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The continuum between healthy ageing and idiopathic Parkinson Disease within a propagation perspective of inflammation and damage: the search for new diagnostic, prognostic and therapeutic targets

Total Cost €


EC-Contrib. €






 PROPAG-AGEING project word cloud

Explore the words cloud of the PROPAG-AGEING project. It provides you a very rough idea of what is the project "PROPAG-AGEING" about.

mandatory    patients    basic    accumulation    lifestyle    ppmi    therapy    somatic    propagation    parkinson    ipsc    ageing    diagnosis    incident    45    cells    never    pathogenesis    followed    profiles    swedish    enter    motor    biomaterials    toxicants       gold    cellular    clinical    neuro    perturbations    functional    str    healthy    repository    65    cohorts    de    brain    twins    conceptualizations    exposure    framework    discovery    discordant    prevalent    performing    risk    druggable    added    therapies    innovative    senescent    mirrored    disability    inflammaging    idiopathic    gt    phenomena    twin    collected    offspring    validation    longitudinally    neurons    molecular    understand    prion    signatures    informative    protocol    dopaminergic    protective    centenarians    first    spreading    identification    disorder    signs    vitro    omic    damage    share    posit    neurodegenerative    mechanisms    indicate    propag    deviating    brains    data    pd    omics    novo    registry       disease    neuronal    co    trajectories    standard    showed   

Project "PROPAG-AGEING" data sheet

The following table provides information about the project.


Organization address
postcode: 40124
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 5˙993˙376 €
 EC max contribution 5˙993˙376 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2019-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
2    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 997˙057.00
3    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 901˙232.00
6    SERVICIO ANDALUZ DE SALUD ES (SEVILLA) participant 671˙167.00
7    PERSONAL GENOMICS SRL IT (VERONA) participant 635˙875.00


 Project objective

Ageing is the major risk factor for idiopathic PARKINSON'S DISEASE (PD), the first motor neurodegenerative disorder (in EU 1% in 65; about 4% in 80). The most recent conceptualizations of ageing and PD indicate that they share basic mechanisms, e.g. accumulation of senescent cells and propagation phenomena such as inflammaging mirrored in PD by neuro-inflammaging in brain that foster a prion-like spreading of neuronal damage. Thus, to fully understand PD pathogenesis and set up innovative neuro-protective therapies it is mandatory to posit PD within the framework of ageing process. The main goal of PROPAG-AGEING is to identify specific cellular and molecular perturbations deviating from healthy ageing trajectories towards PD. To this aim the project will exploit four large, very informative EXISTING COHORTS where biomaterials are available: i) de novo PD patients (before any therapy) followed longitudinally, including the largest repository of PD patients, i.e. PPMI; ii) centenarians and their offspring (CO) who never showed clinical signs of motor disability; iii) old twins of the Swedish Twin Registry (STR) followed longitudinally for >45 years, assessed for lifestyle and exposure to toxicants, and where incident and prevalent cases of PD discordant twins have been collected, including brains. The most informative sample from these cohorts will be studied in a DISCOVERY PHASE by an integrated set of omics to identify molecular signatures whose results will enter in a VALIDATION PHASE exploiting the four large cohorts, and performing functional in in vitro studies using dopaminergic neurons obtained by PD somatic cells from PD patients and centenarians via iPSC protocol. An added value is that omic data in centenarians and CO are available, and will represent the gold standard of healthy ageing. This approach will allow to identify new molecular profiles for early diagnosis and therapy (identification of druggable targets) of PD and signatures of healthy ageing.


