EVA

Markers for emphysema versus airway disease in COPD

 Coordinatore HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH 

 Organization address address: Ingolstaedter Landstrasse 1
city: MUENCHEN
postcode: 85764

contact info
Titolo: Dr.
Nome: Juergen
Cognome: Ertel
Email: send email
Telefono: +49 89 3187 3022
Fax: +49 89 3187 2212

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://www.eva-copd.eu/
 Totale costo 3˙952˙828 €
 EC contributo 2˙984˙025 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-10-01   -   2012-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

 Organization address address: Ingolstaedter Landstrasse 1
city: MUENCHEN
postcode: 85764

contact info
Titolo: Dr.
Nome: Juergen
Cognome: Ertel
Email: send email
Telefono: +49 89 3187 3022
Fax: +49 89 3187 2212

DE (MUENCHEN) coordinator 0.00
2    ACADEMISCH ZIEKENHUIS LEIDEN

 Organization address address: Albinusdreef 2
city: LEIDEN
postcode: 2333 ZA

contact info
Titolo: Dr.
Nome: E.M.
Cognome: Reinhard
Email: send email
Telefono: +31 71 5248117
Fax: +31 1 5266927

NL (LEIDEN) participant 0.00
3    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

 Organization address address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015

contact info
Titolo: Mr.
Nome: Regis
Cognome: Copin
Email: send email
Telefono: +33 1 60872506
Fax: +33 1 60872513

FR (PARIS 15) participant 0.00
4    EUROPEAN RESPIRATORY SOCIETY

 Organization address address: Avenue Sainte Luce 4
city: LAUSANNE
postcode: 1004

contact info
Titolo: Mrs
Nome: Werner
Cognome: Bill
Email: send email
Telefono: +41 21 2130101
Fax: +41 21 2130100

CH (LAUSANNE) participant 0.00
5    FUNDACIO PRIVADA PARC CIENTIFIC DE BARCELONA

 Organization address address: Baldiri i Reixac, 10-12
city: BARCELONA
postcode: 8028

contact info
Titolo: Mr.
Nome: Moises
Cognome: Tarté
Email: send email
Telefono: +34 934037036

ES (BARCELONA) participant 0.00
6    INSTYTUT GRUZLICY I CHOROB PLUC

 Organization address address: UL. PLOCKA 26
city: WARSZAWA
postcode: 1138

contact info
Titolo: Prof.
Nome: Kazimirz
Cognome: Roszkowski-Sliz
Email: send email
Telefono: +48 22 4312 213
Fax: +48 22 4312452

PL (WARSZAWA) participant 0.00
7    MEDIZINISCHE HOCHSCHULE HANNOVER

 Organization address address: Carl-Neuberg-Strasse 1
city: HANNOVER
postcode: 30625

contact info
Titolo: Mr.
Nome: Norbert
Cognome: Langhorst
Email: send email
Telefono: +49 511 5326481
Fax: +49 511 5326487

DE (HANNOVER) participant 0.00
8    ORSZAGOS KORANYI TBE ES PULMONOLOGIAI INTEZET

 Organization address address: UTCA PIHENO 1
city: BUDAPEST
postcode: 1529

contact info
Titolo: Ms.
Nome: Erzsébet
Cognome: Szászné Bagaméry
Email: send email
Telefono: +36 1 3913345
Fax: +36 1 3943521

HU (BUDAPEST) participant 0.00
9    P & M VENGE AB

 Organization address address: SKOLGATAN 23
city: UPPSALA
postcode: 75312

contact info
Titolo: Prof.
Nome: Per
Cognome: Venge
Email: send email
Telefono: +46 18 6114246
Fax: +46 18 128084

SE (UPPSALA) participant 0.00
10    PHILIPPS UNIVERSITAET MARBURG

 Organization address address: Biegenstrasse 10
city: MARBURG
postcode: 35032

contact info
Titolo: Dr.
Nome: Jamilan
Cognome: Michel
Email: send email
Telefono: +49 6421 99 12123
Fax: +49 6421 28 26382

DE (MARBURG) participant 0.00
11    THE UNIVERSITY OF MANCHESTER

 Organization address address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL

contact info
Titolo: Ms.
Nome: Cheryl
Cognome: Holmes
Email: send email
Telefono: +44 161 946 4224
Fax: +44 161 946 4223

