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SERWOM SIGNED

Understanding Serotonergic Regulation of Working Memory

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SERWOM project word cloud

Explore the words cloud of the SERWOM project. It provides you a very rough idea of what is the project "SERWOM" about.

pfc    understand    pathophysiology    model    local    modulation    additionally    circuit    signaling    respectively    2afc    neurotransmission    levels    combine    integrity    executive    mode    depression    gabaergic    optical    reverse    behavioral    ineffective    exhibit    cell    performed    deficits    trained    schizophrenia    cellular    patients    dorsal    ultimately    therapeutic    mouse    record    memory    image    influencing    alternative    functions    prefrontal    symptoms    period    types    cortex    forced    serotonergic    receptor    regulation    performance    treatments    helping    suffering    mostly    expressed    subtypes    cortical    wm    delay    interneurons    altered    characterizing    inhibition    dr    delayed    alterations    mesoscopic    causal    simultaneously    central    stimulation    critical    serotonin    imaging    ht    execute    modulates    health    raphe    read    pyramidal    functional    selectively    release    cognitive    correlate    optogenetic    electrical    silencing    mechanism    photon    mental    maintenance    psychiatric    mice    manipulate   

Project "SERWOM" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 212˙933.00

Map

 Project objective

Functional integrity of the prefrontal cortex (PFC) is essential for higher ‘executive’ functions such as working memory (WM). Serotonin (5-HT) modulates GABAergic neurotransmission in the PFC through different 5-HT receptor subtypes that are selectively expressed in distinct GABAergic cell types. Altered GABAergic neurotransmission in the PFC of patients suffering from schizophrenia and depression is believed to be central to their pathophysiology. Currently available treatments targeting 5-HT signaling have addressed different mental health symptoms but typically not cognitive capabilities. Therefore, characterizing the causal role of distinct GABAergic cell types on circuit activity is a critical step in understanding the circuit mechanism of WM. This proposal focuses on the role of 5-HT in the regulation of inhibition in cortical activity and their consequences in influencing WM maintenance. I will simultaneously image the electrical activities of pyramidal and distinct GABAergic interneurons while well-trained mice execute a delayed two alternative forced choice (2AFC) task to read out WM during the delay period. Imaging will be performed in both wide-field and two-photon imaging mode to record cortical activity at the mesoscopic (cortex-wide) and local (PFC) levels, respectively. I will combine optical imaging with optogenetic stimulation/silencing to manipulate GABAergic interneurons in the PFC and serotonin release in the dorsal raphe (DR) during the execution of the 2AFC task. Additionally, I will use a mouse model of schizophrenia that is known to exhibit WM deficits to correlate possible alterations in serotonin signaling during cellular-level WM maintenance with WM performance at the behavioral level. This could allow us to understand why many psychiatric treatments are mostly ineffective at improving cognitive abilities and how modulation of the serotonergic system could reverse these effects, ultimately helping to develop new therapeutic treatments.

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lastchecktime (2020-10-25 14:27:28) correctly updated