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TRAIN-ERS SIGNED

Endoplasmic Reticulum Stress in Health and Disease

Total Cost €

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EC-Contrib. €

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Partnership

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Project "TRAIN-ERS" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://www.train-ers.eu
 Total cost 3˙628˙756 €
 EC max contribution 3˙628˙756 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2019-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 797˙023.00
2    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 525˙751.00
3    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 501˙120.00
4    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 273˙287.00
5    RANDOX TEORANTA IE (DONEGALL) participant 265˙674.00
6    GOETEBORGS UNIVERSITET SE (GOETEBORG) participant 263˙659.00
7    LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG AT (WIEN) participant 255˙934.00
8    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 249˙216.00
9    UNIVERSITAET STUTTGART DE (STUTTGART) participant 249˙216.00
10    FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE ES (L'HOSPITALET DE LLOBREGAT) participant 247˙872.00
11    OPTIMATA LTD IL (TEL AVIV) participant 0.00
12    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) participant 0.00
13    BioScale, Inc US (Lexington) partner 0.00
14    Carpmaels & Ransford UK (London) partner 0.00
15    Lalui Leadership CZ (HLUBOKA NAD VLTAVOU) partner 0.00
16    MANNKIND CORPORATION US (VALENCIA) partner 0.00
17    RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN DE (AACHEN) partner 0.00
18    UNIVERSITATSKLINIKUM HEIDELBERG DE (HEIDELBERG) partner 0.00

Map

 Project objective

Endoplasmic reticulum (ER) stress is emerging as a common feature in the pathology of numerous diseases including cancer, neurodegenerative disorders, metabolic syndromes and inflammatory diseases. Thus ER stress represents a potential therapeutic intervention point to be exploited to develop novel therapies, diagnostic tools and markers for these diseases. However, exploitation is hampered by the shortage of scientists with interdisciplinary training that can navigate with ease between the academic, industrial and clinical sectors, and that have the scientific and complementary skills, together with an innovative outlook, to convert research findings into commercial and clinical applications. This proposal will bring young researchers together with world-leading academics, clinicians and industry personnel, who are united in (1) their goal of forming a network of excellence aimed at understanding the ER stress response mechanistically and quantitatively and (2) applying this understanding to identify and validate the most suitable intervention points in order to provide innovative knowledge-driven strategies for the treatment of ER stress-associated diseases. The TRAIN-ERS network will provide early stage researchers (ESRs) with high quality scientific and complementary skills training combined with international, intersectoral work experience. This will produce highly trained, innovative, creative and entrepreneurial ESRs with greatly enhanced career prospects, who will continue to advance the state of the art in the Biomedical field in their further careers, and will confidently navigate at the interface of academic, clinical and private sector research. The TRAIN-ERS research programme will provide the ESR’s with the knowledge and the cutting edge scientific and technical skills that will drive our understanding and exploitation of the ER stress response for therapeutic and diagnostic purposes.

 Deliverables

List of deliverables.
TRAIN-ERS Facebook and Twitter accounts Websites, patent fillings, videos etc. 2019-05-07 19:21:22
ESR recruitment Documents, reports 2019-05-07 19:21:22
Website and data sharing platform Websites, patent fillings, videos etc. 2019-05-07 19:21:22

