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BRILLIANCE SIGNED

Bright, coherent and focused light to resolve neural circuits

Total Cost €

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EC-Contrib. €

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Partnership

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 BRILLIANCE project word cloud

Explore the words cloud of the BRILLIANCE project. It provides you a very rough idea of what is the project "BRILLIANCE" about.

nm    tomography    technique    discoveries    microscopes    resolving    exceptional    ultra    detection    microscopy    propagation    automatic    fundamental    imaginable    imaging    resolution    neuroimaging    3d    prohibitive    samples    cutting    sized    neural    spans    nanoprobe    tissue    perspectives    nanopositioning    unprecedented    sufficient    underlie    rays    acquisition    integrative    combining    prone    entails    function    exploration    synaptic    interdisciplinary    mm    brain    overarching    limitations    generating    multiscale    distances    data    setup    sectioning    rapid    carefully    full    tool    cubic    image    soft    create    nano    visible    therapeutic    collection    free    connections    circuits    volumes    neurosciences    circuit    hardly    errors    probe    facilitates    nanometre    edge    cryogenics    coherent    reconstruction    preservation    conceivable    power    designed    unreachable    contrast    view    visualize    preparation    electron    spatial    ray    light    opaque    penetrating    holographic    millimetre    thin    overcome    maps    space    brilliant    isotropic   

Project "BRILLIANCE" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN SYNCHROTRON RADIATION FACILITY 

Organization address
address: 71 AVENUE DES MARTYRS
city: GRENOBLE
postcode: 38000
website: www.esrf.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙430˙275 €
 EC max contribution 1˙430˙275 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN SYNCHROTRON RADIATION FACILITY FR (GRENOBLE) coordinator 1˙430˙275.00

Map

 Project objective

The overarching goal of this project is to establish a novel technique for neuroimaging to probe large tissue volumes at the nanometre scale. Currently only electron microscopes are capable of generating data with sufficient resolving power for comprehensive exploration of the neural circuits that underlie brain function. With state of the art systems, imaging just one cubic mm of brain entails years of data collection, ultra-thin sectioning which is prone to errors and data loss, and prohibitive costs. Each circuit unit spans over large distances, thus access to millimetre sized volumes of view is essential for both fundamental and therapeutic discoveries in neurosciences. Today this is an unreachable goal. In contrast, X-ray microscopy facilitates rapid imaging of large samples but the resolving power is not sufficient to visualize neural connections. Thus, at present, resolving large neural circuits is hardly imaginable. The aim of this project is to overcome these limitations and to develop an integrative approach which will open new research perspectives. X-ray holographic nano-tomography is a 3D coherent imaging technique which is capable of generating exceptional contrast in soft tissue through phase contrast. The penetrating power of X-rays and the full-field, free space propagation setup enable rapid multiscale imaging of large samples which are opaque to visible light. By combining a highly brilliant X-ray nanoprobe, a carefully designed nanopositioning system, a cutting edge detection system and cryogenics for sample preservation, isotropic 3D spatial resolution better than 30 nm is conceivable. The objectives of this interdisciplinary project are to 1) develop a system for imaging neural circuits at synaptic level in large tissue volumes, including methods for sample preparation, image acquisition and image reconstruction 2) develop an automatic image analysis tool 3) create unprecedented maps of brain circuits with immediate impact in neurosciences.

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The information about "BRILLIANCE" are provided by the European Opendata Portal: CORDIS opendata.

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