SYNFLOW

Innovative Synthesis in Continuous-Flow Processes for Sustainable Chemical Production

 Coordinatore RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN 

 Organization address address: Templergraben 55
city: AACHEN
postcode: 52062

contact info
Titolo: Prof.
Nome: Ernst
Cognome: Schmachtenberg
Email: send email
Telefono: +49 241 80 90490
Fax: +49 241 80 92490

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://www.synflow.eu
 Totale costo 15˙990˙878 €
 EC contributo 10˙978˙076 €
 Programma FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
 Code Call FP7-NMP-2009-LARGE-3
 Funding Scheme CP-IP
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-09-01   -   2014-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN

 Organization address address: Templergraben 55
city: AACHEN
postcode: 52062

contact info
Titolo: Prof.
Nome: Ernst
Cognome: Schmachtenberg
Email: send email
Telefono: +49 241 80 90490
Fax: +49 241 80 92490

DE (AACHEN) coordinator 1˙932˙947.50
2    EVONIK INDUSTRIES AG

 Organization address address: RELLINGHAUSER STRASSE 1-11
city: ESSEN
postcode: 45128

contact info
Titolo: Mr.
Nome: Alexander
Cognome: Sauer
Email: send email
Telefono: +49 6181 59 5148

DE (ESSEN) participant 797˙346.00
3    THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS

 Organization address address: NORTH STREET 66 COLLEGE GATE
city: ST ANDREWS FIFE
postcode: KY16 9AJ

contact info
Titolo: Dr.
Nome: Alisdair
Cognome: Gibson
Email: send email
Telefono: 441334000000
Fax: 441334000000

UK (ST ANDREWS FIFE) participant 785˙770.00
4    FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN NURNBERG

 Organization address address: SCHLOSSPLATZ 4
city: ERLANGEN
postcode: 91054

contact info
Titolo: Ms.
Nome: Ulrike
Cognome: Hermann
Email: send email
Telefono: +49 9131 852 4043
Fax: +49 9131 852 6239

DE (ERLANGEN) participant 743˙480.00
5    INVITE GMBH

 Organization address address: KAISER WILHELM ALLEE
city: LEVERKUSEN
postcode: 51373

contact info
Titolo: Dr.
Nome: Thomas
Cognome: Bieringer
Email: send email
Telefono: +49 214 31203101

DE (LEVERKUSEN) participant 589˙750.00
6    BAYER TECHNOLOGY SERVICES GMBH

 Organization address address: Kaiser-Wilhelm-Allee
city: LEVERKUSEN
postcode: 51368

contact info
Titolo: Mr.
Nome: Klaus-Jürgen
Cognome: Maharowski
Email: send email
Telefono: +49 214 30 39098
Fax: +49 214 30 35865

DE (LEVERKUSEN) participant 589˙056.00
7    BRITEST LBG

 Organization address address: Garsington Road Oxford Business Park
city: OXFORD
postcode: OX4 2HN

contact info
Titolo: Mrs.
Nome: Sue
Cognome: Fleet
Email: send email
Telefono: +44 1928 515683
Fax: +44 1928 515677

UK (OXFORD) participant 556˙800.00
8    THE UNIVERSITY OF NOTTINGHAM

 Organization address address: University Park
city: NOTTINGHAM
postcode: NG7 2RD

contact info
Titolo: Mr.
Nome: Paul
Cognome: Cartledge
Email: send email
Telefono: +44 115 9515 679
Fax: +44 115 9513 633

UK (NOTTINGHAM) participant 538˙351.00
9    DECHEMA GESELLSCHAFT FUER CHEMISCHE TECHNIK UND BIOTECHNOLOGIE E.V.

 Organization address address: Theodor-Heuss-Allee 25
city: FRANKFURT
postcode: 60486

contact info
Titolo: Ms.
Nome: Roberta
Cognome: Jablonski
Email: send email
Telefono: +49 69 7564 357
Fax: +49 69 7564 257

DE (FRANKFURT) participant 531˙348.00
10    DANMARKS TEKNISKE UNIVERSITET

 Organization address address: Anker Engelundsvej 1, Building 101A
city: KONGENS LYNGBY
postcode: 2800

contact info
Titolo: Prof.
Nome: Rasmus
Cognome: Fehrmann
Email: send email
Telefono: +45 4525 2389
Fax: +45 45883136

DK (KONGENS LYNGBY) participant 462˙660.00
11    UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II.

