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SERWOM SIGNED

Understanding Serotonergic Regulation of Working Memory

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SERWOM project word cloud

Explore the words cloud of the SERWOM project. It provides you a very rough idea of what is the project "SERWOM" about.

alterations    symptoms    suffering    deficits    executive    raphe    alternative    levels    therapeutic    behavioral    functional    pathophysiology    signaling    additionally    central    model    forced    health    delayed    silencing    2afc    mechanism    pyramidal    correlate    performed    read    modulates    functions    electrical    mode    patients    influencing    execute    simultaneously    serotonin    cell    altered    image    mental    mice    neurotransmission    expressed    record    serotonergic    memory    performance    trained    pfc    treatments    imaging    mesoscopic    circuit    receptor    integrity    cortical    inhibition    reverse    characterizing    mostly    depression    mouse    stimulation    ht    selectively    combine    critical    wm    schizophrenia    subtypes    optical    photon    helping    cellular    optogenetic    modulation    manipulate    respectively    local    period    gabaergic    causal    maintenance    ultimately    regulation    ineffective    interneurons    dr    dorsal    cortex    psychiatric    types    exhibit    cognitive    understand    release    prefrontal    delay   

Project "SERWOM" data sheet

The following table provides information about the project.

Coordinator		 IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 212˙933.00

Map

 Project objective

Functional integrity of the prefrontal cortex (PFC) is essential for higher ‘executive’ functions such as working memory (WM). Serotonin (5-HT) modulates GABAergic neurotransmission in the PFC through different 5-HT receptor subtypes that are selectively expressed in distinct GABAergic cell types. Altered GABAergic neurotransmission in the PFC of patients suffering from schizophrenia and depression is believed to be central to their pathophysiology. Currently available treatments targeting 5-HT signaling have addressed different mental health symptoms but typically not cognitive capabilities. Therefore, characterizing the causal role of distinct GABAergic cell types on circuit activity is a critical step in understanding the circuit mechanism of WM. This proposal focuses on the role of 5-HT in the regulation of inhibition in cortical activity and their consequences in influencing WM maintenance. I will simultaneously image the electrical activities of pyramidal and distinct GABAergic interneurons while well-trained mice execute a delayed two alternative forced choice (2AFC) task to read out WM during the delay period. Imaging will be performed in both wide-field and two-photon imaging mode to record cortical activity at the mesoscopic (cortex-wide) and local (PFC) levels, respectively. I will combine optical imaging with optogenetic stimulation/silencing to manipulate GABAergic interneurons in the PFC and serotonin release in the dorsal raphe (DR) during the execution of the 2AFC task. Additionally, I will use a mouse model of schizophrenia that is known to exhibit WM deficits to correlate possible alterations in serotonin signaling during cellular-level WM maintenance with WM performance at the behavioral level. This could allow us to understand why many psychiatric treatments are mostly ineffective at improving cognitive abilities and how modulation of the serotonergic system could reverse these effects, ultimately helping to develop new therapeutic treatments.

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The information about "SERWOM" are provided by the European Opendata Portal: CORDIS opendata.

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