Opendata, web and dolomites

PRIME SIGNED

Prevention and Remediation of Insulin Multimorbidity in Europe

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PRIME project word cloud

Explore the words cloud of the PRIME project. It provides you a very rough idea of what is the project "PRIME" about.

insulin    repurposing    diabetes    prime    appears    data    integrating    society    syndrome    mechanisms    drug    compulsive    biomarkers    team    cell    medical    interventions    cohort    battery    cognition    population    somatic    understand    alzheimer    mhealth    candidate    patients    disorder    largely    implicated    necessitating    molecule    clinicians    animal    medication    illnesses    multimorbidity    lifestyle    extend    insulinopathies    life    diet    leverage    aberrant    monitored    underlying    mechanism    underestimated    clinical    introduces    guidelines    validating    care    public    educational    policy    peripheral    clarify    obesity    metabolic    extends    brain    prior    lifespan    multidisciplinary    mental    innovative    prevention    compulsivity    world    validate    brings    health    posit    interdisciplinary    diagnosis    signalling    linking    causes    comorbidity    burden    tools    socioeconomic    central    autism    altered    exercise    pilot    causal    registry    inform    humans    models    dementias    body    disease    obsessive   

Project "PRIME" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 6˙000˙001 €
 EC max contribution 6˙000˙000 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 1˙231˙026.00
2    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 549˙993.00
3    SEMMELWEIS EGYETEM HU (BUDAPEST) participant 500˙000.00
4    DRUG TARGET ID BV NL (NIJMEGEN) participant 400˙000.00
5    AARHUS UNIVERSITET DK (AARHUS C) participant 399˙998.00
6    UNIVERSITATSKLINIKUM HEIDELBERG DE (HEIDELBERG) participant 380˙000.00
7    Concentris Research Management GmbH DE (Fürstenfeldbruck) participant 360˙000.00
8    ISTITUTO SUPERIORE DI SANITA IT (ROMA) participant 350˙000.00
9    UNIVERSITETET I BERGEN NO (BERGEN) participant 350˙000.00
10    BIOTRIAL FR (RENNES) participant 310˙000.00
11    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 300˙000.00
12    FUNDACIO INSTITUT D'INVESTIGACIO SANITARIA PERE VIRGILI (IISPV) ES (TARRAGONA) participant 249˙997.00
13    MACHINE2LEARN BV NL (AMSTERDAM) participant 160˙000.00
14    ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT DE (MANNHEIM) participant 159˙995.00
15    INSTITUT CATALA DE LA SALUT ES (BARCELONA) participant 148˙988.00
16    THE EUROPEAN BRAIN COUNCIL AISBL BE (BRUXELLES) participant 90˙000.00
17    STICHTING BURO ECNP NL (UTRECHT) participant 60˙000.00

Map

 Project objective

PRIME introduces the novel concept of insulin signalling as a key mechanism underlying the multimorbidity of major mental and somatic illnesses. It is well known that aberrant insulin signalling causes high health and socioeconomic burden through its role in diabetes, metabolic syndrome, and obesity. We posit that the impact of ‘insulinopathies’ is still largely underestimated, since insulin multimorbidity also extends to the brain, where altered insulin signalling appears to be implicated in dementias such as Alzheimer disease and – based on our pilot work - in mental illnesses characterized by compulsivity, especially obsessive compulsive disorder and autism. We therefore further posit that insulin multimorbidity evolves throughout life, necessitating a lifespan approach. PRIME brings together a multidisciplinary team to (1) extend our understanding of insulin multimorbidity across the lifespan, (2) understand the causal mechanisms linking somatic and mental insulin-related illnesses, (3) develop tools for early diagnosis, improved clinical care, and prevention of insulin-related lifespan multimorbidity. We will leverage the world’s largest registry, clinical cohort, and population data sets to identify and validate new insulinopathies. Through an interdisciplinary battery of innovative approaches, we will clarify the causal mechanisms linking peripheral and central insulin signalling to body-brain comorbidity, integrating across animal models and studies in humans from molecule to cell, brain, cognition, and behaviour. Our prior evidence enables PRIME to bring the new knowledge to society, based on e.g. repurposing medication and lifestyle interventions (diet/exercise monitored by mHealth assessment), identifying and validating novel drug targets, developing and testing candidate biomarkers, and by improving existing medical guidelines and policy. Furthermore, educational approaches to inform clinicians, patients, and general public will be developed.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PRIME" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PRIME" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.3.1.1.)

ESPACE (2020)

Human Cell Atlas of the Pancreas

Read More  

BRAINTIME (2020)

Molecular atlas of the brain across the human lifespan

Read More  

BIND (2020)

Brain Involvement iN Dystrophinopathies

Read More