Opendata, web and dolomites

RoleOfNEinPerception SIGNED

The role of noradrenaline in human perception: from single neuron to whole brain and behavior

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 RoleOfNEinPerception project word cloud

Explore the words cloud of the RoleOfNEinPerception project. It provides you a very rough idea of what is the project "RoleOfNEinPerception" about.

impoverished    experiments    liminal    neuronal    recorded    yield    refining    events    ne    resolution    external    cortical    reality    single    markers    proxy    subjective    brain    thereby    opportunity    regions    complementary    healthy    spatio    wakefulness    patients    ratio    incorporation    pharmacologically    play    perceptual    markedly    correlates    carefully    rare    promise    anesthesia    coeruleus    reinstated    recordings    drive    manipulating    exceptional    volunteers    reporting    momentary    basis    correlative    absent    give    neurons    individual    locus    link    comprehensively    how    neural    recovery    pupillometry    signals    subjects    underpinnings    lfp    shed    threshold    eeg    missing    record    neuron    noradrenaline    simultaneous    light    directionally    aid    lc    context    sensitive    paradigms    neurobiological    perception    causal    suggests    manipulate    noise    levels    precisely    signal    auditory    fmri    linking    sleep    enhanced    conscious    trial    localized    neurosurgical    experimental    visual    plays    temporal    bi    whereas    performing   

Project "RoleOfNEinPerception" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website http://medicine.mytau.org/nir/
 Total cost 182˙509 €
 EC max contribution 182˙509 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 182˙509.00

Map

 Project objective

How do external events become part of our subjective reality? Correlative evidence suggests that the locus coeruleus-noradrenaline (LC-NE) system might play a key role in this process: LC-NE activity is markedly reduced in sleep and anesthesia and reinstated upon recovery of conscious perception, while during wakefulness it correlates with markers of conscious perception. However causal evidence, as well as sensitive experimental paradigms that carefully manipulate awareness in this context, are absent. This proposal aims at providing this missing causal link by pharmacologically manipulating NE levels bi-directionally in healthy volunteers performing liminal visual and auditory perceptual tasks, while reporting their subjective perceptual state. Neural signals will be recorded using simultaneous EEG-fMRI allowing high spatio-temporal resolution. If indeed NE plays a causal role in enabling conscious perception then reduced NE activity will increase perceptual threshold and give rise to impoverished neural responses, whereas enhanced NE activity will aid perceptual incorporation and effectively drive neuronal activity in high-order cortical regions. In a complementary set of experiments I will use a rare opportunity to record single-neuron and LFP activity from neurosurgical patients performing the same perceptual tasks while using pupillometry as a proxy for momentary NE levels. The exceptional signal-to-noise ratio of these recordings will allow linking precisely localized neuronal activity, momentary NE levels, and perception on a trial-by-trial basis, thereby refining and extending the EEG-fMRI results. The ability to manipulate and measure NE levels in subjects reporting their subjective state in sensitive perceptual paradigms, together with comprehensively examining neuronal activity from the level of individual neurons to the whole brain, promise to yield unique results that will shed new light on the neurobiological underpinnings of conscious perception.

 Publications

year authors and title journal last update
List of publications.
2016 Hagar Gelbard-Sagiv, Nathan Faivre, Liad Mudrik, Christof Koch
Low-level awareness accompanies “unconscious” high-level processing during continuous flash suppression
published pages: 3, ISSN: 1534-7362, DOI: 10.1167/16.1.3
Journal of Vision 16/1 2019-06-18

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ROLEOFNEINPERCEPTION" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ROLEOFNEINPERCEPTION" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Cartesian Networks (2020)

Cartesian Networks in Early Modern Europe: A Quantitative and Interdisciplinary Approach

Read More  

DIGILEAD (2020)

Digital leadership, well-being and performance in organizations

Read More  

MarshFlux (2020)

The effect of future global climate and land-use change on greenhouse gas fluxes and microbial processes in salt marshes

Read More