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Opendata, web and dolomites

ISOTOPICS SIGNED

ISOTOPIC LABELING FOR DRUG INNOVATION

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

ISOTOPICS project word cloud

Explore the words cloud of the ISOTOPICS project. It provides you a very rough idea of what is the project "ISOTOPICS" about.

innovation labeled interdisciplinary series first solutions risking absorption consequently interactive streamline rates molecules strategy techniques display therapeutic expert accelerate experts trials metabolism secondments molecule efficient huge labeling expertise plan excretion discovery candidates successfully scarcity drugs class stage chemists engagement isotopic industry attrition chemistry biologics critically de excessive clinical innovative profile taught closely dramatically evaluation medicinal revival relationships pharmacokinetic pharmacodynamic diseases radiochemists programs vivo combined training urgently pressing lack receptor disciplinary chemistries occupancy larger efficacy ddd issue beneficial identification isotopically synthesis timeline inter pharmaceutical train small drug earlier radiochemistry generation profound isotopics

Project "ISOTOPICS" data sheet

The following table provides information about the project.

Coordinator	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 website: www.cea.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	http://www.isotopics-project.eu/
Total cost	3˙948˙843 €
EC max contribution	3˙948˙843 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 website: www.cea.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS 15)	coordinator	1˙051˙502.00
2	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	1˙093˙151.00
3	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	527˙318.00
4	ASTRAZENECA AB ASTRAZENECA AB Organization address address: Vastra Maelarhamnen city: SODERTAELJE postcode: 151 85 website: www.astrazeneca.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (SODERTAELJE)	participant	263˙659.00
5	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	262˙875.00
6	UCB BIOPHARMA SRL UCB BIOPHARMA SRL Organization address address: ALLEE DE LA RECHERCHE 60 city: BRUXELLES postcode: 1070 website: www.ucb.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	250˙560.00
7	UNIVERSITE DE LIEGE UNIVERSITE DE LIEGE Organization address address: PLACE DU 20 AOUT 7 city: LIEGE postcode: 4000 website: www.ulg.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LIEGE)	participant	250˙560.00
8	SANOFI-AVENTIS DEUTSCHLAND GMBH SANOFI-AVENTIS DEUTSCHLAND GMBH Organization address address: BRUNINGSTRASSE 50 city: FRANKFURT AM MAIN postcode: 65929 website: www.sanofi.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	249˙216.00
9	UCB PHARMA SA UCB PHARMA SA Organization address address: ALLEE DE LA RECHERCHE 60 city: BRUXELLES postcode: 1070 website: www.ucb.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	0.00
10	INSTN INSTN Organization address address: n.a. city: Saclay postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Saclay)	partner	0.00
11	LERMIT LERMIT Organization address address: n.a. city: Chatenay-Malabry postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Chatenay-Malabry)	partner	0.00
12	Société de Chimie Thérapeutique Société de Chimie Thérapeutique Organization address address: n.a. city: Chatenay-Malabry postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Chatenay-Malabry)	partner	0.00
13	UNIVERSITE PARIS-SUD UNIVERSITE PARIS-SUD Organization address address: RUE GEORGES CLEMENCEAU 15 city: ORSAY CEDEX postcode: 91405 website: www.u-psud.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (ORSAY CEDEX)	partner	0.00

Map

Project objective

Excessive attrition rates during clinical trials dramatically impact on Drug Discovery and Development (DDD). Absorption, Distribution, Metabolism and Excretion studies carried out on larger series of drug candidates at an earlier stage of the DDD timeline and evaluation of drug efficacy through better assessment of pharmacokinetic/pharmacodynamic relationships, target engagement and receptor occupancy are critically important approaches for de-risking drug innovation since they facilitate early identification of the candidates that display the best in vivo profile. When successfully implemented, this strategy can accelerate the discovery of new therapeutic solutions to existing and emerging diseases, and enhance European pharmaceutical innovation. For implementation, large sets of isotopically-labeled molecules are required and consequently, a huge revival of labeling techniques is urgently needed. Another crucial issue is the scarcity of expert radiochemists in Europe and the lack of first class training programs in this inter-disciplinary field merging chemistry, radiochemistry and medicinal chemistry. The aims of ISOTOPICS are: i) to train the next generation of European chemists with expertise in isotopic labeling and advanced medicinal chemistry through a first-class taught and research training program combined with a highly interactive secondments plan; ii) to develop innovative and general isotopic labeling chemistry and radiochemistry to streamline the synthesis of labeled small-molecule drugs and biologics; iii) to work closely with the European pharmaceutical industry to apply the new labeling methods to drugs currently in development in order to provide solutions to the most pressing problems in drug innovation. This highly interdisciplinary project is expected to have a profound beneficial impact on drug innovation in Europe by providing novel efficient techniques and new experts in the fields of labeling and medicinal chemistries.