 Organization address address: Corso Umberto I 40
city: NAPOLI
postcode: 80138

contact info
Titolo: Prof.
Nome: Nino
Cognome: Grizzuti
Email: send email
Telefono: +39 081 7682285
Fax: +39 081 2391800

IT (NAPOLI) participant 450˙800.00
12    ASTRAZENECA UK LIMITED

 Organization address address: STANHOPE GATE 15
city: LONDON
postcode: W1K 1LN

contact info
Titolo: Dr.
Nome: Hans-Jürgen
Cognome: Federsel
Email: send email
Telefono: +46 8 55327063
Fax: +46 8 55324276

UK (LONDON) participant 423˙151.00
13    UNIVERSITAT ROVIRA I VIRGILI

 Organization address address: CARRER DE ESCORXADOR
city: TARRAGONA
postcode: 43003

contact info
Titolo: Prof.
Nome: Carmen
Cognome: Claver
Email: send email
Telefono: +34 977 559574

ES (TARRAGONA) participant 371˙984.00
14    UNIVERSITATEA DIN BUCURESTI

 Organization address address: MIHAIL KOGALNICEANU STREET 36-46 SECTOR V
city: BUCURESTI
postcode: 50107

contact info
Titolo: Prof.
Nome: Vasile
Cognome: Parvulescu
Email: send email
Telefono: +40 21 4100241
Fax: +40 21 4100241

RO (BUCURESTI) participant 363˙000.00
15    THE UNIVERSITY OF WARWICK

 Organization address address: Kirby Corner Road - University House -
city: COVENTRY
postcode: CV4 8UW

contact info
Titolo: Dr.
Nome: Peter
Cognome: Hedges
Email: send email
Telefono: +44 247 652 3716
Fax: +44 247 652 4991

UK (COVENTRY) participant 287˙822.00
16    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Ms.
Nome: Renata
Cognome: Schaeffer
Email: send email
Telefono: +44 1223 333543

UK (CAMBRIDGE) participant 279˙221.00
17    UPPSALA UNIVERSITET

 Organization address address: SANKT OLOFSGATAN 10 B
city: UPPSALA
postcode: 751 05

contact info
Titolo: Prof.
Nome: Pher G.
Cognome: Andersson
Email: send email
Telefono: +46 18 471 3801
Fax: +46 18 471 3818

SE (UPPSALA) participant 263˙958.00
18    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Ms.
Nome: Armelle
Cognome: Barelli
Email: send email
Telefono: +33 5 61 33 60 80
Fax: +33 5 62 17 29 01

FR (PARIS) participant 250˙228.00
19    JOHNSON MATTHEY PLC.

 Organization address address: FARRINGDON STREET 25 - 5th floor
city: LONDON
postcode: EC4A 4AB

contact info
Titolo: Mr.
Nome: Alan
Cognome: Herbert
Email: send email
Telefono: +44 118 9242126
Fax: +44 1189 242306

UK (LONDON) participant 218˙321.50
20    GOETEBORGS UNIVERSITET

 Organization address address: VASAPARKEN
city: GOETEBORG
postcode: 405 30

contact info
Titolo: Dr.
Nome: Ludde
Cognome: Edgren
Email: send email
Telefono: +46 31 7862783
Fax: +46 31 7864355

SE (GOETEBORG) participant 210˙840.00
21    UNIVERSITE DE RENNES I

 Organization address address: RUE DU THABOR 2
city: RENNES CEDEX
postcode: 35065

contact info
Titolo: Ms.
Nome: Yolaine
Cognome: Bompays
Email: send email
Telefono: +33 2 23 23 37 23
Fax: +33 2 23 23 58 76

FR (RENNES CEDEX) participant 191˙200.00
22    STOCKHOLMS UNIVERSITET

 Organization address address: Universitetsvaegen 10
city: STOCKHOLM
postcode: 10691

contact info
Titolo: Prof.
Nome: Pher
Cognome: Andersson
Email: send email
Telefono: +46 8162720

