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miniNO SIGNED

Associative mechanisms linking a defective minipuberty to the appearance of mental and nonmental disorders: infantile NO replenishment as a new therapeutic possibility

Total Cost €

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EC-Contrib. €

0

Partnership

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 miniNO project word cloud

Explore the words cloud of the miniNO project. It provides you a very rough idea of what is the project "miniNO" about.

comorbidities    cohorts    assembled    first    quality    mental    signaling    interdisciplinary    screening    life    created    burdens    societal    nitric    transient    gender    individuals    diagnostic    pituitary    adult    lifestyle    prematurity    preventive    impose    basic    molecular    options    clinical    endocrinologists    environmental    financial    time    mechanisms    abnormalities    social    treatment    millions    preclinical    learning    hearing    alterations    deficiency    renowned    maturation    gonadal    disorders    lifelong    impairments    metabolic    validating    reduce    personalized    causative    oxide    autism    geneticists    scientists    alt    clinicians    multimorbidity    prematurely    combining    premature    tools    appear    later    axis    minipuberty    therapeutic    minino    preterm    activation    pediatric    impairements    psychiatrists    born    cardiovascular    sme    infantile    infancy    brain    birth    newly    altered    genetic    hypothalamic    anosmia    data    memory    cognition    paving    association    infertility    neuroscientists    concerning    biomarkers    tests   

Project "miniNO" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 6˙487˙770 €
 EC max contribution 6˙487˙770 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2025-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 943˙750.00
2    CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CH (LAUSANNE) participant 1˙338˙243.00
3    CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE FR (LILLE) participant 742˙188.00
4    EREVNITIKO PANEPISTIMIAKO INSTITUTOMELETIS KE ANTIMETOPISIS GENETIKONKE KAKOETHON NOSIMATON TIS PEDIKISILIKIAS EL (ATHINA) participant 617˙500.00
5    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) participant 578˙332.00
6    UNIVERSITE DE LILLE FR (LILLE) participant 539˙605.00
7    BIOGAZELLE NV BE (ZWIJNAARDE) participant 499˙000.00
8    UNIVERSITAET zu LUEBECK DE (LUBECK) participant 481˙025.00
9    INSERM TRANSFERT SA FR (PARIS) participant 400˙375.00
10    UNIVERSITE DE GENEVE CH (GENEVE) participant 347˙750.00

Map

 Project objective

The miniNO project aims to identify the key causative mechanisms of the lifelong multimorbidity associated with preterm birth. Prematurity is associated with altThe miniNO project aims to identify the key causative mechanisms of the lifelong multimorbidity associated with preterm birth. Prematurity is associated with alterations in the maturation of the hypothalamic-pituitary-gonadal axis, and specifically with its transient activation during infancy, known as minipuberty. miniNO will study for the first time the association between premature birth and alterations in minipuberty and infantile nitric oxide (NO) signaling in the brain, and comorbidities that appear later on in life. The project is based on robust preclinical data and previous clinical studies, and will exploit data concerning premature birth and minipuberty in existing cohorts as well as newly created cohorts. We will identify the molecular association between NO deficiency, altered minipuberty and multimorbidity combining mental (e.g. autism, social cognition, learning and memory impairments) and non-mental disorders (e.g. anosmia, hearing loss, metabolic abnormalities, cardiovascular impairements and infertility) as well as gender, environmental and lifestyle factors. For this, we have assembled a unique interdisciplinary consortium of renowned basic scientists (neuroscientists) and clinicians (pediatric and adult endocrinologists, psychiatrists, geneticists) and an SME to implement the project results. By validating the causative mechanisms of the multimorbidity related to preterm birth, we will propose and develop novel diagnostic and preventive tools, including screening tests for biomarkers and newly identified genetic factors, for altered minipuberty, thus paving the way to personalized treatment and new therapeutic options very early in life. miniNO is expected to improve the quality of life of millions of prematurely born individuals and reduce the financial and societal burdens they impose.

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The information about "MININO" are provided by the European Opendata Portal: CORDIS opendata.

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