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PROFID SIGNED

Implementation of personalised risk prediction and prevention of sudden cardiac death after myocardial infarction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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 PROFID project word cloud

Explore the words cloud of the PROFID project. It provides you a very rough idea of what is the project "PROFID" about.

implantable    public    icd    randomised    sudden    absolute    run    treatment    risks    composition    personalised    implantation    optimally    score    regions    considerable    unexpectedly    healthcare    myocardial    predict    350    mi    occurs    severe    complications    potentially    scd    expenditures    left    historical    prophylactic    participation    cardiac    opinion    health    benefit    700    cardioverter    death    guidelines    payers    routine    registries    gt    minutes    device    suddenly    lvef    economic    infarction    tool    makers    post    beating    trials    yearly    ventricular    successfully    stops    patient    clinical    risk    inherent    fraction    leaders    patients    accounting    companies    35    pilot    is    deaths    datasets    untreated    urgently    international    hospital    defibrillator    majority    decision    software    recommend    prevented    dies    chains    care    parallel    individual    minority    policy    le    cohorts    profid    ejection    geographies    heart    validate    insurance    incidence    20    prevent   

Project "PROFID" data sheet

The following table provides information about the project.

Coordinator
LEIPZIG HEART INSTITUTE GMBH 

Organization address
address: RUSSENSTRASSE 69A
city: LEIPZIG
postcode: 4289
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 23˙381˙704 €
 EC max contribution 19˙884˙569 € (85%)
 Programme 1. H2020-EU.3.1.6. (Health care provision and integrated care)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme IA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIPZIG HEART INSTITUTE GMBH DE (LEIPZIG) coordinator 7˙076˙062.00
2    CRI - THE CLINICAL RESEARCH INSTITUTE GMBH DE (MUNCHEN) participant 6˙767˙383.00
3    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 931˙250.00
4    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 899˙168.00
5    UNIVERSITY OF YORK UK (YORK NORTH YORKSHIRE) participant 767˙806.00
6    UNIVERSITAT BAYREUTH DE (BAYREUTH) participant 399˙625.00
7    UNIVERSITY OF LEEDS UK (LEEDS) participant 295˙000.00
8    SOCIETE EUROPEENNE DE CARDIOLOGIE FR (BIOT SOPHIA ANTIPOLIS) participant 248˙125.00
9    Catalyze B.V. NL (AMSTERDAM-DUIVENDRECHT) participant 243˙687.00
10    QS INSTITUTO DE INVESTIGACION E INNOVACION SL ES (MADRID) participant 221˙628.00
11    DEUTSCHE HERZSTIFTUNG EV DE (FRANKFURT AM MAIN) participant 198˙750.00
12    SLASKI UNIWERSYTET MEDYCZNY W KATOWICACH PL (KATOWICE) participant 185˙437.00
13    FAKULTNI NEMOCNICE OLOMOUC CZ (OLOMOUC) participant 185˙000.00
14    REGION STOCKHOLM SE (STOCKHOLM) participant 185˙000.00
15    SEMMELWEIS EGYETEM HU (BUDAPEST) participant 185˙000.00
16    THE HEALTH CORPORATION - RAMBAM IL (HAIFA) participant 185˙000.00
17    BARMER ERSATZKASSE DE (WUPPERTAL) participant 172˙708.00
18    CLINIQUE PASTEUR SA FR (TOULOUSE CEDEX 3) participant 167˙562.00
19    ISTITUTO AUXOLOGICO ITALIANO IT (MILANO) participant 151˙875.00
20    ASTON UNIVERSITY UK (BIRMINGHAM) participant 150˙000.00
21    AARHUS UNIVERSITETSHOSPITAL DK (AARHUS) participant 135˙000.00
22    INSTITUTO INVESTIGACION SANITARIA FUNDACION JIMENEZ DIAZ ES (MADRID) participant 83˙500.00
23    AARHUS UNIVERSITET DK (AARHUS C) participant 50˙000.00

Map

 Project objective

Sudden cardiac death (SCD) is a major public health problem accounting for ~20% of all deaths in Europe with an estimated yearly incidence of ~350-700,000, often in patients with previous myocardial infarction (MI). In SCD, the heart suddenly and unexpectedly stops beating. If untreated, the patient dies within minutes, but SCD can be successfully prevented by an implantable cardioverter-defibrillator (ICD). The ICD is highly effective, but is associated with potentially severe complications and high healthcare costs. Based on historical evidence, guidelines recommend prophylactic ICD implantation in post-MI patients with left ventricular ejection fraction (LVEF)≤35% to prevent SCD. However, only a minority of these patients will ever need the device. In addition, in absolute numbers the majority of SCD cases occurs in patients with LVEF>35% who are currently not considered for prophylactic ICD. Due to the inherent risks and considerable health care expenditures, a personalised treatment approach for ICD implantation is urgently required. Using state-of-the-art methods and large clinical datasets from established international cohorts and registries across different European geographies, PROFID will develop a clinical decision support tool (risk score) to predict the individual SCD risk and identify those post-MI patients that will optimally benefit from an ICD. Two parallel randomised clinical trials will validate implementation of the risk score to determine ICD implantation, while health economic analyses will assess its economic impact on health care systems. A software tool for clinical use of the risk score will be implemented, and a pilot run in 3 European regions with participation of insurance companies and authorities. The unique composition of the consortium with key opinion leaders, patient organisations, large hospital chains, payers, policy makers and state authorities across Europe, will ensure implementation into routine clinical practice.

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The information about "PROFID" are provided by the European Opendata Portal: CORDIS opendata.

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