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ULTRAPLACAD

ULTRAsensitive PLAsmonic devices for early CAncer Diagnosis

Total Cost €

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EC-Contrib. €

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Partnership

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 ULTRAPLACAD project word cloud

Explore the words cloud of the ULTRAPLACAD project. It provides you a very rough idea of what is the project "ULTRAPLACAD" about.

time    circuit    diagnosis    industrial    sensitivity    minutes    mass    techniques    readout    technologies    specificity    interventions    competencies    enhanced    surface    colorectal    therapeutic    fluorescence    performed    microrna    full    limited    cancer    improvement    groups    bimodal    biomarkers    compact    biomolecular    direct    invasive    assays    chips    platform    microscopy    1000    automated    detection    holding    integrating    platforms    manufacturing    circulating    blood    reflect    nanostructures    fluids    chemical    dna    prototype    chip    disciplinary    fabricated    device    disposable    resonance    first    minimal    shown    plasmon    functionalized    microfluidic    autoantibodies    modifications    approache    spectroscopy    body    barriers    world    detect    spread    chain    pathological    prognosis    fabrication    tumor    proven    inventor    ranging    imaging    sensing    plasmonic    suitable    respectively    team    ultrasensitive    lack    cross   

Project "ULTRAPLACAD" data sheet

The following table provides information about the project.

Coordinator
NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS 

Organization address
address: VIALE MEDAGLIE D'ORO 305
city: ROME
postcode: 136
website: www.inbb.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.ultraplacad.eu
 Total cost 6˙026˙455 €
 EC max contribution 6˙026˙455 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2018-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS IT (ROME) coordinator 833˙487.00
2    AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH AT (WIEN) participant 972˙708.00
3    HORIBA FRANCE SAS FR (LONGJUMEAU) participant 646˙922.00
4    Teknologian tutkimuskeskus VTT Oy FI (Espoo) participant 630˙536.00
5    FUTURE DIAGNOSTICS SOLUTIONS BV NL (Wijchen) participant 524˙375.00
6    ISTITUTI FISIOTERAPICI OSPITALIERI IT (ROMA) participant 407˙375.00
7    GINOLIS OY FI (OULUNSALO) participant 403˙125.00
8    UNIVERSITEIT TWENTE NL (ENSCHEDE) participant 343˙750.00
9    USTAV FOTONIKY A ELEKTRONIKY AV CR V.V.I. CZ (PRAHA 8) participant 313˙125.00
10    UNIVERSITAET SIEGEN DE (SIEGEN) participant 307˙300.00
11    SCRIBA NANOTECNOLOGIE SRL IT (BOLOGNA) participant 270˙250.00
12    UNIVERSITA DEGLI STUDI DI FERRARA IT (FERRARA) participant 213˙750.00
13    AMIRES SRO CZ (PRAHA 6) participant 159˙750.00

Map

 Project objective

Cancer biomarkers circulating in body fluids have been shown to reflect the pathological process and for this reason can be used for cancer diagnosis, prognosis and choice for therapeutic interventions. It is proven that their detection is a key to new minimal-invasive detection approaches. However, barriers to wide spread use of similar approaches are lack of test sensitivity, specificity and limited availability of low cost detection platforms. This project is focused at developing a compact plasmonic-based device with integrated microfluidic circuit and functionalized nanostructures for the detection of DNA, microRNA and tumor autoantibodies cancer biomarkers.

The aim is to detect cancer biomarkers circulating in blood with improvement in sensitivity of factor up to 1000, reduction in cost of platform of factor ranging from 2 to 4 compared to today’s available techniques and analysis time less than 60 minutes. The proposed detection approache will provide ultrasensitive detection of biomolecular systems with no need for complex sample chemical modifications thus allowing direct and simple assays to be performed. Within the project a bimodal industrial prototype will be developed integrating novel surface plasmon resonance imaging and plasmon-enhanced fluorescence sensing technologies, respectively. Automated fabrication processes suitable for low cost mass production will be developed and applied to produce disposable integrated chips. Prototype will be specifically fabricated for early diagnosis and prognosis of colorectal cancer. The team includes partners holding cross-disciplinary competencies needed to achieve the proposed results, including two of the first five plasmon resonance groups in the world, the inventor of surface plasmon microscopy – also known as surface plasmon resonance imaging- and plasmon-enhanced fluorescence spectroscopy, and full European value chain including disposable chip and readout platforms design, development and manufacturing.

