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DOLORisk: Understanding risk factors and determinants for neuropathic pain

Total Cost €


EC-Contrib. €






Project "DOLORisk" data sheet

The following table provides information about the project.


Organization address
city: OXFORD
postcode: OX1 2JD

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 5˙981˙219 €
 EC max contribution 5˙981˙219 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
2    LUNDS UNIVERSITET SE (LUND) participant 686˙250.00
3    UNIVERSITY OF DUNDEE UK (DUNDEE) participant 586˙880.00
5    NEUROSCIENCE TECHNOLOGIES SLP ES (Barcelona) participant 466˙588.00
9    AARHUS UNIVERSITET DK (AARHUS C) participant 403˙576.00
10    UNIVERSITEIT GENT BE (GENT) participant 386˙282.00
11    MENTIS CURA EHF IS (REYKJAVIK) participant 177˙500.00
12    AARHUS UNIVERSITETSHOSPITAL DK (AARHUS) participant 138˙440.00


 Project objective

Neuropathic pain (NP) is common (population prevalence of 7-8%) and will present a rising health burden in the future. NP results in significant morbidity, reduces quality of life and has a major deleterious impact on health in aging. The reason why some subjects develop neuropathic pain and others do not following the same injury is not known. The exact nature of risk factors for NP and their interaction are currently poorly understood and will be the focus of this project. We will establish an international consortium of leading researchers in the field of NP (DOLORisk consortium) involving members of established academic European consortia studying pain/genomics and neuropathy as well as the SMEs Neuroscience Technologies and Mentis Cura. The project will be highly translational and the starting point will be the study of patients with NP or at risk of developing NP. Specific objectives will be to: 1) Identify the influence of demographic factors, environmental/societal and clinical factors on the risk of developing and maintenance of NP 2) To apply modern genomics to validate (using a targeted approach) and find novel (using genome wide association) genetic risk factors for NP. 3) Use tissue samples and patient derived cells from Biobanks to validate of molecular pathways contributing to chronic pain in patients. 4) To determine if patient stratification using physiological (sensory profile, endogenous analgesic mechanisms and nerve excitability) and psychological factors can predict NP risk and progression. 5) Development of a risk model/algorithm for (severe) NP, combining measurable genetic and environmental factors.

Our aim is to understand pain pathophysiology in terms of risk factors and protective mechanisms ranging from molecular pathways to societal impacts. The desired impact is to provide a firm platform to improve diagnosis and stratify patients according to risk profile, employ preventive strategies and ultimately develop novel therapeutics.


List of deliverables.
Generation of a protein interaction network using transcriptional profiling and pain risk associated gene outcommes Websites, patent fillings, videos etc. 2020-01-14 16:23:14
Submission package clinical study 5 Documents, reports 2019-10-08 14:19:27
Submission package clinical study 7 Documents, reports 2019-10-08 14:19:27
All approvals package clinical study 2 Documents, reports 2019-04-18 15:52:52
Submission package clinical study 4 Documents, reports 2019-04-18 15:52:52
Submission package clinical study 6 Documents, reports 2019-04-18 15:52:52

Take a look to the deliverables list in detail:  detailed list of DOLORisk deliverables.


