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ROBUSTNET SIGNED

Quantitative developmental genetic analysis of phenotypic buffering and cryptic variation

Total Cost €

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EC-Contrib. €

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Partnership

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 ROBUSTNET project word cloud

Explore the words cloud of the ROBUSTNET project. It provides you a very rough idea of what is the project "ROBUSTNET" about.

cell    critical    derive    random    biomedical    cellular    fundamental    mutation    noise    elucidate    randomness    environment    physiological    theoretical    remarkable    developmental    output    genetic    evolution    stabilisation    last    molecules    attractive    transformation    environmental    individual    subject    sciences    epithelial    elegans    molecular    invariant    imaging    genes    patterning    contribution    buffering    model    successful    itself    mechanisms    lack    animals    variation    appropriate    precise    life    precision    fertilised    remained    debuffering    principles    considerable    follow    time    underlying    traits    correct    biological    genomics    concentration    robustness    surge    ensures    fluctuations    property    pervades    organism    thereby    tissue    phenotypic    instrumental    accumulation    stability    outputs    15    context    experimental    seam    stereotypical    outcomes    stochastic    isogenic    operate    background    integrative    genetics    framework    diseases    egg    normal   

Project "ROBUSTNET" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
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surname: n.a.
function: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.imperial.ac.uk/people/m.barkoulas
 Total cost 1˙499˙745 €
 EC max contribution 1˙499˙745 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 1˙499˙745.00

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 Project objective

Randomness pervades life and biological systems are continuously subject to variation. This variation may be stochastic, due to random fluctuations in the concentration of critical molecules, genetic, due to mutation accumulation, or environmental, because of changes in the environment over time. It is therefore remarkable how biological systems manage to operate with so much precision. The property of a system to produce an invariant output in the presence of considerable noise is called robustness. Development itself is highly robust to noise and this is instrumental for the successful transformation of a fertilised egg into a multi-cellular individual. Developmental robustness ensures the stability of phenotypic traits, including correct cell numbers in a given tissue. While research on developmental robustness has seen a surge over the last 15 years, most studies have remained theoretical, and we still lack appropriate experimental systems to elucidate the mechanisms via which robust outputs are achieved. We propose here to follow a system-wide, integrative approach to study the mechanisms, evolution and consequences of developmental robustness in a multi-cellular model organism. To this end, C. elegans is a very attractive system because developmental patterning is highly stereotypical and animals are isogenic, thereby allowing precise control of the genetic background. Focusing on a new experimental model, the epithelial seam cell number variation, and using comprehensive molecular developmental genetics, genomics and imaging we will derive principles about the contribution of genes to stabilisation of developmental outcomes and will develop a developmental framework for phenotypic buffering. Understanding the fundamental mechanisms underlying developmental robustness is highly relevant to biomedical sciences, as many diseases can be understood in the context of debuffering of normal physiological states.

 Publications

year authors and title journal last update
List of publications.
2017 Dimitris Katsanos, Sneha L. Koneru, Lamia Mestek Boukhibar, Nicola Gritti, Ritobrata Ghose, Peter J. Appleford, Maria Doitsidou, Alison Woollard, Jeroen S. van Zon, Richard J. Poole, Michalis Barkoulas
Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number
published pages: e2002429, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.2002429
PLOS Biology 15/11 2019-05-29
2018 Guled A. Osman, Michael K. Fasseas, Sneha L. Koneru, Clara L. Essmann, Kyros Kyrou, Mandayam A. Srinivasan, Gaotian Zhang, Peter Sarkies, Marie-Anne Félix, Michalis Barkoulas
Natural Infection of C. elegans by an Oomycete Reveals a New Pathogen-Specific Immune Response
published pages: 640-648.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.01.029
Current Biology 28/4 2019-05-29

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