Deliverables

List of deliverables.
Network-wide Periodic Network meetings	Other	2020-03-27 09:15:34
Cascade reactions to construct 14C-heterocycles and derivatizing peptides and proteins from K14CN	Documents, reports	2020-03-27 09:17:10
N-Methylation/C-carbonylation from CO2 for the [14C]radiolabeling of small-molecule drugs	Documents, reports	2020-03-27 09:17:17
Cu(III)-catalyzed [18F]fluorination of arenes and heteroarenes	Documents, reports	2020-03-27 09:17:25
Development of new hydrophilic and air-resistant RuNps for [2H/3H]labeling of drugs & biologics	Documents, reports	2020-03-27 09:15:19
New methods for [2H/3H]labeling of small molecules drugs and peptides	Documents, reports	2020-03-27 09:15:11
Scientific meeting reports	Documents, reports	2020-03-27 09:16:45
Dissemination of main results	Other	2020-03-27 09:16:28
Development, evaluation and applications of new methods for asymmetric [18F]fluorination	Documents, reports	2020-03-27 09:17:36
New methods for [2H/3H]labeling of biologics	Documents, reports	2020-03-27 09:17:02
Defence of PhD Thesis	Documents, reports	2020-03-27 09:16:12
Development of a novel automated radio-chemistry system for [11C]carbonylation	Documents, reports	2020-03-27 09:14:49
Training in information technology skills	Documents, reports	2020-03-27 09:15:25
Microfluidic [11C]carbonylation screening under radical initiated conditions	Documents, reports	2020-03-27 09:14:35
Results dissemination	Documents, reports	2020-03-27 09:15:57
Development of Suzuki protein chemistry for the [18F]labeling of proteins	Documents, reports	2020-03-27 09:17:52
Improvement of employability	Documents, reports	2020-03-27 09:16:04
Network-wide interdisciplinary scientific training	Websites, patent fillings, videos etc.	2020-03-27 09:15:49
Development of a photochemical flow process for addition of [18F]CHF to (hetero)aromatics	Documents, reports	2020-03-27 09:14:28
Development of new fluoro- and difluoromethyl-sulfonyl reagents for the production of [18F]labeled alkenes	Documents, reports	2020-03-27 09:17:44
Public Engagement	Websites, patent fillings, videos etc.	2020-03-27 09:16:52
Website and Newsletters	Websites, patent fillings, videos etc.	2020-03-27 09:16:20
Application of N-methylation and C-carbonylation from CO2 to [11C]labeling	Documents, reports	2020-03-27 09:15:04
Patents, research and review publications, assistance for creation of start-ups and incubation	Documents, reports	2020-03-27 09:16:37
Supervisory Board of the Network	Documents, reports	2020-02-17 17:33:06
Communication and presentation skills	Documents, reports	2020-02-17 17:33:24
ESR recruitment process	Other	2020-02-17 17:33:23

