Explore the words cloud of the miniNO project. It provides you a very rough idea of what is the project "miniNO" about.
The following table provides information about the project.
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
|EC max contribution
|6˙487˙770 € (100%)
1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
|from 2020-01-01 to 2025-12-31
Take a look of project's partnership.
|INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
|CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
|CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE
|EREVNITIKO PANEPISTIMIAKO INSTITUTOMELETIS KE ANTIMETOPISIS GENETIKONKE KAKOETHON NOSIMATON TIS PEDIKISILIKIAS
|QUEEN MARY UNIVERSITY OF LONDON
|UNIVERSITE DE LILLE
|UNIVERSITAET zu LUEBECK
|INSERM TRANSFERT SA
|UNIVERSITE DE GENEVE
The miniNO project aims to identify the key causative mechanisms of the lifelong multimorbidity associated with preterm birth. Prematurity is associated with altThe miniNO project aims to identify the key causative mechanisms of the lifelong multimorbidity associated with preterm birth. Prematurity is associated with alterations in the maturation of the hypothalamic-pituitary-gonadal axis, and specifically with its transient activation during infancy, known as minipuberty. miniNO will study for the first time the association between premature birth and alterations in minipuberty and infantile nitric oxide (NO) signaling in the brain, and comorbidities that appear later on in life. The project is based on robust preclinical data and previous clinical studies, and will exploit data concerning premature birth and minipuberty in existing cohorts as well as newly created cohorts. We will identify the molecular association between NO deficiency, altered minipuberty and multimorbidity combining mental (e.g. autism, social cognition, learning and memory impairments) and non-mental disorders (e.g. anosmia, hearing loss, metabolic abnormalities, cardiovascular impairements and infertility) as well as gender, environmental and lifestyle factors. For this, we have assembled a unique interdisciplinary consortium of renowned basic scientists (neuroscientists) and clinicians (pediatric and adult endocrinologists, psychiatrists, geneticists) and an SME to implement the project results. By validating the causative mechanisms of the multimorbidity related to preterm birth, we will propose and develop novel diagnostic and preventive tools, including screening tests for biomarkers and newly identified genetic factors, for altered minipuberty, thus paving the way to personalized treatment and new therapeutic options very early in life. miniNO is expected to improve the quality of life of millions of prematurely born individuals and reduce the financial and societal burdens they impose.
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The information about "MININO" are provided by the European Opendata Portal: CORDIS opendata.
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