SAVEME

"A Modular Nanosystems Platform for Advanced Cancer Management: Nano-vehicles; Tumor Targeting and Penetration Agents; Molecular Imaging, Degradome based Therapy"

 Coordinatore TEL AVIV UNIVERSITY 

 Organization address address: RAMAT AVIV
city: TEL AVIV
postcode: 69978

contact info
Titolo: Ms.
Nome: Lea
Cognome: Pais
Email: send email
Telefono: +972 3 6408774
Fax: +972 3 6409697

 Nazionalità Coordinatore Israel [IL]
 Sito del progetto http://fp7-saveme.com/
 Totale costo 13˙809˙085 €
 EC contributo 10˙500˙000 €
 Programma FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
 Code Call FP7-NMP-2010-LARGE-4
 Funding Scheme CP-IP
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-03-01   -   2015-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY

 Organization address address: RAMAT AVIV
city: TEL AVIV
postcode: 69978

contact info
Titolo: Ms.
Nome: Lea
Cognome: Pais
Email: send email
Telefono: +972 3 6408774
Fax: +972 3 6409697

IL (TEL AVIV) coordinator 842˙728.00
2    BAR ILAN UNIVERSITY

 Organization address address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900

contact info
Titolo: Ms.
Nome: Billy
Cognome: Mikanovsky
Email: send email
Telefono: +972 3 5342379
Fax: +972 3 6353277

IL (RAMAT GAN) participant 1˙123˙440.00
3    UNIVERSITAETSKLINIKUM HEIDELBERG

 Organization address address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120

contact info
Nome: Thorsten
Cognome: Brietz
Email: send email
Telefono: +49 6221 567086
Fax: +49 6221 565460

DE (HEIDELBERG) participant 967˙806.00
4    MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER

 Organization address address: TEL HASHOMER SHEBA MEDICAL CENTER
city: RAMAT GAN
postcode: 52621

contact info
Titolo: Prof.
Nome: Shlomo
Cognome: Noy
Email: send email
Telefono: +972 3 530 3379
Fax: +972 3 5303338

IL (RAMAT GAN) participant 873˙865.00
5    KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

 Organization address address: ISMANINGER STRASSE 22
city: MUENCHEN
postcode: 81675

contact info
Nome: Renate
Cognome: Rädlein
Email: send email
Telefono: +49 89 4140 2842
Fax: +49 89 4140 4926

DE (MUENCHEN) participant 630˙670.00
6    WEIZMANN INSTITUTE OF SCIENCE

 Organization address address: HERZL STREET 234
city: REHOVOT
postcode: 7610001

contact info
Titolo: Ms.
Nome: Talia
Cognome: Tzahor
Email: send email
Telefono: +972 8 934 4026
Fax: +972 8 934 4165

IL (REHOVOT) participant 601˙107.00
7    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES

 Organization address address: PASEO MIRAMON PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C 182
city: SAN SEBASTIAN
postcode: 20009

contact info
Titolo: Mr.
Nome: Alfonso
Cognome: Egaña
Email: send email
Telefono: +34 943 00 53 00
Fax: +34 943 00 53 01

ES (SAN SEBASTIAN) participant 584˙000.00
8    SHEMYAKIN AND OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY - RUSSIAN ACADEMY OF SCIENCE

 Organization address address: UL. MIKLUKHO MAKLAYA 16/10
city: MOSCOW
postcode: 117997

contact info
Titolo: Prof.
Nome: Sergey
Cognome: Zavriev
Email: send email
Telefono: +7 495 3351511
Fax: +7 495 3350812

RU (MOSCOW) participant 560˙636.00
9    FUNDACION CIDETEC

 Organization address address: Parque Tecnologico de Miramon, Paseo Miramon 196
city: DONOSTIA - SAN SEBASTIAN
postcode: 20009

contact info
Titolo: Dr.
Nome: Iraida
Cognome: Loinaz
Email: send email
Telefono: +34 943 309022
Fax: +34 943 309136

ES (DONOSTIA - SAN SEBASTIAN) participant 553˙020.00
10    UNIVERSITY OF EAST ANGLIA

 Organization address address: EARLHAM ROAD
city: NORWICH
postcode: NR4 7TJ

contact info
Titolo: Dr.
Nome: Alan
Cognome: Walker
Email: send email
Telefono: +44 1603 591481
Fax: +44 1603 591550

UK (NORWICH) participant 504˙200.00
11    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Dr.
Nome: Elke
Cognome: Lammertyn
Email: send email
Telefono: +32 16 320621
Fax: +32 16 326515

BE (LEUVEN) participant 470˙236.00
12    ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA

 Organization address address: Via Zamboni 33
city: BOLOGNA
postcode: 40126

contact info
Titolo: Ms.
Nome: Verdania
Cognome: Bandini
Email: send email
Telefono: +39 051 209974
Fax: +39 051 2098115

IT (BOLOGNA) participant 461˙600.00
13    OSM-DAN LTD.

