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SERWOM SIGNED

Understanding Serotonergic Regulation of Working Memory

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SERWOM project word cloud

Explore the words cloud of the SERWOM project. It provides you a very rough idea of what is the project "SERWOM" about.

signaling    serotonin    stimulation    raphe    ultimately    dorsal    deficits    pfc    cortical    wm    2afc    levels    performance    pyramidal    execute    treatments    release    mental    health    delay    depression    altered    mechanism    prefrontal    influencing    memory    selectively    maintenance    mesoscopic    period    integrity    cell    understand    ineffective    local    performed    gabaergic    functional    mice    model    patients    simultaneously    regulation    modulates    types    mostly    receptor    central    inhibition    correlate    photon    combine    therapeutic    additionally    optogenetic    image    neurotransmission    psychiatric    causal    mode    imaging    read    mouse    cognitive    record    serotonergic    ht    cellular    dr    forced    schizophrenia    functions    subtypes    reverse    critical    delayed    respectively    trained    suffering    cortex    symptoms    expressed    electrical    pathophysiology    interneurons    optical    behavioral    alternative    manipulate    helping    characterizing    exhibit    alterations    modulation    circuit    executive    silencing   

Project "SERWOM" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 212˙933.00

Map

 Project objective

Functional integrity of the prefrontal cortex (PFC) is essential for higher ‘executive’ functions such as working memory (WM). Serotonin (5-HT) modulates GABAergic neurotransmission in the PFC through different 5-HT receptor subtypes that are selectively expressed in distinct GABAergic cell types. Altered GABAergic neurotransmission in the PFC of patients suffering from schizophrenia and depression is believed to be central to their pathophysiology. Currently available treatments targeting 5-HT signaling have addressed different mental health symptoms but typically not cognitive capabilities. Therefore, characterizing the causal role of distinct GABAergic cell types on circuit activity is a critical step in understanding the circuit mechanism of WM. This proposal focuses on the role of 5-HT in the regulation of inhibition in cortical activity and their consequences in influencing WM maintenance. I will simultaneously image the electrical activities of pyramidal and distinct GABAergic interneurons while well-trained mice execute a delayed two alternative forced choice (2AFC) task to read out WM during the delay period. Imaging will be performed in both wide-field and two-photon imaging mode to record cortical activity at the mesoscopic (cortex-wide) and local (PFC) levels, respectively. I will combine optical imaging with optogenetic stimulation/silencing to manipulate GABAergic interneurons in the PFC and serotonin release in the dorsal raphe (DR) during the execution of the 2AFC task. Additionally, I will use a mouse model of schizophrenia that is known to exhibit WM deficits to correlate possible alterations in serotonin signaling during cellular-level WM maintenance with WM performance at the behavioral level. This could allow us to understand why many psychiatric treatments are mostly ineffective at improving cognitive abilities and how modulation of the serotonergic system could reverse these effects, ultimately helping to develop new therapeutic treatments.

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