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TweeTERS SIGNED

Coupling of Optical tweezers with Tip-enhanced Raman Spectroscopy for single-molecule investigation of supramolecular systems

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TweeTERS project word cloud

Explore the words cloud of the TweeTERS project. It provides you a very rough idea of what is the project "TweeTERS" about.

types    mechanistic    enhaced    spatial    supra    reversible    guest    mechanical    measuring    ing    nearfield    shuttle    binding    principles    host    create    force    operation    covalent    powerfull    accessible    optical    synthetic    quantitative    stations    ters    disentangle    chemical    kinetics    displacements    individual    hybrid    tweeters    nanometer    time    nm    questions    sensitivity    explored    events    sensitive    orientations    molecular    motors    few    un    coupling    fundamental    single    chemistry    bonds    behavior    manipulation    inter    strength    regime    species    molecule    experiments    tool    merge    techinque    hydrogen    dynamics    interactions    relation    provides    macrocycle    governing    physicochemical    tip    forces    trapping    characterization    shuttling    breaking    scanning    nearly    microscopy    switching    probe    conformational    resolution    mechanisms    ot    supramolecular    spectroscopy    unanswered    technological    piconewton    combining    quantified    underlying    raman    improvement   

Project "TweeTERS" data sheet

The following table provides information about the project.

Coordinator		 FUNDACION IMDEA NANOCIENCIA 

Organization address
address: CIUDAD UNIVERSITARIA DE CANTOBLANCO - CALLE FARADAY 9
city: MADRID
postcode: 28049
website: http://www.nanociencia.imdea.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION IMDEA NANOCIENCIA ES (MADRID) coordinator 160˙932.00

Map

 Project objective

Quantitative information on the dynamics and mechanistic principles behind supramolecular systems can be investigated in the single-molecule regime by measuring the nanometer displacements resulting from the application of picoNewton forces in optical trapping (OT) experiments. In particular, the mechanical strength of non-covalent interactions can be quantified when studying the reversible breaking/formation of hydrogen bonds on individual host-guest systems or the switching of a macrocycle between binding stations in a molecular shuttle. However, the fundamental chemical mechanisms behind the obtained real-time operational kinetics are not accessible with OT experiments and fundamental questions about the physicochemical processes underlying real-operation remain unanswered. The goal of this project is to merge OT for single-molecule optical force microscopy experiments with tip-enhaced Raman spectroscopy (TERS). TERS is a powerfull nearfield-based techinque based on the coupling of Raman spectroscopy and scanning probe microscopy. It provides chemical characterization with single molecule sensitivity and few-nm spatial resolution. Since Raman spectroscopy is sensitive to molecular species, inter and intra molecular interactions and orientations; by combining OT-optical force microscopy with TERS, we will access the underlying physicochemical processes triggering specific shuttling events in molecular motors and other types of supramolecular systems. In particular, we aim to create a hybrid tool that can disentangle the relation between mechanical, conformational and chemical properties of individual synthetic supramolecular systems and the non-covalent interactions governing their behavior, with single-molecule sensitivity and spatial resolution in the range of 10 nm. TweeTERS will lead to a major technological improvement in the single-molecule manipulation field and in particular, in the nearly un-explored field of single-molecule supra-molecular chemistry.

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