List of deliverables.
Plan for Using and Disseminating Foreground Documents, reports 2020-04-07 19:15:35
Project website Websites, patent fillings, videos etc. 2020-04-07 19:15:34

Take a look to the deliverables list in detail:  detailed list of PROPAG-AGEING deliverables.


year authors and title journal last update
List of publications.
2018 Rita Ostan, Daniela Monti, Daniela Mari, Beatrice Arosio, Davide Gentilini, Evelyn Ferri, Giuseppe Passarino, Francesco De Rango, Patrizia D’Aquila, Stefano Mariotti, Renato Pasquali, Flaminia Fanelli, Laura Bucci, Claudio Franceschi, Giovanni Vitale
Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians: Association With Functional Status and Mortality
published pages: 802-810, ISSN: 1079-5006, DOI: 10.1093/gerona/gly194
The Journals of Gerontology: Series A 74/6 2020-04-07
2017 Diana L. Santos Ferreira, Dylan M. Williams, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, George Davey Smith, Marjo-Riitta Jarvelin, Debbie A. Lawlor
Association of pre-pregnancy body mass index with offspring metabolic profile: Analyses of 3 European prospective birth cohorts
published pages: e1002376, ISSN: 1549-1676, DOI: 10.1371/journal.pmed.1002376
PLOS Medicine 14/8 2020-04-07
2018 Panteleimon G. Takis, Veronica Ghini, Leonardo Tenori, Paola Turano, Claudio Luchinat
Uniqueness of the NMR approach to metabolomics
published pages: 115300, ISSN: 0165-9936, DOI: 10.1016/j.trac.2018.10.036
TrAC Trends in Analytical Chemistry 2020-04-07
2019 Gianluca Storci, Sabrina De Carolis, Alessio Papi, Maria Giulia Bacalini, Noémie Gensous, Elena Marasco, Anna Tesei, Francesco Fabbri, Chiara Arienti, Michele Zanoni, Anna Sarnelli, Spartaco Santi, Fabiola Olivieri, Emanuela Mensà, Silvia Latini, Manuela Ferracin, Stefano Salvioli, Paolo Garagnani, Claudio Franceschi, Massimiliano Bonafè
Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians
published pages: 1845-1858, ISSN: 1350-9047, DOI: 10.1038/s41418-018-0255-8
Cell Death & Differentiation 26/9 2020-04-07
2018 Vittorio Calabrese, Aurelia Santoro, Angela Trovato Salinaro, Sergio Modafferi, Maria Scuto, Ferdaous Albouchi, Daniela Monti, James Giordano, Mario Zappia, Claudio Franceschi, Edward J Calabrese
Hormetic approaches to the treatment of Parkinson\'s disease: Perspectives and possibilities
published pages: 1641-1662, ISSN: 0360-4012, DOI: 10.1002/jnr.24244
Journal of Neuroscience Research 96/10 2020-04-07
2019 Maria Conte, Morena Martucci, Marco Sandri, Claudio Franceschi, Stefano Salvioli
The Dual Role of the Pervasive “Fattish” Tissue Remodeling With Age
published pages: , ISSN: 1664-2392, DOI: 10.3389/fendo.2019.00114
Frontiers in Endocrinology 10 2020-04-07
2018 Maria Conte, Rita Ostan, Cristina Fabbri, Aurelia Santoro, Giulia Guidarelli, Giovanni Vitale, Daniela Mari, Federica Sevini, Miriam Capri, Marco Sandri, Daniela Monti, Claudio Franceschi, Stefano Salvioli
Human Aging and Longevity Are Characterized by High Levels of Mitokines
published pages: 600-607, ISSN: 1079-5006, DOI: 10.1093/gerona/gly153
The Journals of Gerontology: Series A 74/5 2020-04-07
2018 Maria Caracausi, Veronica Ghini, Chiara Locatelli, Martina Mericio, Allison Piovesan, Francesca Antonaros, Maria Chiara Pelleri, Lorenza Vitale, Rosa Anna Vacca, Federica Bedetti, Maria Chiara Mimmi, Claudio Luchinat, Paola Turano, Pierluigi Strippoli, Guido Cocchi
Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-20834-y
Scientific Reports 8/1 2020-04-07
2019 Alessia Vignoli, Leonardo Tenori, Betti Giusti, Panteleimon G. Takis, Serafina Valente, Nazario Carrabba, Daniela Balzi, Alessandro Barchielli, Niccolò Marchionni, Gian Franco Gensini, Rossella Marcucci, Claudio Luchinat, Anna Maria Gori
NMR-based metabolomics identifies patients at high risk of death within two years after acute myocardial infarction in the AMI-Florence II cohort
published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-018-1240-2
BMC Medicine 17/1 2020-04-07
2019 Paolo Abondio, Marco Sazzini, Paolo Garagnani, Alessio Boattini, Daniela Monti, Claudio Franceschi, Donata Luiselli, Cristina Giuliani
The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity
published pages: 222, ISSN: 2073-4425, DOI: 10.3390/genes10030222
Genes 10/3 2020-04-07
2018 Cristina Giuliani, Paolo Garagnani, Claudio Franceschi
Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework
published pages: 745-772, ISSN: 0009-7330, DOI: 10.1161/circresaha.118.312562
Circulation Research 123/7 2020-04-07
2019 Veličković, Petar; Fedus, William; Hamilton, William L; Liò, Pietro; Bengio, Yoshua; Hjelm, R Devon
Deep Graph Infomax
published pages: , ISSN: , DOI: 10.17863/CAM.40744
2 2020-04-07
2019 Alessia Vignoli, Veronica Ghini, Gaia Meoni, Cristina Licari, Panteleimon G. Takis, Leonardo Tenori, Paola Turano, Claudio Luchinat
High-Throughput Metabolomics by 1D NMR
published pages: 968-994, ISSN: 1433-7851, DOI: 10.1002/anie.201804736
Angewandte Chemie International Edition 58/4 2020-04-07
2019 Claudio Franceschi, Paolo Garagnani, Noémie Gensous, Maria Giulia Bacalini, Maria Conte, Stefano Salvioli
Accelerated bio‐cognitive aging in Down syndrome: State of the art and possible deceleration strategies
published pages: e12903, ISSN: 1474-9718, DOI: 10.1111/acel.12903
Aging Cell 18/3 2020-04-07
2017 Claudio Franceschi, Paolo Garagnani, Giovanni Vitale, Miriam Capri, Stefano Salvioli
Inflammaging and ‘Garb-aging’
published pages: 199-212, ISSN: 1043-2760, DOI: 10.1016/j.tem.2016.09.005
Trends in Endocrinology & Metabolism 28/3 2020-04-07
2017 Maria Giulia Bacalini, Joris Deelen, Chiara Pirazzini, Marco De Cecco, Cristina Giuliani, Catia Lanzarini, Francesco Ravaioli, Elena Marasco, Diana van Heemst, H. Eka D. Suchiman, Roderick Slieker, Enrico Giampieri, Rina Recchioni, Fiorella Mercheselli, Stefano Salvioli, Giovanni Vitale, Fabiola Olivieri, Annemieke M. W. Spijkerman, Martijn E. T. Dollé, John M. Sedivy, Gastone Castellani, Claudio Franceschi, Pieternella E. Slagboom, Paolo Garagnani
Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process
published pages: glw185, ISSN: 1079-5006, DOI: 10.1093/gerona/glw185
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2020-04-07
2016 Panteleimon G. Takis, Leonardo Tenori, Enrico Ravera, Claudio Luchinat
Gelified Biofluids for High-Resolution Magic Angle Spinning 1 H NMR Analysis: The Case of Urine
published pages: 1054-1058, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.6b04318
Analytical Chemistry 89/2 2020-04-07
2017 Panteleimon G. Takis, Hartmut Schäfer, Manfred Spraul, Claudio Luchinat
Deconvoluting interrelationships between concentrations and chemical shifts in urine provides a powerful analysis tool