 Deliverables

List of deliverables.
End user workshop organized and feedback collected Other 2019-10-04 10:05:59
Webpage of the project fully operational Other 2019-10-04 10:05:58
Development of the dissemination and communication strategy and project brochure & templates Documents, reports 2019-10-04 10:05:58

Take a look to the deliverables list in detail:  detailed list of ULTRAPLACAD deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Roberta D’Agata, Maria Giuffrida, Giuseppe Spoto
Peptide Nucleic Acid-Based Biosensors for Cancer Diagnosis
published pages: 1951, ISSN: 1420-3049, DOI: 10.3390/molecules22111951
Molecules 22/11 2019-10-04
2018 Elisabetta D’Aversa, Giulia Breveglieri, Patrizia Pellegatti, Giovanni Guerra, Roberto Gambari, Monica Borgatti
Non-invasive fetal sex diagnosis in plasma of early weeks pregnants using droplet digital PCR
published pages: , ISSN: 1076-1551, DOI: 10.1186/s10020-018-0016-7
Molecular Medicine 24/1 2019-10-04
2018 Matteo Allegretti, Beatrice Casini, Chiara Mandoj, Stefania Benini, Laurent Alberti, Mariangela Novello, Elisa Melucci, Laura Conti, Renato Covello, Edoardo Pescarmona, Giuseppe Maria Milano, Alessio Annovazzi, Vincenzo Anelli, Virginia Ferraresi, Roberto Biagini, Patrizio Giacomini
Precision diagnostics of Ewing’s sarcoma by liquid biopsy: circulating EWS-FLI1 fusion transcripts
published pages: 175883591877433, ISSN: 1758-8359, DOI: 10.1177/1758835918774337
Therapeutic Advances in Medical Oncology 10 2019-10-04
2017 Barbora Špačková, N. Scott Lynn, Jiří Slabý, Hana Šípová, Jiří Homola
A Route to Superior Performance of a Nanoplasmonic Biosensor: Consideration of Both Photonic and Mass Transport Aspects
published pages: 1019-1025, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.7b01319
ACS Photonics 5/3 2019-10-04
2016 Finotti, A; Tremante, E; Gasparello, J; Fabbri, E ; Bianchi, N; Allegretti, M ; Giacomini, P; Gambari, R
A liquid biopsy model: circulating miRNA levels in mice bearing colorectal carcinoma tumor xenografts
published pages: Vol 38, Supp 1, , ISSN: , DOI:
International Journal of Molecular Medicine 2019-10-04
2018 Agnes T. Reiner, Stefan Fossati, Jakub Dostalek
Biosensor platform for parallel surface plasmon-enhanced epifluorescence and surface plasmon resonance detection
published pages: 594-601, ISSN: 0925-4005, DOI: 10.1016/j.snb.2017.10.116
Sensors and Actuators B: Chemical 257 2019-10-04
2018 Matteo Allegretti, Alessandra Fabi, Simonetta Buglioni, Aline Martayan, Laura Conti, Edoardo Pescarmona, Gennaro Ciliberto, Patrizio Giacomini
Tearing down the walls: FDA approves next generation sequencing (NGS) assays for actionable cancer genomic aberrations
published pages: , ISSN: 1756-9966, DOI: 10.1186/s13046-018-0702-x
Journal of Experimental & Clinical Cancer Research 37/1 2019-10-04
2018 Christian Petri, Ulrich Jonas
Synthesis and Characterization of Novel Photocrosslinkable Poly(2-Oxazoline)-Based Hydrogel Systems for the Application as Biosensor Matrix
published pages: , ISSN: , DOI:
2019-10-04
2018 J. Gasparello, A. Finotti, R. Gambari
Novel trends in microRNA based theranostics
published pages: , ISSN: , DOI:
2019-10-04
2018 N. Scott Lynn, Jiří Homola
Microfluidic Analyte Transport to Nanorods for Photonic and Electrochemical Sensing Applications
published pages: 12031-12036, ISSN: 0947-6539, DOI: 10.1002/chem.201802757
Chemistry - A European Journal 24/46 2019-10-04
2018 Janneke Veerbeek, Raymond Steen, Wouter Vijselaar, W. Frederik Rurup, Saša Korom, Andrea Rozzi, Roberto Corradini, Loes Segerink, Jurriaan Huskens
Selective Functionalization with PNA of Silicon Nanowires on Silicon Oxide Substrates
published pages: 11395-11404, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.8b02401
Langmuir 34/38 2019-10-04
2018 Andrea Rozzi, Roberto Corradini
Advanced PNA-based sensor systems
published pages: , ISSN: , DOI:
2019-10-04
2018 N. G. Quillis, N. Sharma, S. Fossati, W. Knoll, J. Dostalek
Responsive polymer networks and brushes for active plasmonics
published pages: , ISSN: , DOI:
Polymer and Biopolymer Brushes: Fundamentals and Applications in Materials Science and Biotechnology 2019-10-04
