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miniNO SIGNED

Associative mechanisms linking a defective minipuberty to the appearance of mental and nonmental disorders: infantile NO replenishment as a new therapeutic possibility

Total Cost €

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EC-Contrib. €

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Partnership

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miniNO project word cloud

Explore the words cloud of the miniNO project. It provides you a very rough idea of what is the project "miniNO" about.

cohorts comorbidities newly adult genetic alterations screening concerning infancy maturation neuroscientists infertility association lifelong diagnostic pituitary impose deficiency gender millions reduce burdens societal preclinical pediatric prematurely anosmia activation clinical disorders environmental prematurity personalized infantile causative axis premature renowned psychiatrists geneticists oxide biomarkers combining sme created data preventive minino preterm scientists cardiovascular therapeutic abnormalities tests cognition signaling later quality transient validating paving lifestyle treatment memory metabolic altered hypothalamic impairements born life tools gonadal appear alt birth autism clinicians assembled social endocrinologists hearing options mechanisms individuals time interdisciplinary molecular first brain mental minipuberty impairments nitric learning financial multimorbidity basic

Project "miniNO" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	6˙487˙770 €
EC max contribution	6˙487˙770 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2019-Two-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2025-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	943˙750.00
2	CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS Organization address address: RUE DU BUGNON 21 city: LAUSANNE postcode: 1011 website: www.chuv.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	1˙338˙243.00
3	CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE Organization address address: AVENUE OSCAR LAMBRET 2 city: LILLE postcode: 59037 website: http://www.chru-lille.fr/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LILLE)	participant	742˙188.00
4	EREVNITIKO PANEPISTIMIAKO INSTITUTOMELETIS KE ANTIMETOPISIS GENETIKONKE KAKOETHON NOSIMATON TIS PEDIKISILIKIAS EREVNITIKO PANEPISTIMIAKO INSTITUTOMELETIS KE ANTIMETOPISIS GENETIKONKE KAKOETHON NOSIMATON TIS PEDIKISILIKIAS Organization address address: 8 LEVADIAS STREET city: ATHINA postcode: 115 27 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	617˙500.00
5	QUEEN MARY UNIVERSITY OF LONDON QUEEN MARY UNIVERSITY OF LONDON Organization address address: 327 MILE END ROAD city: LONDON postcode: E1 4NS website: http://www.qmul.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	578˙332.00
6	UNIVERSITE DE LILLE UNIVERSITE DE LILLE Organization address address: 42 RUE PAUL DUEZ city: LILLE postcode: 59800 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LILLE)	participant	539˙605.00
7	BIOGAZELLE NV BIOGAZELLE NV Organization address address: TECHNOLOGIEPARK 82 city: ZWIJNAARDE postcode: 9052 website: http://www.biogazelle.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZWIJNAARDE)	participant	499˙000.00
8	UNIVERSITAET zu LUEBECK UNIVERSITAET zu LUEBECK Organization address address: RATZEBURGER ALLEE 160 city: LUBECK postcode: 23562 website: http://www.uni-luebeck.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LUBECK)	participant	481˙025.00
9	INSERM TRANSFERT SA INSERM TRANSFERT SA Organization address address: RUE WATT 7 city: PARIS postcode: 75013 website: www.inserm-transfert.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	400˙375.00
10	UNIVERSITE DE GENEVE UNIVERSITE DE GENEVE Organization address address: RUE DU GENERAL DUFOUR 24 city: GENEVE postcode: 1211 website: www.unige.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	participant	347˙750.00

Map

Project objective

The miniNO project aims to identify the key causative mechanisms of the lifelong multimorbidity associated with preterm birth. Prematurity is associated with altThe miniNO project aims to identify the key causative mechanisms of the lifelong multimorbidity associated with preterm birth. Prematurity is associated with alterations in the maturation of the hypothalamic-pituitary-gonadal axis, and specifically with its transient activation during infancy, known as minipuberty. miniNO will study for the first time the association between premature birth and alterations in minipuberty and infantile nitric oxide (NO) signaling in the brain, and comorbidities that appear later on in life. The project is based on robust preclinical data and previous clinical studies, and will exploit data concerning premature birth and minipuberty in existing cohorts as well as newly created cohorts. We will identify the molecular association between NO deficiency, altered minipuberty and multimorbidity combining mental (e.g. autism, social cognition, learning and memory impairments) and non-mental disorders (e.g. anosmia, hearing loss, metabolic abnormalities, cardiovascular impairements and infertility) as well as gender, environmental and lifestyle factors. For this, we have assembled a unique interdisciplinary consortium of renowned basic scientists (neuroscientists) and clinicians (pediatric and adult endocrinologists, psychiatrists, geneticists) and an SME to implement the project results. By validating the causative mechanisms of the multimorbidity related to preterm birth, we will propose and develop novel diagnostic and preventive tools, including screening tests for biomarkers and newly identified genetic factors, for altered minipuberty, thus paving the way to personalized treatment and new therapeutic options very early in life. miniNO is expected to improve the quality of life of millions of prematurely born individuals and reduce the financial and societal burdens they impose.

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The information about "MININO" are provided by the European Opendata Portal: CORDIS opendata.

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