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01587-0
Nature Communications 8/1 2020-04-07
2018 Aurelia Santoro, Rita Ostan, Marco Candela, Elena Biagi, Patrizia Brigidi, Miriam Capri, Claudio Franceschi
Gut microbiota changes in the extreme decades of human life: a focus on centenarians
published pages: 129-148, ISSN: 1420-682X, DOI: 10.1007/s00018-017-2674-y
Cellular and Molecular Life Sciences 75/1 2020-04-07
2017 Claudio Franceschi, Stefano Salvioli, Paolo Garagnani, Magda de Eguileor, Daniela Monti, Miriam Capri
Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00982
Frontiers in Immunology 8 2020-04-07
2018 Cristina Giuliani, Marco Sazzini, Chiara Pirazzini, Maria Giulia Bacalini, Elena Marasco, Guido Alberto Gnecchi Ruscone, Fang Fang, Stefania Sarno, Davide Gentilini, Anna Maria Di Blasio, Paolina Crocco, Giuseppe Passarino, Daniela Mari, Daniela Monti, Benedetta Nacmias, Sandro Sorbi, Carlo Salvarani, Mariagrazia Catanoso, Davide Pettener, Donata Luiselli, Svetlana Ukraintseva, Anatoliy Yashin, Claudio Franceschi, Paolo Garagnani
Impact of demography and population dynamics on the genetic architecture of human longevity
published pages: , ISSN: 1945-4589, DOI: 10.18632/aging.101515
Aging 2020-04-07
2017 T. Guastafierro, M. G. Bacalini, A. Marcoccia, D. Gentilini, S. Pisoni, A. M. Di Blasio, A. Corsi, C. Franceschi, D. Raimondo, A. Spanò, P. Garagnani, F. Bondanini
Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome
published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-017-0389-4
Clinical Epigenetics 9/1 2020-04-07
2017 Beatrice Arosio, Rita Ostan, Daniela Mari, Sarah Damanti, Francesco Ronchetti, Sara Arcudi, Maria Scurti, Claudio Franceschi, Daniela Monti
Cognitive status in the oldest old and centenarians: a condition crucial for quality of life methodologically difficult to assess
published pages: 185-194, ISSN: 0047-6374, DOI: 10.1016/j.mad.2017.02.010
Mechanisms of Ageing and Development 165 2020-04-07
2017 Danielle Fernandes Durso, Maria Giulia Bacalini, Claudia Sala, Chiara Pirazzini, Elena Marasco, Massimiliano Bonafé, Ítalo Faria do Valle, Davide Gentilini, Gastone Castellani, Ana Maria Caetano Faria, Claudio Franceschi, Paolo Garagnani, Christine Nardini
\"Acceleration of leukocytes’ epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer\"
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.15573
Oncotarget 8/14 2020-04-07
2017 Noémie Gensous, Maria Giulia Bacalini, Chiara Pirazzini, Elena Marasco, Cristina Giuliani, Francesco Ravaioli, Giacomo Mengozzi, Claudia Bertarelli, Maria Giustina Palmas, Claudio Franceschi, Paolo Garagnani
The epigenetic landscape of age-related diseases: the geroscience perspective
published pages: 549-559, ISSN: 1389-5729, DOI: 10.1007/s10522-017-9695-7
Biogerontology 18/4 2020-04-07
2018 Yunzhang Wang, Nancy L. Pedersen, Sara Hägg
Implementing a method for studying longitudinal DNA methylation variability in association with age
published pages: 866-874, ISSN: 1559-2294, DOI: 10.1080/15592294.2018.1521222
Epigenetics 13/8 2020-04-07
2018 Dylan M. Williams, Ida K. Karlsson, Nancy L. Pedersen, Sara Hägg
Circulating insulin-like growth factors and Alzheimer disease
published pages: e291-e297, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000004854