2018 Noemi Bellassai, Almudena Marti, Giuseppe Spoto, Jurriaan Huskens
Low-fouling, mixed-charge poly- l -lysine polymers with anionic oligopeptide side-chains
published pages: , ISSN: 2050-7518, DOI: 10.1039/C8TB01619D
Journal of Materials Chemistry B 2019-10-04
2018 Jessica Gasparello, Matteo Allegretti, Elisa Tremante, Enrica Fabbri, Carla Azzurra Amoreo, Paolo Romania, Elisa Melucci, Katia Messana, Monica Borgatti, Patrizio Giacomini, Roberto Gambari, Alessia Finotti
Liquid biopsy in mice bearing colorectal carcinoma xenografts: gateways regulating the levels of circulating tumor DNA (ctDNA) and miRNA (ctmiRNA)
published pages: , ISSN: 1756-9966, DOI: 10.1186/s13046-018-0788-1
Journal of Experimental & Clinical Cancer Research 37/1 2019-10-04
2018 Christian Stelling, Stefan Fossati, Jakub Dostalek, Markus Retsch
Surface plasmon modes of nanomesh-on-mirror nanocavities prepared by nanosphere lithography
published pages: 17983-17989, ISSN: 2040-3364, DOI: 10.1039/C8NR05499A
Nanoscale 10/37 2019-10-04
2018 Noemi Bellassai, Giuseppe Spoto
Surface Plasmon Resonance Imaging Biosensors for Cancer Diagnosis: Detection of Circulating Tumor DNA
published pages: , ISSN: , DOI:
2019-10-04
2018 Jacopo Movilli, Andrea Rozzi, Roberto Ricciardi, Roberto Corradini, Jurriaan Huskens
Control of Probe Density at DNA Biosensor Surfaces Using Poly( l -lysine) with Appended Reactive Groups
published pages: , ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00733
Bioconjugate Chemistry 2019-10-04
2018 Alessia Finotti, Matteo Allegretti, Jessica Gasparello, Patrizio Giacomini, Demetrios Spandidos, Giuseppe Spoto, Roberto Gambari
Liquid biopsy and PCR-free ultrasensitive detection systems in oncology (Review)
published pages: , ISSN: 1019-6439, DOI: 10.3892/ijo.2018.4516
International Journal of Oncology 2019-10-04
2018 Papi C, A. Finotti, R. Gambari, J Gasparello
Strategie innovative per lo sviluppo di nuovi approcci teranostici: studio del profilo di espressione di microRNA in patologie genetiche e tumorali mediante NGS e ddPCR
published pages: , ISSN: , DOI:
2019-10-04
2016 G. Donelli, A. Finotti, R. Gambari
A liquid biopsy model in mice bearing colorectal carcinoma xenografts: analysis of tumor derived microRNAs
published pages: , ISSN: , DOI:
2019-10-04
2016 Alex Manicardi, Alessandro Bertucci, Andrea Rozzi, Roberto Corradini
A Bifunctional Monomer for On-Resin Synthesis of Polyfunctional PNAs and Tailored Induced-Fit Switching Probes
published pages: 5452-5455, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.6b02363
Organic Letters 18/21 2019-10-04
2016 Simone Hageneder, Martin Bauch, Jakub Dostalek
Plasmonically amplified bioassay – Total internal reflection fluorescence vs. epifluorescence geometry
published pages: 225-231, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2016.05.023
Talanta 156-157 2019-10-04
2016 Roberto Gambari, Eleonora Brognara, Demetrios Spandidos, Enrica Fabbri
Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: Νew trends in the development of miRNA therapeutic strategies in oncology (Review)
published pages: 5-32, ISSN: 1019-6439, DOI: 10.3892/ijo.2016.3503
International Journal of Oncology 49(1) 2019-10-04
2017 Raquel Mejia-Ariza, Jessica Rosselli, Christian Breukers, Alex Manicardi, Leon W. M. M. Terstappen, Roberto Corradini, Jurriaan Huskens
DNA Detection by Flow Cytometry using PNA-Modified Metal-Organic Framework Particles
published pages: 4180-4186, ISSN: 0947-6539, DOI: 10.1002/chem.201605803
Chemistry - A European Journal 23/17 2019-10-04
2017 Massimiliano Donato Verona, Vincenzo Verdolino, Ferruccio Palazzesi, Roberto Corradini
Focus on PNA Flexibility and RNA Binding using Molecular Dynamics and Metadynamics
published pages: 42799, ISSN: 2045-2322, DOI: 10.1038/srep42799
Scientific Reports 7 2019-10-04
2017 Roberta D\'Agata, Pasquale Palladino, Giuseppe Spoto
Streptavidin-coated gold nanoparticles: critical role of oligonucleotides on stability and fractal aggregation
published pages: 1-11, ISSN: 2190-4286, DOI: 10.3762/bjnano.8.1
Beilstein Journal of Nanotechnology 8 2019-10-04

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