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PROFID SIGNED

Implementation of personalised risk prediction and prevention of sudden cardiac death after myocardial infarction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PROFID project word cloud

Explore the words cloud of the PROFID project. It provides you a very rough idea of what is the project "PROFID" about.

mi    device    heart    fraction    patients    le    predict    scd    accounting    hospital    implantation    20    left    potentially    ejection    companies    software    post    datasets    health    sudden    healthcare    prevent    absolute    recommend    randomised    pilot    parallel    is    incidence    profid    cardiac    risks    cardioverter    historical    gt    myocardial    international    composition    trials    score    clinical    yearly    makers    successfully    untreated    policy    700    death    considerable    dies    prophylactic    leaders    defibrillator    urgently    minutes    routine    majority    icd    benefit    implantable    35    run    beating    tool    insurance    patient    chains    regions    registries    treatment    geographies    infarction    opinion    deaths    minority    optimally    suddenly    economic    risk    individual    expenditures    severe    care    occurs    prevented    payers    unexpectedly    personalised    stops    complications    guidelines    inherent    decision    lvef    validate    participation    cohorts    350    ventricular    public   

Project "PROFID" data sheet

The following table provides information about the project.

Coordinator
LEIPZIG HEART INSTITUTE GMBH 

Organization address
address: RUSSENSTRASSE 69A
city: LEIPZIG
postcode: 4289
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 23˙381˙704 €
 EC max contribution 19˙884˙569 € (85%)
 Programme 1. H2020-EU.3.1.6. (Health care provision and integrated care)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme IA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIPZIG HEART INSTITUTE GMBH DE (LEIPZIG) coordinator 7˙076˙062.00
2    CRI - THE CLINICAL RESEARCH INSTITUTE GMBH DE (MUNCHEN) participant 6˙767˙383.00
3    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 931˙250.00
4    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 899˙168.00
5    UNIVERSITY OF YORK UK (YORK NORTH YORKSHIRE) participant 767˙806.00
6    UNIVERSITAT BAYREUTH DE (BAYREUTH) participant 399˙625.00
7    UNIVERSITY OF LEEDS UK (LEEDS) participant 295˙000.00
8    SOCIETE EUROPEENNE DE CARDIOLOGIE FR (BIOT SOPHIA ANTIPOLIS) participant 248˙125.00
9    Catalyze B.V. NL (AMSTERDAM-DUIVENDRECHT) participant 243˙687.00
10    QS INSTITUTO DE INVESTIGACION E INNOVACION SL ES (MADRID) participant 221˙628.00
11    DEUTSCHE HERZSTIFTUNG EV DE (FRANKFURT AM MAIN) participant 198˙750.00
12    SLASKI UNIWERSYTET MEDYCZNY W KATOWICACH PL (KATOWICE) participant 185˙437.00
13    FAKULTNI NEMOCNICE OLOMOUC CZ (OLOMOUC) participant 185˙000.00
14    REGION STOCKHOLM SE (STOCKHOLM) participant 185˙000.00
15    SEMMELWEIS EGYETEM HU (BUDAPEST) participant 185˙000.00
16    THE HEALTH CORPORATION - RAMBAM IL (HAIFA) participant 185˙000.00
17    BARMER ERSATZKASSE DE (WUPPERTAL) participant 172˙708.00
18    CLINIQUE PASTEUR SA FR (TOULOUSE CEDEX 3) participant 167˙562.00
19    ISTITUTO AUXOLOGICO ITALIANO IT (MILANO) participant 151˙875.00
20    ASTON UNIVERSITY UK (BIRMINGHAM) participant 150˙000.00
21    AARHUS UNIVERSITETSHOSPITAL DK (AARHUS) participant 135˙000.00
22    INSTITUTO INVESTIGACION SANITARIA FUNDACION JIMENEZ DIAZ ES (MADRID) participant 83˙500.00
23    AARHUS UNIVERSITET DK (AARHUS C) participant 50˙000.00

Map

 Project objective

Sudden cardiac death (SCD) is a major public health problem accounting for ~20% of all deaths in Europe with an estimated yearly incidence of ~350-700,000, often in patients with previous myocardial infarction (MI). In SCD, the heart suddenly and unexpectedly stops beating. If untreated, the patient dies within minutes, but SCD can be successfully prevented by an implantable cardioverter-defibrillator (ICD). The ICD is highly effective, but is associated with potentially severe complications and high healthcare costs. Based on historical evidence, guidelines recommend prophylactic ICD implantation in post-MI patients with left ventricular ejection fraction (LVEF)≤35% to prevent SCD. However, only a minority of these patients will ever need the device. In addition, in absolute numbers the majority of SCD cases occurs in patients with LVEF>35% who are currently not considered for prophylactic ICD. Due to the inherent risks and considerable health care expenditures, a personalised treatment approach for ICD implantation is urgently required. Using state-of-the-art methods and large clinical datasets from established international cohorts and registries across different European geographies, PROFID will develop a clinical decision support tool (risk score) to predict the individual SCD risk and identify those post-MI patients that will optimally benefit from an ICD. Two parallel randomised clinical trials will validate implementation of the risk score to determine ICD implantation, while health economic analyses will assess its economic impact on health care systems. A software tool for clinical use of the risk score will be implemented, and a pilot run in 3 European regions with participation of insurance companies and authorities. The unique composition of the consortium with key opinion leaders, patient organisations, large hospital chains, payers, policy makers and state authorities across Europe, will ensure implementation into routine clinical practice.

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The information about "PROFID" are provided by the European Opendata Portal: CORDIS opendata.

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