 Organization address address: Pekeris Street 4
city: REHOVOT
postcode: 76702

contact info
Titolo: Dr.
Nome: Pnina
Cognome: Dan
Email: send email
Telefono: +972 9 9460012
Fax: +972 8 9361486

IL (REHOVOT) participant 381˙640.00
14    nHance Technologies Limited

 Organization address address: 5 BRUTON WAY
city: London
postcode: W13 0BY

contact info
Titolo: Dr.
Nome: Nadipalli
Cognome: Prasad
Email: send email
Telefono: +44 20 88107582

UK (London) participant 359˙023.00
15    FILARETE SERVIZI SRL

 Organization address address: VIALE ORTLES 22 4
city: MILANO MI
postcode: 20139

contact info
Titolo: Prof.
Nome: Paolo
Cognome: Milani
Email: send email
Telefono: +39 256660163

IT (MILANO MI) participant 356˙800.00
16    BENCAR AB

 Organization address address: DAG HAMMARKJOLD VAG 52B
city: UPPSALA
postcode: 75183

contact info
Titolo: Prof.
Nome: Bengt
Cognome: Långström
Email: send email
Telefono: +46 70 249 3909

SE (UPPSALA) participant 338˙496.00
17    JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN

 Organization address address: GRUNEBURGPLATZ 1
city: FRANKFURT AM MAIN
postcode: 60323

contact info
Titolo: Prof.
Nome: Joerg
Cognome: Kreuter
Email: send email
Telefono: +49 69 798 29682
Fax: +49 69 798 29546

DE (FRANKFURT AM MAIN) participant 252˙748.00
18    VEREIN ZUR FOERDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG AM WILHELMINENSPITAL DER STADT WIEN

 Organization address address: Montleartstrasse 37
city: WIEN
postcode: 1160

contact info
Titolo: Prof.
Nome: Peter
Cognome: Knoll
Email: send email
Telefono: 431492000000
Fax: +43 1491503609

AT (WIEN) participant 229˙064.00
19    RESEARCH AND PRODUCTION COMPLEX NANOSYSTEM LLC

 Organization address address: 7TH KOZHUKHOVSKAYA 20
city: MOSKVA
postcode: 115193

contact info
Titolo: Dr.
Nome: Svetlana
Cognome: Gelperina
Email: send email
Telefono: +7 495 679 87 33
Fax: +7 495 679 87 33

RU (MOSKVA) participant 165˙200.00
20    ASCEND TECHNOLOGIES LIMITED

 Organization address address: TOMKYNS CLOSE 14
city: EASTLEIGH HAMPSHIRE
postcode: SO53 4HL

contact info
Titolo: Prof.
Nome: Victor
Cognome: Popov
Email: send email
Telefono: 447901000000

UK (EASTLEIGH HAMPSHIRE) participant 133˙578.00
21    COLOROBBIA ITALIA SPA

 Organization address address: VIA PIETRAMARINA 53
city: SOVIGLIANA VINCI
postcode: 50059

contact info
Titolo: Ms.
Nome: Poala
Cognome: Terreni
Email: send email
Telefono: +39 0571709764
Fax: +39 0571709850

IT (SOVIGLIANA VINCI) participant 56˙451.00
22    GEMS PET SYSTEMS AB

 Organization address address: HUSBYBORG
city: UPPSALA
postcode: 75015

contact info
Titolo: Dr.
Nome: Bengt
Cognome: Nielsen
Email: send email
Telefono: +46 8 55950046
Fax: +46 8 55950015

SE (UPPSALA) participant 40˙162.00
23    COLOROBBIA CONSULTING SRL

 Organization address address: VIA PIETRAMARINA 53
city: SOVIGLIANA
postcode: 50053

contact info
Titolo: Dr.
Nome: Laura
Cognome: Niccolai
Email: send email
Telefono: 3905870000000
Fax: 3905870000000

IT (SOVIGLIANA) participant 13˙530.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

iron    tumor    pet    complexes    ga    mr    modular    camera    integrating    diagnostics    diagnosis    platform    oxide    mp    imaging    degradome    agents    shell    anti    therapeutic    sirnas    mri    molecular    selective    nanosystems    active    functionalized    dota    linked    gamma    layer    core    nanoparticles    nano   

 Obiettivo del progetto (Objective)

'SaveMe project will address current urgent needs for pancreatic cancer diagnosis and treatment by exploiting partners’ expertise and most recent research achievements for the design and development of novel modular nanosystems platform integrating new functionalized nano-core particles and active agents. The modular platform will enable the design of diverse active nanosystems per diagnostic or therapeutic application as defined by their active agent compositions. For diagnostics, superior tracers will be developed for molecular MR/PET and gamma camera imaging, enabling efficient diagnosis and guided surgery respectively. Novel functionalized nano-core systems will be conjugated with semi-confluent active shell layer. Three types of shell layers will be design: (1) novel iron oxide nanoparticles as advanced MRI contrast agents and/or (2) DOTA complexes for MRI (with Gd3), or PET (with Ga-68), or gamma camera (with Ga-69); (3) Integrating within one tracer both iron oxide nanoparticles and DOTA-Ga-68 complexes for a sequential or simultaneous MR/PET imaging. For therapeutics, active nanosystems will be developed to deliver (1) therapeutic siRNAs or (2) anti-MP-inhibitory-scFVs. These non-classic anti-tumor drugs will be designed based on an extensive tumor degradome analysis for combining blockage of selective matrix MPs, thus preventing basic invasive and metastasis steps, with siRNA based neutralization of secondary molecular effects induced by the specific protease inhibition. Individualized degradome analysis will be developed for potential profiling of anti-MP and siRNAs based therapy per patient. To facilitate the above diagnostics and therapeutic effects, advanced tumor targeting and penetration active agents will be linked to nano-core functionalized groups, including a biocompatible PEG layer linked to tumor selective MMP substrate molecules and highly safe and potent novel somatostatin analogue peptides targeting SSTR overexpression.'

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