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Coupling of Optical tweezers with Tip-enhanced Raman Spectroscopy for single-molecule investigation of supramolecular systems

Total Cost €


EC-Contrib. €






 TweeTERS project word cloud

Explore the words cloud of the TweeTERS project. It provides you a very rough idea of what is the project "TweeTERS" about.

nanometer    powerfull    strength    macrocycle    synthetic    inter    nearly    switching    dynamics    reversible    forces    un    conformational    behavior    few    force    disentangle    resolution    hydrogen    operation    molecular    improvement    chemical    explored    stations    principles    molecule    underlying    microscopy    ters    guest    scanning    raman    coupling    regime    sensitivity    binding    characterization    kinetics    quantified    ot    displacements    questions    orientations    accessible    individual    piconewton    fundamental    tweeters    events    create    merge    optical    supramolecular    tip    nearfield    bonds    tool    mechanistic    unanswered    types    physicochemical    trapping    ing    species    governing    breaking    techinque    shuttle    single    provides    measuring    combining    time    relation    hybrid    sensitive    nm    spatial    mechanical    interactions    host    enhaced    covalent    motors    supra    shuttling    technological    probe    experiments    quantitative    chemistry    mechanisms    manipulation    spectroscopy   

Project "TweeTERS" data sheet

The following table provides information about the project.


Organization address
city: MADRID
postcode: 28049

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2022-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION IMDEA NANOCIENCIA ES (MADRID) coordinator 160˙932.00


 Project objective

Quantitative information on the dynamics and mechanistic principles behind supramolecular systems can be investigated in the single-molecule regime by measuring the nanometer displacements resulting from the application of picoNewton forces in optical trapping (OT) experiments. In particular, the mechanical strength of non-covalent interactions can be quantified when studying the reversible breaking/formation of hydrogen bonds on individual host-guest systems or the switching of a macrocycle between binding stations in a molecular shuttle. However, the fundamental chemical mechanisms behind the obtained real-time operational kinetics are not accessible with OT experiments and fundamental questions about the physicochemical processes underlying real-operation remain unanswered. The goal of this project is to merge OT for single-molecule optical force microscopy experiments with tip-enhaced Raman spectroscopy (TERS). TERS is a powerfull nearfield-based techinque based on the coupling of Raman spectroscopy and scanning probe microscopy. It provides chemical characterization with single molecule sensitivity and few-nm spatial resolution. Since Raman spectroscopy is sensitive to molecular species, inter and intra molecular interactions and orientations; by combining OT-optical force microscopy with TERS, we will access the underlying physicochemical processes triggering specific shuttling events in molecular motors and other types of supramolecular systems. In particular, we aim to create a hybrid tool that can disentangle the relation between mechanical, conformational and chemical properties of individual synthetic supramolecular systems and the non-covalent interactions governing their behavior, with single-molecule sensitivity and spatial resolution in the range of 10 nm. TweeTERS will lead to a major technological improvement in the single-molecule manipulation field and in particular, in the nearly un-explored field of single-molecule supra-molecular chemistry.

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