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PROFID SIGNED

Implementation of personalised risk prediction and prevention of sudden cardiac death after myocardial infarction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PROFID project word cloud

Explore the words cloud of the PROFID project. It provides you a very rough idea of what is the project "PROFID" about.

le    prevent    risks    public    urgently    gt    care    validate    historical    software    prophylactic    routine    majority    stops    implantable    treatment    700    minutes    infarction    device    makers    deaths    ejection    hospital    death    clinical    profid    international    sudden    myocardial    complications    score    chains    registries    companies    prevented    leaders    risk    suddenly    patients    accounting    post    guidelines    20    tool    health    randomised    cohorts    pilot    recommend    fraction    healthcare    heart    patient    mi    considerable    yearly    trials    untreated    350    individual    35    participation    potentially    implantation    regions    inherent    absolute    benefit    policy    geographies    defibrillator    payers    is    scd    cardiac    composition    lvef    predict    unexpectedly    icd    insurance    economic    personalised    datasets    optimally    parallel    severe    cardioverter    opinion    incidence    occurs    expenditures    run    ventricular    beating    successfully    left    dies    decision    minority   

Project "PROFID" data sheet

The following table provides information about the project.

Coordinator
LEIPZIG HEART INSTITUTE GMBH 

Organization address
address: RUSSENSTRASSE 69A
city: LEIPZIG
postcode: 4289
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 23˙381˙704 €
 EC max contribution 19˙884˙569 € (85%)
 Programme 1. H2020-EU.3.1.6. (Health care provision and integrated care)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme IA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIPZIG HEART INSTITUTE GMBH DE (LEIPZIG) coordinator 7˙076˙062.00
2    CRI - THE CLINICAL RESEARCH INSTITUTE GMBH DE (MUNCHEN) participant 6˙767˙383.00
3    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 931˙250.00
4    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 899˙168.00
5    UNIVERSITY OF YORK UK (YORK NORTH YORKSHIRE) participant 767˙806.00
6    UNIVERSITAT BAYREUTH DE (BAYREUTH) participant 399˙625.00
7    UNIVERSITY OF LEEDS UK (LEEDS) participant 295˙000.00
8    SOCIETE EUROPEENNE DE CARDIOLOGIE FR (BIOT SOPHIA ANTIPOLIS) participant 248˙125.00
9    Catalyze B.V. NL (AMSTERDAM-DUIVENDRECHT) participant 243˙687.00
10    QS INSTITUTO DE INVESTIGACION E INNOVACION SL ES (MADRID) participant 221˙628.00
11    DEUTSCHE HERZSTIFTUNG EV DE (FRANKFURT AM MAIN) participant 198˙750.00
12    SLASKI UNIWERSYTET MEDYCZNY W KATOWICACH PL (KATOWICE) participant 185˙437.00
13    FAKULTNI NEMOCNICE OLOMOUC CZ (OLOMOUC) participant 185˙000.00
14    REGION STOCKHOLM SE (STOCKHOLM) participant 185˙000.00
15    SEMMELWEIS EGYETEM HU (BUDAPEST) participant 185˙000.00
16    THE HEALTH CORPORATION - RAMBAM IL (HAIFA) participant 185˙000.00
17    BARMER ERSATZKASSE DE (WUPPERTAL) participant 172˙708.00
18    CLINIQUE PASTEUR SA FR (TOULOUSE CEDEX 3) participant 167˙562.00
19    ISTITUTO AUXOLOGICO ITALIANO IT (MILANO) participant 151˙875.00
20    ASTON UNIVERSITY UK (BIRMINGHAM) participant 150˙000.00
21    AARHUS UNIVERSITETSHOSPITAL DK (AARHUS) participant 135˙000.00
22    INSTITUTO INVESTIGACION SANITARIA FUNDACION JIMENEZ DIAZ ES (MADRID) participant 83˙500.00
23    AARHUS UNIVERSITET DK (AARHUS C) participant 50˙000.00

Map

 Project objective

Sudden cardiac death (SCD) is a major public health problem accounting for ~20% of all deaths in Europe with an estimated yearly incidence of ~350-700,000, often in patients with previous myocardial infarction (MI). In SCD, the heart suddenly and unexpectedly stops beating. If untreated, the patient dies within minutes, but SCD can be successfully prevented by an implantable cardioverter-defibrillator (ICD). The ICD is highly effective, but is associated with potentially severe complications and high healthcare costs. Based on historical evidence, guidelines recommend prophylactic ICD implantation in post-MI patients with left ventricular ejection fraction (LVEF)≤35% to prevent SCD. However, only a minority of these patients will ever need the device. In addition, in absolute numbers the majority of SCD cases occurs in patients with LVEF>35% who are currently not considered for prophylactic ICD. Due to the inherent risks and considerable health care expenditures, a personalised treatment approach for ICD implantation is urgently required. Using state-of-the-art methods and large clinical datasets from established international cohorts and registries across different European geographies, PROFID will develop a clinical decision support tool (risk score) to predict the individual SCD risk and identify those post-MI patients that will optimally benefit from an ICD. Two parallel randomised clinical trials will validate implementation of the risk score to determine ICD implantation, while health economic analyses will assess its economic impact on health care systems. A software tool for clinical use of the risk score will be implemented, and a pilot run in 3 European regions with participation of insurance companies and authorities. The unique composition of the consortium with key opinion leaders, patient organisations, large hospital chains, payers, policy makers and state authorities across Europe, will ensure implementation into routine clinical practice.

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The information about "PROFID" are provided by the European Opendata Portal: CORDIS opendata.

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