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BRILLIANCE SIGNED

Bright, coherent and focused light to resolve neural circuits

Total Cost €

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EC-Contrib. €

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Partnership

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 BRILLIANCE project word cloud

Explore the words cloud of the BRILLIANCE project. It provides you a very rough idea of what is the project "BRILLIANCE" about.

preservation    sufficient    limitations    neural    nano    isotropic    acquisition    rays    detection    volumes    automatic    sectioning    nanopositioning    image    perspectives    unprecedented    light    neuroimaging    errors    conceivable    visualize    interdisciplinary    opaque    thin    hardly    cubic    designed    prone    underlie    generating    function    probe    cutting    nanometre    preparation    rapid    circuits    reconstruction    3d    maps    create    exceptional    synaptic    visible    millimetre    discoveries    spatial    resolving    distances    soft    tool    microscopes    fundamental    coherent    cryogenics    spans    connections    combining    tissue    brilliant    multiscale    neurosciences    brain    nanoprobe    contrast    electron    prohibitive    circuit    ultra    unreachable    facilitates    free    integrative    entails    microscopy    sized    samples    imaginable    carefully    imaging    therapeutic    space    collection    nm    propagation    data    power    mm    exploration    tomography    edge    setup    technique    overarching    resolution    ray    overcome    holographic    view    penetrating    full   

Project "BRILLIANCE" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN SYNCHROTRON RADIATION FACILITY 

Organization address
address: 71 AVENUE DES MARTYRS
city: GRENOBLE
postcode: 38000
website: www.esrf.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙430˙275 €
 EC max contribution 1˙430˙275 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN SYNCHROTRON RADIATION FACILITY FR (GRENOBLE) coordinator 1˙430˙275.00

Map

 Project objective

The overarching goal of this project is to establish a novel technique for neuroimaging to probe large tissue volumes at the nanometre scale. Currently only electron microscopes are capable of generating data with sufficient resolving power for comprehensive exploration of the neural circuits that underlie brain function. With state of the art systems, imaging just one cubic mm of brain entails years of data collection, ultra-thin sectioning which is prone to errors and data loss, and prohibitive costs. Each circuit unit spans over large distances, thus access to millimetre sized volumes of view is essential for both fundamental and therapeutic discoveries in neurosciences. Today this is an unreachable goal. In contrast, X-ray microscopy facilitates rapid imaging of large samples but the resolving power is not sufficient to visualize neural connections. Thus, at present, resolving large neural circuits is hardly imaginable. The aim of this project is to overcome these limitations and to develop an integrative approach which will open new research perspectives. X-ray holographic nano-tomography is a 3D coherent imaging technique which is capable of generating exceptional contrast in soft tissue through phase contrast. The penetrating power of X-rays and the full-field, free space propagation setup enable rapid multiscale imaging of large samples which are opaque to visible light. By combining a highly brilliant X-ray nanoprobe, a carefully designed nanopositioning system, a cutting edge detection system and cryogenics for sample preservation, isotropic 3D spatial resolution better than 30 nm is conceivable. The objectives of this interdisciplinary project are to 1) develop a system for imaging neural circuits at synaptic level in large tissue volumes, including methods for sample preparation, image acquisition and image reconstruction 2) develop an automatic image analysis tool 3) create unprecedented maps of brain circuits with immediate impact in neurosciences.

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The information about "BRILLIANCE" are provided by the European Opendata Portal: CORDIS opendata.

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