year authors and title journal last update
List of publications.
2019 Weihua Meng, Mark J. Adams, Colin N. A. Palmer, Jingchunzi Shi, Adam Auton, Kathleen A. Ryan, Joanne M. Jordan, Braxton D. Mitchell, Rebecca D. Jackson, Michelle S. Yau, Andrew M. McIntosh, Blair H. Smith
Genome-wide association study of knee pain identifies associations with GDF5 and COL27A1 in UK Biobank
published pages: 1-8, ISSN: 2399-3642, DOI: 10.1038/s42003-019-0568-2
Communications Biology 2/1 2019-10-07
2019 Elke Veirman, Dimitri M. L. Van Ryckeghem, Annick De Paepe, Olivia J. Kirtley, Geert Crombez
Multidimensional screening for predicting pain problems in adults
published pages: 1, ISSN: 2471-2531, DOI: 10.1097/pr9.0000000000000775
PAIN Reports 4(2019) 2019-10-07
2019 Wei Wei, Salih Tuna, Michael J. Keogh, Katherine R. Smith, Timothy J. Aitman, Phil L. Beales, David L. Bennett, Daniel P. Gale, Maria A. K. Bitner-Glindzicz, Graeme C. Black, Paul Brennan, Perry Elliott, Frances A. Flinter, R. Andres Floto, Henry Houlden, Melita Irving, Ania Koziell, Eamonn R. Maher, Hugh S. Markus, Nicholas W. Morrell, William G. Newman, Irene Roberts, John A. Sayer, Kenneth G. C
Germline selection shapes human mitochondrial DNA diversity
published pages: eaau6520, ISSN: 0036-8075, DOI: 10.1126/science.aau6520
Science 364/6442 2019-09-04
2019 Lucy A. McDermott, Greg A. Weir, Andreas C. Themistocleous, Andrew R. Segerdahl, Iulia Blesneac, Georgios Baskozos, Alex J. Clark, Val Millar, Liam J. Peck, Daniel Ebner, Irene Tracey, Jordi Serra, David L. Bennett
Defining the Functional Role of NaV1.7 in Human Nociception
published pages: 905-919.e8, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.01.047
Neuron 101/5 2019-09-04
2019 Georgios Baskozos, John M. Dawes, Jean S. Austin, Ana Antunes-Martins, Lucy McDermott, Alex J. Clark, Teodora Trendafilova, Jon G. Lees, Stephen B. McMahon, Jeffrey S. Mogil, Christine Orengo, David L. Bennett
Comprehensive analysis of long noncoding RNA expression in dorsal root ganglion reveals cell-type specificity and dysregulation after nerve injury
published pages: 463-485, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000001416
PAIN 160/2 2019-09-04
2017 Eva L. Feldman, Klaus-Armin Nave, Troels S. Jensen, David L.H. Bennett
New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain
published pages: 1296-1313, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.02.005
Neuron 93/6 2019-09-04
2017 Greg A Weir, Steven J Middleton, Alex J Clark, Tarun Daniel, Nikita Khovanov, Stephen B McMahon, David L Bennett
Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source
published pages: 2570-2585, ISSN: 0006-8950, DOI: 10.1093/brain/awx201
Brain 140/10 2019-09-04
2017 Astrid J Terkelsen, Páll Karlsson, Giuseppe Lauria, Roy Freeman, Nanna B Finnerup, Troels S Jensen
The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes
published pages: 934-944, ISSN: 1474-4422, DOI: 10.1016/s1474-4422(17)30329-0
The Lancet Neurology 16/11 2019-09-04
2018 Rikke Heide, Hugh Bostock, Lise Ventzel, Peter Grafe, Joseph Bergmans, Anders Fuglsang-Frederiksen, Nanna B. Finnerup, Hatice Tankisi
Axonal excitability changes and acute symptoms of oxaliplatin treatment: In vivo evidence for slowed sodium channel inactivation
published pages: 694-706, ISSN: 1388-2457, DOI: 10.1016/j.clinph.2017.11.015
Clinical Neurophysiology 129/3 2019-09-04
2018 Mathilde M.V. Pascal, Andreas C. Themistocleous, Ralf Baron, Andreas Binder, Didier Bouhassira, Geert Crombez, Nanna B. Finnerup, Janne Gierthmühlen, Yelena Granovsky, Leif Groop, Harry L. Hebert, Troels S. Jensen, Kristinn Johnsen, Mark I. McCarthy, Weihua Meng, Colin N.A. Palmer, Andrew S.C. Rice, Jordi Serra, Romà Solà, David Yarnitsky, Blair H. Smith, Nadine Attal, David L.H. Bennett
DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain
published pages: 63, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.14576.1
Wellcome Open Research 3 2019-05-24
