TROCAR

Translational Research on Combating Antimicrobial Resistance

 Coordinatore CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER 

 Organization address address: CALLE ROSSELLO 149 PUERTA BJS
city: BARCELONA
postcode: 8036

contact info
Titolo: Prof.
Nome: Ramon
Cognome: Gomis
Email: send email
Telefono: +34 93 227 9884
Fax: +34 93 227 9885

 Nazionalità Coordinatore Spain [ES]
 Totale costo 3˙948˙928 €
 EC contributo 2˙999˙444 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Funding Scheme CP-FP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-01-01   -   2012-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

 Organization address address: CALLE ROSSELLO 149 PUERTA BJS
city: BARCELONA
postcode: 8036

contact info
Titolo: Prof.
Nome: Ramon
Cognome: Gomis
Email: send email
Telefono: +34 93 227 9884
Fax: +34 93 227 9885

ES (BARCELONA) coordinator 0.00
2    ACADEMISCH ZIEKENHUIS GRONINGEN

 Organization address address: Hanzeplein 1
city: GRONINGEN
postcode: 9713 GZ

contact info
Titolo: Dr.
Nome: Jan.J.
Cognome: Breeuwsma
Email: send email
Telefono: 31503638377
Fax: 31503633041

NL (GRONINGEN) participant 0.00
3    ETHNIKI SCHOLI DIMOSIAS YGEIAS

 Organization address address: LEOFOROS ALEXANDRAS 196
city: ATHENS
postcode: 11521

contact info
Titolo: Prof.
Nome: Anastasia
Cognome: Roumelioti
Email: send email
Telefono: 302106000000
Fax: 302106000000

EL (ATHENS) participant 0.00
4    EUROPEAN SOCIETY OF CLINICAL MICROBIOLOGY AND INFECTIOUS DISEASES E.V

 Organization address address: HAINBUCHENSTRASSE 65
city: MUNCHEN 80
postcode: 8000

contact info
Titolo: Ms.
Nome: Barbara
Cognome: Siegrist
Email: send email
Telefono: 41616867793
Fax: 41616867798

DE (MUNCHEN 80) participant 0.00
5    HEALTH PROTECTION AGENCY HPA

 Organization address address: Central Office - 7th Floor, Holborn Gate - High Holborn 330
city: LONDON
postcode: WC1V 7PP

contact info
Titolo: Ms.
Nome: Geetha
Cognome: Naathan
Email: send email
Telefono: +440208327 6923
Fax: 4402080000000

UK (LONDON) participant 0.00
6    INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA

 Organization address address: "Avenida da Republica, Estacao Agronomica Nacional"
city: OEIRAS
postcode: 2784-505

contact info
Titolo: Dr.
Nome: Margarida
Cognome: Martinez
Email: send email
Telefono: 351214000000
Fax: 351214000000

PT (OEIRAS) participant 0.00
7    ROBERT KOCH-INSTITUT

 Organization address address: Nordufer 20
city: Berlin
postcode: 13353

contact info
Titolo: Prof.
Nome: Wolfgang
Cognome: Witte
Email: send email
Telefono: 493944000000
Fax: 493944000000

DE (Berlin) participant 0.00
8    SERVICIO MADRILENO DE SALUD

 Organization address address: PLAZA CARLOS TRIAS BERTRAN 7
city: MADRID
postcode: 28020

contact info
Titolo: Ms.
Nome: Isabel
Cognome: Crespo
Email: send email
Telefono: 34913368147
Fax: 34913369016

ES (MADRID) participant 0.00
9    SISTEMAS GENOMICOS SL

 Organization address address: RONDA G MARCONI - PARQUE TECNOLOGICO DE VALENCIA 6
city: PATERNA
postcode: 46980

contact info
Titolo: Mr.
Nome: David
Cognome: García Alfonso
Email: send email
Telefono: +34 902 364 669
Fax: +34 902 364 669

ES (PATERNA) participant 0.00
10    TERVEYDEN JA HYVINVOINNIN LAITOS

 Organization address address: MANNERHEIMINTIE 166
city: HELSINKI
postcode: 300

contact info
Titolo: Mr.
Nome: Jaakko
Cognome: Penttinen
Email: send email
Telefono: +358 20 610 8203
Fax: +358 20 610 8225

FI (HELSINKI) participant 0.00
11    UNIVERSITA' DEGLI STUDI DI SIENA

 Organization address address: VIA BANCHI DI SOTTO 55
city: SIENA
postcode: 53100

contact info
Titolo: Prof.
Nome: Silvano
Cognome: Focardi
Email: send email
Telefono: 390577000000
Fax: 390577000000

