of the PLASTINET project. It provides you a very rough idea of what is the project "PLASTINET" about.

entwined    identity    representative    chimaera    discovered    derivatives    cross    marsupial    examine    consistent    evolution    proper    mammals    improvement    implantation    cell    embryological    dogma    ve    consequently    founder    hitherto    lineage    experimentation    formal    extraembryonic    networks    restriction    forms    origin    naive    pluripotent    plasticity    form    mammalian    epiblast    unlike    evolutionary    tissues    stem    producing    fresh    ineffective    paradigm    underlaid    species    undergo    iuml    transcription    renewal    disciplinary    blastocyst    animals    elusive    comprised    vivo    trophoblast    mouse    biomedical    regulatory    farm    forebears    governing    concomitant    potencies    structures    livestock    template    hypothesise    days    moulded    transcriptomics    specification    determined    fertilisation    molecular    embryos    biological    human    core    modulation    employ    exclude    suppress    source    uncover    embryonic    pluripotency    computational    textbook    cells    competent    primates    intrinsic    indicate    logic    compatible    embryo    definitions    few    hypoblast    na    generally    ancestral    competence    obtain    capture    signal    self    segregation    extended   

Project "PLASTINET" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙499˙970 €
 EC max contribution 2˙499˙970 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 2˙499˙970.00

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 Project objective

A few days after fertilisation mammalian embryos form a blastocyst comprised of three tissues; trophoblast and hypoblast are the forebears of extraembryonic structures, while naive epiblast cell are the pluripotent source of the embryo proper. Classical mouse embryological studies indicate that lineage potencies are determined concomitant with segregation of the three founder tissues. Textbook definitions of pluripotency thus exclude extraembryonic potential. Consistent with this paradigm, mouse embryonic stem cells are generally ineffective in producing trophoblast or hypoblast derivatives. However, we have discovered that human naïve pluripotent cells have high intrinsic competence for trophoblast formation. Furthermore, unlike in mouse, extraembryonic transcription factors are present in human epiblast in vivo. These findings challenge the dogma of early lineage restriction but may be compatible with the ancestral origin of pluripotency. We hypothesise that extraembryonic plasticity underlaid by entwined regulatory networks is the evolutionary template of pluripotency. Consequently, signal modulation to suppress extraembryonic specification may be crucial for capture of stem cells representative of naïve epiblast in most mammals. We will examine human and non-human primates, farm animals in which embryos undergo extended development before implantation, and a marsupial in which pluripotent cells are generated from the trophoblast. In a cross-disciplinary approach we will employ transcriptomics, embryo and stem cell experimentation, and formal computational modelling to uncover the core biological program moulded by evolution into different forms. We aim to establish hitherto elusive chimaera-competent embryonic stem cells from species of importance for research, biomedical applications and livestock improvement. We will obtain fresh insight into the molecular logic governing early development, lineage plasticity, pluripotent identity, and stem cell self-renewal.

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The information about "PLASTINET" are provided by the European Opendata Portal: CORDIS opendata.

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