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PRIME SIGNED

Prevention and Remediation of Insulin Multimorbidity in Europe

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PRIME project word cloud

Explore the words cloud of the PRIME project. It provides you a very rough idea of what is the project "PRIME" about.

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Project "PRIME" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 6˙000˙001 €
 EC max contribution 6˙000˙000 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 1˙231˙026.00
2    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 549˙993.00
3    SEMMELWEIS EGYETEM HU (BUDAPEST) participant 500˙000.00
4    DRUG TARGET ID BV NL (NIJMEGEN) participant 400˙000.00
5    AARHUS UNIVERSITET DK (AARHUS C) participant 399˙998.00
6    UNIVERSITATSKLINIKUM HEIDELBERG DE (HEIDELBERG) participant 380˙000.00
7    Concentris Research Management GmbH DE (Fürstenfeldbruck) participant 360˙000.00
8    ISTITUTO SUPERIORE DI SANITA IT (ROMA) participant 350˙000.00
9    UNIVERSITETET I BERGEN NO (BERGEN) participant 350˙000.00
10    BIOTRIAL FR (RENNES) participant 310˙000.00
11    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 300˙000.00
12    FUNDACIO INSTITUT D'INVESTIGACIO SANITARIA PERE VIRGILI (IISPV) ES (TARRAGONA) participant 249˙997.00
13    MACHINE2LEARN BV NL (AMSTERDAM) participant 160˙000.00
14    ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT DE (MANNHEIM) participant 159˙995.00
15    INSTITUT CATALA DE LA SALUT ES (BARCELONA) participant 148˙988.00
16    THE EUROPEAN BRAIN COUNCIL AISBL BE (BRUXELLES) participant 90˙000.00
17    STICHTING BURO ECNP NL (UTRECHT) participant 60˙000.00

Map

 Project objective

PRIME introduces the novel concept of insulin signalling as a key mechanism underlying the multimorbidity of major mental and somatic illnesses. It is well known that aberrant insulin signalling causes high health and socioeconomic burden through its role in diabetes, metabolic syndrome, and obesity. We posit that the impact of ‘insulinopathies’ is still largely underestimated, since insulin multimorbidity also extends to the brain, where altered insulin signalling appears to be implicated in dementias such as Alzheimer disease and – based on our pilot work - in mental illnesses characterized by compulsivity, especially obsessive compulsive disorder and autism. We therefore further posit that insulin multimorbidity evolves throughout life, necessitating a lifespan approach. PRIME brings together a multidisciplinary team to (1) extend our understanding of insulin multimorbidity across the lifespan, (2) understand the causal mechanisms linking somatic and mental insulin-related illnesses, (3) develop tools for early diagnosis, improved clinical care, and prevention of insulin-related lifespan multimorbidity. We will leverage the world’s largest registry, clinical cohort, and population data sets to identify and validate new insulinopathies. Through an interdisciplinary battery of innovative approaches, we will clarify the causal mechanisms linking peripheral and central insulin signalling to body-brain comorbidity, integrating across animal models and studies in humans from molecule to cell, brain, cognition, and behaviour. Our prior evidence enables PRIME to bring the new knowledge to society, based on e.g. repurposing medication and lifestyle interventions (diet/exercise monitored by mHealth assessment), identifying and validating novel drug targets, developing and testing candidate biomarkers, and by improving existing medical guidelines and policy. Furthermore, educational approaches to inform clinicians, patients, and general public will be developed.

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The information about "PRIME" are provided by the European Opendata Portal: CORDIS opendata.

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