Neurology 90/4 2020-04-07
2018 Francesco Ravaioli, Maria Bacalini, Claudio Franceschi, Paolo Garagnani
Age-Related Epigenetic Derangement upon Reprogramming and Differentiation of Cells from the Elderly
published pages: 39, ISSN: 2073-4425, DOI: 10.3390/genes9010039
Genes 9/1 2020-04-07
2018 Hagg, Sara; Pedersen, Nancy; Jylhava, Juulia; Williams, Dylan
A frailty index for UK Biobank participants
published pages: , ISSN: 1758-535X, DOI: 10.1101/233692
The journals of gerontology. Series A, Biological sciences and medical sciences. 2 2020-04-07
2015 Steve Horvath, Chiara Pirazzini, Maria Giulia Bacalini, Davide Gentilini, Anna Maria Di Blasio, Massimo Delledonne, Daniela Mari, Beatrice Arosio, Daniela Monti, Giuseppe Passarino, Francesco De Rango, Patrizia D\'Aquila, Cristina Giuliani, Elena Marasco, Sebastiano Collino, Patrick Descombes, Paolo Garagnani, Claudio Franceschi
Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring
published pages: 1159-1170, ISSN: 1945-4589, DOI: 10.18632/aging.100861
Aging 7/12 2020-04-07
2015 Deborah Finkel, Marie Ernsth-Bravell, Nancy L. Pedersen
Temporal Dynamics of Motor Functioning and Cognitive Aging
published pages: 109-116, ISSN: 1079-5006, DOI: 10.1093/gerona/glv110
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 71/1 2020-04-07
2018 Claudio Franceschi, Paolo Garagnani, Cristina Morsiani, Maria Conte, Aurelia Santoro, Andrea Grignolio, Daniela Monti, Miriam Capri, Stefano Salvioli
The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates
published pages: , ISSN: 2296-858X, DOI: 10.3389/fmed.2018.00061
Frontiers in Medicine 5 2020-04-07
2016 Johanna Sieurin, Petter Gustavsson, Caroline Elise Weibull, Adina Leiah Feldman, Giselle Maria Petzinger, Margaret Gatz, Nancy Lee Pedersen, Karin Wirdefeldt
Personality traits and the risk for Parkinson disease: a prospective study
published pages: 169-175, ISSN: 0393-2990, DOI: 10.1007/s10654-015-0062-1
European Journal of Epidemiology 31/2 2020-04-07
2016 Fei Yang, Anna L.V. Johansson, Nancy L. Pedersen, Fang Fang, Margaret Gatz, Karin Wirdefeldt
Socioeconomic status in relation to Parkinsonʼs disease risk and mortality
published pages: e4337, ISSN: 0025-7974, DOI: 10.1097/MD.0000000000004337
Medicine 95/30 2020-04-07
2017 Carol E. Franz, Deborah Finkel, Matthew S. Panizzon, Kelly Spoon, Kaare Christensen, Margaret Gatz, William S. Kremen, Robert Krueger, Jenae Neiderhiser, Chandra Reynolds, Nancy L. Pedersen
Facets of Subjective Health From Early Adulthood to Old Age
published pages: 149-171, ISSN: 0898-2643, DOI: 10.1177/0898264315625488
Journal of Aging and Health 29/1 2020-04-07
2015 Jesper O.E. Carlson, Margaret Gatz, Nancy L. Pedersen, Caroline Graff, Inger Nennesmo, Anna-Karin Lindström, Lotte Gerritsen
Antemortem Prediction of Braak Stage
published pages: 1061-1070, ISSN: 0022-3069, DOI: 10.1097/NEN.0000000000000251
Journal of Neuropathology & Experimental Neurology 74/11 2020-04-07
2016 Kari Berglund, Chandra A. Reynolds, Alexander Ploner, Lotte Gerritsen, Iiris Hovatta, Nancy L. Pedersen, Sara Hägg
Longitudinal decline of leukocyte telomere length in old age and the association with sex and genetic risk
published pages: 1398-1415, ISSN: 1945-4589, DOI: 10.18632/aging.100995
Aging 8/7 2020-04-07

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