2018 Chongyang Han, Andreas C Themistocleous, Mark Estacion, Fadia B Dib-Hajj, Iulia Blesneac, Lawrence Macala, Carl Fratter, David L Bennett, Stephen G. Waxman, Sulayman D. Dib-Hajj
The novel activity of carbamazepine as an activation modulator extends from NaV1.7 mutations to the NaV1.8-S242T mutant channel from a patient with painful diabetic neuropathy
published pages: mol.118.113076, ISSN: 0026-895X, DOI: 10.1124/mol.118.113076
Molecular Pharmacology 2019-05-24
2018 Andreas C. Themistocleous, Geert Crombez, Georgios Baskozos, David L. Bennett
Using stratified medicine to understand, diagnose, and treat neuropathic pain
published pages: S31-S42, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000001301
PAIN 159 2019-05-24
2018 Andrew R Segerdahl, Andreas C Themistocleous, Dean Fido, David L Bennett, Irene Tracey
A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy
published pages: 357-364, ISSN: 0006-8950, DOI: 10.1093/brain/awx337
Brain 141/2 2019-05-24
2018 Weihua Meng, Mark J. Adams, Harry L. Hebert, Ian J. Deary, Andrew M. McIntosh, Blair H. Smith
A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N = 223,773)
published pages: 180-186, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2018.01.023
EBioMedicine 28 2019-05-24
2018 Christine B. Sieberg, Caitlin Taras, Aya Gomaa, Chelsea Nickerson, Cindy Wong, Catherine Ward, Georgios Baskozos, David L.H. Bennett, Juan D. Ramirez, Andreas C. Themistocleous, Andrew S.C. Rice, Pallai R. Shillo, Solomon Tesfaye, Robert R. Edwards, Nick A. Andrews, Charles Berde, Michael Costigan
Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients
published pages: e651, ISSN: 2471-2531, DOI: 10.1097/PR9.0000000000000651
PAIN Reports 3/3 2019-05-24
2018 Natalie R. van Zuydam, Emma Ahlqvist, Niina Sandholm, Harshal Deshmukh, N. William Rayner, Moustafa Abdalla, Claes Ladenvall, Daniel Ziemek, Eric Fauman, Neil R. Robertson, Paul M. McKeigue, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Annalisa Perna, Erica Rurali, M. Loredana Marcovecchio, Robert P. Igo, Rany M. Salem, Norberto Perico, Maria Lajer, Annemari Käräjämäki, Minako Imamura, Michiaki Kubo, Atsushi Takahashi, Xueling Sim, Jianjun Liu, Rob M. van Dam, Guozhi Jiang, Claudia H.T. Tam, Andrea O.Y. Luk, Heung Man Lee, Cadmon K.P. Lim, Cheuk Chun Szeto, Wing Yee So, Juliana C.N. Chan, Su Fen Ang, Rajkumar Dorajoo, Ling Wang, Tan Si Hua Clara, Amy-Jayne McKnight, Seamus Duffy, Marcus G. Pezzolesi, Michel Marre, Beata Gyorgy, Samy Hadjadj, Linda T. Hiraki, Tarunveer S. Ahluwalia, Peter Almgren, Christina-Alexandra Schulz, Marju Orho-Melander, Allan Linneberg, Cramer Christensen, Daniel R. Witte, Niels Grarup, Ivan Brandslund, Olle Melander, Andrew D. Paterson, David Tregouet, Alexander P. Maxwell, Su Chi Lim, Ronald C.W. Ma, E Shyong Tai, Shiro Maeda, Valeriya Lyssenko, Tiinamaija Tuomi, Andrzej S. Krolewski, Stephen S. Rich, Joel N. Hirschhorn, Jose C. Florez, David Dunger, Oluf Pedersen, Torben Hansen, Peter Rossing, Giuseppe Remuzzi, Mary Julia Brosnan, Colin N.A. Palmer, Per-Henrik Groop, Helen M. Colhoun, Leif C. Groop, Mark I. McCarthy
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes
published pages: 1414-1427, ISSN: 0012-1797, DOI: 10.2337/db17-0914
Diabetes 67/7 2019-05-24
2017 Harry L Hébert, Bridget Shepherd, Keith Milburn, Abirami Veluchamy, Weihua Meng, Fiona Carr, Louise A Donnelly, Roger Tavendale, Graham Leese, Helen M Colhoun, Ellie Dow, Andrew D Morris, Alexander S Doney, Chim C Lang, Ewan R Pearson, Blair H Smith, Colin N A Palmer
Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS)
published pages: 380-381j, ISSN: 0300-5771, DOI: 10.1093/ije/dyx140
International Journal of Epidemiology 47/2 2019-05-28
2016 Giorgio Cruccu, Nanna B. Finnerup, Troels S. Jensen, Joachim Scholz, Marc Sindou, Peter Svensson, Rolf-Detlef Treede, Joanna M. Zakrzewska, Turo Nurmikko
Trigeminal neuralgia
published pages: 220-228, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000002840
Neurology 87/2 2019-05-24
