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SERWOM SIGNED

Understanding Serotonergic Regulation of Working Memory

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SERWOM project word cloud

Explore the words cloud of the SERWOM project. It provides you a very rough idea of what is the project "SERWOM" about.

alternative    executive    electrical    raphe    ineffective    ht    stimulation    memory    pfc    performed    behavioral    altered    mode    receptor    silencing    cell    alterations    integrity    cellular    correlate    optical    dr    selectively    additionally    types    read    psychiatric    combine    record    forced    understand    levels    circuit    serotonin    deficits    imaging    health    signaling    model    performance    mechanism    critical    characterizing    cognitive    functional    therapeutic    inhibition    helping    reverse    influencing    execute    exhibit    delayed    gabaergic    mouse    respectively    manipulate    maintenance    pathophysiology    dorsal    optogenetic    wm    trained    period    mental    functions    regulation    treatments    subtypes    central    simultaneously    schizophrenia    patients    modulation    neurotransmission    2afc    local    expressed    serotonergic    mice    ultimately    mostly    release    suffering    image    modulates    delay    photon    depression    mesoscopic    interneurons    symptoms    pyramidal    cortical    prefrontal    causal    cortex   

Project "SERWOM" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 212˙933.00

Map

 Project objective

Functional integrity of the prefrontal cortex (PFC) is essential for higher ‘executive’ functions such as working memory (WM). Serotonin (5-HT) modulates GABAergic neurotransmission in the PFC through different 5-HT receptor subtypes that are selectively expressed in distinct GABAergic cell types. Altered GABAergic neurotransmission in the PFC of patients suffering from schizophrenia and depression is believed to be central to their pathophysiology. Currently available treatments targeting 5-HT signaling have addressed different mental health symptoms but typically not cognitive capabilities. Therefore, characterizing the causal role of distinct GABAergic cell types on circuit activity is a critical step in understanding the circuit mechanism of WM. This proposal focuses on the role of 5-HT in the regulation of inhibition in cortical activity and their consequences in influencing WM maintenance. I will simultaneously image the electrical activities of pyramidal and distinct GABAergic interneurons while well-trained mice execute a delayed two alternative forced choice (2AFC) task to read out WM during the delay period. Imaging will be performed in both wide-field and two-photon imaging mode to record cortical activity at the mesoscopic (cortex-wide) and local (PFC) levels, respectively. I will combine optical imaging with optogenetic stimulation/silencing to manipulate GABAergic interneurons in the PFC and serotonin release in the dorsal raphe (DR) during the execution of the 2AFC task. Additionally, I will use a mouse model of schizophrenia that is known to exhibit WM deficits to correlate possible alterations in serotonin signaling during cellular-level WM maintenance with WM performance at the behavioral level. This could allow us to understand why many psychiatric treatments are mostly ineffective at improving cognitive abilities and how modulation of the serotonergic system could reverse these effects, ultimately helping to develop new therapeutic treatments.

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