Take a look to the deliverables list in detail: detailed list of ISOTOPICS deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Choon Wee Kee, Osman Tack, Florian Guibbal, Thomas C. Wilson, Patrick G. Isenegger, Mateusz ImioÅ‚ek, Stefan Verhoog, Michael Tilby, Giulia Boscutti, Sharon Ashworth, Juliette Chupin, Roxana Kashani, Adeline W. J. Poh, Jane K. Sosabowski, Sven Macholl, Christophe Plisson, Bart Cornelissen, Michael C. Willis, Jan Passchier, Benjamin G. Davis, VÃ©ronique Gouverneur 18 F-Trifluoromethanesulfinate Enables Direct Câ€“H 18 F-Trifluoromethylation of Native Aromatic Residues in Peptides published pages: 1180-1185, ISSN: 0002-7863, DOI: 10.1021/jacs.9b11709	Journal of the American Chemical Society 142/3	2020-03-05
2019	MÃ©gane Valero, Donia Bouzouita, Alberto Palazzolo, Jens Atzrodt, Christophe Dugave, Simon Tricard, Sophie Feuillastre, GrÃ©gory Pieters, Bruno Chaudret, Volker Derdau NHC-Stabilized Iridium Nanoparticles as Novel Catalysts in Hydrogen Isotope Exchange Reactions of Anilines published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201914369	Angewandte Chemie International Edition	2020-01-28
2019	MÃ©lodie Ferrat, Kenneth Dahl, Christer Halldin, Magnus Schou â€œIn-loopâ€ carbonylation - a simplified method for carbon-11 labeling of drugs and radioligands published pages: , ISSN: 0362-4803, DOI: 10.1002/jlcr.3805	Journal of Labelled Compounds and Radiopharmaceuticals	2020-01-14
2019	Malvika Sardana, Joakim Bergman, Cecilia Ericsson, Lee Peter Kingston, Magnus Schou, Christophe Dugave, Davide Audisio, Charles S. Elmore Visible-Light Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling published pages: , ISSN: 0022-3263, DOI: 10.1021/acs.joc.9b02575	The Journal of Organic Chemistry	2019-12-16
2019	Juan M. Asensio, Donia Bouzouita, Piet W. N. M. van Leeuwen, Bruno Chaudret Ïƒ-Hâ€“H, Ïƒ-Câ€“H, and Ïƒ-Siâ€“H Bond Activation Catalyzed by Metal Nanoparticles published pages: , ISSN: 0009-2665, DOI: 10.1021/acs.chemrev.9b00368	Chemical Reviews	2019-11-18
2019	Kaisa Horkka, Kenneth Dahl, Jonas Bergare, Charles S. Elmore, Christer Halldin, Magnus Schou Rapid and Efficient Synthesis of 11 C-Labeled Benzimidazolones Using [ 11 C]Carbon Dioxide published pages: 1846-1849, ISSN: 2365-6549, DOI: 10.1002/slct.201803561	ChemistrySelect 4/6	2019-10-15
2018	Ryan A. Bragg, Malvika Sardana, Markus Artelsmair, Charles S. Elmore New trends and applications in carboxylation for isotope chemistry published pages: 934-948, ISSN: 0362-4803, DOI: 10.1002/jlcr.3633	Journal of Labelled Compounds and Radiopharmaceuticals 61/13	2019-10-15
2019	Laura Trump, Agostinho Lemos, BÃ©nÃ©dicte Lallemand, Patrick Pasau, JoÃ«l Mercier, Christian Lemaire, AndrÃ© Luxen, Christophe Genicot Late-Stage 18 F-Difluoromethyl Labeling of N-Heteroaromatics with High Molar Activity for PET Imaging published pages: 13149-13154, ISSN: 1433-7851, DOI: 10.1002/anie.201907488	Angewandte Chemie International Edition 58/37	2019-09-26
2019	MÃ©gane Valero, Daniel Becker, Kristof Jess, Remo Weck, Jens Atzrodt, Thomas Bannenberg, Volker Derdau, Matthias Tamm Directed Iridiumâ€Catalyzed Hydrogen Isotope Exchange Reactions of Phenylacetic Acid Esters and Amides published pages: 6517-6522, ISSN: 0947-6539, DOI: 10.1002/chem.201901449	Chemistry â€“ A European Journal 25/26	2019-09-26
2019	MÃ©gane Valero, Anurag Mishra, Jennifer Blass, Remo Weck, Volker Derdau Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions published pages: , ISSN: 2191-1363, DOI: 10.1002/open.201900204	ChemistryOpen	2019-09-26
2019	Karen Hinsinger, GrÃ©gory Pieters The Emergence of Carbon Isotope Exchange published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201905368	Angewandte Chemie International Edition	2019-09-26
