Opendata, web and dolomites

RoleOfNEinPerception SIGNED

The role of noradrenaline in human perception: from single neuron to whole brain and behavior

Total Cost €


EC-Contrib. €






 RoleOfNEinPerception project word cloud

Explore the words cloud of the RoleOfNEinPerception project. It provides you a very rough idea of what is the project "RoleOfNEinPerception" about.

rare    promise    subjects    events    thereby    pupillometry    play    neurons    missing    neuronal    light    reinstated    correlative    shed    cortical    plays    localized    opportunity    lfp    give    locus    recorded    experiments    liminal    precisely    signals    comprehensively    context    refining    momentary    subjective    drive    sensitive    patients    causal    whereas    single    anesthesia    perceptual    carefully    neural    regions    perception    trial    neurobiological    recordings    correlates    aid    eeg    volunteers    ratio    auditory    markedly    manipulate    individual    linking    sleep    ne    how    exceptional    basis    absent    spatio    proxy    healthy    wakefulness    noradrenaline    yield    manipulating    levels    pharmacologically    markers    brain    signal    underpinnings    record    paradigms    simultaneous    visual    temporal    external    suggests    enhanced    threshold    conscious    neurosurgical    resolution    experimental    recovery    lc    complementary    reality    incorporation    noise    impoverished    neuron    fmri    link    performing    bi    coeruleus    directionally    reporting   

Project "RoleOfNEinPerception" data sheet

The following table provides information about the project.


Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website
 Total cost 182˙509 €
 EC max contribution 182˙509 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 182˙509.00


 Project objective

How do external events become part of our subjective reality? Correlative evidence suggests that the locus coeruleus-noradrenaline (LC-NE) system might play a key role in this process: LC-NE activity is markedly reduced in sleep and anesthesia and reinstated upon recovery of conscious perception, while during wakefulness it correlates with markers of conscious perception. However causal evidence, as well as sensitive experimental paradigms that carefully manipulate awareness in this context, are absent. This proposal aims at providing this missing causal link by pharmacologically manipulating NE levels bi-directionally in healthy volunteers performing liminal visual and auditory perceptual tasks, while reporting their subjective perceptual state. Neural signals will be recorded using simultaneous EEG-fMRI allowing high spatio-temporal resolution. If indeed NE plays a causal role in enabling conscious perception then reduced NE activity will increase perceptual threshold and give rise to impoverished neural responses, whereas enhanced NE activity will aid perceptual incorporation and effectively drive neuronal activity in high-order cortical regions. In a complementary set of experiments I will use a rare opportunity to record single-neuron and LFP activity from neurosurgical patients performing the same perceptual tasks while using pupillometry as a proxy for momentary NE levels. The exceptional signal-to-noise ratio of these recordings will allow linking precisely localized neuronal activity, momentary NE levels, and perception on a trial-by-trial basis, thereby refining and extending the EEG-fMRI results. The ability to manipulate and measure NE levels in subjects reporting their subjective state in sensitive perceptual paradigms, together with comprehensively examining neuronal activity from the level of individual neurons to the whole brain, promise to yield unique results that will shed new light on the neurobiological underpinnings of conscious perception.


year authors and title journal last update
List of publications.
2016 Hagar Gelbard-Sagiv, Nathan Faivre, Liad Mudrik, Christof Koch
Low-level awareness accompanies “unconscious” high-level processing during continuous flash suppression
published pages: 3, ISSN: 1534-7362, DOI: 10.1167/16.1.3
Journal of Vision 16/1 2019-06-18

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ROLEOFNEINPERCEPTION" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ROLEOFNEINPERCEPTION" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

InProSMod (2021)

Cholinergic and NMDAR-dependent recruitment of Layer 1 Interneuron shapes cortical motor Processing through network States Modulation

Read More  

NeoPur (2019)

New treatments and novel diagnostic tests for neonatal seizures based on purinergic signaling.

Read More  


An integrated hypothesis for cognitive and positive symptoms in schizophrenia

Read More