2017 Ralf Baron, Christoph Maier, Nadine Attal, Andreas Binder, Didier Bouhassira, Giorgio Cruccu, Nanna B. Finnerup, Maija Haanpää, Per Hansson, Philipp Hüllemann, Troels S. Jensen, Rainer Freynhagen, Jeffrey D. Kennedy, Walter Magerl, Tina Mainka, Maren Reimer, Andrew S.C. Rice, Märta Segerdahl, Jordi Serra, Sören Sindrup, Claudia Sommer, Thomas Tölle, Jan Vollert, Rolf-Detlef Treede
Peripheral neuropathic pain
published pages: 261-272, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000000753
PAIN 158/2 2019-05-24
2017 Harry L. Hébert, Abirami Veluchamy, Nicola Torrance, Blair H. Smith
Risk factors for neuropathic pain in diabetes mellitus
published pages: 1, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000000785
PAIN 158/4 2019-05-24
2015 Oliver van Hecke, Peter R. Kamerman, Nadine Attal, Ralf Baron, Gyda Bjornsdottir, David L.H. Bennett, Michael I. Bennett, Didier Bouhassira, Luda Diatchenko, Roy Freeman, Rainer Freynhagen, Maija Haanpää, Troels S. Jensen, Srinivasa N. Raja, Andrew S.C. Rice, Zeʼev Seltzer, Thorgeir E. Thorgeirsson, David Yarnitsky, Blair H. Smith
Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies
published pages: 2337-2353, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000000335
PAIN 156/11 2019-05-24
2017 Jan Vollert, Christoph Maier, Nadine Attal, David L.H. Bennett, Didier Bouhassira, Elena K. Enax-Krumova, Nanna B. Finnerup, Rainer Freynhagen, Janne Gierthmühlen, Maija Haanpää, Per Hansson, Philipp Hüllemann, Troels S. Jensen, Walter Magerl, Juan D. Ramirez, Andrew S.C. Rice, Sigrid Schuh-Hofer, Märta Segerdahl, Jordi Serra, Pallai R. Shillo, Soeren Sindrup, Solomon Tesfaye, Andreas C. Themistocleous, Thomas R. Tölle, Rolf-Detlef Treede, Ralf Baron
Stratifying patients with peripheral neuropathic pain based on sensory profiles
published pages: 1446-1455, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000000935
PAIN 158/8 2019-05-24
2016 Donna L. Kennedy, Harriet I. Kemp, Deborah Ridout, David Yarnitsky, Andrew S.C. Rice
Reliability of conditioned pain modulation
published pages: 2410-2419, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000000689
PAIN 157/11 2019-05-24
2016 Nanna B. Finnerup, Simon Haroutounian, Peter Kamerman, Ralf Baron, David L.H. Bennett, Didier Bouhassira, Giorgio Cruccu, Roy Freeman, Per Hansson, Turo Nurmikko, Srinivasa N. Raja, Andrew S.C. Rice, Jordi Serra, Blair H. Smith, Rolf-Detlef Treede, Troels S. Jensen
Neuropathic pain
published pages: 1599-1606, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000000492
PAIN 157/8 2019-05-24
2016 Andreas C. Themistocleous, Juan D. Ramirez, Pallai R. Shillo, Jonathan G. Lees, Dinesh Selvarajah, Christine Orengo, Solomon Tesfaye, Andrew S.C. Rice, David L.H. Bennett
The Pain in Neuropathy Study (PiNS)
published pages: 1132-1145, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000000491
PAIN 157/5 2019-05-24
2017 Luana Colloca, Taylor Ludman, Didier Bouhassira, Ralf Baron, Anthony H. Dickenson, David Yarnitsky, Roy Freeman, Andrea Truini, Nadine Attal, Nanna B. Finnerup, Christopher Eccleston, Eija Kalso, David L. Bennett, Robert H. Dworkin, Srinivasa N. Raja
Neuropathic pain
published pages: 17002, ISSN: 2056-676X, DOI: 10.1038/nrdp.2017.2
Nature Reviews Disease Primers 3 2019-05-24
2018 Abirami Veluchamy, Harry L. Hébert, Weihua Meng, Colin N.A. Palmer, Blair H. Smith
Systematic review and meta-analysis of genetic risk factors for neuropathic pain
published pages: 825-848, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000001164
PAIN 159/5 2019-05-28
2018 Iulia Blesneac, Andreas C. Themistocleous, Carl Fratter, Linus J. Conrad, Juan D. Ramirez, James J. Cox, Solomon Tesfaye, Pallai R. Shillo, Andrew S.C. Rice, Stephen J. Tucker, David L.H. Bennett
Rare Nav1.7 variants associated with painful diabetic peripheral neuropathy
published pages: 1, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000001116
PAIN 2019-05-28

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The information about "DOLORISK" are provided by the European Opendata Portal: CORDIS opendata.

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