IT (SIENA) participant 0.00
12    UNIVERSITE DE CAEN BASSE-NORMANDIE

 Organization address address: ESPLANADE DE LA PAIX
city: CAEN CEDEX 05

contact info
Titolo: Prof.
Nome: Josette
Cognome: Travert
Email: send email
Telefono: 33231565315
Fax: 33231566085

FR (CAEN CEDEX 05) participant 0.00
13    UNIVERSITE PARIS-SUD

 Organization address address: RUE GEORGES CLEMENCEAU 15
city: ORSAY
postcode: 91405

contact info
Titolo: Ms.
Nome: Sandra
Cognome: Mereu
Email: send email
Telefono: +33 1 69 15 37 22
Fax: +33 1 69 15 55 99

FR (ORSAY) participant 0.00
14    UNIVERSITY OF BATH

 Organization address address: CLAVERTON DOWN
city: BATH
postcode: BA2 7AY

contact info
Titolo: Mr.
Nome: Pete
Cognome: Hompstead
Email: send email
Telefono: 441225000000
Fax: 441225000000

UK (BATH) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

nosocomial    methicillin    mrsa    clones    isolates    countries    virulent    staphylococcus    persistence    appear    collection    provides    bacteria    settings    drug    environment    acinetobacter    enterococcus    hospital    pseudomonas    resistance    bioinformatics    hirics    genetic    laboratories    spp    risk    strains    warning    vre    health    care    epidemic    vancomycin    tools    baumannii    aeruginosa    resistant    hospitals    spread    acute    data    pathogens    basis    genes    trocar    community    aureus    facilities   

 Obiettivo del progetto (Objective)

'The health care systems of most European countries are based on a continuum from acute care hospitals, though other health care facilities to the community. Such a framework provides the perfect opportunity for the wide-spread dissemination of high-risk resistant clones or genetic resistant elements. The driving concept of TROCAR is to investigate the fundamentals of the epidemiology of new highly virulent multiresistant strains of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus spp., Extended-spectrum, metallo- and acquired AmpC beta-lactamase producing Enterobacteriaceae, multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii will focus on three major strategic aims: 1. The definition of the major high-risk resistant clones based on an appropriate representative collection and new clinical strains obtained during molecular epidemiological studies, in hospitals and laboratories collaborating with their respective National Excellence Laboratories in European countries using a standardised protocol. 2. The promotion of collaborative European research to investigate, by genomic and proteomic approaches, specific traits associated with virulence, transmission, persistence and resistance of epidemic clones in comparison with non-epidemic clones as well as resistance determinants and their genetic location in horizontal gene transfer units and their genetic environment. 3. The development of bioinformatics tools to fully exploit the genomics data and allow the rapid identification of resistant strains with heightened epidemic potential. By combining the outputs of the project it will be possible to provide tools for monitoring the spread of key community and nosocomial pathogens, to provide the scientific basis for an early warning system when isolates of a particular epidemicity appear in the community and nosocomial settings, to characterise specific genetic elements carrying resistance genes encoding, and to establish t'

Introduzione (Teaser)

Through most of Europe, the healthcare system ranges from acute care in hospital to other care facilities in the community. Unfortunately, this system facilitates the spread of drug-resistant bacteria.

Descrizione progetto (Article)

The 'Translational research on combating antimicrobial resistance' (Trocar) project aims to define major high-risk clones (HiRiCs) that are largely responsible for spreading resistance. By providing the basis from which to create suitable bioinformatics tools and the proper infrastructure, the Trocar project will realise its end goal of being able to recommend novel control measures to limit or prevent the spread of highly virulent multi-drug resistant clones

Two catalogues of strains, one for methicillin-resistant Staphylococcus aureus (MRSA) and another for vancomycin-resistant Enterococcus spp. (VRE) have been obtained. From these, five MRSA- and two VRE-specific HiRiCs were chosen to generate genome sequences.

Project partners have also identified four Pseudomonas aeruginosa and two Acinetobacter baumannii HiRiCs, which are currently being sequenced. In parallel, they have developed an interactive web-based mapping tool that displays the geographical abundance of clones of S. aureus/MRSA using a Google-map interface.

To model the evolution of HiRiCs, Trocar researchers have studied the dynamics and persistence of Enterococcus faecium clones in an ongoing collection from bacteremic patients, who have traces of bacteria in their blood. Large volumes of sequence data down to nucleotide level from major bacterial disease agents have been generated.

The resistome, the set of antibiotic-resistant genes of A. baumannii is under investigation. Study results showing that biofilm formation of aggregates of bacteria increases survival rate on dry surfaces. This contributes to its persistence in the hospital environment.

The Trocar website provides more information on the project's activities to date. Details of project impact and goals for the future as well as intricate information on each of the eight workpackages is clearly outlined.

By being able to monitor the spread of key community and hospital pathogens, an early warning system can be set up when certain isolates appear in hospital and community settings.

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