SE (STOCKHOLM) participant 140˙042.00
23    Evonik Oxeno GmbH

 Organization address city: Marl
postcode: 45772

contact info
Titolo: Dr.
Nome: Dietrich
Cognome: Maschmeyer
Email: send email
Telefono: +49 2365 49 4961
Fax: +49 2365 49 804961

DE (Marl) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

reactor    flexible    synflow    technologies    inefficient    vision    synthesis    performance    catalytic    chemicals    fine    flow    operations    pharmaceutical    academic    wise    superior    conceptual    engineering    continuous    represented    methodology    reaction    shift    industrial    batch    medium    demonstrated    chemical    intermediates    separate    comprising    sustainable    pharmaceuticals    industries    molecular    catalyst   

 Obiettivo del progetto (Objective)

'The SYNFLOW vision is the paradigm shift from batch-wise large volume processes in pharmaceuticals, fine chemicals and intermediates production comprising many separate unit operations towards highly integrated but yet flexible catalytic continuous flow processing. For this purpose, SYNFLOW develops a unique integrative approach combining molecular understanding of synthesis and catalysis with engineering science in process design and plant concepts, aiming at an efficiency breakthrough in process development and operation. The SYNFLOW mission is to overcome the traditional way of linear process development providing individual solutions for specific products, and to demonstrate the technological, economic and ecological superiority of truly „designing“ processes by application of advanced chemical and engineering knowledge. The SYNFLOW concept is based on the definition of generic challenges with industrial relevance, represented by Case Studies provided by the industrial consortium members. Catalyst development, studies of the underlying chemical target transformations (synthetic methodology), tailored reaction engineering, conceptual process design and process evaluation interact closely in order to substantiate the SYNFLOW vision. Its success will be demonstrated on a relevant production scale as a reference for the entire European Chemical Industry. The SYNFLOW consortium brings together major industrial producers from the Pharmaceuticals, Fine Chemicals and Intermediates sectors, providers of process technology and technical catalyst supply. A number of high-ranked academic partners ensures the availability of comprehensive expertise for the suggested Case Studies. Dissemination of the results is guaranteed by the participation of DECHEMA and Britest. SYNFLOW presents a holistic approach to central challenges of the European Chemical Industries and therefore a highly promising candidate to fulfill the crucial issues of the NMP-2009-3.2-1 call.'

Introduzione (Teaser)

Traditional industrial-scale chemical production is inefficient and unsuitable for the flexible and sustainable production of chemicals. An EU-funded project worked to develop integrated catalytic continuous flow processes for low-to-medium-scale chemical production.

Descrizione progetto (Article)

In ideal continuous flow processes, the substrates flow into the reactor and come in contact with the immobilised catalyst to undergo a chemical transformation. The resulting product then leaves the reactor in a pure form, ready for further use without the need for additional separation or purification steps.

To achieve this ambitious goal, a team of 13 academic and 6 industrial partners from all over Europe collaborated in the project http://www.synflow.eu (SYNFLOW) (Innovative synthesis in continuous-flow processes for sustainable chemical production). They integrated molecular catalysts, immobilisation strategies and reaction engineering.

The project developed a basis for new and widely applicable sustainable technologies for low-to-medium-scale chemical and pharmaceutical production. The vision of SYNFLOW was to realise a shift from batch-wise processes comprising many separate unit operations to highly integrated and flexible catalytic continuous flow processing.

Scientists successfully demonstrated the concept of catalytic process design. Continuous flow processes resulted in superior performance, advantageous for small-to-medium-scale chemical and pharmaceutical manufacturing. Sustainable process design methodology was based on experimental results and conceptual insight.

The project targeted fine and specialty chemicals and pharmaceutical industries, which are characterised by a large diversity of synthesised chemical structures. To demonstrate the broad impact of the SYNFLOW concept, the prototypical case studies served as examples for generic challenges in these fields.

Project partners performed six industrial case studies, defined by certain industrial partners. The case studies represented reaction types such as C-N and C-C bond formation and stoichiometric reductions, notorious for waste generation and inefficient resource and energy utilisation.

SYNFLOW provided guidelines on the commercial viability, safety, eco-friendliness and performance of the project's technologies. Demonstrated evidence for superior process performance provides distinct potential business advantages of continuous flow processes.

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