Take a look to the deliverables list in detail:  detailed list of TRAIN-ERS deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Annika Hantusch, Kushal K. Das, Ana J. García-Sáez, Thomas Brunner, Markus Rehm
Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance
published pages: , ISSN: 2041-4889, DOI: 10.1038/s41419-018-0464-6
Cell Death & Disease 9/4 2019-10-08
2018 J. Catharina Duvigneau, Andreia Luís, Adrienne M. Gorman, Afshin Samali, Doris Kaltenecker, Richard Moriggl, Andrey V. Kozlov
Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases
published pages: , ISSN: 1043-4666, DOI: 10.1016/j.cyto.2018.10.018
Cytokine 2019-10-07
2018 Doris Kaltenecker, Madeleine Themanns, Kristina M. Mueller, Katrin Spirk, Tobias Suske, Olaf Merkel, Lukas Kenner, Andreia Luís, Andrey Kozlov, Johannes Haybaeck, Mathias Müller, Xiaonan Han, Richard Moriggl
Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression
published pages: , ISSN: 1043-4666, DOI: 10.1016/j.cyto.2018.10.010
Cytokine 2019-10-07
2019 Joanna Obacz, Tony Avril, Camila Rubio-Patiño, Jozef P. Bossowski, Aeid Igbaria, Jean-Ehrland Ricci, Eric Chevet
Regulation of tumor-stroma interactions by the unfolded protein response
published pages: 279-296, ISSN: 1742-464X, DOI: 10.1111/febs.14359
The FEBS Journal 286/2 2019-10-07
2018 Camila Rubio-Patiño, Jozef P. Bossowski, Eric Chevet, Jean-Ehrland Ricci
Reshaping the Immune Tumor Microenvironment Through IRE1 Signaling
published pages: 607-614, ISSN: 1471-4914, DOI: 10.1016/j.molmed.2018.05.005
Trends in Molecular Medicine 24/7 2019-10-07
2018 Alexandra Papaioannou, Arisa Higa, Gwénaële Jégou, Florence Jouan, Raphael Pineau, Laure Saas, Tony Avril, Olivier Pluquet, Eric Chevet
Alterations of EDEM 1 functions enhance ATF 6 pro‐survival signaling
published pages: 4146-4164, ISSN: 1742-464X, DOI: 10.1111/febs.14669
The FEBS Journal 285/22 2019-10-03
2019 Antonio Carlesso, Leif A. Eriksson
Selective Inhibition of IRE1 Signalling mediated by MKC9989: New Insights from Molecular Docking and Molecular Dynamics Simulations
published pages: 3199-3203, ISSN: 2365-6549, DOI: 10.1002/slct.201900810
ChemistrySelect 4/11 2019-10-03
2019 Mohamed Mahameed, Thomas Wilhelm, Odai Darawshi, Akram Obiedat, Weiss-Sadan Tommy, Chetan Chintha, Thomas Schubert, Afshin Samali, Eric Chevet, Leif A. Eriksson, Michael Huber, Boaz Tirosh
The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors
published pages: , ISSN: 2041-4889, DOI: 10.1038/s41419-019-1523-3
Cell Death & Disease 10/4 2019-10-03
2019 Amado Carreras-Sureda, Fabián Jaña, Hery Urra, Sylvere Durand, David E. Mortenson, Alfredo Sagredo, Galdo Bustos, Younis Hazari, Eva Ramos-Fernández, Maria L. Sassano, Philippe Pihán, Alexander R. van Vliet, Matías González-Quiroz, Angie K. Torres, Cheril Tapia-Rojas, Martijn Kerkhofs, Rubén Vicente, Randal J. Kaufman, Nibaldo C. Inestrosa, Christian Gonzalez-Billault, R. Luke Wiseman, Patr
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics
published pages: 755-767, ISSN: 1465-7392, DOI: 10.1038/s41556-019-0329-y
Nature Cell Biology 21/6 2019-10-03
2019 Marion Maurel, Joanna Obacz, Tony Avril, Yong‐Ping Ding, Olga Papadodima, Xavier Treton, Fanny Daniel, Eleftherios Pilalis, Johanna Hörberg, Wenyang Hou, Marie‐Claude Beauchamp, Julien Tourneur‐Marsille, Dominique Cazals‐Hatem, Lucia Sommerova, Afshin Samali, Jan Tavernier, Roman Hrstka, Aurélien Dupont, Delphine Fessart, Frédéric Delom, Martin E Fernandez‐Zapico, Gregor Jansen, Leif
Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation
published pages: e10120, ISSN: 1757-4676, DOI: 10.15252/emmm.201810120
EMBO Molecular Medicine 11/6 2019-10-03
2018 Antonio Carlesso, Chetan Chintha, Adrienne M. Gorman, Afshin Samali, Leif A. Eriksson
Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain
published pages: 13313-13322, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b01404
ACS Omega 3/10 2019-10-03
2019 Behnaz Ahangarian Abhari, Nicole McCarthy, Marie Le Berre, Michelle Kilcoyne, Lokesh Joshi, Patrizia Agostinis, Simone Fulda
Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress
published pages: , ISSN: 2041-4889, DOI: 10.1038/s41419-019-1381-z
Cell Death & Disease 10/3 2019-10-03
2019 Antonio Carlesso, Chetan Chintha, Adrienne M. Gorman, Afshin Samali, Leif A. Eriksson
Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-39939-z
Scientific Reports 9/1 2019-10-03
