Explore the words cloud of the SENSORTHALAMUS project. It provides you a very rough idea of what is the project "SENSORTHALAMUS" about.
The following table provides information about the project.
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
|Coordinator Country||Spain [ES]|
|Total cost||1˙966˙770 €|
|EC max contribution||1˙966˙770 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-07-01 to 2020-06-30|
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|1||AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS||ES (MADRID)||coordinator||1˙966˙770.00|
The cerebral cortex is organized into highly specialized sensory areas. Thus, it is fundamental to understand how these areas acquire and maintain their identity and functional organization. Challenging normal brain development and forcing the brain to the limits of plasticity, offers us the possibility to shed light on these issues. Accordingly, we shall use prenatal sensory deprivation as a model to understand the mechanisms underlying early neuroplasticity, events that could influence the natural organization of sensory cortical areas. Early sensory deprivation produces profound changes in the cortex, provoking the reorganization of both the deprived and the spared cortical territories. Classically, this adaptation is thought to require sensory experience from the intact sensory modalities. However, our recent data from embryonic deprived mice challenge this view, suggesting that a component independent of experience contributes to this reorganization and that the thalamus plays a pivotal role in these events. Hence, we now propose to adopt multidisciplinary and innovative approaches to characterize the structural, genetic and functional rearrangements in the thalamus following embryonic sensory deprivation, and to define the factors and mechanisms that drive cortical specificity. Experimental results from sensory deprived animals in which the thalamus and gene expression is manipulated in vivo, will be integrated to explain when and how neuroplastic cortical adaptations are triggered in the deprived brain. To further understand the rewiring capacity of thalamic neurons and their potential role in sensory restoration, we will adopt a high-risk, high-gain approach to reprogramme nuclei specific thalamic neurons. The novel information obtained will establish how sensory inputs and thalamocortical connections govern cortical activity and architecture, ultimately sculpting perceptual behaviour.
|year||authors and title||journal||last update|
Henrik Gezelius, VerÃ³nica Moreno-Juan, Cecilia Mezzera, Sudhir Thakurela, Luis Miguel RodrÃguez-Malmierca, Jelena Pistolic, Vladimir Benes, Vijay K. Tiwari, Guillermina LÃ³pez-Bendito
Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes
published pages: , ISSN: 1047-3211, DOI: 10.1093/cercor/bhw290
Henrik Gezelius, Guillermina LÃ³pez-Bendito
Thalamic neuronal specification and early circuit formation
published pages: 830-843, ISSN: 1932-8451, DOI: 10.1002/dneu.22460
|Developmental Neurobiology 77/7||2020-04-24|
Martina Riva, Ioana Genescu, ChloÃ© Habermacher, David Orduz, Fanny Ledonne, Filippo M Rijli, Guillermina LÃ³pez-Bendito, Eva Coppola, Sonia Garel, Maria Cecilia Angulo, Alessandra Pierani
Activity-dependent death of transient Cajal-Retzius neurons is required for functional cortical wiring
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.50503
Gezelius H, LÃ³pez-Bendito G.
Thalamic neuronal specification and early circuit formation.
published pages: , ISSN: 1932-8451, DOI:
Gezelius H, Moreno-Juan V, Mezzera C, Thakurela S, RodrÃguez-Malmierca LM, Pistolic J, Benes V, Tiwari VK, LÃ³pez-Bendito G.
Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes.
published pages: , ISSN: 1460-2199, DOI:
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