Explore the words cloud of the INTESTINANOS project. It provides you a very rough idea of what is the project "INTESTINANOS" about.
The following table provides information about the project.
|Coordinator Country||Sweden [SE]|
|Total cost||1˙706˙250 €|
|EC max contribution||1˙706˙250 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-09-01 to 2020-08-31|
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|1||UPPSALA UNIVERSITET||SE (UPPSALA)||coordinator||1˙706˙250.00|
My research program explores molecular interplay between drug, dosage form and the complex environment of the gastrointestinal tract (GIT). Drug molecules currently being discovered to cure e.g. CNS diseases, cancer and the metabolic syndrome show poor water solubility and 70-90% of recently discovered drugs have too poor solubility to allow absorption from the GIT. For such compounds the dosage form can significantly improve the absorption. My long-term goal is to establish a computational platform that predicts, from molecular structures and computational tools, the development potential of drug molecules to well-functioning orally administered medicines. A major gap to understand drug performance in the intestine is the poor knowledge of the dynamics of solubilizing lipoidal nanostructures (micelles, vesicles, oil droplets) present in the fluid. This project explores restructuring of these lipid colloids in response to intake of food or dosage forms, enzymatic digestion, absorption and transit along the GIT. Novel experimental tools are developed to reveal the impact of these nanostructures on drug solubilization, supersaturation and likelihood of precipitation in vivo, all being important for drug absorption. The experimental results are fed into in silico models taking use of Molecular Dynamics simulations to develop a computational platform predicting drug performance in the dynamic intestinal milieu. The novel tools designed herein will allow dosage forms that improve performance and increase drug absorption after oral administration to, for the first time, be designed by computational means. The results of this project, in particular the novel in silico tools exploring rearrangement of lipoidal nanostructures, are highly important to related areas such as GIT disease models and food processing but also have wider applications in e.g. studies of intracellular vesicle rearrangements and transport processes in plants.
|year||authors and title||journal||last update|
Per Larsson, Linda C. AlskÃ¤r, Christel A. S. BergstrÃ¶m
Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion: A Coarse-Grained Molecular Dynamics Simulation Approach
published pages: 4145-4153, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.7b00397
|Molecular Pharmaceutics 14/12||2019-05-29|
Christel A.S. BergstrÃ¶m, Per Larsson
Computational prediction of drug solubility in water-based systems: Qualitative and quantitative approaches used in the current drug discovery and development setting
published pages: 185-193, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2018.01.044
|International Journal of Pharmaceutics 540/1-2||2019-05-29|
Andrew J. Clulow, Albin Parrow, Adrian Hawley, Jamal Khan, Anna C. Pham, Per Larsson, Christel A. S. BergstrÃ¶m, Ben J. Boyd
Characterization of Solubilizing Nanoaggregates Present in Different Versions of Simulated Intestinal Fluid
published pages: 10869-10881, ISSN: 1520-6106, DOI: 10.1021/acs.jpcb.7b08622
|The Journal of Physical Chemistry B 121/48||2019-05-29|
Janneke Keemink, Christel A. S. BergstrÃ¶m
Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations
published pages: , ISSN: 0724-8741, DOI: 10.1007/s11095-017-2327-8
|Pharmaceutical Research 35/4||2019-05-29|
Amjad Alhalaweh, Ahmad Alzghoul, Denny Mahlin, Christel A.S. BergstrÃ¶m
Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability
published pages: 312-317, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2015.08.101
|International Journal of Pharmaceutics 495/1||2019-04-18|
Linda C AlskÃ¤r, Janneke Keemink, Jenny Johannesson, Christopher JH Porter, Christel AS BergstrÃ¶m
Impact of Drug Physicochemical Properties on Lipolysis-triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations
published pages: , ISSN: 1543-8384, DOI:
Khadijah Edueng, Denny Mahlin, Christel A. S. BergstrÃ¶m
The Need for Restructuring the Disordered Science of Amorphous Drug Formulations
published pages: 1754-1772, ISSN: 0724-8741, DOI: 10.1007/s11095-017-2174-7
|Pharmaceutical Research 34/9||2019-04-18|
Linda C. AlskÃ¤r, Christel A. S. BergstrÃ¶m
Models for Predicting Drug Absorption From Oral Lipid-Based Formulations
published pages: 141-147, ISSN: 2198-6428, DOI: 10.1007/s40610-015-0023-1
|Current Molecular Biology Reports 1/4||2019-05-27|
Michael Holmboe, Per Larsson, Jamshed Anwar, Christel A. S. BergstrÃ¶m
Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations
published pages: 12732-12740, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.6b03008
Linda C. AlskÃ¤r, Christopher J. H. Porter, Christel A. S. BergstrÃ¶m
Tools for Early Prediction of Drug Loading in Lipid-Based Formulations
published pages: 251-261, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.5b00704
|Molecular Pharmaceutics 13/1||2019-05-27|
Christel A.S. BergstrÃ¶m, William N. Charman, Christopher J.H. Porter
Computational prediction of formulation strategies for beyond-rule-of-5 compounds
published pages: 6-21, ISSN: 0169-409X, DOI: 10.1016/j.addr.2016.02.005
|Advanced Drug Delivery Reviews 101||2019-05-27|
Khadijah Edueng, Denny Mahlin, Per Larsson, Christel A.S. BergstrÃ¶m
Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways
published pages: , ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2017.04.015
|Journal of Controlled Release 256||2019-05-27|
PÃ¤r Matsson, Christel A S BergstrÃ¶m
Computational modeling to predict the functions and impact of drug transporters
published pages: , ISSN: 2193-9616, DOI: 10.1186/s40203-015-0012-3
|In Silico Pharmacology 3/1||2019-05-27|
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