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Coupling of Optical tweezers with Tip-enhanced Raman Spectroscopy for single-molecule investigation of supramolecular systems

Total Cost €


EC-Contrib. €






 TweeTERS project word cloud

Explore the words cloud of the TweeTERS project. It provides you a very rough idea of what is the project "TweeTERS" about.

supramolecular    strength    dynamics    tool    spatial    covalent    scanning    relation    nm    inter    reversible    trapping    behavior    techinque    fundamental    piconewton    events    physicochemical    provides    host    tweeters    optical    orientations    measuring    enhaced    microscopy    mechanistic    binding    sensitive    macrocycle    hydrogen    molecular    improvement    disentangle    switching    merge    ing    mechanisms    regime    raman    technological    displacements    experiments    coupling    nanometer    probe    chemical    conformational    ters    unanswered    interactions    operation    molecule    quantitative    synthetic    shuttling    hybrid    questions    un    supra    accessible    guest    combining    create    underlying    characterization    individual    single    tip    explored    stations    motors    powerfull    forces    nearly    few    ot    mechanical    principles    species    manipulation    governing    bonds    resolution    spectroscopy    sensitivity    time    force    shuttle    breaking    quantified    kinetics    chemistry    types    nearfield   

Project "TweeTERS" data sheet

The following table provides information about the project.


Organization address
city: MADRID
postcode: 28049

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2022-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION IMDEA NANOCIENCIA ES (MADRID) coordinator 160˙932.00


 Project objective

Quantitative information on the dynamics and mechanistic principles behind supramolecular systems can be investigated in the single-molecule regime by measuring the nanometer displacements resulting from the application of picoNewton forces in optical trapping (OT) experiments. In particular, the mechanical strength of non-covalent interactions can be quantified when studying the reversible breaking/formation of hydrogen bonds on individual host-guest systems or the switching of a macrocycle between binding stations in a molecular shuttle. However, the fundamental chemical mechanisms behind the obtained real-time operational kinetics are not accessible with OT experiments and fundamental questions about the physicochemical processes underlying real-operation remain unanswered. The goal of this project is to merge OT for single-molecule optical force microscopy experiments with tip-enhaced Raman spectroscopy (TERS). TERS is a powerfull nearfield-based techinque based on the coupling of Raman spectroscopy and scanning probe microscopy. It provides chemical characterization with single molecule sensitivity and few-nm spatial resolution. Since Raman spectroscopy is sensitive to molecular species, inter and intra molecular interactions and orientations; by combining OT-optical force microscopy with TERS, we will access the underlying physicochemical processes triggering specific shuttling events in molecular motors and other types of supramolecular systems. In particular, we aim to create a hybrid tool that can disentangle the relation between mechanical, conformational and chemical properties of individual synthetic supramolecular systems and the non-covalent interactions governing their behavior, with single-molecule sensitivity and spatial resolution in the range of 10 nm. TweeTERS will lead to a major technological improvement in the single-molecule manipulation field and in particular, in the nearly un-explored field of single-molecule supra-molecular chemistry.

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