2018	Niels Rothermel, Donia Bouzouita, Tobias RÃ¶ther, Iker deâ€…Rosal, Simon Tricard, Romuald Poteau, Torsten Gutmann, Bruno Chaudret, Hansâ€Heinrich Limbach, Gerd Buntkowsky Surprising Differences of Alkane Câ€H Activation Catalyzed by Ruthenium Nanoparticles: Complex Surfaceâ€Substrate Recognition? published pages: 4243-4247, ISSN: 1867-3880, DOI: 10.1002/cctc.201801022	ChemCatChem 10/19	2019-09-26
2019	Agostinho Lemos, Christian Lemaire, AndrÃ© Luxen Progress in Difluoroalkylation of Organic Substrates by Visible Light Photoredox Catalysis published pages: 1500-1537, ISSN: 1615-4150, DOI: 10.1002/adsc.201801121	Advanced Synthesis & Catalysis 361/7	2019-09-26
2019	Alberto Palazzolo, Sophie Feuillastre, Viktor Pfeifer, SÃ©bastien Garcia-Argote, Donia Bouzouita, Simon Tricard, CÃ©line Chollet, Elodie Marcon, David-Alexandre Buisson, Sophie Cholet, FranÃ§ois Fenaille, Guy Lippens, Bruno Chaudret, GrÃ©gory Pieters Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen-Isotope Exchange published pages: 4891-4895, ISSN: 1433-7851, DOI: 10.1002/anie.201813946	Angewandte Chemie International Edition 58/15	2019-09-26
2018	Antonio Del Vecchio, Gianluca Destro, FrÃ©dÃ©ric Taran, Davide Audisio Recent developments in heterocycle labeling with carbon isotopes published pages: 988-1007, ISSN: 0362-4803, DOI: 10.1002/jlcr.3666	Journal of Labelled Compounds and Radiopharmaceuticals 61/13	2019-09-26
2018	Antonio Delâ€…Vecchio, Fabien CaillÃ©, Arnaud Chevalier, Olivier Loreau, Kaisa Horkka, Christer Halldin, Magnus Schou, Nathalie Camus, Pascal Kessler, Bertrand Kuhnast, FrÃ©dÃ©ric Taran, Davide Audisio Late-Stage Isotopic Carbon Labeling of Pharmaceutically Relevant Cyclic Ureas Directly from CO 2 published pages: 9744-9748, ISSN: 1433-7851, DOI: 10.1002/anie.201804838	Angewandte Chemie International Edition 57/31	2019-09-26
2018	Gabriele Pupo, Francesco Ibba, David M. H. Ascough, Anna Chiara Vicini, Paolo Ricci, Kirsten E. Christensen, Lukas Pfeifer, John Richard Morphy, John M. Brown, Robert S. Paton, VÃ©ronique Gouverneur Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis published pages: 638-642, ISSN: 0036-8075, DOI: 10.1126/science.aar7941	Science 360/6389	2019-09-26
2018	Matthew K. Bilyard, Henry J. Bailey, LluÃs Raich, Maria A. Gafitescu, Takuya Machida, Javier IglÃ©sias-FernÃ¡ndez, Seung Seo Lee, Christopher D. Spicer, Carme Rovira, Wyatt W. Yue, Benjamin G. Davis Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis published pages: 235-240, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0644-7	Nature 563/7730	2019-09-26
2018	Philipp Gotico, Antonio Delâ€…Vecchio, Davide Audisio, Annamaria Quaranta, Zakaria Halime, Winfried Leibl, Ally Aukauloo Visible-Light-Driven Reduction of CO 2 to CO and Its Subsequent Valorization in Carbonylation Chemistry and 13 C Isotope Labeling published pages: 715-719, ISSN: 2367-0932, DOI: 10.1002/cptc.201800012	ChemPhotoChem 2/8	2019-09-26
2019	Gabriele Pupo, Anna Chiara Vicini, David M. H. Ascough, Francesco Ibba, Kirsten E. Christensen, Amber L. Thompson, John M. Brown, Robert S. Paton, VÃ©ronique Gouverneur Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of Î²-Fluoroamines published pages: 2878-2883, ISSN: 0002-7863, DOI: 10.1021/jacs.8b12568	Journal of the American Chemical Society 141/7	2019-09-26
2018	Gianluca Destro, Olivier Loreau, Elodie Marcon, FrÃ©dÃ©ric Taran, Thibault Cantat, Davide Audisio Dynamic Carbon Isotope Exchange of Pharmaceuticals with Labeled CO 2 published pages: , ISSN: 0002-7863, DOI: 10.1021/jacs.8b12140	Journal of the American Chemical Society	2019-09-26
2019	MÃ©gane Valero, Volker Derdau Highlights of aliphatic C (sp 3 )-H Hydrogen Isotope Exchange Reactions published pages: , ISSN: 0362-4803, DOI: 10.1002/jlcr.3783	Journal of Labelled Compounds and Radiopharmaceuticals	2019-09-26

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