SYSTEMTB
Systems biology of Mycobacterium tuberculosis
| Coordinatore | FUNDACIO CENTRE DE REGULACIO GENOMICA
Organization address
address: CARRER DOCTOR AIGUADER 88 contact info |
| Nazionalità Coordinatore | Spain [ES] |
| Totale costo | 13˙841˙311 € |
| EC contributo | 10˙562˙601 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2009-two-stage |
| Funding Scheme | CP-IP |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-04-01 - 2014-09-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
FUNDACIO CENTRE DE REGULACIO GENOMICA
Organization address
address: CARRER DOCTOR AIGUADER 88 contact info |
ES (BARCELONA) | coordinator | 1˙528˙837.00 |
| 2 |
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH
Organization address
address: Raemistrasse 101 contact info |
CH (ZUERICH) | participant | 1˙345˙851.00 |
| 3 |
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Organization address
address: Meyerhofstrasse 1 contact info |
DE (HEIDELBERG) | participant | 1˙308˙514.00 |
| 4 |
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Organization address
address: Hofgartenstrasse 8 contact info |
DE (MUENCHEN) | participant | 1˙034˙185.00 |
| 5 |
MEDICAL RESEARCH COUNCIL
Organization address
address: NORTH STAR AVENUE POLARIS HOUSE contact info |
UK (SWINDON) | participant | 895˙544.00 |
| 6 |
WAGENINGEN UNIVERSITY
Organization address
address: DROEVENDAALSESTEEG 4 contact info |
NL (WAGENINGEN) | participant | 748˙151.00 |
| 7 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | participant | 688˙948.00 |
| 8 |
INSTYTUT BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK
Organization address
address: PAWINSKIEGO 5A contact info |
PL (WARSZAWA) | participant | 643˙110.00 |
| 9 |
"USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I."
Organization address
address: FLEMINGOVO NAM. 542/2 contact info |
CZ (PRAHA 6) | participant | 485˙521.00 |
| 10 |
LIONEX GMBH
Organization address
address: Salzdahlumer Strasse 196 contact info |
DE (BRAUNSCHWEIG) | participant | 479˙240.00 |
| 11 |
HUMBOLDT-UNIVERSITAT ZU BERLIN
Organization address
address: UNTER DEN LINDEN 6 contact info |
DE (BERLIN) | participant | 467˙100.00 |
| 12 |
OMNIA MOLECULAR S.L.
Organization address
address: Calle JOSEP SAMITIER - PARC CIENTIFIC DE BARCELONA 1-5 contact info |
ES (BARCELONA) | participant | 460˙000.00 |
| 13 |
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Organization address
address: DUOMO 6 contact info |
IT (VERCELLI) | participant | 369˙600.00 |
| 14 |
KATHOLIEKE UNIVERSITEIT LEUVEN
Organization address
address: Oude Markt 13 contact info |
BE (LEUVEN) | participant | 108˙000.00 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'Tuberculosis (TB) is a re-emerging global health threat caused by Mycobacterium tuberculosis (Mtb). One third of the world's population is infected with Mtb and new infections occur at a rate of one per second. Despite global research efforts, mechanisms underlying pathogenesis, virulence and persistence of Mtb infection remain poorly understood. Simple reductionist approaches are insufficient to understand its complex biology. The grand goal of the SysteMTb project is to establish a Systems Biology framework to understand key features of Mtb and its interactions with the host which, in turn, will provide new insights and a solid (model based) knowledge for the development of novel and cost-effective strategies to combat tuberculosis. To achieve this, SysteMTb will: i) generate and integrate quantitative data sets of Mtb (e.g. transcriptomics, proteomics, metabolomics, structural genomics, lipidomics, glycomics) alone, or in the presence of host macrophages, ii) develop computer models at different appropriate levels of system complexity with emphasis on metabolism, regulatory networks and transcription regulation, and iii) identify new possible targets for therapeutic intervention based on computer modelling. The combination of these approaches will provide a rational framework to understand mycobacterial physiology during infection and to identify essential nodes that are optimal for effective therapeutic interventions.'
Introduzione (Teaser)
Tuberculosis (TB) is a re-emerging global health threat affecting one third of the world population. Understanding the mechanisms of pathogenesis, virulence and persistence of Mycobacterium tuberculosis (MTb) infection will enable addressing it in a more efficient manner.