UK (MANCHESTER) participant 0.00
12    UNIVERSITA DEGLI STUDI DI FERRARA

 Organization address address: SAVONAROLA 9
city: FERRARA
postcode: 44100

contact info
Titolo: Prof.
Nome: Patrizio
Cognome: Bianchi
Email: send email
Telefono: +39 0532 455033
Fax: +39 0532 245951

IT (FERRARA) participant 0.00
13    UNIVERSITAETSKLINIKUM FREIBURG

 Organization address address: HUGSTETTER STRASSE 49
city: FREIBURG
postcode: 79106

contact info
Nome: Gerhard
Cognome: Henniger
Email: send email
Telefono: +49 761 270 1920
Fax: +49 761 270 1889

DE (FREIBURG) participant 0.00
14    UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NATIONAL HEALTH SERVICE TRUST

 Organization address address: CLIFFORD BRIDGE ROAD
city: COVENTRY
postcode: CV2 2DX

contact info
Titolo: Mr.
Nome: Andrew
Cognome: Hardy
Email: send email
Telefono: +44 2476967606
Fax: +44 2476966056

UK (COVENTRY) participant 0.00
15    UNIVERSITY OF LEICESTER

 Organization address address: University Road
city: LEICESTER
postcode: LE1 7RH

contact info
Titolo: Ms.
Nome: Marie
Cognome: Singer
Email: send email
Telefono: +44 116 223 1799
Fax: +44 116 252 2028

UK (LEICESTER) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

phenotypes    blood    linked    controls    pathogenesis    markers    bronchial    inflammatory    obstruction    pathologies    leukocytes    computer    material    lung    pulmonary    scans    emphysema    gene    rna    hypothesis    obstructive    sub    protein    patients    predisposition    ct    data    differential    density    chronic    tomography    genetic    airway    dna    specifically    disease    expression    either    eva    wall    therapeutic    copd    versus   

 Obiettivo del progetto (Objective)

'COPD is characterized by emphysema (destruction of the lung alveoli) and airway disease (inflammation and thickening of the bronchial wall) both of which lead to airway obstruction. These two features co-exist in most patients but some patients present with only emphysema (E) or only airway disease (A). The aim of the project is to identify markers specific to E and A of COPD. Our hypothesis is that the mechanisms leading to these pathologies are distinct with respect to the type of inflammatory response and in terms of genetic predisposition. The differential pathogenesis for emphysema (E) and inflammatory airway disease (A) entails that in the two forms of COPD are linked to different markers at the DNA, RNA and protein level. Using computer tomography (CT) scans for selection of patients with emphysema only and airway disease only, we will obtain material from lung (leukocytes, bronchial cells) and blood (leukocytes), and will analyse elements of gene expression (SNP array, transcriptome). Data analysis will be done for E versus A (EvA) and versus a control cohort leading to identification of markers linked specifically to either E or A. These markers will be elements involved in a differential pathogenesis for the different disease processes in COPD. They can be used for diagnostic approaches and as therapeutic targets.'

Introduzione (Teaser)

Chronic obstructive pulmonary disease ranks high on the global mortality list. It is characterised by emphysema and airway disease, both of which lead to airway obstruction.

Descrizione progetto (Article)

Although most chronic obstructive pulmonary disease (COPD) patients have both emphysema and airway disease, in some cases only one of the features is present. The 'Markers for emphysema versus airway disease in COPD' (EVA) project aims to identify markers linked specifically to emphysema and airway disease at the DNA, RNA and protein levels. The EU-funded project is working on the hypothesis that the processes leading to these pathologies can be differentiated with regard to inflammatory response and genetic predisposition.

Participating clinical centres have to date recruited some 180 cases and 170 healthy controls. Computer tomography (CT) scans are being used to select patients with either emphysema or airway disease. Image analysis will further define emphysema based on density of the lung tissue, and airway disease based on thickness of the airway wall. By plotting airway wall area against lung density, patients can be identified as having emphysema only or airway disease only.

Material obtained from lungs and blood will be analysed for elements of gene expression. However, crucial analysis will be performed in a single batch at the end of the study, when all samples have been collected. At that point, DNA, RNA and protein data will be available for cases as well as controls. This will help EVA produce the results required to identify markers specifically associated with emphysema and airway disease sub-phenotypes.

As elements of the differential pathogenesis for the different disease processes in COPD, these markers will be extremely useful for diagnosing the sub-phenotypes. Such markers will also provide a basis for exploring targets for new therapeutic approaches to COPD. This will also afford greater opportunities to better manage the disease.

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