2017 T Avril, E Vauléon, E Chevet
Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers
published pages: e373-e373, ISSN: 2157-9024, DOI: 10.1038/oncsis.2017.72
Oncogenesis 6/8 2019-10-03
2018 Josip Skoko, Jan Rožanc, Emilie M. Charles, Leonidas G. Alexopoulos, Markus Rehm
Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma
published pages: , ISSN: 1471-2121, DOI: 10.1186/s12860-018-0180-1
BMC Cell Biology 19/1 2019-10-03
2019 Behnaz Ahangarian Abhari, Nicole McCarthy, Patrizia Agostinis, Simone Fulda
NF-κB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis
published pages: 269-277, ISSN: 1360-8185, DOI: 10.1007/s10495-018-1507-2
Apoptosis 24/3-4 2019-10-03
2017 Tony Avril, Amandine Etcheverry, Raphaël Pineau, Joanna Obacz, Gwénaële Jegou, Florence Jouan, Pierre-Jean Le Reste, Masumeh Hatami, Rivka R. Colen, Brett L. Carlson, Paul A. Decker, Jann N. Sarkaria, Elodie Vauléon, Dan Cristian Chiforeanu, Anne Clavreul, Jean Mosser, Eric Chevet, Véronique Quillien
CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma
published pages: 7360-7374, ISSN: 1078-0432, DOI: 10.1158/1078-0432.ccr-17-1549
Clinical Cancer Research 23/23 2019-10-03
2018 Cynthia Lebeaupin, Deborah Vallée, Younis Hazari, Claudio Hetz, Eric Chevet, Béatrice Bailly-Maitre
Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease
published pages: 927-947, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.06.008
Journal of Hepatology 69/4 2019-10-03
2019 Doultsinos D, McMahon M, Voutetaki K, Obacz J, Pineau R, Jouan F, Le Reste P-J, Obiedat A, Samal J, Patterson JB, Zheng Q, Samali A, Pandit A, Tirosh B, Chatziioannou A, Chevet E, Avril T.
Constitutive IRE1α signaling maintains glioblastoma cell differentiation
published pages: , ISSN: , DOI: 10.1101/59463
BioRXiv 2019-10-03
2019 Dimitrios Doultsinos, Mari McMahon, Konstantinos Voutetakis, Joanna Obacz, Raphael Pineau, Florence Jouan, Pierre-Jean Le Reste, Akram Obiedat, Juhi Samal, John B. Patterson, Qingping Zheng, Afshin Samali, Abhay Pandit, Boaz Tirosh, Aristotelis Chatziioannou, View ORCID ProfileEric Chevet, Tony Avril
Control of glioblastoma differentiated-to-stem cell reprogramming by IRElα/XBPls signaling
published pages: , ISSN: , DOI: 10.1101/594630
BioRXiv 2019-10-03
2018 Stéphanie Lhomond, Tony Avril, Nicolas Dejeans, Konstantinos Voutetakis, Dimitrios Doultsinos, Mari McMahon, Raphaël Pineau, Joanna Obacz, Olga Papadodima, Florence Jouan, Heloise Bourien, Marianthi Logotheti, Gwénaële Jégou, Néstor Pallares‐Lupon, Kathleen Schmit, Pierre‐Jean Le Reste, Amandine Etcheverry, Jean Mosser, Kim Barroso, Elodie Vauléon, Marion Maurel, Afshin Samali, John B P
Dual IRE1 RNase functions dictate glioblastoma development
published pages: e7929, ISSN: 1757-4676, DOI: 10.15252/emmm.201707929
EMBO Molecular Medicine 10/3 2019-07-08
2018 L. Montibeller, J. de Belleroche
Amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genes
published pages: , ISSN: 1355-8145, DOI: 10.1007/s12192-018-0897-y
Cell Stress and Chaperones 2019-07-08
2018 Alexander R. van Vliet, Maria Livia Sassano, Patrizia Agostinis
The Unfolded Protein Response and Membrane Contact Sites: Tethering as a Matter of Life and Death?
published pages: 251525641877051, ISSN: 2515-2564, DOI: 10.1177/2515256418770512
Contact 1 2019-05-07
2018 Aitor Almanza, Antonio Carlesso, Chetan Chintha, Stuart Creedican, Dimitrios Doultsinos, Brian Leuzzi, Andreia Luís, Nicole McCarthy, Luigi Montibeller, Sanket More, Alexandra Papaioannou, Franziska Püschel, Maria Livia Sassano, Josip Skoko, Patrizia Agostinis, Jackie de Belleroche, Leif A. Eriksson, Simone Fulda, Adrienne M. Gorman, Sandra Healy, Andrey Kozlov, Cristina Muñoz-Pinedo, Markus Rehm, Eric Chevet, Afshin Samali
Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications
published pages: , ISSN: 1742-464X, DOI: 10.1111/febs.14608
The FEBS Journal 2019-05-07
2018 Rola Jaafar, Katarzyna Mnich, Sarah Dolan, Jennifer Hillis, Aitor Almanza, Susan E. Logue, Afshin Samali, Adrienne M. Gorman
RIP2 enhances cell survival by activation of NF-ĸB in triple negative breast cancer cells
published pages: 115-121, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2018.02.034
Biochemical and Biophysical Research Communications 497/1 2019-05-07
2018 Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05763-8
Nature Communications 9/1 2019-05-07

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